| 1 | FURIN, KISS1
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| Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing.
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| Harihar S, Pounds KM, Iwakuma T, Seidah NG, Welch DR.
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| PLoS One 9(1):e84958. doi: 10.1371/journal.pone.0084958. eCollection 2014.
2014
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| 2 | FURIN, PTGS2
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| Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells.
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| Brant KA, Leikauf GD.
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| Mol Carcinog 53(3):192-200. doi: 10.1002/mc.21963. Epub 2012 Oct 12.
2014
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| 3 | FURIN, PAX6, PCSK1, PCSK2
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| Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets.
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| Chen Y, Cao W, Zhou S, Shen L, Wen J.
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| Exp Biol Med (Maywood) 238(11):1259-64. doi: 10.1177/1535370213502627. Epub 2013 Sep 18.
2013
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| 4 | FURIN, PCSK1, PCSK2
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| Decreased hypothalamic prohormone convertase expression in huntington disease patients.
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| van Wamelen DJ, Aziz NA, Zhao J, Balesar R, Unmehopa U, Roos RA, Swaab DF.
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| J Neuropathol Exp Neurol 72(12):1126-34. doi: 10.1097/NEN.0000000000000010.
2013
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| 5 | ANGPTL3, FURIN
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| Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.
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| Essalmani R, Susan-Resiga D, Chamberland A, Asselin MC, Canuel M, Constam D, Creemers JW, Day R, Gauthier D, Prat A, Seidah NG.
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| J Biol Chem 288(37):26410-8. doi: 10.1074/jbc.M113.501304. Epub 2013 Aug 5.
2013
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| 6 | FURIN, MMP17, PROCR, SERPINE2
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| Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition.
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| Boulaftali Y, François D, Venisse L, Jandrot-Perrus M, Arocas V, Bouton MC.
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| Arterioscler Thromb Vasc Biol 33(7):1647-54. doi: 10.1161/ATVBAHA.113.301494. Epub 2013 May 9.
2013
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| 7 | FURIN
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| The proprotein convertase furin is required for trophoblast syncytialization.
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| Zhou Z, Zhang Q, Lu X, Wang R, Wang H, Wang YL, Zhu C, Lin HY, Wang H.
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| Cell Death Dis 4:e593. doi: 10.1038/cddis.2013.106.
2013
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| 8 | FURIN, PIANP, PILRA
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| Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein convertases precedes its plasma membrane localization.
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| Evdokimov K, Biswas S, Adrian M, Weber J, Schledzewski K, Winkler M, Goerdt S, Géraud C.
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| Biochem Biophys Res Commun 434(1):22-7. doi: 10.1016/j.bbrc.2013.03.073. Epub 2013 Apr 2.
2013
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| 9 | FURIN, PCSK5, PCSK6
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| Proprotein convertases in high-density lipoprotein metabolism.
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| Choi S, Korstanje R.
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| Biomark Res 1(1):27. doi: 10.1186/2050-7771-1-27.
2013
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| 10 | FURIN, NOTCH1, SRC
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| The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells.
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| Ma YC, Shi C, Zhang YN, Wang LG, Liu H, Jia HT, Zhang YX, Sarkar FH, Wang ZS.
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| PLoS One 7(3):e33414. doi: 10.1371/journal.pone.0033414. Epub 2012 Mar 30.
2012
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| 11 | FURIN, SRC
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| The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.
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| Shi C, Ma Y, Liu H, Zhang Y, Wang Z, Jia H.
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| Mol Cell Biochem 362(1-2):65-70. doi: 10.1007/s11010-011-1128-3. Epub 2011 Oct 25.
2012
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| 12 | C1QTNF12, FURIN
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| Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity.
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| Wei Z, Lei X, Seldin MM, Wong GW.
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| J Biol Chem 287(43):35804-14. doi: 10.1074/jbc.M112.365965. Epub 2012 Aug 31.
