| 1 | CLEC14A, FLT4, KDR
|
| Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.
|
| Lee S, Rho SS, Park H, Park JA, Kim J, Lee IK, Koh GY, Mochizuki N, Kim YM, Kwon YG.
|
| J Clin Invest 127(2):457-471. doi: 10.1172/JCI85145. Epub 2016 Dec 19.
2017
|
| 2 | FLT4, HLMN1
|
| A novel FLT4 mutation identified in a patient with Milroy disease.
|
| DiGiovanni RM, Erickson RP, Ohlson EC, Bernas M, Witte MH.
|
| Lymphology 47(1):44-7.
2014
|
| 3 | CCBE1, FLT4, VEGFC
|
| Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.
|
| Le Guen L, Karpanen T, Schulte D, Harris NC, Koltowska K, Roukens G, Bower NI, van Impel A, Stacker SA, Achen MG, Schulte-Merker S, Hogan BM.
|
| Development 141(6):1239-49. doi: 10.1242/dev.100495. Epub 2014 Feb 12.
2014
|
| 4 | FLT4, HLMN1
|
| FLT4/VEGFR3 and Milroy disease: novel mutations, a review of published variants and database update.
|
| Gordon K, Spiden SL, Connell FC, Brice G, Cottrell S, Short J, Taylor R, Jeffery S, Mortimer PS, Mansour S, Ostergaard P.
|
| Hum Mutat 34(1):23-31. doi: 10.1002/humu.22223. Epub 2012 Oct 16. Review.
2013
|
| 5 | FLT4, HLMN1, PCLD
|
| Mutations in the VEGFR3 signaling pathway explain 36% of familial lymphedema.
|
| Mendola A, Schlögel MJ, Ghalamkarpour A, Irrthum A, Nguyen HL, Fastré E, Bygum A, van der Vleuten C, Fagerberg C, Baselga E, Quere I, Mulliken JB, Boon LM, Brouillard P, Vikkula M; Lymphedema Research Group.
|
| Mol Syndromol 4(6):257-66. doi: 10.1159/000354097. Epub 2013 Aug 21.
2013
|
| 6 | FLT4, VEGFC
|
| Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity.
|
| Singh N, Tiem M, Watkins R, Cho YK, Wang Y, Olsen T, Uehara H, Mamalis C, Luo L, Oakey Z, Ambati BK.
|
| Blood 121(20):4242-9. doi: 10.1182/blood-2012-08-453043. Epub 2013 Mar 8.
2013
|
| 7 | FLT4, NRP2
|
| Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations.
|
| Partanen TA, Vuola P, Jauhiainen S, Lohi J, Salminen P, Pitkäranta A, Häkkinen SK, Honkonen K, Alitalo K, Ylä-Herttuala S.
|
| Angiogenesis 16(1):137-46. doi: 10.1007/s10456-012-9305-x. Epub 2012 Sep 9.
2013
|
| 8 | DLL4, FLT4, KDR, NOTCH1
|
| Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
|
| Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, Duarte A, Pytowski B, Adams RH.
|
| Nature 484(7392):110-4. doi: 10.1038/nature10908.
2012
|
| 9 | FLT4
|
| Expression and localization of VEGF receptors in human fetal skeletal tissues.
|
| Marini M, Sarchielli E, Toce M, Acocella A, Bertolai R, Ciulli C, Orlando C, Sgambati E, Vannelli GB.
|
| Histol Histopathol 27(12):1579-87.
2012
|
| 10 | FLT4
|
| Vascular endothelial growth factor receptor-3 directly interacts with phosphatidylinositol 3-kinase to regulate lymphangiogenesis.
|
| Coso S, Zeng Y, Opeskin K, Williams ED.
|
| PLoS One 7(6):e39558. doi: 10.1371/journal.pone.0039558. Epub 2012 Jun 22.
2012
|
| 11 | COL18A1, FLT4
|
| Characterization of the interaction between endostatin short peptide and VEGF receptor 3.
|
| Han KY, Azar DT, Sabri A, Lee H, Jain S, Lee BS, Chang JH.
|
| Protein Pept Lett 19(9):969-74.
