| 1 | FUT1, FUT2, FUT3, FUT6, FUT8, GFUS
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| Altered expression of fucosylation pathway genes is associated with poor prognosis and tumor metastasis in non‑small cell lung cancer.
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| Park S, Lim JM, Chun JN, Lee S, Kim TM, Kim DW, Kim SY, Bae DJ, Bae SM, So I, Kim HG, Choi JY, Jeon JH.
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| Int J Oncol. Feb;56(2):559-567. doi: 10.3892/ijo.2019.4953. Epub 2019 Dec 2020
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| 2 | FUT2
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| FUT2 Variants Confer Susceptibility to Familial Otitis Media.
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| Santos-Cortez RLP, Chiong CM, Frank DN, Ryan AF, Giese APJ, Bootpetch Roberts T, Daly KA, Steritz MJ, Szeremeta W, Pedro M, Pine H, Yarza TKL, Scholes MA, Llanes EGDV, Yousaf S, Friedman N, Tantoco MLC, Wine TM, Labra PJ, Benoit J, Ruiz AG, de la Cruz RAR, Greenlee C, Yousaf A, Cardwell J, Nonato RMA, Ray D, Ong KMC, So E, Robertson CE, Dinwiddie J, Lagrana-Villagracia SM; University of Washington Center for Mendelian Genomics (UWCMG), Gubbels SP, Shaikh RS, Cass SP, Einarsdottir E, Lee NR, Schwartz DA, Gloria-Cruz TLI, Bamshad MJ, Yang IV, Kere J, Abes GT, Prager JD, Riazuddin S, Chan AL, Yoon PJ, Nickerson DA, Cutiongco-de la Paz EM, Streubel SO, Reyes-Quintos MRT, Jenkins HA, Mattila P, Chan KH, Mohlke KL, Leal SM, Hafrén L, Chonmaitree T, Sale MM, Ahmed ZM.
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| Am J Hum Genet 103(5):679-690. doi: 10.1016/j.ajhg.2018.09.010. Epub 2018 Oct 25.
2018
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| 3 | FUT2, FUT3
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| How Fucose of Blood Group Glycotopes Programs Human Gut Microbiota.
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| Kononova SV.
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| Biochemistry (Mosc) Sep;82(9):973-989. doi: 10.1134/S0006297917090012 2017
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| 4 | FUT2
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| Innate Susceptibility to Norovirus Infections Influenced by FUT2 Genotype in a United States Pediatric Population.
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| Currier RL, Payne DC, Staat MA, Selvarangan R, Shirley SH, Halasa N, Boom JA, Englund JA, Szilagyi PG, Harrison CJ, Klein EJ, Weinberg GA, Wikswo ME, Parashar U, Vinjé J, Morrow AL.
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| Clin Infect Dis 60(11):1631-8. doi: 10.1093/cid/civ165. Epub 2015 Mar 5.
2015
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| 5 | FUT2, FUT3, FUT6
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| Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population.
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| Duell EJ, Bonet C, Muñoz X, Lujan-Barroso L, Weiderpass E, Boutron-Ruault MC, Racine A, Severi G, Canzian F, Rizzato C, Boeing H, Overvad K, Tjønneland A, Argüelles M, Sánchez-Cantalejo E, Chamosa S, Huerta JM, Barricarte A, Khaw KT, Wareham N, Travis RC, Trichopoulou A, Trichopoulos D, Yiannakouris N, Palli D, Agnoli C, Tumino R, Naccarati A, Panico S, Bueno-de-Mesquita HB, Siersema PD, Peeters PH, Ohlsson B, Lindkvist B, Johansson I, Ye W, Johansson M, Fenger C, Riboli E, Sala N, González CA.
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| Int J Cancer. Feb 15;136(4):880-93. doi: 10.1002/ijc.29034. Epub 2014 Jul 1 2015
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| 6 | FUT2
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| Faecal microbiota composition in adults is associated with the FUT2 gene determining the secretor status.
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| Wacklin P, Tuimala J, Nikkilä J, Sebastian Tims, Mäkivuokko H, Alakulppi N, Laine P, Rajilic-Stojanovic M, Paulin L, de Vos WM, Mättö J.
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| PLoS One 9(4):e94863. doi: 10.1371/journal.pone.0094863. eCollection 2014.
2014
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| 7 | FUT1, FUT2, FUT4, FUT9
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| Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract.
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| Wang CM, Hu SG, Ru YF, Yao GX, Ma WB, Gu YH, Chu C, Wang SL, Zhou ZM, Liu Q, Zhou YC, Zhang YL.
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| Int J Mol Sci 14(11):23188-202. doi: 10.3390/ijms141123188.
2013
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| 8 | FUT2, GIF
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| Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.
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| Chery C, Hehn A, Mrabet N, Oussalah A, Jeannesson E, Besseau C, Alberto JM, Gross I, Josse T, Gérard P, Guéant-Rodriguez RM, Freund JN, Devignes J, Bourgaud F, Peyrin-Biroulet L, Feillet F, Guéant JL.
