| 1 | CYB5R3, FOXO1
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| Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure.
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| Fan J, Du W, Kim-Muller JY, Son J, Kuo T, Larrea D, Garcia C, Kitamoto T, Kraakman MJ, Owusu-Ansah E, Cirulli V, Accili D.
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| Mol Metab. Apr;34:97-111. doi: 10.1016/j.molmet.2019.12.008. Epub 2020 Feb 4 2020
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| 2 | FOXO1, TRIM47
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| TRIM47 Promotes the Development of Glioma by Ubiquitination and Degradation of FOXO1.
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| Wei H, Ding C, Zhuang H, Hu W.
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| Onco Targets Ther. Dec 31;13:13401-13411. doi: 10.2147/OTT.S264459. 2020
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| 3 | FOXO1, PTPMT1
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| FoxO1 localizes to mitochondria of adipose tissue and is affected by nutrient stress.
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| Lettieri-Barbato D, Ioannilli L, Aquilano K, Ciccarone F, Rosina M, Ciriolo MR.
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| Metabolism. Jun;95:84-92. doi: 10.1016/j.metabol.2019.04.006. Epub 2019 Apr 8. 2019
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| 4 | AKT1, EPS8L3, FOXO1
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| Overexpression of EPS8L3 promotes cell proliferation by inhibiting the transactivity of FOXO1 in HCC.
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| Zeng CX, Tang LY, Xie CY, Li FX, Zhao JY, Jiang N, Tong Z, Fu SB, Wen FJ, Feng WS.
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| Neoplasma 65(5):701-707. doi: 10.4149/neo_2018_170725N503. Epub 2018 Jun 17.
2018
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| 5 | FOXO1, PKNOX1
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| The transcription factor Prep1 controls hepatic insulin sensitivity and gluconeogenesis by targeting nuclear localization of FOXO1.
|
| Kulebyakin K, Penkov D, Blasi F, Akopyan Z, Tkachuk V.
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| Biochem Biophys Res Commun 481(1-2):182-188. doi: 10.1016/j.bbrc.2016.10.146. Epub 2016 Nov 1.
2016
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| 6 | FOXO1, LAMTOR5, PCK1
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| The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells.
|
| Shi H, Fang R, Li Y, Li L, Zhang W, Wang H, Chen F, Zhang S, Zhang X, Ye L.
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| Cancer Lett. Nov 28;382(2):147-156. doi: 10.1016/j.canlet.2016.08.025. Epub 2016 Sep 5 2016
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| 7 | FOXO1, IL17R, ZFAT
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| Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells.
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| Iwaihara Y, Ishikura S, Doi K, Tsunoda T, Fujimoto T, Okamura T, Shirasawa S.
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| Anticancer Res 35(8):4419-23.
2015
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| 8 | FOXO1, TBX21
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| Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function.
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| Deng Y, Kerdiles Y, Chu J, Yuan S, Wang Y, Chen X, Mao H, Zhang L, Zhang J, Hughes T, Deng Y, Zhang Q, Wang F, Zou X, Liu CG, Freud AG, Li X, Caligiuri MA, Vivier E, Yu J.
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| Immunity 42(3):457-70. doi: 10.1016/j.immuni.2015.02.006.
2015
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| 9 | FOXO1, GAS6, VCAM1
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| Growth arrest-specific 6 regulates thrombin-induced expression of vascular cell adhesion molecule-1 through forkhead box O1 in endothelial cells.
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| Bertin FR, Lemarié CA, Robins RS, Blostein MD.
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| J Thromb Haemost 13(12):2260-72. doi: 10.1111/jth.13156. Epub 2015 Nov 20.
2015
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| 10 | FOXO1, MYH7
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| Activation of Foxo1 by insulin resistance promotes cardiac dysfunction and β-myosin heavy chain gene expression.
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| Qi Y, Zhu Q, Zhang K, Thomas C, Wu Y, Kumar R, Baker KM, Xu Z, Chen S, Guo S.
