Citations for
1FOXP3, SRSF1
Splicing factor SRSF1 controls autoimmune-related molecular pathways in regulatory T cells distinct from FoxP3.
Cassidy MF, Herbert ZT, Moulton VR.
Mol Immunol. Dec;152:140-152. doi: 10.1016/j.molimm.2022.10.017. Epub 2022 Nov 8. 2022
2FOXP3, KAT5, PDCD5
Cellular functions of programmed cell death 5.
Li G, Ma D, Chen Y.
Biochim Biophys Acta 1863(4):572-80. doi: 10.1016/j.bbamcr.2015.12.021. Epub 2016 Jan 8. Review. 2016
3FOXP3, TET2, TET3
Control of Foxp3 stability through modulation of TET activity.
Yue X, Trifari S, Äijö T, Tsagaratou A, Pastor WA, Zepeda-Martínez JA, Lio CW, Li X, Huang Y, Vijayanand P, Lähdesmäki H, Rao A.
J Exp Med 213(3):377-97. doi: 10.1084/jem.20151438. Epub 2016 Feb 22. 2016
4FOXP3, IPEX
Clinical Case of Immune Dysregulation, Polyendocrinopaty, Enteropathy, X-Linked (IPEX) Syndrome with Severe Immune Deficiency and Late Onset of Endocrinopathy and Enteropathy.
Savova R, Arshinkova M, Houghton J, Konstantinova M, Gaydarova M, Georgieva E, Popova G, Genova V, Tomova N, Anadoliiska A, Koprivarova K.
Case Rep Med 2014:564926. doi: 10.1155/2014/564926. Epub 2014 Jun 1. 2014
5FOXP3, MECP2
MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation.
Li C, Jiang S, Liu SQ, Lykken E, Zhao LT, Sevilla J, Zhu B, Li QJ.
Proc Natl Acad Sci U S A roc Natl Acad Sci U S A. 2014 Jun 23. pii: 201401505. [Epub ahead of print] 2014
6FOXP3, UXT
UXT is a novel regulatory factor of regulatory T cells associated with Foxp3.
Li W, Wang L, Jiang C, Li H, Zhang K, Xu Y, Hao Q, Li M, Xue X, Qin X, Zhang C, Wang H, Zhang W, Zhang Y.
Eur J Immunol 44(2):533-44. doi: 10.1002/eji.201343394. Epub 2013 Nov 29. 2014
7FOXP3, PIM1
PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation.
Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y, Li B.
J Biol Chem 289(39):26872-81. doi: 10.1074/jbc.M114.586651. Epub 2014 Aug 5. 2014
8FOXP3, TNFRSF18
Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.
Tone Y, Kidani Y, Ogawa C, Yamamoto K, Tsuda M, Peter C, Waldmann H, Tone M.
J Immunol 192(8):3915-24. doi: 10.4049/jimmunol.1302174. Epub 2014 Mar 14. 2014
9CREBBP, EP300, FOXP3
Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function.
Liu Y, Wang L, Han R, Beier UH, Akimova T, Bhatti T, Xiao H, Cole PA, Brindle PK, Hancock WW.
Mol Cell Biol 34(21):3993-4007. doi: 10.1128/MCB.00919-14. 2014
10FOXP3, IKZF2, SATB1
FoxP3, Helios, and SATB1: roles and relationships in regulatory T cells.
Grzanka J, Leveson-Gower D, Golab K, Wang XJ, Marek-Trzonkowska N, Krzystyniak A, Wardowska A, Mills JM, Trzonkowski P, Witkowski P.
Int Immunopharmacol 16(3):343-7. doi: 10.1016/j.intimp.2013.02.004. Epub 2013 Feb 18. 2013
11FOXP3, IKZF2
Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans.
Himmel ME, MacDonald KG, Garcia RV, Steiner TS, Levings MK.