2012
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| 13 | FURIN, SERPINE1
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| Plasminogen activator inhibitor 1 is an intracellular inhibitor of furin proprotein convertase.
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| Bernot D, Stalin J, Stocker P, Bonardo B, Scroyen I, Alessi MC, Peiretti F.
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| J Cell Sci 124(Pt 8):1224-30. doi: 10.1242/jcs.079889. Epub 2011 Mar 15. 2011
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| 14 | CD109, FURIN
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| Processing of CD109 by furin and its role in the regulation of TGF-beta signaling.
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| Hagiwara S, Murakumo Y, Mii S, Shigetomi T, Yamamoto N, Furue H, Ueda M, Takahashi M.
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| Oncogene 29(15):2181-91. Epub 2010 Jan 25.PMID: 20101215 2010
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| 15 | FURIN, SEMA3F
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| Furin processing of semaphorin 3F determines its anti-angiogenic activity by regulating direct binding and competition for neuropilin.
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| Parker MW, Hellman LM, Xu P, Fried MG, Vander Kooi CW.
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| Biochemistry 49(19):4068-75. 2010
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| 16 | FURIN, HFE, TFR2
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| Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation.
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| Poli M, Luscieti S, Gandini V, Maccarinelli F, Finazzi D, Silvestri L, Roetto A, Arosio P.
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| Haematologica 95(11):1832-40. Epub 2010 Jul 15.
2010
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| 17 | FURIN, GORASP2, MMP14
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| Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen.
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| Roghi C, Jones L, Gratian M, English WR, Murphy G.
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| FEBS J 277(15):3158-75. doi: 10.1111/j.1742-4658.2010.07723.x. Epub 2010 Jul 1.
2010
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| 18 | FURIN
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| Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection.
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| Lei RX, Shi H, Peng XM, Zhu YH, Cheng J, Chen GH.
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| Hepatology 50(3):763-71.PMID: 19492430 2009
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| 19 | FURIN
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| Characterization of genotype-specific carboxyl-terminal cleavage sites of hepatitis B virus e antigen precursor and identification of furin as the candidate enzyme.
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| Ito K, Kim KH, Lok AS, Tong S.
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| J Virol 83(8):3507-17. Epub 2009 Feb 4.PMID: 19193799 2009
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| 20 | FURIN
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| Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling.
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| Thompson C, McMahon S, Bossé Y, Dubois CM, Stankova J, Rola-Pleszczynski M.
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| Am J Respir Cell Mol Biol 39(2):227-34. Epub 2008 Mar 6.PMID: 18323532 2008
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| 21 | FURIN
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| The Ca2+-binding capacity of epidermal furin is disrupted by H2O2-mediated oxidation in vitiligo.
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| Spencer JD, Gibbons NC, Böhm M, Schallreuter KU.
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| Endocrinology 149(4):1638-45. Epub 2008 Jan 3.PMID: 18174282 2008
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| 22 | FURIN
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| Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis.
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| Silvestri L, Pagani A, Camaschella C.
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| Blood 111(2):924-31. Epub 2007 Oct 15.PMID: 17938254 2008
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| 23 | FURIN
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| Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin.
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| Valore EV, Ganz T.
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| Blood Cells Mol Dis 40(1):132-8. Epub 2007 Oct 1.PMID: 17905609 2008
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| 24 | APBA3, FURIN
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| Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network.
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| Han J, Wang Y, Wang S, Chi C.
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| J Cell Sci 121(Pt 13):2217-23. Epub 2008 Jun 10.
2008
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| 25 | ATP6AP1, FURIN
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| Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.
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| Louagie E, Taylor NA, Flamez D, Roebroek AJ, Bright NA, Meulemans S, Quintens R, Herrera PL, Schuit F, Van de Ven WJ, Creemers JW.
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| Proc Natl Acad Sci U S A 105(34):12319-24. doi: 10.1073/pnas.0800340105. Epub 2008 Aug 19.
