| 1 | FGFR4, FOXC1, ITGA7
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| Forkhead box C1 promotes colorectal cancer metastasis through transactivating ITGA7 and FGFR4 expression.
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| Liu J, Zhang Z, Li X, Chen J, Wang G, Tian Z, Qian M, Chen Z, Guo H, Tang G, Huang W, Tian D, Wang D, Nie Y, Fan D, Wu K, Xia L.
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| Oncogene 37(41):5477-5491. doi: 10.1038/s41388-018-0355-4. Epub 2018 Jun 8.
2018
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| 2 | FOXC1, FOXF2, FOXQ1, GMDS
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| Disruptions in a cluster of computationally identified enhancers near FOXC1 and GMDS may influence brain development.
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| Haliburton GD, McKinsey GL, Pollard KS.
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| Neurogenetics Jan;17(1):1-9. doi: 10.1007/s10048-015-0458-9. Epub 2015 Sep 17 2016
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| 3 | FOXC1, FOXF2, GMDS, IRF4, RG6
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| Molecular characterization of a novel ring 6 chromosome using next generation sequencing.
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| Zhang R, Chen X, Li P, Lu X, Liu Y, Li Y, Zhang L, Xu M, Cram DS.
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| Mol Cytogenet. Apr 21;9:33. doi: 10.1186/s13039-016-0245-9. eCollection 2016 2016
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| 4 | FOXC1
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| Foxc1 is required for early stage telencephalic vascular development.
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| Prasitsak T, Nandar M, Okuhara S, Ichinose S, Ota MS, Iseki S.
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| Dev Dyn ev Dyn. 2015 Mar 2. doi: 10.1002/dvdy.24269. [Epub ahead of print]
2015
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| 5 | DWM2, FOXC1
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| Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth.
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| Haldipur P, Gillies GS, Janson OK, Chizhikov VV, Mithal DS, Miller RJ, Millen KJ.
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| Elife 3. doi: 10.7554/eLife.03962.
2014
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| 6 | FOXC1
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| Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease.
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| French CR, Seshadri S, Destefano AL, Fornage M, Arnold CR, Gage PJ, Skarie JM, Dobyns WB, Millen KJ, Liu T, Dietz W, Kume T, Hofker M, Emery DJ, Childs SJ, Waskiewicz AJ, Lehmann OJ.
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| J Clin Invest 124(11):4877-81. doi: 10.1172/JCI75109. Epub 2014 Sep 24.
2014
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| 7 | FOXC1
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| Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.
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| Omatsu Y, Seike M, Sugiyama T, Kume T, Nagasawa T.
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| Nature 508(7497):536-40. doi: 10.1038/nature13071. Epub 2014 Mar 2.
2014
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| 8 | FOXC1, PITX2
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| Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease.
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| French CR, Seshadri S, Destefano AL, Fornage M, Arnold CR, Gage PJ, Skarie JM, Dobyns WB, Millen KJ, Liu T, Dietz W, Kume T, Hofker M, Emery DJ, Childs SJ, Waskiewicz AJ, Lehmann OJ.
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| J Clin Invest 124(11):4877-81. doi: 10.1172/JCI75109.
2014
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| 9 | FOXC1
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| Foxc1 gene null mutation causes ectopic budding and kidney hypoplasia but not dysplasia.
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| Komaki F, Miyazaki Y, Niimura F, Matsusaka T, Ichikawa I, Motojima M.
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| Cells Tissues Organs 198(1):22-7. doi: 10.1159/000351291. Epub 2013 Jul 3.
2013
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| 10 | FOXC1
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| Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2.
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| Sun J, Ishii M, Ting MC, Maxson R.
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| Development 140(5):1034-44. doi: 10.1242/dev.085225. Epub 2013 Jan 23.
2013
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| 11 | FOXC1
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| High level of FOXC1 expression is associated with poor prognosis in pancreatic ductal adenocarcinoma.
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| Wang L, Gu F, Liu CY, Wang RJ, Li J, Xu JY.
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| Tumour Biol 34(2):853-8. doi: 10.1007/s13277-012-0617-7. Epub 2012 Dec 16.
2013
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| 12 | FGF8, FOXC1
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| Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of syngnathia.
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| Inman KE, Purcell P, Kume T, Trainor PA.
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| PLoS Genet 9(12):e1003949. doi: 10.1371/journal.pgen.1003949. Epub 2013 Dec 19.
2013
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| 13 | DEL6PD, FOXC1
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| Pre- and postnatal phenotype of 6p25 deletions involving the FOXC1 gene.
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| Delahaye A, Khung-Savatovsky S, Aboura A, Guimiot F, Drunat S, Alessandri JL, Gérard M, Bitoun P, Boumendil J, Robin S, Huel C, Guilherme R, Serero S, Gressens P, Elion J, Verloes A, Benzacken B, Delezoide AL, Pipiras E.
