Citations for
1FUS, SNPH
Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations
Salam S, Tacconelli S, Smith BN, Mitchell JC, Glennon E, Nikolaou N, Houart C, Vance C.
Sci Rep. Jun 30;11(1):13613. doi: 10.1038/s41598-021-93189-6. 2021
2ETM4, ETM5, FUS, TENM4
Genetics of essential tremor.
Tio M, Tan EK.
Parkinsonism Relat Disord. Jan;22 Suppl 1:S176-8. doi: 10.1016/j.parkreldis.2015.09.022. Epub 2015 Sep 14 2016
3FUS, PSMD12, SFPQ, UBA1, VCP
Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.
Wang T, Jiang X, Chen G, Xu J.
Neurobiol Aging 36(1):527-35. doi: 10.1016/j.neurobiolaging.2014.07.044. 2015
4FUS, HSPD1
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
Deng J, Yang M, Chen Y, Chen X, Liu J, Sun S, Cheng H, Li Y, Bigio EH, Mesulam M, Xu Q, Du S, Fushimi K, Zhu L, Wu JY.
PLoS Genet 11(9):e1005357. doi: 10.1371/journal.pgen.1005357. eCollection 2015 Sep. 2015
5EWSR1, FUS
A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins.
Thomsen C, Grundevik P, Elias P, Ståhlberg A, Aman P.
FASEB J 27(12):4965-74. doi: 10.1096/fj.13-234435. Epub 2013 Aug 23. 2013
6ALS6, FUS
ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN.
Groen EJ, Fumoto K, Blokhuis AM, Engelen-Lee J, Zhou Y, van den Heuvel DM, Koppers M, van Diggelen F, van Heest J, Demmers JA, Kirby J, Shaw PJ, Aronica E, Spliet WG, Veldink JH, van den Berg LH, Pasterkamp RJ.
Hum Mol Genet 22(18):3690-704. doi: 10.1093/hmg/ddt222. Epub 2013 May 15. 2013
7ALS6, ATXN2, FUS
Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis.
Farg MA, Soo KY, Warraich ST, Sundaramoorthy V, Blair IP, Atkin JD.
Hum Mol Genet 22(4):717-28. doi: 10.1093/hmg/dds479. Epub 2012 Nov 19. 2013
8ALS6, FUS, PRMT1
Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations.
Tradewell ML, Yu Z, Tibshirani M, Boulanger MC, Durham HD, Richard S.
Hum Mol Genet 21(1):136-49. Epub 2011 Sep 28. 2012
9ETM4, FUS
Exome Sequencing Identifies FUS Mutations as a Cause of Essential Tremor.
Merner ND, Girard SL, Catoire H, Bourassa CV, Belzil VV, Rivière JB, Hince P, Levert A, Dionne-Laporte A, Spiegelman D, Noreau A, Diab S, Szuto A, Fournier H, Raelson J, Belouchi M, Panisset M, Cossette P, Dupré N, Bernard G, Chouinard S, Dion PA, Rouleau GA.
Am J Hum Genet 91(2):313-9. Epub 2012 Aug 2. 2012
10FUS, MAPT
Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.
Orozco D, Tahirovic S, Rentzsch K, Schwenk BM, Haass C, Edbauer D.
EMBO Rep 13(8):759-64. doi: 10.1038/embor.2012.90. Epub 2012 Jun 19. 2012
11FUS
TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements.
Tan AY, Riley TR, Coady T, Bussemaker HJ, Manley JL.
Proc Natl Acad Sci U S A 109(16):6030-5. doi: 10.1073/pnas.1203028109. Epub 2012 Mar 29. 2012
12FUS, PLEC
Fused in sarcoma (FUS) interacts with the cytolinker protein plectin: implications for FUS subcellular localization and function.
Thomsen C, Udhane S, Runnberg R, Wiche G, Ståhlberg A, Aman P.
Exp Cell Res 318(5):653-61. doi: 10.1016/j.yexcr.2011.12.019. Epub 2012 Jan 4. 2012
13ALS6, FUS, TNPO1
Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
Zhang ZC, Chook YM.
Proc Natl Acad Sci U S A 109(30):12017-21. doi: 10.1073/pnas.1207247109. Epub 2012 Jul 9. 2012
14ETM4, FUS
Exome sequencing identifies FUS mutations as a cause of essential tremor.
Merner ND, Girard SL, Catoire H, Bourassa CV, Belzil VV, Rivière JB, Hince P, Levert A, Dionne-Laporte A, Spiegelman D, Noreau A, Diab S, Szuto A, Fournier H, Raelson J, Belouchi M, Panisset M, Cossette P, Dupré N, Bernard G, Chouinard S, Dion PA, Rouleau GA.