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| Biochimie 95(5):995-1001. doi: 10.1016/j.biochi.2013.01.022. Epub 2013 Feb 8.
2013
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| 9 | FUT2
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| A novel role for inducible Fut2 in angiogenesis.
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| Tsou PS, Ruth JH, Campbell PL, Isozaki T, Lee S, Marotte H, Domino SE, Koch AE, Amin MA.
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| Angiogenesis 16(1):195-205. doi: 10.1007/s10456-012-9312-y. Epub 2012 Oct 12.
2013
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| 10 | CDX2, FUT2, MYC
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| Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition.
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| Sakuma K, Aoki M, Kannagi R.
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| Proc Natl Acad Sci U S A 109(20):7776-81. doi: 10.1073/pnas.1111135109. Epub 2012 Apr 30.
2012
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| 11 | FUT1, FUT2
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| Macrophages regulate expression of α1,2-fucosyltransferase genes in human endometrial epithelial cells.
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| Nakamura H, Jasper MJ, Hull ML, Aplin JD, Robertson SA.
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| Mol Hum Reprod 18(4):204-15. doi: 10.1093/molehr/gar070. Epub 2011 Nov 3.
2012
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| 12 | FUT2, FUT3
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| Histo-blood group gene polymorphisms as potential genetic modifiers of the development of coronary artery lesions in patients with Kawasaki disease.
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| Yamamura K, Ihara K, Ikeda K, Nagata H, Mizuno Y, Hara T.
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| Int J Immunogenet. Apr;39(2):119-25. doi: 10.1111/j.1744-313X.2011.01065.x. Epub 2011 Nov 25 2012
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| 13 | FUT2
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| FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection.
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| Smyth DJ, Cooper JD, Howson JM, Clarke P, Downes K, Mistry T, Stevens H, Walker NM, Todd JA.
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| Diabetes 60(11):3081-4. doi: 10.2337/db11-0638.
2011
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| 14 | FUT2
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| Macrophage-derived LIF and IL1B regulate alpha(1,2)fucosyltransferase 2 (Fut2) expression in mouse uterine epithelial cells during early pregnancy.
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| Jasper MJ, Care AS, Sullivan B, Ingman WV, Aplin JD, Robertson SA.
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| Biol Reprod 84(1):179-88. doi: 10.1095/biolreprod.110.085399. Epub 2010 Sep 23.
2011
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| 15 | FUT2
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| Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
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| McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI; International IBD Genetics Consortium.
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| Hum Mol Genet 19(17):3468-76. Epub 2010 Jun 22.PMID: 20570966 2010
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| 16 | FUT2, FUT3
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| Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes.
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| Teresa DB, Santos RA, Takahashi CS, Carrara HH, Moreira HW, Mattos LC, Lia-Neto N, Cunha LA, Bassi CL, Soares EG, Donadi EA, Mello ER, Soares CP.
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| Tumour Biol 31(5):401-9. Epub 2010 Jun 1.PMID: 20514537 2010
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| 17 | FUT2
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| Infection-associated FUT2 (Fucosyltransferase 2) genetic variation and impact on functionality assessed by in vivo studies.
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| Silva LM, Carvalho AS, Guillon P, Seixas S, Azevedo M, Almeida R, Ruvoën-Clouet N, Reis CA, Le Pendu J, Rocha J, David L.
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| Glycoconj J 27(1):61-8. Epub 2009 Sep 16.PMID: 19757028 2010
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| 18 | CARD9, DNMT3A, ERAP2, FUT2, PTGER4, TNFSF11
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| Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
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| Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M.
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| Nat Genet 42(12):1118-25.
2010
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| 19 | FUT1, FUT2
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| RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation.
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| Palumberi D, Aldi S, Ermini L, Ziche M, Finetti F, Donnini S, Rosati F.
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| J Cell Biochem 111(1):229-38.
2010
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| 20 | FUT2
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| Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa.
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| Magalhães A, Gomes J, Ismail MN, Haslam SM, Mendes N, Osório H, David L, Le Pendu J, Haas R, Dell A, Borén T, Reis CA.
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| Glycobiology 19(12):1525-36. Epub 2009 Aug 25.PMID: 19706747 2009
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| 21 | FUT2
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| A natural history of FUT2 polymorphism in humans.
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| Ferrer-Admetlla A, Sikora M, Laayouni H, Esteve A, Roubinet F, Blancher A, Calafell F, Bertranpetit J, Casals F.
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| Mol Biol Evol 26(9):1993-2003. Epub 2009 Jun 1.PMID: 19487333 2009
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| 22 | FUT2
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| Common variants of FUT2 are associated with plasma vitamin B12 levels.
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| Hazra A, Kraft P, Selhub J, Giovannucci EL, Thomas G, Hoover RN, Chanock SJ, Hunter DJ.
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| Nat Genet 40(10):1160-2. Epub 2008 Sep 7.PMID: 18776911 2008
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| 23 | FUT2
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| Distinct single nucleotide polymorphism pattern at the FUT2 promoter among human populations.