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| Am J Med Genet A 158A(10):2430-8. doi: 10.1002/ajmg.a.35548. Epub 2012 Aug 17. 2012
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| 14 | FOXC1, MSX2
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| Initiation of early osteoblast differentiation events through the direct transcriptional regulation of Msx2 by FOXC1.
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| Mirzayans F, Lavy R, Penner-Chea J, Berry FB.
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| PLoS One 7(11):e49095. doi: 10.1371/journal.pone.0049095. Epub 2012 Nov 7.
2012
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| 15 | FOXC1, FOXC2
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| Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.
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| Danciu TE, Chupreta S, Cruz O, Fox JE, Whitman M, Ińiguez-Lluhí JA.
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| J Biol Chem 287(22):18318-29. doi: 10.1074/jbc.M112.339424. Epub 2012 Apr 5.
2012
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| 16 | FOXC1, MMP7
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| The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression.
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| Sizemore ST, Keri RA.
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| J Biol Chem 287(29):24631-40. doi: 10.1074/jbc.M112.375865. Epub 2012 May 29.
2012
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| 17 | DEL6PD, FOXC1, PITX2
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| PITX2 and FOXC1 spectrum of mutations in ocular syndromes.
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| Reis LM, Tyler RC, Volkmann Kloss BA, Schilter KF, Levin AV, Lowry RB, Zwijnenburg PJ, Stroh E, Broeckel U, Murray JC, Semina EV.
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| Eur J Hum Genet 20(12):1224-33. doi: 10.1038/ejhg.2012.80. Epub 2012 May 9.
2012
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| 18 | AXR1, DEL6PD, FOXC1
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| Axenfeld-Rieger anomaly and Axenfeld-Rieger syndrome: Clinical, molecular-cytogenetic, and DNA array analyses of three patients with chromosomal defects at 6p25.
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| Tonoki H, Harada N, Shimokawa O, Yosozumi A, Monzaki K, Satoh K, Kosaki R, Sato A, Matsumoto N, Iizuka S.
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| Am J Med Genet A 155(12):2925-32. doi: 10.1002/ajmg.a.33858. Epub 2011 Oct 18.
2011
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| 19 | FOXA1, FOXA2, FOXA3, FOXC1, FOXC2, FOXO1, FOXO3, FOXO4, FOXP2, FOXP3
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| The evolution of Fox genes and their role in development and disease.
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| Hannenhalli S, Kaestner KH.
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| Nat Rev Genet 10(4):233-40. Review. 2009
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| 20 | DEL6PD, DWM2, FOXC1
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| FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation.
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| Aldinger KA, Lehmann OJ, Hudgins L, Chizhikov VV, Bassuk AG, Ades LC, Krantz ID, Dobyns WB, Millen KJ.
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| Nat Genet 41(9):1037-42. Epub 2009 Aug 9.
2009
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| 21 | AXR1, FOXC1, PITX2, RIEG1
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| Axenfeld-Rieger syndrome and spectrum of PITX2 and FOXC1 mutations.
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| Tümer Z, Bach-Holm D.
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| Eur J Hum Genet 17(12):1527-39. Epub 2009 Jun 10.
2009
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| 22 | FOXC1, IRID1
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| Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia.
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| Ito YA, Footz TK, Berry FB, Mirzayans F, Yu M, Khan AO, Walter MA.
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| Invest Ophthalmol Vis Sci. 50(8):3573-9. 2009
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| 23 | FOXO1, FOXC1, AXR1
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| FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A.
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| Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MA.
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| Hum Mol Genet 17(4):490-505. Epub 2007 Nov 9. 2008
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| 24 | CXCR4, FOXC1, FOXC2
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| Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration.
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| Hayashi H, Kume T.
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| Biochem Biophys Res Commun 367(3):584-9. Epub 2008 Jan 8. 2008
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| 25 | AXRI, FOXC1
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| A novel mutation in the FOXC1 gene in a family with Axenfeld-Rieger syndrome and Peters' anomaly.
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| Weisschuh N, Wolf C, Wissinger B, Gramer E.
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| Clin Genet 74(5):476-80. Epub 2008 May 21.
2008
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| 26 | DEL6PD, FOXC1, AXRI
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| Clinical presentation of a variant of Axenfeld-Rieger syndrome associated with subtelomeric 6p deletion.
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| Martinez-Glez V, Lorda-Sanchez I, Ramirez JM, Ruiz-Barnes P, Rodriguez de Alba M, Diego-Alvarez D, Ramos C, Searby CC, Nishimura DY, Ayuso C.
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| Eur J Med Genet 50(2):120-7. Epub 2006 Oct 28. 2007
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| 27 | AXR1, FOXC1, PITX2, RIEG1
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| Genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma patients with FOXC1 and PITX2 mutations.