2012
|
| 12 | FLT4, VEGFC
|
| VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.
|
| Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K.
|
| Nat Cell Biol 13(10):1202-13. doi: 10.1038/ncb2331.
2011
|
| 13 | FLT4, RSPO1, VEGFC
|
| Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3.
|
| Gore AV, Swift MR, Cha YR, Lo B, McKinney MC, Li W, Castranova D, Davis A, Mukouyama YS, Weinstein BM.
|
| Development 138(22):4875-86. doi: 10.1242/dev.068460. Epub 2011 Oct 17.
2011
|
| 14 | FLT4, KDR, TMEM204
|
| Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.
|
| Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K.
|
| Genes Dev 24(9):875-80.PMID: 20439428 2010
|
| 15 | EFNB2, FLT4, KDR
|
| Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.
|
| Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi U, Barberis A, Benjamin LE, Mäkinen T, Nobes CD, Adams RH.
|
| Nature 465(7297):483-6. 2010
|
| 16 | FLT4, NRP2, VEGFC
|
| Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.
|
| Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A.
|
| J Cell Biol 188(1):115-30. doi: 10.1083/jcb.200903137.
2010
|
| 17 | FLT4, VEGFC
|
| Analysis of the coding regions of VEGFR3 and VEGFC in Milroy disease and other primary lymphoedemas.
|
| Connell FC, Ostergaard P, Carver C, Brice G, Williams N, Mansour S, Mortimer PS, Jeffery S; Lymphoedema Consortium.
|
| Hum Genet 124(6):625-31. Epub 2008 Nov 12.
2009
|
| 18 | FLT4, PCLD
|
| Recessive primary congenital lymphoedema caused by a VEGFR3 mutation.
|
| Ghalamkarpour A, Holnthoner W, Saharinen P, Boon LM, Mulliken JB, Alitalo K, Vikkula M.
|
| J Med Genet 46(6):399-404. Epub 2009 Mar 15.
2009
|
| 19 | FLT4, HLMN1
|
| Three children with Milroy disease and de novo mutations in VEGFR3.
|
| Carver C, Brice G, Mansour S, Ostergaard P, Mortimer P, Jeffery S.
|
| Clin Genet 71(2):187-9. No abstract available. 2007
|
| 20 | FLT4,HLMN
|
| A novel VEGFR3 mutation causes Milroy disease.
|
| Butler MG, Dagenais SL, Rockson SG, Glover TW.
|
| Am J Med Genet A 143(11):1212-7. 2007
|
| 21 | HLMN1, FLT4
|
| Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations.
|
| Ghalamkarpour A, Morlot S, Raas-Rothschild A, Utkus A, Mulliken JB, Boon LM, Vikkula M.
|
| Clin Genet 70(4):330-5. 2006
|
| 22 | FIGF, FLT1, FLT4, KDR, NRP1, NRP2, PGF, VEGFA, VEGFB, VEGFC
|
| Biology of vascular endothelial growth factors.
|
| Roy H, Bhardwaj S, Yl-Herttuala S.
|
| FEBS Lett 580(12):2879-87. Epub 2006 Apr 17. 2006
|
| 23 | HLMN1, FLT4
|
| Milroy disease and the VEGFR-3 mutation phenotype.
|
| Brice G, Child AH, Evans A, Bell R, Mansour S, Burnand K, Sarfarazi M, Jeffery S, Mortimer P.
|
| J Med Genet 42(2):98-102. 2005
|
| 24 | XLKD1, FIGF, VEGFC, PROX1, FLT4, LCP2, ANGPT1, ANGPTL1, ANGPT4, TEK, EFNB2, FOXC2, PDPN
|
| Lymphangiogenesis in development and human disease.
|
| Alitalo K, Tammela T, Petrova TV.
|
| Nature 438(7070):946-53. Review. 2005
|
| 25 | FLT4
|
| Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) in human prostate.
|
| Li R, Younes M, Wheeler TM, Scardino P, Ohori M, Frolov A, Ayala G.
