Citations for
1FRAS1, FREM1, FREM2
Mesenchymal expression of the FRAS1/FREM2 gene unit is decreased in the developing fetal diaphragm of nitrofen-induced congenital diaphragmatic hernia.
Takahashi T, Friedmacher F, Zimmer J, Puri P.
Pediatr Surg Int 32(2):135-40. doi: 10.1007/s00383-015-3824-7. Epub 2015 Oct 30. 2016
2FREM1
Gene Expression of FRAS1-Related Extracellular Matrix 1 Is Decreased in Nitrofen-Induced Congenital Diaphragmatic Hernia.
Takahashi T, Friedmacher F, Puri P.
Eur J Pediatr Surg 26(1):81-5. doi: 10.1055/s-0035-1559884. Epub 2015 Sep 18. 2016
3FRAS1, FREM1, FREM2, GREM1, GRIP1, ITGA8
Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.
Kohl S, Hwang DY, Dworschak GC, Hilger AC, Saisawat P, Vivante A, Stajic N, Bogdanovic R, Reutter HM, Kehinde EO, Tasic V, Hildebrandt F.
J Am Soc Nephrol 25(9):1917-22. doi: 10.1681/ASN.2013101103. Epub 2014 Apr 3. 2014
4FREM1
Development of monoclonal antibodies to interrogate functional domains and isoforms of FREM1 protein.
Yuan XY, Liu LR, Krawchenko A, Sainsbury J, Zhao L, Plummer F, Yang X, Luo M.
Monoclon Antib Immunodiagn Immunother 33(2):129-40. doi: 10.1089/mab.2013.0058. 2014
5BNAR, FREM1
Novel FREM1 mutations expand the phenotypic spectrum associated with Manitoba-oculo-tricho-anal (MOTA) syndrome and bifid nose renal agenesis anorectal malformations (BNAR) syndrome.
Nathanson J, Swarr DT, Singer A, Liu M, Chinn A, Jones W, Hurst J, Khalek N, Zackai E, Slavotinek A.
Am J Med Genet A 161A(3):473-8. doi: 10.1002/ajmg.a.35736. Epub 2013 Feb 8. 2013
6FREM1
Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.
Beck TF, Veenma D, Shchelochkov OA, Yu Z, Kim BJ, Zaveri HP, van Bever Y, Choi S, Douben H, Bertin TK, Patel PI, Lee B, Tibboel D, de Klein A, Stockton DW, Justice MJ, Scott DA.
Hum Mol Genet 22(5):1026-38. doi: 10.1093/hmg/dds507. Epub 2012 Dec 5. 2013
7BNAR, FREM1
Evidence for additional FREM1 heterogeneity in Manitoba oculotrichoanal syndrome.
Mateo RK, Johnson R, Lehmann OJ.
Mol Vis 18:1301-11. Epub 2012 May 30. 2012
8BNAR, FREM1
Evidence for additional FREM1 heterogeneity in Manitoba oculotrichoanal syndrome.
Mateo RK, Johnson R, Lehmann OJ.
Mol Vis 18:1301-11. Epub 2012 May 30. 2012
9BNAR, FREM1
Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.
Kiyozumi D, Takeichi M, Nakano I, Sato Y, Fukuda T, Sekiguchi K.
J Cell Biol 197(5):677-89. doi: 10.1083/jcb.201203065. Epub 2012 May 21. 2012
10FREM1
Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice.
Vissers LE, Cox TC, Maga AM, Short KM, Wiradjaja F, Janssen IM, Jehee F, Bertola D, Liu J, Yagnik G, Sekiguchi K, Kiyozumi D, van Bokhoven H, Marcelis C, Cunningham ML, Anderson PJ, Boyadjiev SA, Passos-Bueno MR, Veltman JA, Smyth I, Buckley MF, Roscioli T.
PLoS Genet 7(9):e1002278. doi: 10.1371/journal.pgen.1002278. Epub 2011 Sep 8. 2011
11BNAR, FREM1
Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1.
Slavotinek AM, Baranzini SE, Schanze D, Labelle-Dumais C, Short KM, Chao R, Yahyavi M, Bijlsma EK, Chu C, Musone S, Wheatley A, Kwok PY, Marles S, Fryns JP, Maga AM, Hassan MG, Gould DB, Madireddy L, Li C, Cox TC, Smyth I, Chudley AE, Zenker M.
J Med Genet 48(6):375-82. Epub 2011 Apr 20. 2011
12FRAS1, FREM1, FREM2, FREM3
The role of Fras1/Frem proteins in the structure and function of basement membrane.
Pavlakis E, Chiotaki R, Chalepakis G.
Int J Biochem Cell Biol 43(4):487-95. Epub 2010 Dec 21. Review. 2011
13FREM1, IL1R1, MYD88
TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB.
Zhang X, Shephard F, Kim HB, Palmer IR, McHarg S, Fowler GJ, O'Neill LA, Kiss-Toth E, Qwarnstrom EE.
J Biol Chem 285(10):7222-32. Epub 2009 Nov 25. Erratum in: J Biol Chem. 2010 Jun 4;285(23):18122. 2010
14BNAR, FRAS1, FREM1, FREM2
FREM1 mutations cause bifid nose, renal agenesis, and anorectal malformations syndrome.
Alazami AM, Shaheen R, Alzahrani F, Snape K, Saggar A, Brinkmann B, Bavi P, Al-Gazali LI, Alkuraya FS.
Am J Hum Genet 85(3):414-8. 2009
15FRAS1, FREM1, FREM2, FREM3
The Fras1/Frem family of extracellular matrix proteins: structure, function, and association with Fraser syndrome and the mouse bleb phenotype.
Petrou P, Makrygiannis AK, Chalepakis G.
Connect Tissue Res 49(3):277-82. 2008
16FRAS1, FREM1, FREM2, FREM3
Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.
Pavlakis E, Makrygiannis AK, Chiotaki R, Chalepakis G.
Histochem Cell Biol 130(4):785-93. Epub 2008 Jun 18. 2008
17FRAS1, FREM1, FREM2, FREM3
Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.
Petrou P, Pavlakis E, Dalezios Y, Chalepakis G.
Matrix Biol 26(8):652-8. Epub 2007 Jun 6. 2007
18FREM1, FREM2, FRAS1, GRIP1
Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.
Kiyozumi D, Sugimoto N, Sekiguchi K.
Proc Natl Acad Sci U S A 103(32):11981-6. Epub 2006 Jul 31. 2006
19FREM1
Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.
Kiyozumi D, Osada A, Sugimoto N, Weber CN, Ono Y, Imai T, Okada A, Sekiguchi K.
Exp Cell Res 306(1):9-23. 2005
20FREM1, FREM3
The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.
Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ.
Proc Natl Acad Sci U S A 101(37):13560-5. Epub 2004 Sep 2. 2004
21FREM1, OVCH2, USP48, TMPRSS7, DDI2, MPN2, TESSP2, C1RL, OVCH1, USP12P1, USP27X, USP30, USP35, USP36, USP37, USP38, USP39, USP40, USP41, USP42, USP43, USP44, USP45, USP46, USP47, MED20, USP50, USP51, USP31, USP32
Human and mouse proteases: a comparative genomic approach.
Puente XS, Sanchez LM, Overall CM, Lopez-Otin C.
Nat Rev Genet 4(7):544-58. Review. 2003