| 1 | FLNB
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| Filamin B extensively regulates transcription and alternative splicing, and is associated with apoptosis in HeLa cells
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| Ma HR, Cao L, Wang F, Cheng C, Jiang R, Zhou H, Xie Z, Wuermanbieke S, Qian Z.
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| Oncol Rep. May;43(5):1536-1546. doi: 10.3892/or.2020.7532. Epub 2020 Mar 4. 2020
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| 2 | FLNB, LRS1
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| Novel in-frame FLNB deletion causes Larsen syndrome in a three-generation pedigree.
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| Hickey SE, Koboldt DC, Mosher TM, Brennan P, Schmalz BA, Crist E, McBride KL, Adler BH, White P, Wilson RK.
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| Cold Spring Harb Mol Case Stud. Dec 13;5(6):a004176. doi: 10.1101/mcs.a004176. Print 2019 Dec. 2019
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| 3 | FLNB, QKI, RBFOX1
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| An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer
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| Li J, Choi PS, Chaffer CL, Labella K, Hwang JH, Giacomelli AO, Kim JW, Ilic N, Doench JG, Ly SH, Dai C, Hagel K, Hong AL, Gjoerup O, Goel S, Ge JY, Root DE, Zhao JJ, Brooks AN, Weinberg RA, Hahn WC.
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| Elife. Jul 30;7:e37184. doi: 10.7554/eLife.37184. 2018
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| 4 | FLNB, LRS1
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| Comparative analysis of the two extremes of FLNB-mutated autosomal dominant disease spectrum: from clinical phenotypes to cellular and molecular findings.
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| Xu Q, Wu N, Cui L, Lin M, Thirumal Kumar D, George Priya Doss C, Wu Z, Shen J, Song X, Qiu G.
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| Am J Transl Res. May 15;10(5):1400-1412. 2018
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| 5 | FLNB, SCTS
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| Recessive Spondylocarpotarsal Synostosis Syndrome Due to Compound Heterozygosity for Variants in MYH3.
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| Cameron-Christie SR, Wells CF, Simon M, Wessels M, Tang CZN, Wei W, Takei R, Aarts-Tesselaar C, Sandaradura S, Sillence DO, Cordier MP, Veenstra-Knol HE, Cassina M, Ludwig K, Trevisson E, Bahlo M, Markie DM, Jenkins ZA, Robertson SP.
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| Am J Hum Genet. Jun 7;102(6):1115-1125. doi: 10.1016/j.ajhg.2018.04.008. Epub 2018 May 24. 2018
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| 6 | FLNA, FLNB
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| Opposing FlnA and FlnB interactions regulate RhoA activation in guiding dynamic actin stress fiber formation and cell spreading. 2017 Apr 1;26(7):1294-1304. doi: 10.1093/hmg/ddx047. PMID:
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| Hu J, Lu J, Goyal A, Wong T, Lian G, Zhang J, Hecht JL, Feng Y, Sheen VL.
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| Hum Mol Genet. Apr 1;26(7):1294-1304. doi: 10.1093/hmg/ddx047 2017
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| 7 | FLNB
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| Filamin B: The next hotspot in skeletal research?
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| Xu Q, Wu N, Cui L, Wu Z, Qiu G.
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| J Genet Genomics. 7 Jul 20;44(7):335-342. doi: 10.1016/j.jgg.2017.04.007. Epub 2017 Jul 6. 2017
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| 8 | ASB2, FLNA, FLNB
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| Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells
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| Spinner CA, Uttenweiler-Joseph S, Metais A, Stella A, Burlet-Schiltz O, Moog-Lutz C, Lamsoul I, Lutz PG.
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| Sci Rep. Nov 5;5:16269. doi: 10.1038/srep16269. 2015
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| 9 | FLNB, FMN1
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| Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate
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| Hu J, Lu J, Lian G, Ferland RJ, Dettenhofer M, Sheen VL.
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| Hum Mol Genet. Sep 1;23(17):4663-73. doi: 10.1093/hmg/ddu186. Epub 2014 Apr 23. 2014
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| 10 | FLNB, HDAC7, VEGFA
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| Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7
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| Su YT, Gao C, Liu Y, Guo S, Wang A, Wang B, Erdjument-Bromage H, Miyagi M, Tempst P, Kao HY.