|
| Prostate 58(2):193-9. 2004
|
| 26 | HLMN1, FLT4
|
| Identification of eight novel VEGFR-3 mutations in families with primary congenital lymphoedema.
|
| Evans AL, Bell R, Brice G, Comeglio P, Lipede C, Jeffery S, Mortimer P, Sarfarazi M, Child AH.
|
| J Med Genet 40(9):697-703. No abstract available. 2003
|
| 27 | FBIH, FLT4, KDR
|
| Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.
|
| Walter JW, North PE, Waner M, Mizeracki A, Blei F, Walker JW, Reinisch JF, Marchuk DA.
|
| Genes Chromosomes Cancer 33(3):295-303. 2002
|
| 28 | FLT4
|
| VEGFR3 gene structure, regulatory region, and sequence polymorphisms.
|
| Iljin K, Karkkainen MJ, Lawrence EC, Kimak MA, Uutela M, Taipale J, Pajusola K, Alhonen L, Halmekyto M, Finegold DN, Ferrell RE, Alitalo K.
|
| FASEB J 15(6):1028-36. 2001
|
| 29 | FLT4
|
| Alternative splicing of the human VEGFGR-3/FLT4 gene as a consequence of an integrated human endogenous retrovirus.
|
| Hughes DC.
|
| J Mol Evol 53(2):77-9. 2001
|
| 30 | FLT4, HLMN1
|
| Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.
|
| Karkkainen MJ, Ferrell RE, Lawrence EC, Kimak MA, Levinson KL, McTigue MA, Alitalo K, Finegold DN.
|
| Nat Genet 25(2):153-9. 2000
|
| 31 | FLT4, HLMN1
|
| Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase.
|
| Irrthum A, Karkkainen MJ, Devriendt K, Alitalo K, Vikkula M.
|
| Am J Hum Genet 67(2):295-301. 2000
|
| 32 | FLT4, HLMN1
|
| Hereditary lymphedema : evidence for linkage and genetic heterogeneity.
|
| Ferrell RE, Levinson KL, Esman JH, Kimak MA, Lawrence EC, Barmada MM, Finegold DN.
|
| Hum Mol Genet 7 : 2073-2078. 1998
|
| 33 | FIGF, FLT1, FLT4, KDR, VEGFA, VEGFB, VEGFC
|
| Vascular endothelial growth factor and its receptors.
|
| Klagsbrun M, D'Amore PA.
|
| Cytokine Growth Factor Rev 7(3):259-70. Review. 1996
|
| 34 | FLT4
|
| Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.
|
| Kaipainen A, Korhonen J, Mustonen T, van Hinsbergh VW, Fang GH, Dumont D, Breitman M, Alitalo K.
|
| Proc Natl Acad Sci U S A 92(8):3566-70. 1995
|
| 35 | FLT4
|
| The FLT4 gene encodes a transmembrane tyrosine kinase related to the vacular endothelial growth factor receptor.
|
| Galland F, et al.
|
| Oncogene 8 : 1233-1240. 1993
|
| 36 | FLT4
|
| FLT4 receptor tyrosine kinase gene mapping to chromosome band 5q35 in relation to the t(2;5), t(5;6), and t(3;5) translocations.
|
| Armstrong E, et al.
|
| Genes Chromosomes Cancer 7 : 144-151. 1993
|
| 37 | FLT4, FGFR4
|
| Localization of two tyrosine kinase receptor genes with respect to the 5q35 chromosomal breakpoint of Ki-I lymphoma cell lines.
|
| Pbusque MJ, et al.
|
| Genes Chromosomes Cancer 8 : 119-126. 1993
|
| 38 | FLT4
|
| Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts.
|
| Pajusola K, et al.
|
| Oncogene 8 : 2931-2937. 1993
|
| 39 | FLT4
|
| FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter.
|
| Aprelikova O, et al.
|
| Cancer Res 52 : 746-748. 1992
|
| 40 | FLT4
|
| Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.
|
| Galland F, et al.
|
| Genomics 13 : 475-478. 1992
|