J Immunol 190(5):2001-8. doi: 10.4049/jimmunol.1201379. Epub 2013 Jan 28. 2013
12FOXP3, MBD2
Mbd2 promotes foxp3 demethylation and T-regulatory-cell function.
Wang L, Liu Y, Han R, Beier UH, Thomas RM, Wells AD, Hancock WW.
Mol Cell Biol 33(20):4106-15. doi: 10.1128/MCB.00144-13. Epub 2013 Aug 26. 2013
13FOXP3, STAT3
FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells.
Hossain DM, Panda AK, Manna A, Mohanty S, Bhattacharjee P, Bhattacharyya S, Saha T, Chakraborty S, Kar RK, Das T, Chatterjee S, Sa G.
Immunity 39(6):1057-69. doi: 10.1016/j.immuni.2013.11.005. Epub 2013 Dec 5. 2013
14FOXP3, LCK, MMP9, SKP2, VEGFA
Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion.
Nakahira K, Morita A, Kim NS, Yanagihara I.
PLoS One 8(10):e77099. doi: 10.1371/journal.pone.0077099. eCollection 2013. 2013
15FOXP3, PARP1
PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3.
Zhang P, Maruyama T, Konkel JE, Abbatiello B, Zamarron B, Wang ZQ, Chen W.
PLoS One 8(8):e71590. doi: 10.1371/journal.pone.0071590. eCollection 2013. 2013
16CDK2, FOXP3
Foxp3 protein stability is regulated by cyclin-dependent kinase 2.
Morawski PA, Mehra P, Chen C, Bhatti T, Wells AD.
J Biol Chem 288(34):24494-502. doi: 10.1074/jbc.M113.467704. Epub 2013 Jul 12. 2013
17FOXP3
Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus.
Toker A, Engelbert D, Garg G, Polansky JK, Floess S, Miyao T, Baron U, Düber S, Geffers R, Giehr P, Schallenberg S, Kretschmer K, Olek S, Walter J, Weiss S, Hori S, Hamann A, Huehn J.
J Immunol 190(7):3180-8. doi: 10.4049/jimmunol.1203473. Epub 2013 Feb 18. 2013
18FOXP3, TRIB1
Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells.
Dugast E, Kiss-Toth E, Docherty L, Danger R, Chesneau M, Pichard V, Judor JP, Pettré S, Conchon S, Soulillou JP, Brouard S, Ashton-Chess J.
J Biol Chem 288(14):10051-60. doi: 10.1074/jbc.M112.448654. Epub 2013 Feb 15. 2013
19FOXP3
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.
Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK.
Proc Natl Acad Sci U S A 109(41):E2784-93. doi: 10.1073/pnas.1202366109. Epub 2012 Sep 17. 2012
20FOXP3
Transcription factor Foxp3 and its protein partners form a complex regulatory network.
Rudra D, deRoos P, Chaudhry A, Niec RE, Arvey A, Samstein RM, Leslie C, Shaffer SA, Goodlett DR, Rudensky AY.
Nat Immunol 13(10):1010-9. doi: 10.1038/ni.2402. Epub 2012 Aug 26. 2012
21FOXP3
Transcription start sites and usage of the first exon of mouse Foxp3 gene.
Fujita T, Fujii H.
Mol Biol Rep 39(10):9613-9. doi: 10.1007/s11033-012-1825-3. Epub 2012 Jun 22. Erratum in: Mol Biol Rep. 2012 Oct;39(10):9835. 2012
22FOXO1, FOXP3
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification.
Samstein RM, Arvey A, Josefowicz SZ, Peng X, Reynolds A, Sandstrom R, Neph S, Sabo P, Kim JM, Liao W, Li MO, Leslie C, Stamatoyannopoulos JA, Rudensky AY.
Cell 151(1):153-66. doi: 10.1016/j.cell.2012.06.053. 2012
23FOXP3, IL2RA
Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-κB.
Camperio C, Caristi S, Fanelli G, Soligo M, Del Porto P, Piccolella E.
