| 1 | FOXC2, RAB3GAP1, RAB3GAP2, SNAP25
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| FOXC1 modulates MYOC secretion through regulation of the exocytic proteins RAB3GAP1, RAB3GAP2 and SNAP25
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| Rasnitsyn A, Doucette L, Seifi M, Footz T, Raymond V, Walter MA.
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| PLoS One. Jun 2;12(6):e0178518. doi: 10.1371/journal.pone.0178518. 2017
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| 2 | FOXC2, SPP1
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| Inorganic phosphate induces cancer cell mediated angiogenesis dependent on forkhead box protein C2 (FOXC2) regulated osteopontin expression.
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| Lin Y, McKinnon KE, Ha SW, Beck GR Jr.
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| Mol Carcinog ol Carcinog. 2014 Apr 2. doi: 10.1002/mc.22153. [Epub ahead of print]
2014
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| 3 | FOXC2
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| Overexpressed FOXC2 in ovarian cancer enhances the epithelial-to-mesenchymal transition and invasion of ovarian cancer cells.
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| Liu B, Han SM, Tang XY, Han L, Li CZ.
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| Oncol Rep 31(6):2545-54. doi: 10.3892/or.2014.3119. Epub 2014 Apr 2.
2014
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| 4 | FOXC2
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| Foxc2 over-expression in bone marrow mesenchymal stem cells stimulates osteogenic differentiation and inhibits adipogenic differentiation.
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| You W, Fan L, Duan D, Tian L, Dang X, Wang C, Wang K.
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| Mol Cell Biochem 386(1-2):125-34.
2014
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| 5 | FOXC2
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| Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells.
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| Ivanov KI, Agalarov Y, Valmu L, Samuilova O, Liebl J, Houhou N, Maby-El Hajjami H, Norrmén C, Jaquet M, Miura N, Zangger N, Ylä-Herttuala S, Delorenzi M, Petrova TV.
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| Mol Cell Biol 33(19):3749-61. doi: 10.1128/MCB.01387-12. Epub 2013 Jul 22.
2013
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| 6 | FOXC2
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| Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells.
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| Ivanov KI, Agalarov Y, Valmu L, Samuilova O, Liebl J, Houhou N, Maby-El Hajjami H, Norrmén C, Jaquet M, Miura N, Zangger N, Ylä-Herttuala S, Delorenzi M, Petrova TV.
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| Mol Cell Biol 33(19):3749-61. doi: 10.1128/MCB.01387-12. Epub 2013 Jul 22.
2013
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| 7 | FOXC2
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| Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis.
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| Gozo MC, Aspuria PJ, Cheon DJ, Walts AE, Berel D, Miura N, Karlan BY, Orsulic S.
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| Cell Death Differ 20(8):1031-42. doi: 10.1038/cdd.2013.34. Epub 2013 May 3.
2013
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| 8 | DEL16Q243, FOXC2, GLMN
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| Microcephaly, intellectual impairment, bilateral vesicoureteral reflux, distichiasis, and glomuvenous malformations associated with a 16q24.3 contiguous gene deletion and a Glomulin mutation.
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| Butler MG, Dagenais SL, Garcia-Perez JL, Brouillard P, Vikkula M, Strouse P, Innis JW, Glover TW.
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| Am J Med Genet A 158A(4):839-49. doi: 10.1002/ajmg.a.35229. Epub 2012 Mar 9.
2012
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| 9 | FOXC1, FOXC2
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| Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.
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| Danciu TE, Chupreta S, Cruz O, Fox JE, Whitman M, Iñiguez-Lluhí JA.
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| J Biol Chem 287(22):18318-29. doi: 10.1074/jbc.M112.339424. Epub 2012 Apr 5.
2012
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| 10 | FOXC2, LPDD
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| Novel mutation in the FOXC2 gene in three generations of a family with lymphoedema-distichiasis syndrome.
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| Sutkowska E, Gil J, Stembalska A, Hill-Bator A, Szuba A.
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| Gene 498(1):96-9. doi: 10.1016/j.gene.2012.01.098. Epub 2012 Feb 14. Erratum in: Gene. 2012 Aug 10;504(2):317.
2012
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| 11 | FOXC2
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| The forkhead transcription factor Foxc2 promotes osteoblastogenesis via up-regulation of integrin β1 expression.
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| Park SJ, Gadi J, Cho KW, Kim KJ, Kim SH, Jung HS, Lim SK.
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| Bone 49(3):428-38. doi: 10.1016/j.bone.2011.05.012. Epub 2011 May 25.
2011
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| 12 | FOXC2
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| The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function.
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| Lidell ME, Seifert EL, Westergren R, Heglind M, Gowing A, Sukonina V, Arani Z, Itkonen P, Wallin S, Westberg F, Fernandez-Rodriguez J, Laakso M, Nilsson T, Peng XR, Harper ME, Enerbäck S.
