| 1 | EIEE79, GABRA1, GABRA5
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| Altered inhibitory synapses in de novo GABRA5 and GABRA1 mutations associated with early onset epileptic encephalopathies.
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| Hernandez CC, XiangWei W, Hu N, Shen D, Shen W, Lagrange AH, Zhang Y, Dai L, Ding C, Sun Z, Hu J, Zhu H, Jiang Y, Macdonald RL.
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| Brain Jul 1;142(7):1938-1954. doi: 10.1093/brain/awz123. 2019
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| 2 | EIEE78, EIEE79, GABRA2, GABRA5
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| De novo variants in GABRA2 and GABRA5 alter receptor function and contribute to early-onset epilepsy
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| Butler KM, Moody OA, Schuler E, Coryell J, Alexander JJ, Jenkins A, Escayg A.
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| Brain Aug 1;141(8):2392-2405. doi: 10.1093/brain/awy171. 2018
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| 3 | GABRA5
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| Partial inactivation of GABAA receptors containing the α5 subunit affects the development of adult-born dentate gyrus granule cells.
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| Deprez F, Vogt F, Floriou-Servou A, Lafourcade C, Rudolph U, Tyagarajan SK, Fritschy JM.
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| Eur J Neurosci 44(5):2258-71. doi: 10.1111/ejn.13329. Epub 2016 Jul 19.
2016
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| 4 | GABRA5
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| α5GABAA receptor deficiency causes autism-like behaviors.
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| Zurek AA, Kemp SW, Aga Z, Walker S, Milenkovic M, Ramsey AJ, Sibille E, Scherer SW, Orser BA.
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| Ann Clin Transl Neurol 3(5):392-8. doi: 10.1002/acn3.303. eCollection 2016 May.
2016
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| 5 | GABRA5
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| The α5 subunit containing GABAA receptors contribute to chronic pain.
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| Bravo-Hernández M, Corleto JA, Barragán-Iglesias P, González-Ramírez R, Pineda-Farias JB, Felix R, Calcutt NA, Delgado-Lezama R, Marsala M, Granados-Soto V.
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| Pain 157(3):613-26. doi: 10.1097/j.pain.0000000000000410.
2016
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| 6 | GABRA5, RDX
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| Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
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| Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, Smart TG, Triller A, Kneussel M.
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| Nat Commun 6:6872. doi: 10.1038/ncomms7872.
2015
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| 7 | GABRA5, GPHN
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| Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation.
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| Brady ML, Jacob TC.
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| Dev Neurobiol 75(11):1241-51. doi: 10.1002/dneu.22280. Epub 2015 Feb 18.
2015
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| 8 | GABRA5
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| The α5GABAA receptor modulates the induction of long-term potentiation at ventral but not dorsal CA1 hippocampal synapses.
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| Pofantis H, Papatheodoropoulos C.
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| Synapse 68(9):394-401. doi: 10.1002/syn.21751. Epub 2014 May 23.
2014
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| 9 | GABRA5, GABRB3
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| Evidence for linkage and association of GABRB3 and GABRA5 to panic disorder.
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| Hodges LM, Fyer AJ, Weissman MM, Logue MW, Haghighi F, Evgrafov O, Rotondo A, Knowles JA, Hamilton SP.
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| Neuropsychopharmacology 39(10):2423-31. doi: 10.1038/npp.2014.92. Epub 2014 May 23.
2014
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| 10 | GABRA5
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| Memory deficits induced by inflammation are regulated by α5-subunit-containing GABAA receptors.
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| Wang DS, Zurek AA, Lecker I, Yu J, Abramian AM, Avramescu S, Davies PA, Moss SJ, Lu WY, Orser BA.
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| Cell Rep 2(3):488-96. doi: 10.1016/j.celrep.2012.08.022. Epub 2012 Sep 20.
2012
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| 11 | GABRA5
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| A reduction in hippocampal GABAA receptor alpha5 subunits disrupts the memory for location of objects in mice.
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| Prut L, Prenosil G, Willadt S, Vogt K, Fritschy JM, Crestani F.
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| Genes Brain Behav 9(5):478-88. doi: 10.1111/j.1601-183X.2010.00575.x. Epub 2010 Feb 17.
2010
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| 12 | GABRA5, GABRB3, GABRG3
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| 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders.
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| Hogart A, Nagarajan RP, Patzel KA, Yasui DH, Lasalle JM.
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| Hum Mol Genet 16(6):691-703.
2007
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| 13 | GABRA5
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| Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons.