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| Circ Heart Fail 8(1):198-208. doi: 10.1161/CIRCHEARTFAILURE.114.001457. Epub 2014 Dec 4.
2015
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| 11 | ANGPTL4, FOXO1, NR3C1
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| Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin.
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| Kuo T, Chen TC, Yan S, Foo F, Ching C, McQueen A, Wang JC.
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| J Lipid Res 55(5):919-28. doi: 10.1194/jlr.M047860. Epub 2014 Feb 24.
2014
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| 12 | AKT1, ALCAM, FOXO1
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| CD166 plays a pro-carcinogenic role in liver cancer cells via inhibition of FOXO proteins through AKT.
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| Yu W, Wang J, Ma L, Tang X, Qiao Y, Pan Q, Yu Y, Sun F.
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| Oncol Rep 32(2):677-83. doi: 10.3892/or.2014.3226. Epub 2014 May 30.
2014
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| 13 | DBH, FOXO1
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| Foxo1 regulates Dbh expression and the activity of the sympathetic nervous system in vivo
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| Kajimura D, Paone R, Mann JJ, Karsenty G.
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| Mol Metab. Jul 29;3(7):770-7. doi: 10.1016/j.molmet.2014.07.006. 2014
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| 14 | FOXO1, MAPKAPK5
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| MK5 activates Rag transcription via Foxo1 in developing B cells.
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| Chow KT, Timblin GA, McWhirter SM, Schlissel MS.
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| J Exp Med 210(8):1621-34. doi: 10.1084/jem.20130498. Epub 2013 Jul 22.
2013
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| 15 | FOXO1, MLXIPL, TNXIP
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| FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells.
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| Kibbe C, Chen J, Xu G, Jing G, Shalev A.
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| J Biol Chem 288(32):23194-202. doi: 10.1074/jbc.M113.473082. Epub 2013 Jun 26.
2013
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| 16 | FOXO1, IRF3
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| FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3.
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| Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B, Shu HB.
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| J Biol Chem 288(18):12596-604. doi: 10.1074/jbc.M112.444794. Epub 2013 Mar 26.
2013
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| 17 | FOXO1
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| FoxO1 is crucial for sustaining cardiomyocyte metabolism and cell survival.
|
| Puthanveetil P, Wan A, Rodrigues B.
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| Cardiovasc Res 97(3):393-403. doi: 10.1093/cvr/cvs426. Epub 2012 Dec 21. Review.
2013
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| 18 | FOXO1
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| FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress.
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| Ponugoti B, Xu F, Zhang C, Tian C, Pacios S, Graves DT.
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| J Cell Biol 203(2):327-43. doi: 10.1083/jcb.201305074. Epub 2013 Oct 21.
2013
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| 19 | E2F1, FOXO1, FOXO3
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| FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function.
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| Shats I, Gatza ML, Liu B, Angus SP, You L, Nevins JR.
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| Cancer Res 73(19):6056-67. doi: 10.1158/0008-5472.CAN-13-0453. Epub 2013 Aug 21.