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| Strungaru MH, Dinu I, Walter MA.
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| Invest Ophthalmol Vis Sci 48(1):228-37. 2007
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| 28 | ASMD2, ASMD3, ASMD4, ASMD5, ASMFD, AXR1, AXR2, FOXC1, IRID1, MAF, PAX6, PITX2, RIEG1, RIEG2
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| Molecular and developmental mechanisms of anterior segment dysgenesis.
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| Sowden JC.
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| Eye 21(10):1310-8. Review. 2007
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| 29 | FOXC1
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| Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development.
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| Zarbalis, K.; Siegenthaler, J. A.; Choe, Y.; May, S. R.; Peterson, A. S.; Pleasure, S. J.
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| Proc. Nat. Acad. Sci. 104: 14002-14007 2007
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| 30 | RIEG1, PITX2, AXRI, FOXC1
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| Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis.
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| Berry FB, Lines MA, Oas JM, Footz T, Underhill DA, Gage PJ, Walter MA.
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| Hum Mol Genet 15(6):905-19. Epub 2006 Jan 31. 2006
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| 31 | AXR1, FOXC1, PITX2, RIEG1
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| Novel Mutations of FOXC1 and PITX2 in Patients with Axenfeld-Rieger Malformations.
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| Weisschuh N, Dressler P, Schuettauf F, Wolf C, Wissinger B, Gramer E.
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| Invest Ophthalmol Vis Sci 47(9):3846-52. 2006
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| 32 | FGF19, FOXC1
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| FGF19 is a target for FOXC1 regulation in ciliary body-derived cells.
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| Tamimi Y, Skarie JM, Footz T, Berry FB, Link BA, Walter MA.
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| Hum Mol Genet 15(21):3229-40. Epub 2006 Sep 25.
2006
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| 33 | DEL6PD, FOXC1, AXRI
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| Axenfeld-Rieger malformation and distinctive facial features: Clues to a recognizable 6p25 microdeletion syndrome.
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| Maclean K, Smith J, St Heaps L, Chia N, Williams R, Peters GB, Onikul E, McCrossin T, Lehmann OJ, Ades LC.
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| Am J Med Genet A 132(4):381-5. Review. 2005
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| 34 | DEL6PD, FOXC1
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| Partial iris hypoplasia in a patient with an interstitial subtelomeric 6p deletion not including the forkhead transcription factor gene FOXC1.
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| Koolen DA, Knoers NV, Nillesen WM, Slabbers GH, Smeets D, de Leeuw N, Sistermans EA, de Vries BB.
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| Eur J Hum Genet 13(11):1169-71. No abstract available. 2005
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| 35 | FOXC1
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| FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner.
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| Berry FB, O'Neill MA, Coca-Prados M, Walter MA.
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| Mol Cell Biol. 25(4):1415-24. 2005
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| 36 | DEL6PD, FOXC1, FOXF2, FOXQ1, RG6
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| FOXC1 gene deletion is associated with eye anomalies in ring chromosome 6.
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| Zhang HZ, Li P, Wang D, Huff S, Nimmakayalu M, Qumsiyeh M, Pober BR.
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| Am J Med Genet A 124(3):280-7. Review. 2004
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| 37 | FOXC1
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| The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions.
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| Murphy TC, Saleem RA, Footz T, Ritch R, McGillivray B, Walter MA.
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| Invest Ophthalmol Vis Sci. 45(8):2531-8. 2004
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| 38 | AXRI, FOXC1
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| A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene.
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| Honkanen RA, Nishimura DY, Swiderski RE, Bennett SR, Hong S, Kwon YH, Stone EM, Sheffield VC, Alward WL.
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| Am J Ophthalmol 135(3):368-75. 2003
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| 39 | FOXC1, AXRI
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| Identification and analysis of a novel mutation in the FOXC1 forkhead domain.
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| Saleem RA, Murphy TC, Liebmann JM, Walter MA.
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| Invest Ophthalmol Vis Sci 44(11):4608-12. 2003
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| 40 | FOXC1
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| Identification of FOXC1 as a TGF-beta1 responsive gene and its involvement in negative regulation of cell growth.
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| Zhou Y, Kato H, Asanoma K, Kondo H, Arima T, Kato K, Matsuda T, Wake N.
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| Genomics 80(5):465-72. 2002
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| 41 | FOXC1
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| FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain.
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| Berry FB, Saleem RA, Walter MA.
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| J Biol Chem 277(12):10292-7. Epub 2002 Jan 08. 2002
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| 42 | AXRI, FOXC1
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| Novel mutation in FOXC1 wing region causing Axenfeld-Rieger anomaly.
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| Panicker SG, Sampath S, Mandal AK, Reddy AB, Ahmed N, Hasnain SE.