Am J Hum Genet. Aug 10;91(2):313-9. doi: 10.1016/j.ajhg.2012.07.002. Epub 2012 Aug 2. 2012
15ALS6, FUS
Identification of a FUS splicing mutation in a large family with amyotrophic lateral sclerosis.
Belzil VV, St-Onge J, Daoud H, Desjarlais A, Bouchard JP, Dupré N, Camu W, Dion PA, Rouleau GA.
J Hum Genet 56(3):247-9. Epub 2010 Dec 16. 2011
16EWSR1, FUS, TAF15
mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.
Spitzer JI, Ugras S, Runge S, Decarolis P, Antonescu C, Tuschl T, Singer S.
Genes Chromosomes Cancer 50(5):338-47. doi: 10.1002/gcc.20858. Epub 2011 Feb 22. 2011
17ALS6, FUS
FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion.
Suzuki N, Aoki M, Warita H, Kato M, Mizuno H, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, Itoyama Y.
J Hum Genet 55(4):252-4. Epub 2010 Mar 12. 2010
18ALS6, FUS
Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.
Corrado L, Del Bo R, Castellotti B, Ratti A, Cereda C, Penco S, Sorarù G, Carlomagno Y, Ghezzi S, Pensato V, Colombrita C, Gagliardi S, Cozzi L, Orsetti V, Mancuso M, Siciliano G, Mazzini L, Comi GP, Gellera C, Ceroni M, D'Alfonso S, Silani V.
J Med Genet 47(3):190-4. Epub 2009 Oct 26.PMID: 19861302 2010
19FUS, TARDBP
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration.
Lagier-Tourenne C, Polymenidou M, Cleveland DW.
Hum Mol Genet 19(R1):R46-64. Epub 2010 Apr 15. Review.PMID: 20400460 2010
20ALS10, ALS6, FUS, TARDBP
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland DW.
Proc Natl Acad Sci U S A 107(30):13318-23. Epub 2010 Jul 12.PMID: 20624952 2010
21ALS1, ALS10, ALS6, ALS8, ALS9, ANG, FUS, SOD1, TARDBP, VAPB
SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations.
Millecamps S, Salachas F, Cazeneuve C, Gordon P, Bricka B, Camuzat A, Guillot-Noël L, Russaouen O, Bruneteau G, Pradat PF, Le Forestier N, Vandenberghe N, Danel-Brunaud V, Guy N, Thauvin-Robinet C, Lacomblez L, Couratier P, Hannequin D, Seilhean D, Le Ber I, Corcia P, Camu W, Brice A, Rouleau G, LeGuern E, Meininger V.
J Med Genet 47(8):554-60. Epub 2010 Jun 24.PMID: 20577002 2010
22ALS6, FUS
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.
Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C.
EMBO J 29(16):2841-57. Epub 2010 Jul 6.PMID: 20606625 2010
23FUS, HDAC6, TARDBP
Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.
Kim SH, Shanware NP, Bowler MJ, Tibbetts RS.
J Biol Chem 285(44):34097-105. Epub 2010 Aug 18. 2010
24ALS6, FUS
Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules.
Bosco DA, Lemay N, Ko HK, Zhou H, Burke C, Kwiatkowski TJ Jr, Sapp P, McKenna-Yasek D, Brown RH Jr, Hayward LJ.
Hum Mol Genet 19(21):4160-75. Epub 2010 Aug 10. 2010
25ALS6, FUS, TARDBP
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr.
Science 323(5918):1205-8. 2009
26ALS6, FUS, TARDBP
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.
Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE.
Science 323(5918):1208-11. 2009
27ALS6, FUS, TARDBP
Rethinking ALS: the FUS about TDP-43.
Lagier-Tourenne C, Cleveland DW.
Cell 136(6):1001-4. Review. 2009
28DDIT3, FUS, NFKBIZ
The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
Göransson M, Andersson MK, Forni C, Ståhlberg A, Andersson C, Olofsson A, Mantovani R, Aman P.
Oncogene 28(2):270-8. Epub 2008 Oct 13. 2009
29FUS
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr.
Science 323(5918):1205-8. 2009
30FUS
RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells.
Doi H, Okamura K, Bauer PO, Furukawa Y, Shimizu H, Kurosawa M, Machida Y, Miyazaki H, Mitsui K, Kuroiwa Y, Nukina N.