2013
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| 20 | FNDC3B, FOXO1
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| Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
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| Lu Y, Vitart V, Burdon KP, Khor CC, Bykhovskaya Y, Mirshahi A, Hewitt AW, Koehn D, Hysi PG, Ramdas WD, Zeller T, Vithana EN, Cornes BK, Tay WT, Tai ES, Cheng CY, Liu J, Foo JN, Saw SM, Thorleifsson G, Stefansson K, Dimasi DP, Mills RA, Mountain J, Ang W, Hoehn R, Verhoeven VJ, Grus F, Wolfs R, Castagne R, Lackner KJ, Springelkamp H, Yang J, Jonasson F, Leung DY, Chen LJ, Tham CC, Rudan I, Vatavuk Z, Hayward C, Gibson J, Cree AJ, MacLeod A, Ennis S, Polasek O, Campbell H, Wilson JF, Viswanathan AC, Fleck B, Li X, Siscovick D, Taylor KD, Rotter JI, Yazar S, Ulmer M, Li J, Yaspan BL, Ozel AB, Richards JE, Moroi SE, Haines JL, Kang JH, Pasquale LR, Allingham RR, Ashley-Koch A; NEIGHBOR Consortium, Mitchell P, Wang JJ, Wright AF, Pennell C, Spector TD, Young TL, Klaver CC, Martin NG, Montgomery GW, Anderson MG, Aung T, Willoughby CE, Wiggs JL, Pang CP, Thorsteinsdottir U, Lotery AJ, Hammond CJ, van Duijn CM, Hauser MA, Rabinowitz YS, Pfeiffer N, Mackey DA, Craig JE, Macgregor S, Wong TY.
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| Nat Genet 45(2):155-63. doi: 10.1038/ng.2506. Epub 2013 Jan 6.
2013
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| 21 | FOXO1, KLF2
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| FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Kruppel-like factor 2.
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| Lee HY, Youn SW, Cho HJ, Kwon YW, Lee SW, Kim SJ, Park YB, Oh BH, Kim HS.
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| Cardiovasc Res 97(1):143-52. doi: 10.1093/cvr/cvs283. Epub 2012 Sep 21.
2013
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| 22 | FOXO1, LIPA
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| FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment.
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| Lettieri Barbato D, Tatulli G, Aquilano K, Ciriolo MR.
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| Cell Death Dis 4:e861. doi: 10.1038/cddis.2013.404.
2013
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| 23 | FOXO1, RHOA, RIPOR2
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| Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration
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| Rougerie P, Largeteau Q, Megrelis L, Carrette F, Lejeune T, Toffali L, Rossi B, Zeghouf M, Cherfils J, Constantin G, Laudanna C, Bismuth G, Mangeney M, Delon J
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| J Immunol. Jan 15;190(2):748-55. doi: 10.4049/jimmunol.1201174. Epub 2012 Dec 14. 2013
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| 24 | FOXO1
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| Novel Foxo1-dependent transcriptional programs control T(reg) cell function.
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| Ouyang W, Liao W, Luo CT, Yin N, Huse M, Kim MV, Peng M, Chan P, Ma Q, Mo Y, Meijer D, Zhao K, Rudensky AY, Atwal G, Zhang MQ, Li MO.
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| Nature 491(7425):554-9. doi: 10.1038/nature11581. Epub 2012 Nov 7.
2012
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| 25 | ATF4, FOXO1
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| FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis.
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| Kode A, Mosialou I, Silva BC, Joshi S, Ferron M, Rached MT, Kousteni S.
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| J Biol Chem 287(12):8757-68. doi: 10.1074/jbc.M111.282897. Epub 2012 Feb 1.
2012
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| 26 | AGRP, FOXO1, GPR17
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| FoxO1 target Gpr17 activates AgRP neurons to regulate food intake.
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| Ren H, Orozco IJ, Su Y, Suyama S, Gutiérrez-Juárez R, Horvath TL, Wardlaw SL, Plum L, Arancio O, Accili D.
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| Cell 149(6):1314-26. doi: 10.1016/j.cell.2012.04.032. Erratum in: Cell. 2013 May 23;153(5):1166.
2012
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| 27 | FOXO1, NR5A1
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| FOXO1 in the ventromedial hypothalamus regulates energy balance.
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| Kim KW, Donato J Jr, Berglund ED, Choi YH, Kohno D, Elias CF, Depinho RA, Elmquist JK.
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| J Clin Invest 122(7):2578-89. doi: 10.1172/JCI62848. Epub 2012 Jun 1.
2012
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| 28 | EDN1, FOXO1
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| FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival.