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| Soejima M, Koda Y.
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| Ann Hematol 87(1):19-25. Epub 2007 Sep 2.PMID: 17805536 2008
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| 24 | FUT2
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| Systematic sequence analysis of the human fucosyltransferase 2 (FUT2) gene identifies novel sequence variations and alleles.
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| Yip SP, Lai SK, Wong ML.
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| Transfusion 47(8):1369-80.PMID: 17655580 2007
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| 25 | FUT2
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| A nonsense mutation (428G-->A) in the fucosyltransferase FUT2 gene affects the progression of HIV-1 infection.
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| Kindberg E, Hejdeman B, Bratt G, Wahren B, Lindblom B, Hinkula J, Svensson L.
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| AIDS 20(5):685-9.PMID: 16514298 2006
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| 26 | FUT2
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| A novel tetrameric short tandem repeat located in the 3' flanking region of the human ABO-secretor gene (FUT2) and association between FUT2 and FUT2/01 loci.
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| Pang H, Soejima M, Koda Y, Kimura H.
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| Hum Biol 76(5):789-95.PMID: 15757249 2004
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| 27 | FUT1, FUT2, H
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| Deficiency of reproductive tract alpha(1,2)fucosylated glycans and normal fertility in mice with targeted deletions of the FUT1 or FUT2 alpha(1,2)fucosyltransferase locus.
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| Domino SE, Zhang L, Gillespie PJ, Saunders TL, Lowe JB.
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| Mol Cell Biol 21(24):8336-45. 2001
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| 28 | FUT2, H
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| An alu-mediated large deletion of the FUT2 gene in individuals with the ABO-Bombay phenotype.
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| Koda Y, Soejima M, Johnson PH, Smart E, Kimura H.
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| Hum Genet 106:80-85 2000
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| 29 | FUT1, FUT2, H
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| Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system.
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| Koda Y, Soejima M, Johnson PH, Smart E, Kimura H.
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| Biochem Biophys Res Commun 238(1):21-5. 1997
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| 30 | FUT2
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| Homozygous expression of a missense mutation at nucleotide 385 in the FUT2 gene associates with the Le(a+b+) partial-secretor phenotype in an Indonesian family.
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| Henry S, et al.
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| Biochem Biophys Res Commun 219 : 675-678. 1996
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| 31 | FUT2, FUT2P
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| Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population : a fusion gene generated by unequal crossover responsible for the enzyme deficiency.
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| Koda Y, et al.
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| Am J Hum Genet 59 : 343-350. 1996
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| 32 | FUT1, FUT2, FUT2P, H
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| Molecular cloning of a human genomic region containing the H blood group alpha(1,2) fucosyltransferase gene and two H locus-related DNA restriction fragments.
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| Rouquier S, et al.
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| J Biol Chem 270 : 4632-4639. 1995
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| 33 | FUT2, FUT2P
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| Sequence and expression of a candidate for the human secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.
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| Kelly RJ, et al.
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| J Biol Chem 270 : 4640-4649. 1995
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| 34 | FUT1, FUT2, FUT3, FUT5, FUT6
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| Relative positions of two clusters of human a-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19.
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| Reguigne-Arnould I, et al.
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| Cytogenet Cell Genet 71 : 158-162. 1995
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| 35 | FUT1, FUT2
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| The fucosyltransferase locus FUT1 maps distal to apolipoprotein loci E and C2 on human chromosome 19.
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| Rouquier S, et al.
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| Cytogenet Cell Genet 66 : 70-71. 1994
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| 36 | LDLR, C3, APOC2, LW, BCAM , FUT2
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| The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man.
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| Lewis M, et al.
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| Ann Hum Genet 52 : 137-144. 1988
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| 37 | FUT2
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| Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase.
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| Kumazaki T, et al.
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| Proc Natl Acad Sci U S A 81 : 4193-4197. 1984
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| 38 | FUT1, FUT2, H
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| H-deficient blood groups of Reunion island. III. alpha-2-L-fucosyltransferase activity in sera of homozygous and heterozygous individuals.
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| Le Pendu J, et al.
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| Am J Hum Genet 35 : 497-507. 1983
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| 39 | C3, FUT2, LE, PEPD, BCAM
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| Genetics and linkage relationships of the C3 polymorphism: discovery of C3-Se linkage and assignment of LES-C3-DM-Se-PEPD-Lu synteny to chromosome 19.
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| Eiberg H, et al.
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| Clin Genet 24 : 159-170. 1983
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| 40 | FUT1, FUT2
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| A new genetic model proposing that the Se gene is a structural gene closely linked to the H gene.
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| Oriol R, et al.
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| Am J Hum Genet 33 : 421-431. 1981
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| 41 | DM1, FUT2, BCAM
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| Confirmation of linkage of the loci for myotonic dystrophy and ABH secretion.
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| Renwick JH, et al.
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| J Med Genet 8 : 407-416. 1971
|