| 1 | FLII, LRRFIP2, NLRP3
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| F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2
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| Burger D, Fickentscher C, de Moerloose P, Brandt KJ.
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| Sci Rep. Jul 19;6:29834. doi: 10.1038/srep29834. 2016
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| 2 | FLII
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| Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression.
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| Kopecki Z, Yang GN, Jackson JE, Melville EL, Calley MP, Murrell DF, Darby IA, O'Toole EA, Samuel MS, Cowin AJ.
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| Oncotarget 6(34):36426-40. doi: 10.18632/oncotarget.5536.
2015
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| 3 | FLII
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| Fibroblast-specific upregulation of Flightless I impairs wound healing.
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| Turner CT, Waters JM, Jackson JE, Arkell RM, Cowin AJ.
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| Exp Dermatol 24(9):692-7. doi: 10.1111/exd.12751. Epub 2015 Jul 14.
2015
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| 4 | FLII, MYH9
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| Flightless I interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling.
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| Arora PD, Wang Y, Bresnick A, Janmey PA, McCulloch CA.
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| Mol Biol Cell 26(12):2279-97. doi: 10.1091/mbc.E14-11-1536. Epub 2015 Apr 15.
2015
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| 5 | FLII, PPARG
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| Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα.
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| Choi JS, Choi SS, Kim ES, Seo YK, Seo JK, Kim EK, Suh PG, Choi JH.
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| Cell Signal 27(3):614-20. doi: 10.1016/j.cellsig.2014.11.035. Epub 2014 Dec 2.
2015
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| 6 | FLII
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| Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering.
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| Kopecki Z, Yang GN, Arkell RM, Jackson JE, Melville E, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ.
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| J Pathol 232(5):541-52. doi: 10.1002/path.4323. Epub 2014 Feb 5.
2014
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| 7 | AMOTL2, FLII, PHLDB2, SPATA13
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| Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.
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| Proszynski TJ, Sanes JR.
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| J Cell Sci 126(Pt 10):2225-35. doi: 10.1242/jcs.121327. Epub 2013 Mar 22.
2013
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| 8 | FLII, MLXIPL
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| Flightless I homolog negatively regulates ChREBP activity in cancer cells.
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| Wu L, Chen H, Zhu Y, Meng J, Li Y, Li M, Yang D, Zhang P, Feng M, Tong X.
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| Int J Biochem Cell Biol 45(11):2688-97. doi: 10.1016/j.biocel.2013.09.004. Epub 2013 Sep 17.
2013
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| 9 | CASP1, FLII, LRRFIP2
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| LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition.
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| Jin J, Yu Q, Han C, Hu X, Xu S, Wang Q, Wang J, Li N, Cao X.
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| Nat Commun 4:2075. doi: 10.1038/ncomms3075.
2013
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| 10 | FLII
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| Cytoskeletal protein Flightless (Flii) is elevated in chronic and acute human wounds and wound fluid: neutralizing its activity in chronic but not acute wound fluid improves cellular proliferation.
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| Ruzehaji N, Grose R, Krumbiegel D, Zola H, Dasari P, Wallace H, Stacey M, Fitridge R, Cowin AJ.
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| Eur J Dermatol 22(6):740-50. doi: 10.1684/ejd.2012.1878.
2012
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| 11 | FLII
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| Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration.
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| Mohammad I, Arora PD, Naghibzadeh Y, Wang Y, Li J, Mascarenhas W, Janmey PA, Dawson JF, McCulloch CA.
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| FASEB J 26(8):3260-72. doi: 10.1096/fj.11-202051. Epub 2012 May 11.
2012
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| 12 | FLII
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| Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway.
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| Kopecki Z, O'Neill GM, Arkell RM, Cowin AJ.
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| J Invest Dermatol 131(7):1450-9. doi: 10.1038/jid.2011.69. Epub 2011 Mar 24.
2011
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| 13 | FLII
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| Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing.
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| Lin CH, Waters JM, Powell BC, Arkell RM, Cowin AJ.