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| Cifarelli V, Lee S, Kim DH, Zhang T, Kamagate A, Slusher S, Bertera S, Luppi P, Trucco M, Dong HH.
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| Mol Endocrinol 26(7):1213-24. doi: 10.1210/me.2011-1276. Epub 2012 May 8.
2012
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| 29 | FOXO1
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| FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development.
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| Sengupta A, Chakraborty S, Paik J, Yutzey KE, Evans-Anderson HJ.
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| Dev Dyn 241(4):803-13. doi: 10.1002/dvdy.23759.
2012
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| 30 | FOXO1, PPP2R2A
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| The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress.
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| Yan L, Guo S, Brault M, Harmon J, Robertson RP, Hamid R, Stein R, Yang E.
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| Biochem J 444(2):239-47. doi: 10.1042/BJ20111606.
2012
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| 31 | FOXO1, FOXO3
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| Kinetics of nuclear-cytoplasmic translocation of Foxo1 and Foxo3A in adult skeletal muscle fibers.
|
| Schachter TN, Shen T, Liu Y, Schneider MF.
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| Am J Physiol Cell Physiol 303(9):C977-90. doi: 10.1152/ajpcell.00027.2012. Epub 2012 Aug 29.
2012
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| 32 | FOXO1, HTT, XBP1
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| Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.
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| Vidal RL, Figueroa A, Court FA, Thielen P, Molina C, Wirth C, Caballero B, Kiffin R, Segura-Aguilar J, Cuervo AM, Glimcher LH, Hetz C.
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| Hum Mol Genet 21(10):2245-62. doi: 10.1093/hmg/dds040. Epub 2012 Feb 14.
2012
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| 33 | FOXO1, FOXP3
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| Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification.
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| Samstein RM, Arvey A, Josefowicz SZ, Peng X, Reynolds A, Sandstrom R, Neph S, Sabo P, Kim JM, Liao W, Li MO, Leslie C, Stamatoyannopoulos JA, Rudensky AY.
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| Cell 151(1):153-66. doi: 10.1016/j.cell.2012.06.053.
2012
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| 34 | FOXO1, NDN, SIRT1, TP53
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| Necdin controls Foxo1 acetylation in hypothalamic arcuate neurons to modulate the thyroid axis.
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| Hasegawa K, Kawahara T, Fujiwara K, Shimpuku M, Sasaki T, Kitamura T, Yoshikawa K.
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| J Neurosci 32(16):5562-72. doi: 10.1523/JNEUROSCI.0142-12.2012.
2012
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| 35 | FOXO1, IL1B, SMPD3
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| Interleukin 1β regulation of FoxO1 protein content and localization: evidence for a novel ceramide-dependent mechanism.
|
| Dobierzewska A, Shi L, Karakashian AA, Nikolova-Karakashian MN.
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| J Biol Chem 287(53):44749-60. doi: 10.1074/jbc.M112.378836. Epub 2012 Oct 26.
2012
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| 36 | FOXO1, MIR96
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| miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells.
|
| Kuhn S, Johnson SL, Furness DN, Chen J, Ingham N, Hilton JM, Steffes G, Lewis MA, Zampini V, Hackney CM, Masetto S, Holley MC, Steel KP, Marcotti W.
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| Proc Natl Acad Sci U S A 108(6):2355-60. Epub 2011 Jan 18.
2011
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| 37 | FOXO1, GADD45A, SIRT1
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| FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide.
|
| Hughes KJ, Meares GP, Hansen PA, Corbett JA.
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| J Biol Chem 286(10):8338-48. Epub 2011 Jan 1.
2011
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| 38 | FOXO1, RUNX2
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| FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion.
|
| Zhang H, Pan Y, Zheng L, Choe C, Lindgren B, Jensen ED, Westendorf JJ, Cheng L, Huang H.
|
| Cancer Res 71(9):3257-67. Epub 2011 Apr 19.