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| Invest Ophthalmol Vis Sci 43(12):3613-6. 2002
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| 43 | FOXC1, DEL6PD, AXRI
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| Ocular developmental abnormalities and glaucoma associated with interstitial 6p25 duplications and deletions.
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| Lehmann OJ, Ebenezer ND, Ekong R, Ocaka L, Mungall AJ, Fraser S, McGill JI, Hitchings RA, Khaw PT, Sowden JC, Povey S, Walter MA, Bhattacharya SS, Jordan T.
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| Invest Ophthalmol Vis Sci 43(6):1843-9. 2002
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| 44 | FOXC1
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| Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1.
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| Saleem RA, Banerjee-Basu S, Berry FB, Baxevanis AD, Walter MA.
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| Am J Hum Genet 68(3):627-41. 2001
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| 45 | FOXC1, FOXC2, LPDD, YNS
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| Truncating mutations in FOXC2 cause multiple lymphedema syndromes.
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| Finegold DN, Kimak MA, Lawrence EC, Levinson KL, Cherniske EM, Pober BR, Dunlap JW, Ferrell RE.
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| Hum Mol Genet 10(11):1185-9. 2001
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| 46 | AXRI, FOXC1
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| A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye.
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| Nishimura DY, Searby CC, Alward WL, Walton D, Craig JE, Mackey DA, Kawase K, Kanis AB, Patil SR, Stone EM, Sheffield VC.
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| Am J Hum Genet 68(2):364-72. 2001
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| 47 | FOXC1
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| The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.
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| Kume T, Jiang H, Topczewska JM, Hogan BL.
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| Genes Dev. 15(18):2470-82. 2001
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| 48 | AXRI, FOXC1, FOXC2
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| Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development.
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| Smith RS, Zabaleta A, Kume T, Savinova OV, Kidson SH, Martin JE, Nishimura DY, Alward WL, Hogan BL, John SW.
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| Hum Mol Genet 9(7):1021-32. 2000
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| 49 | AXRI, FOXC1
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| Axenfeld-Rieger syndrome resulting from mutation of the FKHL7 gene on chromosome 6p25.
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| Mirzayans F, Gould DB, Heon E, Billingsley GD, Cheung JC, Mears AJ, Walter MA.
|
| Eur J Hum Genet 8(1):71-4. 2000
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| 50 | FOXC1
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| Chromosomal duplication involving the forkhead transcription factor gene FOXC1 causes iris hypoplasia and glaucoma.
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| Lehmann OJ, Ebenezer ND, Jordan T, Fox M, Ocaka L, Payne A, Leroy BP, Clark BJ, Hitchings RA, Povey S, Khaw PT, Bhattacharya SS.
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| Am J Hum Genet 67(5):1129-35. 2000
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| 51 | DEL6PD, FOXC1, TFAP2A
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| An interstitial deletion of 6p24-p25 proximal to the FKHL7 locus and including AP-2alpha that affects anterior eye chamber development.
|
| Davies AF, Mirza G, Flinter F, Ragoussis J.
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| J Med Genet 36(9):708-10 1999
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| 52 | AXRI, FOXC1
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| The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25.
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| Nishimura DY, Swiderski RE, Alward WL, Searby CC, Patil SR, Bennet SR, Kanis AB, Gastier JM, Stone EM, Sheffield VC.
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| Nat Genet 19(2):140-7. 1998
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| 53 | AXRI, FOXC1
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| The Forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus.
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| Kume T, Deng KY, Winfrey V, Gould DB, Walter MA, Hogan BL.
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| Cell 93(6):985-96. 1998
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| 54 | AXRI, FOXC1
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| Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly.
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| Mears AJ, Jordan T, Mirzayans F, Dubois S, Kume T, Parlee M, Ritch R, Koop B, Kuo WL, Collins C, Marshall J, Gould DB, Pearce W, Carlsson P, Enerback S, Morissette J, Bhattacharya S, Hogan B, Raymond V, Walter MA.
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| Am J Hum Genet 63(5):1316-28. 1998
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| 55 | AXRI, FOXC1
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| Familial glaucoma iridogoniodysplasia maps to a 6p25 region implicated in primary congenital glaucoma and iridogoniodysgenesis anomaly.
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| Jordan T, Ebenezer N, Manners R, McGill J, Bhattacharya S.
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| Am J Hum Genet 61(4):882-8. 1997
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| 56 | FOXF1, FOXC1, FOXD1, FOXD4, FOXI1, FOXE3
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| Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12).
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| Larsson C, Hellqvist M, Pierrou S, White I, Enerback S, Carlsson P.
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| Genomics 30(3):464-9. 1995
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| 57 | FOXC1, FOXD1, FOXD4, FOXE3, FOXF1, FOXI1, FOXL1
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| Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.
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| Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P.
|
| EMBO J 13(20) : 5002-12. 1994
|