Citations for
F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2
Burger D, Fickentscher C, de Moerloose P, Brandt KJ.
Sci Rep. Jul 19;6:29834. doi: 10.1038/srep29834. 2016
Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression.
Kopecki Z, Yang GN, Jackson JE, Melville EL, Calley MP, Murrell DF, Darby IA, O'Toole EA, Samuel MS, Cowin AJ.
Oncotarget 6(34):36426-40. doi: 10.18632/oncotarget.5536. 2015
Fibroblast-specific upregulation of Flightless I impairs wound healing.
Turner CT, Waters JM, Jackson JE, Arkell RM, Cowin AJ.
Exp Dermatol 24(9):692-7. doi: 10.1111/exd.12751. Epub 2015 Jul 14. 2015
Flightless I interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling.
Arora PD, Wang Y, Bresnick A, Janmey PA, McCulloch CA.
Mol Biol Cell 26(12):2279-97. doi: 10.1091/mbc.E14-11-1536. Epub 2015 Apr 15. 2015
Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα.
Choi JS, Choi SS, Kim ES, Seo YK, Seo JK, Kim EK, Suh PG, Choi JH.
Cell Signal 27(3):614-20. doi: 10.1016/j.cellsig.2014.11.035. Epub 2014 Dec 2. 2015
Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering.
Kopecki Z, Yang GN, Arkell RM, Jackson JE, Melville E, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ.
J Pathol 232(5):541-52. doi: 10.1002/path.4323. Epub 2014 Feb 5. 2014
Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.
Proszynski TJ, Sanes JR.
J Cell Sci 126(Pt 10):2225-35. doi: 10.1242/jcs.121327. Epub 2013 Mar 22. 2013
Flightless I homolog negatively regulates ChREBP activity in cancer cells.
Wu L, Chen H, Zhu Y, Meng J, Li Y, Li M, Yang D, Zhang P, Feng M, Tong X.
Int J Biochem Cell Biol 45(11):2688-97. doi: 10.1016/j.biocel.2013.09.004. Epub 2013 Sep 17. 2013
LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition.
Jin J, Yu Q, Han C, Hu X, Xu S, Wang Q, Wang J, Li N, Cao X.
Nat Commun 4:2075. doi: 10.1038/ncomms3075. 2013
Cytoskeletal protein Flightless (Flii) is elevated in chronic and acute human wounds and wound fluid: neutralizing its activity in chronic but not acute wound fluid improves cellular proliferation.
Ruzehaji N, Grose R, Krumbiegel D, Zola H, Dasari P, Wallace H, Stacey M, Fitridge R, Cowin AJ.
Eur J Dermatol 22(6):740-50. doi: 10.1684/ejd.2012.1878. 2012
Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration.
Mohammad I, Arora PD, Naghibzadeh Y, Wang Y, Li J, Mascarenhas W, Janmey PA, Dawson JF, McCulloch CA.
FASEB J 26(8):3260-72. doi: 10.1096/fj.11-202051. Epub 2012 May 11. 2012
Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway.
Kopecki Z, O'Neill GM, Arkell RM, Cowin AJ.
J Invest Dermatol 131(7):1450-9. doi: 10.1038/jid.2011.69. Epub 2011 Mar 24. 2011
Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing.
Lin CH, Waters JM, Powell BC, Arkell RM, Cowin AJ.
Mamm Genome 22(5-6):341-52. doi: 10.1007/s00335-011-9320-z. Epub 2011 Mar 13. 2011
Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase.
Higashi T, Ikeda T, Murakami T, Shirakawa R, Kawato M, Okawa K, Furuse M, Kimura T, Kita T, Horiuchi H.
J Biol Chem 285(21):16231-8. Epub 2010 Mar 11. 2010
Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene (88).
Hayashi T, Funato Y, Terabayashi T, Morinaka A, Sakamoto R, Ichise H, Fukuda H, Yoshida N, Miki H.
J Biol Chem 285(24):18586-93. doi: 10.1074/jbc.M110.106468. Epub 2010 Apr 16. 2010
Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I.
Jeong KW, Lee YH, Stallcup MR.
J Biol Chem 284(43):29298-309. doi: 10.1074/jbc.M109.037010. Epub 2009 Aug 31. 2009
Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK.
Xu J, Liao L, Qin J, Xu J, Liu D, Songyang Z.
J Biol Chem 284(21):14377-85. doi: 10.1074/jbc.M807770200. Epub 2009 Mar 17. 2009
Flightless-I, a gelsolin family member and transcriptional regulator, preferentially binds directly to activated cytosolic CaMK-II.
Seward ME, Easley CA 4th, McLeod JJ, Myers AL, Tombes RM.
FEBS Lett 582(17):2489-95. doi: 10.1016/j.febslet.2008.06.037. Epub 2008 Jun 25. 2008
Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity.
Li J, Yin HL, Yuan J.
J Cell Biol 181(2):321-33. doi: 10.1083/jcb.200711082. Epub 2008 Apr 14. 2008
Flightless I deficiency enhances wound repair by increasing cell migration and proliferation.
Cowin AJ, Adams DH, Strudwick XL, Chan H, Hooper JA, Sander GR, Rayner TE, Matthaei KI, Powell BC, Campbell HD.
J Pathol 211(5):572-81. 2007
Flightless I homolog negatively modulates the TLR pathway.
Wang T, Chuang TH, Ronni T, Gu S, Du YC, Cai H, Sun HQ, Yin HL, Chen X.
J Immunol 176(3):1355-62. 2006
The flightless I protein and the gelsolin family in nuclear hormone receptor-mediated signalling.
Archer SK, Behm CA, Claudianos C, Campbell HD.
Biochem Soc Trans 32(Pt 6):940-2. Review. 2004
Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development.
Campbell HD, Fountain S, McLennan IS, Berven LA, Crouch MF, Davy DA, Hooper JA, Waterford K, Chen KS, Lupski JR, Ledermann B, Young IG, Matthaei KI.
Mol Cell Biol 22(10):3518-26. 2002
Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL.
Campbell HD, Fountain S, Young IG, Claudianos C, Hoheisel JD, Chen KS, Lupski JR.
Genomics 42(1):46-54. 1997
Cloning mammary cell cDNAs from 17q12-q23 using interspecific somatic cell hybrids and subtractive hybridization.
Cerosaletti KM, et al.
Genomics 25 : 226-237. 1995
The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2.
Chen KS, et al.
Am J Hum Genet 56 : 175-182. 1995
The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in caenorhabditis elegans and humans.
Campbell HD, et al.
Proc Natl Acad Sci U S A 90 : 11386-11390. 1993