2011
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| 39 | FOXO1, VCAM1
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| Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo.
|
| Ferdous A, Morris J, Abedin MJ, Collins S, Richardson JA, Hill JA.
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| Proc Natl Acad Sci U S A 108(39):16307-12. Epub 2011 Sep 19.
2011
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| 40 | FOXO1
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| FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.
|
| Zhang X, Yalcin S, Lee DF, Yeh TY, Lee SM, Su J, Mungamuri SK, Rimmelé P, Kennedy M, Sellers R, Landthaler M, Tuschl T, Chi NW, Lemischka I, Keller G, Ghaffari S.
|
| Nat Cell Biol 13(9):1092-9. doi: 10.1038/ncb2293.
2011
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| 41 | CNKSR1, FOXO1
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| CNK1 and other scaffolds for Akt/FoxO signaling.
|
| Fritz RD, Radziwill G.
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| Biochim Biophys Acta 1813(11):1971-7. doi: 10.1016/j.bbamcr.2011.02.008. Epub 2011 Feb 12. Review.
2011
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| 42 | CTSL, FOXO1
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| The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.
|
| Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y.
|
| Biochem J 427(1):171-8. 2010
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| 43 | ATG7, FOXO1, FOXO1B, FOXO3, FOXO3B, FOXO4, FOXO6
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| Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
|
| Zhao Y, Yang J, Liao W, Liu X, Zhang H, Wang S, Wang D, Feng J, Yu L, Zhu WG.
|
| Nat Cell Biol 12(7):665-75. Epub 2010 Jun 13.PMID: 20543840 2010
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| 44 | FOXO1, RUNX2
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| Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis.
|
| Teixeira CC, Liu Y, Thant LM, Pang J, Palmer G, Alikhani M.
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| J Biol Chem 285(40):31055-65. Epub 2010 Jul 22.
2010
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| 45 | FOXO1, TLR4
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| FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages.
|
| Fan W, Morinaga H, Kim JJ, Bae E, Spann NJ, Heinz S, Glass CK, Olefsky JM.
|
| EMBO J 29(24):4223-36. Epub 2010 Nov 2.
2010
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| 46 | FOXO1, MAP3K7, NLK
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| Regulation of FOXO1 by TAK1-Nemo-like kinase pathway.
|
| Kim S, Kim Y, Lee J, Chung J.
|
| J Biol Chem 285(11):8122-9. Epub 2010 Jan 8.
2010
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| 47 | EWSR1, FLI1, FOXO1
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| FOXO1 is a direct target of EWS-Fli1 oncogenic fusion protein in Ewing's sarcoma cells.
|
| Yang L, Hu HM, Zielinska-Kwiatkowska A, Chansky HA.
|
| Biochem Biophys Res Commun 402(1):129-34. doi: 10.1016/j.bbrc.2010.09.129. Epub 2010 Oct 8.
2010
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| 48 | FOXA1, FOXA2, FOXA3, FOXC1, FOXC2, FOXO1, FOXO3, FOXO4, FOXP2, FOXP3
|
| The evolution of Fox genes and their role in development and disease.
|
| Hannenhalli S, Kaestner KH.
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| Nat Rev Genet 10(4):233-40. Review. 2009
|
| 49 | FGFR4, FOXO1
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| FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action.
|
| Shin DJ, Osborne TF.
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| J Biol Chem 284(17):11110-20. Epub 2009 Feb 23.
2009
|
| 50 | FOXO1, TXNIP
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| Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells.
|
| Li X, Rong Y, Zhang M, Wang XL, LeMaire SA, Coselli JS, Zhang Y, Shen YH.
|
| Biochem Biophys Res Commun 381(4):660-5. Epub 2009 Feb 28.
2009
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| 51 | FOXO1, FOXO3, FOXO4, FOXO6
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| The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors.
|
| Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB.
|
| J Biol Chem 284(16):10334-42. Epub 2009 Feb 24.