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| Mamm Genome 22(5-6):341-52. doi: 10.1007/s00335-011-9320-z. Epub 2011 Mar 13.
2011
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| 14 | DAAM1, DIAPH1, FLII
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| Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase.
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| Higashi T, Ikeda T, Murakami T, Shirakawa R, Kawato M, Okawa K, Furuse M, Kimura T, Kita T, Horiuchi H.
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| J Biol Chem 285(21):16231-8. Epub 2010 Mar 11. 2010
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| 15 | FLII, NXN, NXNL1
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| Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene (88).
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| Hayashi T, Funato Y, Terabayashi T, Morinaka A, Sakamoto R, Ichise H, Fukuda H, Yoshida N, Miki H.
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| J Biol Chem 285(24):18586-93. doi: 10.1074/jbc.M110.106468. Epub 2010 Apr 16.
2010
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| 16 | ACTL6A, ESR1, FLII
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| Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I.
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| Jeong KW, Lee YH, Stallcup MR.
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| J Biol Chem 284(43):29298-309. doi: 10.1074/jbc.M109.037010. Epub 2009 Aug 31. 2009
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| 17 | FLII, SGK3
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| Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK.
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| Xu J, Liao L, Qin J, Xu J, Liu D, Songyang Z.
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| J Biol Chem 284(21):14377-85. doi: 10.1074/jbc.M807770200. Epub 2009 Mar 17.
2009
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| 18 | FLII
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| Flightless-I, a gelsolin family member and transcriptional regulator, preferentially binds directly to activated cytosolic CaMK-II.
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| Seward ME, Easley CA 4th, McLeod JJ, Myers AL, Tombes RM.
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| FEBS Lett 582(17):2489-95. doi: 10.1016/j.febslet.2008.06.037. Epub 2008 Jun 25.
2008
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| 19 | FLII
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| Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity.
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| Li J, Yin HL, Yuan J.
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| J Cell Biol 181(2):321-33. doi: 10.1083/jcb.200711082. Epub 2008 Apr 14.
2008
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| 20 | FLII
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| Flightless I deficiency enhances wound repair by increasing cell migration and proliferation.
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| Cowin AJ, Adams DH, Strudwick XL, Chan H, Hooper JA, Sander GR, Rayner TE, Matthaei KI, Powell BC, Campbell HD.
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| J Pathol 211(5):572-81.
2007
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| 21 | FLII
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| Flightless I homolog negatively modulates the TLR pathway.
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| Wang T, Chuang TH, Ronni T, Gu S, Du YC, Cai H, Sun HQ, Yin HL, Chen X.
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| J Immunol 176(3):1355-62.
2006
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| 22 | FLII
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| The flightless I protein and the gelsolin family in nuclear hormone receptor-mediated signalling.
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| Archer SK, Behm CA, Claudianos C, Campbell HD.
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| Biochem Soc Trans 32(Pt 6):940-2. Review.
2004
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| 23 | FLII
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| Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development.
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| Campbell HD, Fountain S, McLennan IS, Berven LA, Crouch MF, Davy DA, Hooper JA, Waterford K, Chen KS, Lupski JR, Ledermann B, Young IG, Matthaei KI.
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| Mol Cell Biol 22(10):3518-26.
2002
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| 24 | FLII, LLGL1
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| Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL.
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| Campbell HD, Fountain S, Young IG, Claudianos C, Hoheisel JD, Chen KS, Lupski JR.
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| Genomics 42(1):46-54. 1997
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| 25 | FLII
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| Cloning mammary cell cDNAs from 17q12-q23 using interspecific somatic cell hybrids and subtractive hybridization.
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| Cerosaletti KM, et al.
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| Genomics 25 : 226-237. 1995
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| 26 | SMS, FLII
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| The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2.
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| Chen KS, et al.
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| Am J Hum Genet 56 : 175-182. 1995
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| 27 | FLII
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| The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in caenorhabditis elegans and humans.
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| Campbell HD, et al.
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| Proc Natl Acad Sci U S A 90 : 11386-11390. 1993
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