PLoS One 7(10):e48303. doi: 10.1371/journal.pone.0048303. Epub 2012 Oct 29. 2012
24FOXP3, LATS2
Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.
Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y.
Cancer Res 71(6):2162-71. Epub 2011 Jan 28. 2011
25FOXP3, JUNB, REL
JunB and c-Rel cooperatively enhance Foxp3 expression during induced regulatory T cell differentiation.
Son JS, Sahoo A, Chae CS, Hwang JS, Park ZY, Im SH.
Biochem Biophys Res Commun 407(1):141-7. Epub 2011 Mar 1. 2011
26FOXP3, KDM5B; KAT8
FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1.
Katoh H, Qin ZS, Liu R, Wang L, Li W, Li X, Wu L, Du Z, Lyons R, Liu CG, Liu X, Dou Y, Zheng P, Liu Y.
Mol Cell 44(5):770-84. doi: 10.1016/j.molcel.2011.10.012. 2011
27FOXP3, NFATC1, SIVA1
Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells.
Hench VK, Su L.
BMC Immunol MC Immunol. 2011 2011
28FOXP3
Foxp3 expression in p53-dependent DNA damage responses.
Jung DJ, Jin DH, Hong SW, Kim JE, Shin JS, Kim D, Cho BJ, Hwang YI, Kang JS, Lee WJ.
J Biol Chem 285(11):7995-8002. Epub 2010 Jan 14.PMID: 20075077 2010
29FOXP3, PAEP
Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14.
Ochanuna Z, Geiger-Maor A, Dembinsky-Vaknin A, Karussis D, Tykocinski ML, Rachmilewitz J.
PLoS One 5(9):e12868. doi: 10.1371/journal.pone.0012868. 2010
30FOXP3, SP3
Proximal human FOXP3 promoter transactivated by NF-kappaB and negatively controlled by feedback loop and SP3.
Eckerstorfer P, Novy M, Burgstaller-Muehlbacher S, Paster W, Schiller HB, Mayer H, Stockinger H.
Mol Immunol 47(11-12):2094-102. doi: 10.1016/j.molimm.2010.04.002. Epub 2010 May 11. 2010
31FOXA1, FOXA2, FOXA3, FOXC1, FOXC2, FOXO1, FOXO3, FOXO4, FOXP2, FOXP3
The evolution of Fox genes and their role in development and disease.
Hannenhalli S, Kaestner KH.
Nat Rev Genet 10(4):233-40. Review. 2009
32FOXP3, LRRC32
Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells.
Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, Unutmaz D.
Proc Natl Acad Sci U S A 106(32):13439-44. Epub 2009 Jul 28.PMID: 19666573 2009
33FOXP3, LRRC32
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM.
Proc Natl Acad Sci U S A 106(32):13445-50. Epub 2009 Jul 27.PMID: 19651619 2009
34FOXP3, RORA
Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3.
Du J, Huang C, Zhou B, Ziegler SF.
J Immunol 180(7):4785-92.PMID: 18354202 2008
35FOXP3
Foxp3 induces IL-4 gene silencing by affecting nuclear translocation of NFkappaB and chromatin structure.
Kwon HK, So JS, Lee CG, Sahoo A, Yi HJ, Park JN, Lim SY, Hwang KC, Jun CD, Chun JS, Im SH.
Mol Immunol 45(11):3205-12. Epub 2008 Apr 18.PMID: 18395799 2008
36FOXP3
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression.
Li B, Samanta A, Song X, Iacono KT, Bembas K, Tao R, Basu S, Riley JL, Hancock WW, Shen Y, Saouaf SJ, Greene MI.
Proc Natl Acad Sci U S A 104(11):4571-6. Epub 2007 Mar 7. 2007
37FOXP3
Foxp3 occupancy and regulation of key target genes during T-cell stimulation.
Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA.
Nature 445(7130):931-5. Epub 2007 Jan 21. 2007
38FOXP3
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.
Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S.
Nature 446(7136):685-9. Epub 2007 Mar 21. 2007
39FOXP3, SKP2
FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2.
Zuo T, Liu R, Zhang H, Chang X, Liu Y, Wang L, Zheng P, Liu Y.
J Clin Invest 117(12):3765-73. 2007
40FOXP3, TLR10
FOXP3 regulates TLR10 expression in human T regulatory cells.
Bell MP, Svingen PA, Rahman MK, Xiong Y, Faubion WA Jr.
J Immunol 179(3):1893-900.PMID: 17641056 2007
41FOXP3
Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation.
Smith EL, Finney HM, Nesbitt AM, Ramsdell F, Robinson MK.
Immunology 119(2):203-11. 2006
42HMOX1, FOXP3
Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression.
Choi BM, Pae HO, Jeong YR, Kim YM, Chung HT.
Biochem Biophys Res Commun 327(4):1066-71. 2005
43FOXC2, LPDD,FOXC1, FOXE1, FOXE3, FOXL2, FOXN1, FOXP2, FOXP3, YNS
The establishment of a predictive mutational model of the forkhead domain through the analyses of FOXC2 missense mutations identified in patients with hereditary lymphedema with distichiasis.
Berry FB, Tamimi Y, Carle MV, Lehmann OJ, Walter MA.
Hum Mol Genet 14(18):2619-27. Epub 2005 Aug 4. 2005
44FOXP3
Control of regulatory T cell development by the transcription factor Foxp3
Hori S, Nomura T, Sakaguchi S.
Science 299(5609):1057-61. 2003
45FOXP3
A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes.
Bassuny WM, Ihara K, Sasaki Y, Kuromaru R, Kohno H, Matsuura N, Hara T.
Immunogenetics 55(3):149-56. Epub 2003 May 16. 2003
46IPEX, FOXP3
Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome.
Owen CJ, Jennings CE, Imrie H, Lachaux A, Bridges NA, Cheetham TD, Pearce SH.
J Clin Endocrinol Metab 88(12):6034-9. 2003
47FOXP3, FOXP3
Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome.
Wildin RS, Smyk-Pearson S, Filipovich AH.
J Med Genet 39(8):537-45. Review. 2002
48FOXP3
Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX).
Kobayashi I, Shiari R, Yamada M, Kawamura N, Okano M, Yara A, Iguchi A, Ishikawa N, Ariga T, Sakiyama Y, Ochs HD, Kobayashi K.
J Med Genet 38(12):874-6. No abstract available. 2001
49FOXP3
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation.
Schubert LA, Jeffery E, Zhang Y, Ramsdell F, Ziegler SF.
J Biol Chem 276(40):37672-9. 2001
50FOXP3
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F.
Nat Genet 27(1):68-73. 2001
51FOXP3, FOXP3
The amount of scurfin protein determines peripheral T cell number and responsiveness.
Khattri R, Kasprowicz D, Cox T, Mortrud M, Appleby MW, Brunkow ME, Ziegler SF, Ramsdell F.
J Immunol 167(11):6312-20. 2001
52IPEX, FOXP3
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.
Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD.
Nat Genet 27(1):20-1. 2001
53IPEX, FOXP3
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.
Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, Levy-Lahad E, Mazzella M, Goulet O, Perroni L, Bricarelli FD, Byrne G, McEuen M, Proll S, Appleby M, Brunkow ME.
Nat Genet 27(1):18-20. 2001
54FOXP3
X-Linked syndrome of polyendocrinopathy, immune dysfunction, and diarrhea maps to Xp11.23-Xq13.3.
Bennett CL, Yoshioka R, Kiyosawa H, Barker DF, Fain PR, Shigeoka AO, Chance PF.
Am J Hum Genet 66(2):461-8. 2000
55FOXP3
JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.
Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, Bowcock AM.
J Clin Invest 106(12):R75-81. 2000