2009
|
| 52 | FOXO1
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| Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes.
|
| Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring HU.
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| J Clin Endocrinol Metab 94(4):1353-60. Epub 2009 Jan 13.
2009
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| 53 | FOXO1, FOXO3, MDM2
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| MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
|
| Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W.
|
| J Biol Chem 284(21):13987-4000. Epub 2009 Mar 25.
2009
|
| 54 | FOXO1, FOXO3, FOXO4, FOXO6, PARP1
|
| Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1.
|
| Sakamaki J, Daitoku H, Yoshimochi K, Miwa M, Fukamizu A.
|
| Biochem Biophys Res Commun 382(3):497-502. Epub 2009 Mar 10. 2009
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| 55 | FOXO1
|
| Foxo1 integrates insulin signaling with mitochondrial function in the liver.
|
| Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF.
|
| Nat Med 15(11):1307-11. Epub 2009 Oct 18.PMID: 19838201 2009
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| 56 | FOXO1, HOXA11
|
| HoxA-11 and FOXO1A cooperate to regulate decidual prolactin expression: towards inferring the core transcriptional regulators of decidual genes.
|
| Lynch VJ, Brayer K, Gellersen B, Wagner GP.
|
| PLoS One 4(9):e6845.PMID: 19727442 2009
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| 57 | FOXO1, PNPLA2
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| FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes.
|
| Chakrabarti P, Kandror KV.
|
| J Biol Chem 284(20):13296-300. Epub 2009 Mar 17.
2009
|
| 58 | FOXO1, POMC
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| FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1.
|
| Yang G, Lim CY, Li C, Xiao X, Radda GK, Li C, Cao X, Han W.
|
| J Biol Chem 284(6):3719-27. Epub 2008 Dec 2.
2009
|
| 59 | ADIPOR1, ADIPOR2, FOXO1
|
| Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element.
|
| Sun X, He J, Mao C, Han R, Wang Z, Liu Y, Chen Y.
|
| FEBS Lett 582(23-24):3401-7. Epub 2008 Sep 19.
2008
|
| 60 | PAX3, FOXO1
|
| Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma.
|
| Kikuchi K, Tsuchiya K, Otabe O, Gotoh T, Tamura S, Katsumi Y, Yagyu S, Tsubai-Shimizu S, Miyachi M, Iehara T, Hosoi H.
|
| Biochem Biophys Res Commun 365(3):568-74. Epub 2007 Nov 20. 2008
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| 61 | FOXO1, FOXC1, AXR1
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| FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A.
|
| Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MA.
|
| Hum Mol Genet 17(4):490-505. Epub 2007 Nov 9. 2008
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| 62 | CDK1, FOXO1
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| Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.
|
| Yuan Z, Becker EB, Merlo P, Yamada T, DiBacco S, Konishi Y, Schaefer EM, Bonni A.
|
| Science 319(5870):1665-8. 2008
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| 63 | FOXO1
|
| O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene.
|
| Kuo M, Zilberfarb V, Gangneux N, Christeff N, Issad T.
|
| FEBS Lett 582(5):829-34. Epub 2008 Feb 14.
2008
|
| 64 | FOXO1, TRIM63
|
| The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.
|
| Waddell DS, Baehr LM, van den Brandt J, Johnsen SA, Reichardt HM, Furlow JD, Bodine SC.
|
| Am J Physiol Endocrinol Metab 295(4):E785-97. Epub 2008 Jul 8.
2008
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| 65 | FOXO1
|
| Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components.
|
| Wu AL, Kim JH, Zhang C, Unterman TG, Chen J.