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| Diabetes 60(2):427-35. doi: 10.2337/db10-0409.
2011
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| 13 | FOXC2
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| FOXC2 is a novel prognostic factor in human esophageal squamous cell carcinoma.
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| Nishida N, Mimori K, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.
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| Ann Surg Oncol 18(2):535-42. doi: 10.1245/s10434-010-1274-y. Epub 2010 Aug 28.
2011
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| 14 | ACDMPV, DEL16Q241, DEL16QO, FOXC2, FOXF1
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| Haploinsufficiencies of FOXF1 and FOXC2 genes associated with lethal alveolar capillary dysplasia and congenital heart disease.
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| Yu S, Shao L, Kilbride H, Zwick DL.
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| Am J Med Genet A 152A(5):1257-62.PMID: 20425831 2010
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| 15 | DEL16Q241, FOXC2, FOXF1
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| Haploinsufficiencies of FOXF1 and FOXC2 genes associated with lethal alveolar capillary dysplasia and congenital heart disease.
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| Yu S, Shao L, Kilbride H, Zwick DL.
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| Am J Med Genet A 152A(5):1257-62. doi: 10.1002/ajmg.a.33378.
2010
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| 16 | FOXA1, FOXA2, FOXA3, FOXC1, FOXC2, FOXO1, FOXO3, FOXO4, FOXP2, FOXP3
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| The evolution of Fox genes and their role in development and disease.
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| Hannenhalli S, Kaestner KH.
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| Nat Rev Genet 10(4):233-40. Review. 2009
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| 17 | FOXC2, ITGB3
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| The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression.
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| Hayashi H, Sano H, Seo S, Kume T.
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| J Biol Chem 283(35):23791-800. Epub 2008 Jun 24.
2008
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| 18 | CXCR4, FOXC1, FOXC2
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| Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration.
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| Hayashi H, Kume T.
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| Biochem Biophys Res Commun 367(3):584-9. Epub 2008 Jan 8. 2008
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| 19 | ANGPT2, FOXC2
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| FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue.
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| Xue Y, Cao R, Nilsson D, Chen S, Westergren R, Hedlund EM, Martijn C, Rondahl L, Krauli P, Walum E, Enerbäck S, Cao Y.
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| Proc Natl Acad Sci U S A 105(29):10167-72. Epub 2008 Jul 11.
2008
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| 20 | FOXC2
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| Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers.
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| Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, Kutok JL, Hartwell K, Richardson AL, Weinberg RA.
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| Proc Natl Acad Sci U S A 104(24):10069-74. Epub 2007 May 30. 2007
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| 21 | FOXC2
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| Mutations in FOXC2 are strongly associated with primary valve failure in veins of the lower limb.
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| Mellor RH, Brice G, Stanton AW, French J, Smith A, Jeffery S, Levick JR, Burnand KG, Mortimer PS; Lymphoedema Research Consortium.
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| Circulation 115(14):1912-20. Epub 2007 Mar 19.
2007
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| 22 | FOXC2, SERPINE1
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| Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression.
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| Fujita H, Kang M, Eren M, Gleaves LA, Vaughan DE, Kume T.
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| Circ Res 98(5):626-34. Epub 2006 Feb 2. 2006
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| 23 | FOXC2
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| Large-scale identification of genes implicated in kidney glomerulus development and function.
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| Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C.
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| EMBO J 25(5):1160-74. Epub 2006 Feb 23. 2006
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| 24 | FOXC2
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| Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs.
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| Ng MY, Andrew T, Spector TD, Jeffery S.
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| J Med Genet 42(3):235-239. 2005
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| 25 | FOXC2, LPDD, YNS
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| Lymphoedema-distichiasis and FOXC2: unreported mutations, de novo mutation estimate, families without coding mutations.
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| Sholto-Douglas-Vernon C, Bell R, Brice G, Mansour S, Sarfarazi M, Child AH, Smith A, Mellor R, Burnand K, Mortimer P, Jeffery S.
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| Hum Genet 117(2-3):238-242. Epub 2005 May 20. 2005
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| 26 | FOXC2, LPDD,FOXC1, FOXE1, FOXE3, FOXL2, FOXN1, FOXP2, FOXP3, YNS
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| The establishment of a predictive mutational model of the forkhead domain through the analyses of FOXC2 missense mutations identified in patients with hereditary lymphedema with distichiasis.
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| Berry FB, Tamimi Y, Carle MV, Lehmann OJ, Walter MA.
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| Hum Mol Genet 14(18):2619-27. Epub 2005 Aug 4. 2005
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| 27 | XLKD1, FIGF, VEGFC, PROX1, FLT4, LCP2, ANGPT1, ANGPTL1, ANGPT4, TEK, EFNB2, FOXC2, PDPN
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| Lymphangiogenesis in development and human disease.
