1 | FOXP3, SRSF1
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| Splicing factor SRSF1 controls autoimmune-related molecular pathways in regulatory T cells distinct from FoxP3.
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| Cassidy MF, Herbert ZT, Moulton VR.
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| Mol Immunol. Dec;152:140-152. doi: 10.1016/j.molimm.2022.10.017. Epub 2022 Nov 8. 2022
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2 | FOXP3, KAT5, PDCD5
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| Cellular functions of programmed cell death 5.
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| Li G, Ma D, Chen Y.
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| Biochim Biophys Acta 1863(4):572-80. doi: 10.1016/j.bbamcr.2015.12.021. Epub 2016 Jan 8. Review.
2016
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3 | FOXP3, TET2, TET3
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| Control of Foxp3 stability through modulation of TET activity.
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| Yue X, Trifari S, Äijö T, Tsagaratou A, Pastor WA, Zepeda-Martínez JA, Lio CW, Li X, Huang Y, Vijayanand P, Lähdesmäki H, Rao A.
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| J Exp Med 213(3):377-97. doi: 10.1084/jem.20151438. Epub 2016 Feb 22.
2016
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4 | FOXP3, IPEX
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| Clinical Case of Immune Dysregulation, Polyendocrinopaty, Enteropathy, X-Linked (IPEX) Syndrome with Severe Immune Deficiency and Late Onset of Endocrinopathy and Enteropathy.
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| Savova R, Arshinkova M, Houghton J, Konstantinova M, Gaydarova M, Georgieva E, Popova G, Genova V, Tomova N, Anadoliiska A, Koprivarova K.
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| Case Rep Med 2014:564926. doi: 10.1155/2014/564926. Epub 2014 Jun 1.
2014
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5 | FOXP3, MECP2
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| MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation.
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| Li C, Jiang S, Liu SQ, Lykken E, Zhao LT, Sevilla J, Zhu B, Li QJ.
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| Proc Natl Acad Sci U S A roc Natl Acad Sci U S A. 2014 Jun 23. pii: 201401505. [Epub ahead of print]
2014
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6 | FOXP3, UXT
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| UXT is a novel regulatory factor of regulatory T cells associated with Foxp3.
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| Li W, Wang L, Jiang C, Li H, Zhang K, Xu Y, Hao Q, Li M, Xue X, Qin X, Zhang C, Wang H, Zhang W, Zhang Y.
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| Eur J Immunol 44(2):533-44. doi: 10.1002/eji.201343394. Epub 2013 Nov 29.
2014
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7 | FOXP3, PIM1
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| PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation.
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| Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y, Li B.
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| J Biol Chem 289(39):26872-81. doi: 10.1074/jbc.M114.586651. Epub 2014 Aug 5.
2014
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8 | FOXP3, TNFRSF18
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| Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.
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| Tone Y, Kidani Y, Ogawa C, Yamamoto K, Tsuda M, Peter C, Waldmann H, Tone M.
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| J Immunol 192(8):3915-24. doi: 10.4049/jimmunol.1302174. Epub 2014 Mar 14.
2014
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9 | CREBBP, EP300, FOXP3
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| Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function.
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| Liu Y, Wang L, Han R, Beier UH, Akimova T, Bhatti T, Xiao H, Cole PA, Brindle PK, Hancock WW.
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| Mol Cell Biol 34(21):3993-4007. doi: 10.1128/MCB.00919-14.
2014
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10 | FOXP3, IKZF2, SATB1
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| FoxP3, Helios, and SATB1: roles and relationships in regulatory T cells.
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| Grzanka J, Leveson-Gower D, Golab K, Wang XJ, Marek-Trzonkowska N, Krzystyniak A, Wardowska A, Mills JM, Trzonkowski P, Witkowski P.
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| Int Immunopharmacol 16(3):343-7. doi: 10.1016/j.intimp.2013.02.004. Epub 2013 Feb 18.
2013
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11 | FOXP3, IKZF2
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| Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans.
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| Himmel ME, MacDonald KG, Garcia RV, Steiner TS, Levings MK.
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| J Immunol 190(5):2001-8. doi: 10.4049/jimmunol.1201379. Epub 2013 Jan 28.