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| Endocrinology 149(3):1407-14. Epub 2007 Dec 13.PMID: 18079193 2008
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| 66 | FOXO1, RFWD2
|
| COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression.
|
| Kato S, Ding J, Pisck E, Jhala US, Du K.
|
| J Biol Chem 283(51):35464-73. Epub 2008 Sep 24.PMID: 18815134 2008
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| 67 | FOXO1,FOXO3
|
| Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age.
|
| Kuningas M, Magi R, Westendorp RG, Slagboom PE, Remm M, van Heemst D.
|
| Eur J Hum Genet 15(3):294-301. Epub 2007 Jan 24. 2007
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| 68 | TEK, FOXO1, ANGPT2
|
| Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress.
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| Chlench S, Mecha Disassa N, Hohberg M, Hoffmann C, Pohlkamp T, Beyer G, Bongrazio M, Da Silva-Azevedo L, Baum O, Pries AR, Zakrzewicz A.
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| FEBS Lett 581(4):673-80. Epub 2007 Jan 22. 2007
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| 69 | FOXO1, OSTN
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| Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.
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| Biochem Biophys Res Commun 364(2):358-65. Epub 2007 Oct 15. 2007
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| 70 | PAX3, FOXO1, CDKN1C
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| PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1.
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| Proc Natl Acad Sci U S A 104(46):18085-90. Epub 2007 Nov 6. 2007
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| 71 | 2F1, FOXO1, FOXO3
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| E2F-1 regulates expression of FOXO1 and FOXO3a.
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| Nowak K, Killmer K, Gessner C, Lutz W.
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| Biochim Biophys Acta 1769(4):244-52. Epub 2007 Apr 6. 2007
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| 72 | FOXO1, SIRT2
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| SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.
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| Cell Metab 6(2):105-14.PMID: 17681146 2007
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| 73 | ANGPT2, FOXO1
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| Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.
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| Daly C, Pasnikowski E, Burova E, Wong V, Aldrich TH, Griffiths J, Ioffe E, Daly TJ, Fandl JP, Papadopoulos N, McDonald DM, Thurston G, Yancopoulos GD, Rudge JS.
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| Proc Natl Acad Sci U S A 103(42):15491-6. Epub 2006 Oct 9. 2006
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| 74 | AGRP,FOXO1
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| Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.
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| Nat Med 12(5):534-40. Epub 2006 Apr 9. 2006
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| 75 | FOXO1
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| Analysis of FOXO1A as a candidate gene for type 2 diabetes.
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| Karim MA, Craig RL, Wang X, Hale TC, Elbein SC.
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| Mol Genet Metab 88(2):171-7. Epub 2006 Feb 23. 2006
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| 76 | FOXO1
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| FOXO1A differentially regulates genes of decidualization.
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| Buzzio OL, Lu Z, Miller CD, Unterman TG, Kim JJ.
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| Endocrinology 147(8):3870-6. Epub 2006 May 11. 2006
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| 77 | FOXO1, IRS2
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| The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.
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| Mol Endocrinol 20(12):3389-99. Epub 2006 Aug 17.
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| 78 | FOXO1,SKP2
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| Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.
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| Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM, Tindall DJ.
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| Proc Natl Acad Sci U S A 102(5):1649-54. Epub 2005 Jan 24. 2005
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| 79 | FOXO1,PAX3,PAX7
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| Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma.
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| Int J Cancer 115(1):85-92. 2005
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| 80 | FOXO1,PAX3
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| Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR.
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| Begum S, Emani N, Cheung A, Wilkins O, Der S, Hamel PA.
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| Oncogene 24(11):1860-72. 2005
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| 81 | FOXO1
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| Regulation of the proapoptotic factor FOXO1 (FKHR) in cardiomyocytes by growth factors and alpha1-adrenergic agonists.
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| Morris JB, Kenney B, Huynh H, Woodcock EA.
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| Endocrinology. 146(10):4370-6. Epub 2005 Jul 14. 2005
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| 82 | NOXO1, FOXO1, FOXA1
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| NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain.
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| Cheng G, Lambeth JD.
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| J Biol Chem 279(6):4737-42. Epub 2003 Nov 14. 2004
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| 83 | FOXO1
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| A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene.