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| Mol Cell Biol. Apr;33(8):1546-60. doi: 10.1128/MCB.01146-12. Epub 2013 Feb 11 2013
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| 11 | FLNA, FLNB, FLNC, PKD2
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| Structural interaction and functional regulation of polycystin-2 by filamin
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| Wang Q, Dai XQ, Li Q, Wang Z, Cantero Mdel R, Li S, Shen J, Tu JC, Cantiello H, Chen XZ.
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| PLoS One. 7(7):e40448. doi: 10.1371/journal.pone.0040448. Epub 2012 Jul 10. 2012
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| 12 | ASB2, FLNA, FLNB
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| Filamins but not Janus kinases are substrates of the ASB2α cullin-ring E3 ubiquitin ligase in hematopoietic cells
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| Lamsoul I, Erard M, van der Ven PF, Lutz PG.
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| PLoS One. ;7(8):e43798. doi: 10.1371/journal.pone.0043798. Epub 2012 Aug 20 2012
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| 13 | FLNA, FLNB, KDR, RAC1, VAV2
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| Filamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2.
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| Del Valle-Pérez B, Martínez VG, Lacasa-Salavert C, Figueras A, Shapiro SS, Takafuta T, Casanovas O, Capellà G, Ventura F, Viñals F.
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| J Biol Chem 285(14):10748-60. Epub 2010 Jan 28. 2010
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| 14 | FLNB, SBF2
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| Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation.
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| Lei SF, Tan LJ, Liu XG, Wang L, Yan H, Guo YF, Liu YZ, Xiong DH, Li J, Yang TL, Chen XD, Guo Y, Deng FY, Zhang YP, Zhu XZ, Levy S, Papasian CJ, Hamilton JJ, Recker RR, Deng HW.
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| Hum Mol Genet 18(9):1661-9. Epub 2008 Nov 27.
2009
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| 15 | FLNA, FLNB
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| Filamins regulate cell spreading and initiation of cell migration.
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| Baldassarre M, Razinia Z, Burande CF, Lamsoul I, Lutz PG, Calderwood DA.
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| PLoS One 4(11):e7830.PMID: 19915675 2009
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| 16 | ATSG1, ATSG3, FLNB, LRS1, SCTS
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| Disease-associated substitutions in the filamin B actin binding domain confer enhanced actin binding affinity in the absence of major structural disturbance: Insights from the crystal structures of filamin B actin binding domains.
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| Sawyer GM, Clark AR, Robertson SP, Sutherland-Smith AJ.
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| J Mol Biol 390(5):1030-47. Epub 2009 Jun 6.PMID: 19505475 2009
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| 17 | SCTS, FLNB
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| Autosomal dominant spondylocarpotarsal synostosis syndrome: phenotypic homogeneity and genetic heterogeneity.
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| Isidor B, Cormier-Daire V, Le Merrer M, Lefrancois T, Hamel A, Le Caignec C, David A, Jacquemont S.
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| Am J Med Genet A 146A(12):1593-7. 2008
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| 18 | FLNB, SCTS
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| Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome.
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| Farrington-Rock C, Kirilova V, Dillard-Telm L, Borowsky AD, Chalk S, Rock MJ, Cohn DH, Krakow D.
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| Hum Mol Genet 17(5):631-41. Epub 2007 Jul 17. 2008
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| 19 | FLNB, SCTS
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| Spondylocarpotarsal synostosis: long-term follow-up of a case due to FLNB mutations.
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| Brunetti-Pierri N, Esposito V, De Brasi D, Mattiacci DM, Krakow D, Lee B, Salerno M.
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| Am J Med Genet A 146A(9):1230-3. No abstract available. 2008
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| 20 | ASB2, FLNA, FLNB
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| ASB2 targets filamins A and B to proteasomal degradation.
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| Heuzé ML, Lamsoul I, Baldassarre M, Lad Y, Lévêque S, Razinia Z, Moog-Lutz C, Calderwood DA, Lutz PG.
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| Blood 112(13):5130-40. Epub 2008 Sep 17.PMID: 18799729 2008
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| 21 | FLNB, ICAM1
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| Filamin B mediates ICAM-1-driven leukocyte transendothelial migration.
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| Kanters E, van Rijssel J, Hensbergen PJ, Hondius D, Mul FP, Deelder AM, Sonnenberg A, van Buul JD, Hordijk PL.