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| Alitalo K, Tammela T, Petrova TV.
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| Nature 438(7070):946-53. Review. 2005
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| 28 | LPDD, FOXC2, YNS
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| A novel frameshift mutation of FOXC2 gene in a family with hereditary lymphedema-distichiasis syndrome associated with renal disease and diabetes mellitus.
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| Yildirim-Toruner C, Subramanian K, El Manjra L, Chen E, Goldstein S, Vitale E.
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| Am J Med Genet 131A(3):281-6. 2004
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| 29 | FOXC2, LPDD
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| FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome.
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| Kriederman BM, Myloyde TL, Witte MH, Dagenais SL, Witte CL, Rennels M, Bernas MJ, Lynch MT, Erickson RP, Caulder MS, Miura N, Jackson D, Brooks BP, Glover TW.
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| Hum Mol Genet 12(10):1179-85. 2003
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| 30 | DDN, FOXC2, WWC1
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| Characterization of KIBRA, a novel WW domain-containing protein.
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| Kremerskothen J, Plaas C, Buther K, Finger I, Veltel S, Matanis T, Liedtke T, Barnekow A.
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| Biochem Biophys Res Commun 300(4):862-7. 2003
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| 31 | FOXC2, LPDD
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| Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24.
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| Brice G, Mansour S, Bell R, Collin JR, Child AH, Brady AF, Sarfarazi M, Burnand KG, Jeffery S, Mortimer P, Murday VA.
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| J Med Genet 39(7):478-83. 2002
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| 32 | FOXC2, LPDD
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| FOXC2 truncating mutation in distichiasis, lymphedema, and cleft palate.
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| Bahuau M, Houdayer C, Tredano M, Soupre V, Couderc R, Vazquez MP.
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| Clin Genet 62(6):470-3. 2002
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| 33 | FOXC2, LPDD
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| Lymphedema-distichiasis syndrome and FOXC2 gene mutation.
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| Traboulsi EI, Al-Khayer K, Matsumoto M, Kimak MA, Crowe S, Wilson SE, Finegold DN, Ferrell RE, Meisler DM.
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| Am J Ophthalmol 134(4):592-6. 2002
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| 34 | FOXC2, LPDD
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| Analysis of lymphoedema-distichiasis families for FOXC2 mutations reveals small insertions and deletions throughout the gene.
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| Bell R, Brice G, Child AH, Murday VA, Mansour S, Sandy CJ, Collin JR, Brady AF, Callen DF, Burnand K, Mortimer P, Jeffery S.
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| Hum Genet 108(6):546-51. 2001
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| 35 | FOXC1, FOXC2, LPDD, YNS
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| Truncating mutations in FOXC2 cause multiple lymphedema syndromes.
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| Finegold DN, Kimak MA, Lawrence EC, Levinson KL, Cherniske EM, Pober BR, Dunlap JW, Ferrell RE.
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| Hum Mol Genet 10(11):1185-9. 2001
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| 36 | FOXC2, LPDD
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| Clinical heterogeneity in lymphoedema-distichiasis with FOXC2 truncating mutations.
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| Erickson RP, Dagenais SL, Caulder MS, Downs CA, Herman G, Jones MC, Kerstjens-Frederikse WS, Lidral AC, McDonald M, Nelson CC, Witte M, Glover TW.
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| J Med Genet 38(11):761-6. 2001
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| 37 | FOXC2
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| FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance.
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| Cederberg A, Gronning LM, Ahren B, Tasken K, Carlsson P, Enerback S.
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| Cell 106(5):563-73. 2001
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| 38 | AXRI, FOXC1, FOXC2
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| Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development.
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| Smith RS, Zabaleta A, Kume T, Savinova OV, Kidson SH, Martin JE, Nishimura DY, Alward WL, Hogan BL, John SW.
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| Hum Mol Genet 9(7):1021-32. 2000
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| 39 | FOXC2, FOXL1, LPDD
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| Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome.
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| Fang J, Dagenais SL, Erickson RP, Arlt MF, Glynn MW, Gorski JL, Seaver LH, Glover TW.
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| Am J Hum Genet 67(6):1382-8. 2000
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| 40 | FOXC2
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| Isolation of the mouse (MFH-1) and human (FKHL14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures.
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| Miura N, Iida K, Kakinuma H, Yang XL, Sugiyama T.
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| Genomics 41(3):489-92. 1997
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| 41 | FOXC2, FOXL1
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| Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development.
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| Kaestner KH, Bleckmann SC, Monaghan AP, Schlondorff J, Mincheva A, Lichter P, Schutz G.
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| Development 122(6):1751-8. 1996
|