| 1 | FZD2, NXN, RBNS4, RBNS5
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| WNT Signaling Perturbations Underlie the Genetic Heterogeneity of Robinow Syndrome.
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| White JJ, Mazzeu JF, Coban-Akdemir Z, Bayram Y, Bahrambeigi V, Hoischen A, van Bon BWM, Gezdirici A, Gulec EY, Ramond F, Touraine R, Thevenon J, Shinawi M, Beaver E, Heeley J, Hoover-Fong J, Durmaz CD, Karabulut HG, Marzioglu-Ozdemir E, Cayir A, Duz MB, Seven M, Price S, Ferreira BM, Vianna-Morgante AM, Ellard S, Parrish A, Stals K, Flores-Daboub J, Jhangiani SN, Gibbs RA; Baylor-Hopkins Center for Mendelian Genomics, Brunner HG, Sutton VR, Lupski JR, Carvalho CMB.
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| Am J Hum Genet 102(1):27-43. doi: 10.1016/j.ajhg.2017.10.002. Epub 2017 Dec 21.
2018
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| 2 | FZD2, RBNS4
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| Nonsense mutations in FZD2 cause autosomal-dominant omodysplasia: Robinow syndrome-like phenotypes.
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| Nagasaki K, Nishimura G, Kikuchi T, Nyuzuki H, Sasaki S, Ogawa Y, Saitoh A.
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| Am J Med Genet A m J Med Genet A. 2018 Jan 31. doi: 10.1002/ajmg.a.38623. [Epub ahead of print]
2018
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| 3 | FZD2
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| Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer.
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| Bian Y, Chang X, Liao Y, Wang J, Li Y, Wang K, Wan X.
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| Oncol Rep 36(2):803-10. doi: 10.3892/or.2016.4885. Epub 2016 Jun 17.
2016
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| 4 | FZD2, RBNS4
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| A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia.
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| Saal HM, Prows CA, Guerreiro I, Donlin M, Knudson L, Sund KL, Chang CF, Brugmann SA, Stottmann RW.
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| Hum Mol Genet 24(12):3399-409. doi: 10.1093/hmg/ddv088. Epub 2015 Mar 10. 2015
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| 5 | FZD2, GATA6, HMGA2
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| Hmga2 is required for canonical WNT signaling during lung development.
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| Singh I, Mehta A, Contreras A, Boettger T, Carraro G, Wheeler M, Cabrera-Fuentes HA, Bellusci S, Seeger W, Braun T, Barreto G.
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| BMC Biol 12:21. doi: 10.1186/1741-7007-12-21.
2014
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| 6 | FZD2
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| A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.
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| Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G.
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| Cell 159(4):844-56. doi: 10.1016/j.cell.2014.10.032.
2014
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| 7 | FZD2
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| Expression of Wnt5a and its receptor Fzd2 is changed in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice.
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| Li X, Guan Y, Chen Y, Zhang C, Shi C, Zhou F, Yu L, Juan J, Wang X.
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| Int J Clin Exp Pathol 6(7):1245-60. Print 2013.
2013
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| 8 | DVL3, FZD2, FZD7, VANGL2
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| Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.
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| Yu H, Ye X, Guo N, Nathans J.
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| Development 139(23):4383-94. doi: 10.1242/dev.083352. Epub 2012 Oct 24.
2012
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| 9 | FZD2, WNT5A
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| Suppression of Frizzled-2-mediated Wnt/CaČ⁺ signaling significantly attenuates intracellular calcium accumulation in vitro and in a rat model of traumatic brain injury.
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| Niu LJ, Xu RX, Zhang P, Du MX, Jiang XD.
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| Neuroscience 213:19-28. doi: 10.1016/j.neuroscience.2012.03.057. Epub 2012 Apr 19.
2012
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| 10 | FZD2, WNT5A
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| Wnt5a regulates distinct signalling pathways by binding to Frizzled2.
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| Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A.
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| EMBO J 29(1):41-54. Epub 2009 Nov 12.PMID: 19910923 2010
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| 11 | FZD1, FZD2
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| Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.
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| Yu H, Smallwood PM, Wang Y, Vidaltamayo R, Reed R, Nathans J.
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| Development 137(21):3707-17. doi: 10.1242/dev.052001.
2010
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| 12 | FZD2, ROR2
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| Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2.
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| Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, Li J, Nishita M, Minami Y, Minoo P.
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| BMC Mol Biol 9:11. doi: 10.1186/1471-2199-9-11.
2008
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| 13 | FZD1, FZD2
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| Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity.
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| Wu J, Klein TJ, Mlodzik M.
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| PLoS Biol 2(7):E158. Epub 2004 Jul 13. 2004
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| 14 | FZD2, ROR2
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| The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
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| Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y.
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| Genes Cells 8(7):645-54.
2003
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| 15 | FZD1, FZD2, FZD7
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| Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.
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| Sagara N, et al.
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| Biochem Biophys Res Commun 252 : 117-122. 1998
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| 16 | FZD2, FZD9, SFRP1, SFRP2, FZD8
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| A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.
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| Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J.
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| J Biol Chem 271(8):4468-76. 1996
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| 17 | FZD2
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| A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1.
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| Zhao Z, et al.
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| Genomics 27 : 370-373. 1995
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