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| J Biol Chem 283(46):31830-9. Epub 2008 Sep 22.PMID: 18809679 2008
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| 22 | FLNB
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| Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway.
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| Jeon YJ, Choi JS, Lee JY, Yu KR, Ka SH, Cho Y, Choi EJ, Baek SH, Seol JH, Park D, Bang OS, Chung CH.
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| Mol Biol Cell 19(12):5116-30. Epub 2008 Sep 24.PMID: 18815275 2008
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| 23 | LRS1, FLNB
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| A molecular and clinical study of Larsen syndrome caused by mutations in FLNB.
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| Bicknell LS, Farrington-Rock C, Shafeghati Y, Rump P, Alanay Y, Alembik Y, Al-Madani N, Firth H, Karimi-Nejad MH, Kim CA, Leask K, Maisenbacher M, Moran E, Pappas JG, Prontera P, de Ravel T, Fryns JP, Sweeney E, Fryer A, Unger S, Wilson LC, Lachman RS, Rimoin DL, Cohn DH, Krakow D, Robertson SP.
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| J Med Genet 44(2):89-98. Epub 2006 Jun 26. 2007
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| 24 | FLNB
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| Filamin B mutations cause chondrocyte defects in skeletal development.
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| Lu J, Lian G, Lenkinski R, De Grand A, Vaid RR, Bryce T, Stasenko M, Boskey A, Walsh C, Sheen V.
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| Hum Mol Genet 16(14):1661-75. Epub 2007 May 17. 2007
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| 25 | FLNB, RUNX2
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| Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner.
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| Zheng L, Baek HJ, Karsenty G, Justice MJ.
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| J Cell Biol 178(1):121-8.
2007
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| 26 | FLNB, ATSG1, ATSG3
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| Mutations in two regions of FLNB result in atelosteogenesis I and III.
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| Farrington-Rock C, Firestein MH, Bicknell LS, Superti-Furga A, Bacino CA, Cormier-Daire V, Le Merrer M, Baumann C, Roume J, Rump P, Verheij JB, Sweeney E, Rimoin DL, Lachman RS, Robertson SP, Cohn DH, Krakow D.
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| Hum Mutat 27(7):705-10. 2006
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| 27 | ATSG1,FLNB
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| Mutations in FLNB cause boomerang dysplasia.
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| Bicknell LS, Morgan T, Bonafe L, Wessels MW, Bialer MG, Willems PJ, Cohn DH, Krakow D, Robertson SP.
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| J Med Genet 42(7):e43. 2005
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| 28 | FLNB, SCTS, LRS1, ATSG1, ATSG3
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| Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis.
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| Krakow D, Robertson SP, King LM, Morgan T, Sebald ET, Bertolotto C, Wachsmann-Hogiu S, Acuna D, Shapiro SS, Takafuta T, Aftimos S, Kim CA, Firth H, Steiner CE, Cormier-Daire V, Superti-Furga A, Bonafe L, Graham JM Jr, Grix A, Bacino CA, Allanson J, Bialer MG, Lachman RS, Rimoin DL, Cohn DH.
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| Nat Genet 36(4):405-10. Epub 2004 Feb 29. 2004
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| 29 | FLNB
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| Tapasin and other chaperones: models of the MHC class I loading complex.
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| Wright CA, Kozik P, Zacharias M, Springer S.
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| Biol Chem 385(9):763-78. Review. 2004
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| 30 | FLNA, FLNB
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| Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.
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| Sheen VL, Feng Y, Graham D, Takafuta T, Shapiro SS, Walsh CA.
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| Hum Mol Genet 11(23):2845-54. 2002
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| 31 | FLNB, FLNC
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| Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.
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| Chakarova C, Wehnert MS, Uhl K, Sakthivel S, Vosberg HP, van der Ven PF, Furst DO.
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| Hum Genet 107(6):597-611. 2000
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| 32 | FLNB
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| Assignment of human filamin gene FLNB to human chromosome band 3p14.3 and identification of YACs containing the complete FLNB transcribed region.
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| Brocker F, et al.
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| Cytogenet Cell Genet 85(3-4):267-268. No abstract available 1999
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| 33 | FLNB, TAPBP
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| Cloning from the thyroid of a protein related to actin binding protein that is recognized by Graves disease immunoglobulins.
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| Leedman PJ, et al.
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| Proc Natl Acad Sci U S A 90 : 5994-5998. 1993
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