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| Bonin RP, Martin LJ, MacDonald JF, Orser BA.
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| J Neurophysiol 98(4):2244-54. Epub 2007 Aug 22.
2007
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| 14 | GABRA5, GABRB3, GABRG3
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| An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder.
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| Ashley-Koch AE, Mei H, Jaworski J, Ma DQ, Ritchie MD, Menold MM, Delong GR, Abramson RK, Wright HH, Hussman JP, Cuccaro ML, Gilbert JR, Martin ER, Pericak-Vance MA.
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| Ann Hum Genet 70(Pt 3):281-92.
2006
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| 15 | GABRA5
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| The GABA type A receptor alpha5 subunit gene is associated with bipolar I disorder.
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| Otani K, Ujike H, Tanaka Y, Morita Y, Katsu T, Nomura A, Uchida N, Hamamura T, Fujiwara Y, Kuroda S.
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| Neurosci Lett 381(1-2):108-13. Epub 2005 Feb 25.
2005
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| 16 | AS, D15F375S1, D15F376S1, DEXI, GABRA5, HERC2P1, HERC2P2, HERC2P3, MKRN3, PWS, UBE3A
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| Integrated YAC contig map of the Prader-Willi/Angelman region on chromosome 15q11-q13 with average STS spacing of 35 kb.
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| Christian SL, Bhatt NK, Martin SA, Sutcliffe JS, Kubota T, Huang B, Mutirangura A, Chinault AC, Beaudet AL, Ledbetter DH.
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| Genome Res 8(2):146-57. 1998
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| 17 | GABRA5, MAFD10
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| Association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) and bipolar affective disorder.
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| Papadimitriou GN, Dikeos DG, Karadima G, Avramopoulos D, Daskalopoulou EG, Vassilopoulos D, Stefanis CN.
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| Am J Med Genet 81(1):73-80. 1998
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| 18 | GABRB3, GABRA5
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| Structure and organization of GABRB3 and GABRA5.
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| Glatt K, et al.
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| Genomics 41 : 63-69. 1997
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| 19 | GABRA5
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| Human gamma-aminobutyric acid-type A receptor alpha5 subunit gene (GABRA5): characterization and structural organization of the 5' flanking region.
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| Kim Y, Glatt H, Xie W, Sinnett D, Lalande M.
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| Genomics 42(3):378-87. 1997
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| 20 | GABRA5, GABRB3, GABRG3, EJM2
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| Linkage analysis between idiopathic generalized epilepsies and the GABA(A) receptor alpha5, beta3 and gamma3 subunit gene cluster on chromosome 15.
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| Sander T, Kretz R, Williamson MP, Elmslie FV, Rees M, Hildmann T, Bianchi A, Bauer G, Sailer U, Scaramelli A, Schmitz B, Gardiner RM, Janz D, Beck-Mannagetta G.
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| Acta Neurol Scand 96(1):1-7. 1997
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| 21 | GABRA5, GABRG3
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| The gamma-aminobutyric acid receptor gamma3 subunit gene (GABRG3) is tightly linked to the alpha5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation.
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| Greger V, et al.
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| Genomics 26 : 258-264. 1995
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| 22 | GABRA5, GABRB3
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| Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution.
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| LaSalle JM, et al.
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| Nat Genet 9 : 386-394. 1995
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| 23 | GABRB3, GABRA5
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| The human gamma-aminobutyric acid receptor subunit beta3 and alpha5 gene cluster in chromosome 15q11-q13 is rich in highly polymorphic (CA)n repeats.
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| Glatt K, et al.
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| Genomics 19 : 157-160. 1994
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| 24 | GABRA3, GABRA5
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| High-resolution mapping of the gamma-aminobutyric acid receptor subunit beta3 and alpha5 gene cluster on chromosome 15q11-q13, and localization of breakpoints in two Angelman syndrome patients.
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| Sinnett D, et al.
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| Am J Hum Genet 52 : 1216-1229. 1993
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| 25 | PWS, GABRA5
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| FISH ordering of reference markers and of the gene for the alpha5 subunit of the gamma-aminobutyric acid receptor (GABRA5) within the Angelman and Prader-Willi syndrome chromosomal regions.
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| Knoll JHM, et al.
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| Hum Mol Genet 2 : 183-189. 1993
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| 26 | GABRA5
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| Dinucleotide repeat polymorphism at the GABAa receptor alpha5 (GABRA5) locus at chromosome 15q11-q13.
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| Glatt KA, et al.
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| Hum Mol Genet 1 : 348. 1992
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