2008
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| 26 | FURIN, PCSK1, PCSK2, PCSK5, PCSK6
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| PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.
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| Dikeakos JD, Mercure C, Lacombe MJ, Seidah NG, Reudelhuber TL.
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| FEBS J 274(16):4094-102. Epub 2007 Jul 20.
2007
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| 27 | ADAM10, ADAM17, FURIN
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| Furin is an endogenous regulator of alpha-secretase associated APP processing.
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| Hwang EM, Kim SK, Sohn JH, Lee JY, Kim Y, Kim YS, Mook-Jung I.
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| Biochem Biophys Res Commun 349(2):654-9. Epub 2006 Aug 22. 2006
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| 28 | FURIN, PCSK1, PCSK2
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| Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
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| Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB.
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| Diabetes 53(1):141-8.
2004
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| 29 | FURIN
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| Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.
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| Fugere M, Limperis PC, Beaulieu-Audy V, Gagnon F, Lavigne P, Klarskov K, Leduc R, Day R.
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| J Biol Chem 277(10):7648-56. 2002
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| 30 | ED1, FURIN, EDA
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| Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia.
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| Chen Y, Molloy SS, Thomas L, Gambee J, Bachinger HP, Ferguson B, Zonana J, Thomas G, Morris NP.
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| Proc Natl Acad Sci U S A 98(13):7218-23. 2001
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| 31 | FURIN
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| Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization.
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| Chen CD, Huff ME, Matteson J, Page L, Phillips R, Kelly JW, Balch WE.
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| EMBO J 20(22):6277-87. 2001
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| 32 | FURIN
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| Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping.
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| Constam DB, Robertson EJ.
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| Development 127(2):245-54. 2000
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| 33 | BMP1, COL5A1, LOX, FURIN
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| Bone morphogenetic protein-1 processes the NH2-terminal propeptide, and a furin-like proprotein convertase processes the COOH-terminal propeptide of pro-alpha1(V) collagen.
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| Imamura Y, Steiglitz BM, Greenspan DS.
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| J Biol Chem 273 : 27511-27517. 1998
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| 34 | FURIN, PCSK6, PCSK1, PCSK2, PCSK4, PCSK5, PCSK7
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| A model for the structure of the P domains in the subtilisin-like prohormone convertases.
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| Lipkind GM, et al.
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| Proc Natl Acad Sci U S A 95(13):7310-5. 1998
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| 35 | BMP4, FURIN
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| BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development.
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| Cui Y, Jean F, Thomas G, Christian JL.
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| EMBO J 17(16):4735-43. 1998
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| 36 | FURIN, PCSK6, PCSK1, PCSK2, PCSK4, PCSK5, PCSK7
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| The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.
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| Seidah NG, et al.
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| Biochimie 76(3-4):197-209. Review. 1994
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| 37 | FURIN, PCSK6, PCSK1, PCSK2, PCSK4, PCSK5, PCSK7
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| Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.
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| Van de Ven WJ, et al.
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| Crit Rev Oncog 4(2):115-36. Review. 1993
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| 38 | PCSK1, PCSK2, FURIN, PCSK4, PCSK5, PCSK6
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| Mammalian subtilisins : the long-sought dibasic processing endoproteases.
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| Barr PJ.
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| Cell 66 : 1-3. 1991
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| 39 | FURIN
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| Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes.
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| Van de Ven WJM, et al.
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| Mol Biol Rep 14 : 265-275. 1990
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| 40 | FURIN
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| Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2.
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| Van den Ouweland AMW, et al.
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| Nucleic Acids Res 18 : 664. 1990
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| 41 | FURIN
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| Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.
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| Bresnahan PA, et al.
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| J Cell Biol 111 : 2851-2859. 1990
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| 42 | FURIN
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| Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.
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| Roebroek AJM, et al.
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| EMBO J 5 : 2197-2202. 1986
|