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| Giampieri C, Centurelli M, Bonafe M, Olivieri F, Cardelli M, Marchegiani F, Cavallone L, Giovagnetti S, Mugianesi E, Carrieri G, Lisa R, Cenerelli S, Testa R, Boemi M, Petropoulou C, Gonos ES, Franceschi C.
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| Gene 327(2):215-9. 2004
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| 84 | FOXO1
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| Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.
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| Zhao X, Gan L, Pan H, Kan D, Majeski M, Adam SA, Unterman TG.
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| Biochem J 378(Pt 3):839-49. 2004
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| 85 | ANGPT1,FOXO1
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| Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1).
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| Daly C, Wong V, Burova E, Wei Y, Zabski S, Griffiths J, Lai KM, Lin HC, Ioffe E, Yancopoulos GD, Rudge JS.
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| Genes Dev 18(9):1060-71. 2004
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| 86 | FOXO1,PAX3
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| Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one case.
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| Gordon A, McManus A, Anderson J, Fisher C, Abe S, Nojima T, Pritchard-Jones K, Shipley J.
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| Cancer Genet Cytogenet 140(1):73-7. 2003
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| 87 | FOXO1,FOXO3
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| FOXO transcription factors as regulators of immune homeostasis: molecules to die for?
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| Birkenkamp KU, Coffer PJ.
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| J Immunol 171(4):1623-9. Review. 2003
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| 88 | FOXO1,PDK4
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| Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation.
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| Furuyama T, Kitayama K, Yamashita H, Mori N.
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| Biochem J 375(Pt 2):365-71. 2003
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| 89 | ARMS, FOXO1, PAX3, PAX7
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| PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.
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| Sorensen PH, Lynch JC, Qualman SJ, Tirabosco R, Lim JF, Maurer HM, Bridge JA, Crist WM, Triche TJ, Barr FG.
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| J Clin Oncol 20(11):2672-9. 2002
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| 90 | FOXO1
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| Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.
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| Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D.
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| Nat Genet 32(2):245-53. 2002
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| 91 | FOXO1
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| Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.
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| del Peso L, Gonzalez VM, Hernandez R, Barr FG, Nunez G.
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| Oncogene 18(51):7328-33. 1999
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| 92 | FOXO1,FOXO1B,FOXO3,FOXO3B
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| Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
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| Anderson MJ, et al.
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| Genomics 47(2):187-99. 1998
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| 93 | FOXO1
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| Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma.
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| Ginsberg JP, Davis RJ, Bennicelli JL, Nauta LE, Barr FG.
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| Cancer Res 58 : 3542-3546. 1998
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| 94 | ARMS,BARMS1,BARMS13,BARMS2,FOXO1,PAX3,PAX7
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| In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma.
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| 95 | ARMS,BARMS1,FOXO1,PAX7
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| Novel formation and amplification of the PAX7--FKHR fusion gene in a case of alveolar rhabdomyosarcoma.
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| Genes Chromosomes Cancer 17 : 7-13. 1996
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| 96 | ARMS,BARMS13,FOXO1,PAX3
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| Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization.
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| Biegel JA, Nycum LM, Valentine V, Barr FG, Shapiro DN.
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| 97 | FOXO1,FOXO1B
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| Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma.
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| Hum Mol Genet 4 : 2355-2362. 1995
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| 98 | FOXO1,PAX3
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| The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.
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| Fredericks WJ, et al.
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| Mol Cell Biol 15 : 1522-1535. 1995
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| 99 | BARMS13,BARMS2,FOXO1,PAX3
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| The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.
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| Oncogene 11 : 545-552. 1995
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| 100 | ARMS,BARMS1,FOXO1,PAX7
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| Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.
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| Davis RJ, et al.
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| Cancer Res 54 : 2869-2872. 1994
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| 101 | FOXO1
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| Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
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| Nat Genet 5 : 230-235. 1993
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| 102 | FOXO1
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| Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.
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