Citations for
1FRS2, MDM2
Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis.
He X, Pang Z, Zhang X, Lan T, Chen H, Chen M, Yang H, Huang J, Chen Y, Zhang Z, Jing W, Peng R, Zhang H.
Am J Surg Pathol 42(9):1143-1155. doi: 10.1097/PAS.0000000000001125. 2018
2FRS2, FRS3
Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis.
Nandi S, Alviña K, Lituma PJ, Castillo PE, Hébert JM.
Neuroscience 369:192-201. doi: 10.1016/j.neuroscience.2017.11.017. Epub 2017 Nov 16. 2018
3FRS2
Loss of peri-Wolffian duct stromal Frs2α expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux.
Narla D, Slagle SB, Schaefer CM, Bushnell DS, Puri P, Bates CM.
Pediatr Res 82(6):1022-1029. doi: 10.1038/pr.2017.175. Epub 2017 Aug 9. 2017
4FRS2
Hyperactivated FRS2α-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients.
Liu J, You P, Chen G, Fu X, Zeng X, Wang C, Huang Y, An L, Wan X, Navone N, Wu CL, McKeehan WL, Zhang Z, Zhong W, Wang F.
Oncogene 35(14):1750-9. doi: 10.1038/onc.2015.239. Epub 2015 Jun 22. 2016
5FRS2
Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors.
Di Giovanni V, Walker KA, Bushnell D, Schaefer C, Sims-Lucas S, Puri P, Bates CM.
Dev Biol 400(1):82-93. doi: 10.1016/j.ydbio.2015.01.018. Epub 2015 Jan 30. 2015
6FRS2
The docking protein FRS2α is a critical regulator of VEGF receptors signaling.
Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M.
Proc Natl Acad Sci U S A 111(15):5514-9. doi: 10.1073/pnas.1404545111. Epub 2014 Apr 2. 2014
7FRS2, PTPN11
Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development.
Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X.
J Cell Sci 127(Pt 3):571-82. doi: 10.1242/jcs.134478. Epub 2013 Nov 27. 2014
8FRS2
Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma.
Zhang K, Chu K, Wu X, Gao H, Wang J, Yuan YC, Loera S, Ho K, Wang Y, Chow W, Un F, Chu P, Yen Y.
Cancer Res 73(4):1298-307. doi: 10.1158/0008-5472.CAN-12-2086. Epub 2013 Feb 7. 2013
9FRS2
Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development.
Madakashira BP, Kobrinski DA, Hancher AD, Arneman EC, Wagner BD, Wang F, Shin H, Lovicu FJ, Reneker LW, Robinson ML.
Development 139(24):4601-12. doi: 10.1242/dev.081737. Epub 2012 Nov 7. 2012
10FRS2
FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.
Zhang J, Liu J, Huang Y, Chang JY, Liu L, McKeehan WL, Martin JF, Wang F.
Circ Res 110(4):e29-39. doi: 10.1161/CIRCRESAHA.111.255950. Epub 2011 Dec 29. 2012
11FGFR2, FRS2
Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium.
Sims-Lucas S, Cusack B, Eswarakumar VP, Zhang J, Wang F, Bates CM.
Development 138(7):1275-80. doi: 10.1242/dev.062158. Epub 2011 Feb 24. 2011
12FRS2, HES1
FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.
Sato T, Shimazaki T, Naka H, Fukami S, Satoh Y, Okano H, Lax I, Schlessinger J, Gotoh N.
Stem Cells 28(9):1661-73. doi: 10.1002/stem.488. 2010
13FGFR1, FRS2, MTOR
FGFR1 forms an FRS2-dependent complex with mTOR to regulate smooth muscle marker gene expression.
Chen PY, Friesel R.
Biochem Biophys Res Commun 382(2):424-9. Epub 2009 Mar 13. 2009
14FRS2
Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia.
Sims-Lucas S, Cullen-McEwen L, Eswarakumar VP, Hains D, Kish K, Becknell B, Zhang J, Bertram JF, Wang F, Bates CM.
Am J Physiol Renal Physiol 297(5):F1208-19. doi: 10.1152/ajprenal.00262.2009. Epub 2009 Sep 9. 2009
15FGFR2, FRS2
Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling.
Ahmed Z, Schüller AC, Suhling K, Tregidgo C, Ladbury JE.
Biochem J 413(1):37-49.PMID: 18373495 2008
16FRS2
Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins.
Krejci P, Masri B, Salazar L, Farrington-Rock C, Prats H, Thompson LM, Wilcox WR.
J Biol Chem 282(5):2929-36. Epub 2006 Dec 4. 2007
17FRS2
Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells.
Manuvakhova M, Thottassery JV, Hays S, Qu Z, Rentz SS, Westbrook L, Kern FG.
Oncogene 25(44):6003-14. Epub 2006 May 8. 2006
18FRS2, FRS3
Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.
Gotoh N, Ito M, Yamamoto S, Yoshino I, Song N, Wang Y, Lax I, Schlessinger J, Shibuya M, Lang RA.
Proc Natl Acad Sci U S A 101(49):17144-9. Epub 2004 Dec 7. 2004
19FRS2
Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes.
Zhou L, McDougall K, Kubu CJ, Verdi JM, Meakin SO.
Mol Biol Rep 30(1):15-25. 2003
20FRS2
Fibroblast growth factor-2-induced signaling through lipid raft-associated fibroblast growth factor receptor substrate 2 (FRS2).
Ridyard MS, Robbins SM.
J Biol Chem 278(16):13803-9. Epub 2003 Feb 05. 2003
21BTBD6, FRS2, GLULD1
Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants
Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K.
Mol Vis 8:171-84. 2002
22FRS2, FRS3
FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.
Yan KS, Kuti M, Yan S, Mujtaba S, Farooq A, Goldfarb MP, Zhou MM.
J Biol Chem 277(19):17088-94. Epub 2002 Feb 27. 2002