J Biol Chem 283(10):6489-500. Epub 2007 Dec 31. 2008
31DDX39, FUS, SARNP, THOC4
Intracellular characterization of DDX39, a novel growth-associated RNA helicase.
Sugiura T, Sakurai K, Nagano Y.
Exp Cell Res 313(4):782-90. Epub 2006 Dec 5. 2007
32FUS, CREB3L1, CREB3L2
Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene.
Mertens F, Fletcher CD, Antonescu CR, Coindre JM, Colecchia M, Domanski HA, Downs-Kelly E, Fisher C, Goldblum JR, Guillou L, Reid R, Rosai J, Sciot R, Mandahl N, Panagopoulos I.
Lab Invest 85(3):408-15. 2005
33FUS, CREB3L2
The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma.
Panagopoulos I, Storlazzi CT, Fletcher CD, Fletcher JA, Nascimento A, Domanski HA, Wejde J, Brosjo O, Rydholm A, Isaksson M, Mandahl N, Mertens F.
Genes Chromosomes Cancer 40(3):218-28. 2004
34FUS, ERG
FUS/ERG gene fusions in Ewing's tumors.
Shing DC, McMullan DJ, Roberts P, Smith K, Chin SF, Nicholson J, Tillman RM, Ramani P, Cullinane C, Coleman N.
Cancer Res 63(15):4568-76. 2003
35FUS
Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation.
Bertrand P, et al.
Oncogene 18(31):4515-21 1999
36FUS
TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis.
Perrotti D, et al.
EMBO J 17 : 4442-4455. 1998
37FUS
Detection of TLS/FUS-CHOP fusion transcripts in myxoid and round cell liposarcomas by nested reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues.
Hisaoka M, et al.
Diagn Mol Pathol 7 : 96-101. 1998
38FUS, TAF15
Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.
Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M.
Gene 221(2):191-8. 1998
39FUS, SFRS13A, SRSF2
Oncoptotein TLS interacts with serine-arginine ptoteins involved in RNA xplicing. involved in RNA splicing.
Yang L, Embree LJ, Tsai S, Hickstein DD.
J Biol Chem 273(43):27761-4. 1998
40ERG, FUS, AMLT1
Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.
Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, Maseki N, Kaneko Y, Sako M, Kobayashi Y, Tojou A, Miura I, Kakuda H, Funabiki T, Horibe K, Hamaguchi H, Akiyama Y, Bessho F, Yanagisawa M, Hayashi Y.
Blood 90(3):1192-9. 1997
41DDIT3, ERG, EWSR1, FUS
Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia.
Panagopoulos I, Lassen C, Isaksson M, Mitelman F, Mandahl N, Aman P.
Oncogene 15(11):1357-62. 1997
42EWSR1, FUS
Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.
Aman P, et al.
Genomics 37 : 1-8. 1996
43DDIT3, ERG, FUS
Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21).
Panagopoulos I, et al.
oncogene 11 : 1133-1137 1995
44FUS
An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.
Ichikawa H, et al.
Cancer Res 54 : 2865-2868. 1994
45FUS, ERG
TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain.
Prasad DDK, et al.
Oncogene 9 : 3717-3729. 1994
46FUS, ERG
Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22).
Panagopoulos I, et al.
Genes Chromosomes Cancer 11 : 256-262. 1994
47FUS, DDIT3
Isolation of asomatic cell hybrid retaining the der(16)t(12;16)(q13;p11.2) from a myxoid liposarcoma cell line.
Schoenmakers HFPM, et al.
Cytogenet Cell Genet 62 : 159-161. 1993
48DDIT3, FUS
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
Crozat A, et al.
Nature 363 : 640-644. 1993
49FUS, DDIT3
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
Rabbitts TH, et al.
Nat Genet 4 : 175-180. 1993
50FUS, DDIT3
Myxoid liposarcoma with t(12;16)(q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12.
Paulien S, et al.
Cancer Res 50 : 7902-7907. 1990
51FUS, DDIT3
Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2.
Eneroth M, et al.
Cancer Genet Cytogenet 48 : 101-107. 1990
52FUS, DDIT3
Translocation t(12;16) in a case of myxoid liposarcoma.
Smith S, et al.
Cancer Genet Cytogenet 26 : 185-186. 1987
53FUS, DDIT3
Cytogenetic studies of adipose tissue tumors. II.Recurrent reciprocal translocation t(12;16)(q13;p11) in myxoid liposarcomas.
Turc-Carel C, et al.
Cancer Genet Cytogenet 23 : 291-299. 1986