2013
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12 | FOXP3, MBD2
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| Mbd2 promotes foxp3 demethylation and T-regulatory-cell function.
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| Wang L, Liu Y, Han R, Beier UH, Thomas RM, Wells AD, Hancock WW.
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| Mol Cell Biol 33(20):4106-15. doi: 10.1128/MCB.00144-13. Epub 2013 Aug 26.
2013
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13 | FOXP3, STAT3
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| FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells.
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| Hossain DM, Panda AK, Manna A, Mohanty S, Bhattacharjee P, Bhattacharyya S, Saha T, Chakraborty S, Kar RK, Das T, Chatterjee S, Sa G.
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| Immunity 39(6):1057-69. doi: 10.1016/j.immuni.2013.11.005. Epub 2013 Dec 5.
2013
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14 | FOXP3, LCK, MMP9, SKP2, VEGFA
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| Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion.
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| Nakahira K, Morita A, Kim NS, Yanagihara I.
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| PLoS One 8(10):e77099. doi: 10.1371/journal.pone.0077099. eCollection 2013.
2013
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15 | FOXP3, PARP1
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| PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3.
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| Zhang P, Maruyama T, Konkel JE, Abbatiello B, Zamarron B, Wang ZQ, Chen W.
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| PLoS One 8(8):e71590. doi: 10.1371/journal.pone.0071590. eCollection 2013.
2013
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16 | CDK2, FOXP3
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| Foxp3 protein stability is regulated by cyclin-dependent kinase 2.
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| Morawski PA, Mehra P, Chen C, Bhatti T, Wells AD.
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| J Biol Chem 288(34):24494-502. doi: 10.1074/jbc.M113.467704. Epub 2013 Jul 12.
2013
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17 | FOXP3
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| Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus.
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| Toker A, Engelbert D, Garg G, Polansky JK, Floess S, Miyao T, Baron U, Düber S, Geffers R, Giehr P, Schallenberg S, Kretschmer K, Olek S, Walter J, Weiss S, Hori S, Hamann A, Huehn J.
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| J Immunol 190(7):3180-8. doi: 10.4049/jimmunol.1203473. Epub 2013 Feb 18.
2013
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18 | FOXP3, TRIB1
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| Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells.
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| Dugast E, Kiss-Toth E, Docherty L, Danger R, Chesneau M, Pichard V, Judor JP, Pettré S, Conchon S, Soulillou JP, Brouard S, Ashton-Chess J.
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| J Biol Chem 288(14):10051-60. doi: 10.1074/jbc.M112.448654. Epub 2013 Feb 15.
2013
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19 | FOXP3
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| Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.
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| Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK.
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| Proc Natl Acad Sci U S A 109(41):E2784-93. doi: 10.1073/pnas.1202366109. Epub 2012 Sep 17.
2012
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20 | FOXP3
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| Transcription factor Foxp3 and its protein partners form a complex regulatory network.
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| Rudra D, deRoos P, Chaudhry A, Niec RE, Arvey A, Samstein RM, Leslie C, Shaffer SA, Goodlett DR, Rudensky AY.
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| Nat Immunol 13(10):1010-9. doi: 10.1038/ni.2402. Epub 2012 Aug 26.
2012
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21 | FOXP3
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| Transcription start sites and usage of the first exon of mouse Foxp3 gene.
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| Fujita T, Fujii H.
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| Mol Biol Rep 39(10):9613-9. doi: 10.1007/s11033-012-1825-3. Epub 2012 Jun 22. Erratum in: Mol Biol Rep. 2012 Oct;39(10):9835.
2012
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22 | FOXO1, FOXP3
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| Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification.
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| Samstein RM, Arvey A, Josefowicz SZ, Peng X, Reynolds A, Sandstrom R, Neph S, Sabo P, Kim JM, Liao W, Li MO, Leslie C, Stamatoyannopoulos JA, Rudensky AY.
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| Cell 151(1):153-66. doi: 10.1016/j.cell.2012.06.053.
2012
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23 | FOXP3, IL2RA
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| Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-κB.
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| Camperio C, Caristi S, Fanelli G, Soligo M, Del Porto P, Piccolella E.
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| PLoS One 7(10):e48303. doi: 10.1371/journal.pone.0048303. Epub 2012 Oct 29.
2012
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24 | FOXP3, LATS2
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| Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.
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| Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y.
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| Cancer Res 71(6):2162-71. Epub 2011 Jan 28.
2011
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25 | FOXP3, JUNB, REL
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| JunB and c-Rel cooperatively enhance Foxp3 expression during induced regulatory T cell differentiation.
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| Son JS, Sahoo A, Chae CS, Hwang JS, Park ZY, Im SH.
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| Biochem Biophys Res Commun 407(1):141-7. Epub 2011 Mar 1.
2011
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26 | FOXP3, KDM5B; KAT8
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| FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1.
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| Katoh H, Qin ZS, Liu R, Wang L, Li W, Li X, Wu L, Du Z, Lyons R, Liu CG, Liu X, Dou Y, Zheng P, Liu Y.
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| Mol Cell 44(5):770-84. doi: 10.1016/j.molcel.2011.10.012.
2011
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27 | FOXP3, NFATC1, SIVA1
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| Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells.
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| Hench VK, Su L.
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| BMC Immunol MC Immunol. 2011 2011
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28 | FOXP3
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| Foxp3 expression in p53-dependent DNA damage responses.
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| Jung DJ, Jin DH, Hong SW, Kim JE, Shin JS, Kim D, Cho BJ, Hwang YI, Kang JS, Lee WJ.
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| J Biol Chem 285(11):7995-8002. Epub 2010 Jan 14.PMID: 20075077 2010
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29 | FOXP3, PAEP
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| Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14.
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| Ochanuna Z, Geiger-Maor A, Dembinsky-Vaknin A, Karussis D, Tykocinski ML, Rachmilewitz J.
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| PLoS One 5(9):e12868. doi: 10.1371/journal.pone.0012868.
2010
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30 | FOXP3, SP3
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| Proximal human FOXP3 promoter transactivated by NF-kappaB and negatively controlled by feedback loop and SP3.
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| Eckerstorfer P, Novy M, Burgstaller-Muehlbacher S, Paster W, Schiller HB, Mayer H, Stockinger H.
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| Mol Immunol 47(11-12):2094-102. doi: 10.1016/j.molimm.2010.04.002. Epub 2010 May 11.
2010
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31 | FOXA1, FOXA2, FOXA3, FOXC1, FOXC2, FOXO1, FOXO3, FOXO4, FOXP2, FOXP3
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| The evolution of Fox genes and their role in development and disease.
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| Hannenhalli S, Kaestner KH.
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| Nat Rev Genet 10(4):233-40. Review. 2009
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32 | FOXP3, LRRC32
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| Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells.
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| Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, Unutmaz D.
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| Proc Natl Acad Sci U S A 106(32):13439-44. Epub 2009 Jul 28.PMID: 19666573 2009
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33 | FOXP3, LRRC32
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| GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
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| Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM.
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| Proc Natl Acad Sci U S A 106(32):13445-50. Epub 2009 Jul 27.PMID: 19651619 2009
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34 | FOXP3, RORA
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| Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3.
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| Du J, Huang C, Zhou B, Ziegler SF.
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| J Immunol 180(7):4785-92.PMID: 18354202 2008
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35 | FOXP3
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| Foxp3 induces IL-4 gene silencing by affecting nuclear translocation of NFkappaB and chromatin structure.
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| Kwon HK, So JS, Lee CG, Sahoo A, Yi HJ, Park JN, Lim SY, Hwang KC, Jun CD, Chun JS, Im SH.
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| Mol Immunol 45(11):3205-12. Epub 2008 Apr 18.PMID: 18395799 2008
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36 | FOXP3
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| FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression.
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| Li B, Samanta A, Song X, Iacono KT, Bembas K, Tao R, Basu S, Riley JL, Hancock WW, Shen Y, Saouaf SJ, Greene MI.
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| Proc Natl Acad Sci U S A 104(11):4571-6. Epub 2007 Mar 7. 2007
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37 | FOXP3
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| Foxp3 occupancy and regulation of key target genes during T-cell stimulation.
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| Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA.
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| Nature 445(7130):931-5. Epub 2007 Jan 21. 2007
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38 | FOXP3
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| Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.
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| Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S.
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| Nature 446(7136):685-9. Epub 2007 Mar 21.
2007
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39 | FOXP3, SKP2
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| FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2.
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| Zuo T, Liu R, Zhang H, Chang X, Liu Y, Wang L, Zheng P, Liu Y.
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| J Clin Invest 117(12):3765-73. 2007
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40 | FOXP3, TLR10
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| FOXP3 regulates TLR10 expression in human T regulatory cells.
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| Bell MP, Svingen PA, Rahman MK, Xiong Y, Faubion WA Jr.
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| J Immunol 179(3):1893-900.PMID: 17641056 2007
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41 | FOXP3
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| Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation.
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| Smith EL, Finney HM, Nesbitt AM, Ramsdell F, Robinson MK.
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| Immunology 119(2):203-11.
2006
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42 | HMOX1, FOXP3
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| Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression.
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| Choi BM, Pae HO, Jeong YR, Kim YM, Chung HT.
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| Biochem Biophys Res Commun 327(4):1066-71. 2005
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43 | FOXC2, LPDD,FOXC1, FOXE1, FOXE3, FOXL2, FOXN1, FOXP2, FOXP3, YNS
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| The establishment of a predictive mutational model of the forkhead domain through the analyses of FOXC2 missense mutations identified in patients with hereditary lymphedema with distichiasis.
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| Berry FB, Tamimi Y, Carle MV, Lehmann OJ, Walter MA.
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| Hum Mol Genet 14(18):2619-27. Epub 2005 Aug 4. 2005
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44 | FOXP3
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| Control of regulatory T cell development by the transcription factor Foxp3
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| Hori S, Nomura T, Sakaguchi S.
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| Science 299(5609):1057-61. 2003
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45 | FOXP3
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| A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes.
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| Bassuny WM, Ihara K, Sasaki Y, Kuromaru R, Kohno H, Matsuura N, Hara T.
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| Immunogenetics 55(3):149-56. Epub 2003 May 16. 2003
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46 | IPEX, FOXP3
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| Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome.
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| Owen CJ, Jennings CE, Imrie H, Lachaux A, Bridges NA, Cheetham TD, Pearce SH.
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| J Clin Endocrinol Metab 88(12):6034-9. 2003
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47 | FOXP3, FOXP3
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| Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome.
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| Wildin RS, Smyk-Pearson S, Filipovich AH.
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| J Med Genet 39(8):537-45. Review. 2002
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48 | FOXP3
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| Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX).
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| Kobayashi I, Shiari R, Yamada M, Kawamura N, Okano M, Yara A, Iguchi A, Ishikawa N, Ariga T, Sakiyama Y, Ochs HD, Kobayashi K.
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| J Med Genet 38(12):874-6. No abstract available. 2001
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49 | FOXP3
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| Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation.
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| Schubert LA, Jeffery E, Zhang Y, Ramsdell F, Ziegler SF.
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| J Biol Chem 276(40):37672-9. 2001
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50 | FOXP3
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| Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
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| Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F.
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| Nat Genet 27(1):68-73. 2001
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51 | FOXP3, FOXP3
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| The amount of scurfin protein determines peripheral T cell number and responsiveness.
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| Khattri R, Kasprowicz D, Cox T, Mortrud M, Appleby MW, Brunkow ME, Ziegler SF, Ramsdell F.
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| J Immunol 167(11):6312-20. 2001
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52 | IPEX, FOXP3
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| The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.
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| Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD.
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| Nat Genet 27(1):20-1. 2001
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53 | IPEX, FOXP3
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| X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.
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| Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, Levy-Lahad E, Mazzella M, Goulet O, Perroni L, Bricarelli FD, Byrne G, McEuen M, Proll S, Appleby M, Brunkow ME.
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| Nat Genet 27(1):18-20. 2001
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54 | FOXP3
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| X-Linked syndrome of polyendocrinopathy, immune dysfunction, and diarrhea maps to Xp11.23-Xq13.3.
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| Bennett CL, Yoshioka R, Kiyosawa H, Barker DF, Fain PR, Shigeoka AO, Chance PF.
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| Am J Hum Genet 66(2):461-8. 2000
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55 | FOXP3
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| JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.
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| Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, Bowcock AM.
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| J Clin Invest 106(12):R75-81. 2000
|