| 1 | EWSR1, FLI1
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| Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding
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| Lee OW, Rodrigues C, Lin SH, Luo W, Jones K, Brown DW, Zhou W, Karlins E, Khan SM, Baulande S, Raynal V, Surdez D, Reynaud S, Rubio RA, Zaidi S, Grossetête S, Ballet S, Lapouble E, Laurence V, Pierron G, Gaspar N, Corradini N, Marec-Bérard P, Rothman N, Dagnall CL, Burdett L, Manning M, Wyatt K, Yeager M, Chari R, Leisenring WM, Kulozik AE, Kriebel J, Meitinger T, Strauch K, Kirchner T, Dirksen U, Mirabello L, Tucker MA, Tirode F, Armstrong GT, Bhatia S, Robison LL, Yasui Y, Romero-Pérez L, Hartmann W, Metzler M, Diver WR, Lori A, Freedman ND, Hoover RN, Morton LM, Chanock SJ, Grünewald TGP, Delattre O, Machiela MJ.
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| Am J Hum Genet. Mar 2;110(3):427-441. doi: 10.1016/j.ajhg.2023.01.017. Epub 2023 Feb 13. 2023
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| 2 | EWSR1, FEZF1, FLI1
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| The Transcription Factor FEZF1, a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes
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| García-García L, Fernández-Tabanera E, Cervera ST, Melero-Fernández de Mera RM, Josa S, González-González L, Rodríguez-Martín C, Grünewald TGP, Alonso J.
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| Cancers (Basel). Nov 12;13(22):5668. doi: 10.3390/cancers13225668. 2021
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| 3 | FLI1, MYH9, TRPV4
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| TRPV4 mediates the Ca2+ influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling.
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| Arora PD, Di Gregorio M, He P, McCulloch CA.
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| J Cell Sci 130(13):2196-2208. doi: 10.1242/jcs.201665. Epub 2017 May 19.
2017
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| 4 | FLI1, GATA1, GFI1B, RUNX1
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| Inherited platelet dysfunction and hematopoietic transcription factor mutations.
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| Songdej N, Rao AK.
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| Platelets latelets. 2016 Jul 27:1-7. [Epub ahead of print]
2016
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| 5 | FLI1
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| Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing.
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| Selvanathan SP, Graham GT, Erkizan HV, Dirksen U, Natarajan TG, Dakic A, Yu S, Liu X, Paulsen MT, Ljungman ME, Wu CH, Lawlor ER, Üren A, Toretsky JA.
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| Proc Natl Acad Sci U S A 112(11):E1307-16. doi: 10.1073/pnas.1500536112. Epub 2015 Mar 3.
2015
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| 6 | CCL2, FLI1
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| Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation.
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| Lennard Richard ML, Nowling TK, Brandon D, Watson DK, Zhang XK.
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| Mol Immunol 63(2):566-73. doi: 10.1016/j.molimm.2014.07.013. Epub 2014 Aug 6.
2015
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| 7 | CCL5, ETS1, FLI1
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| The Fli-1 transcription factor regulates the expression of CCL5/RANTES.
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| Lennard Richard ML, Sato S, Suzuki E, Williams S, Nowling TK, Zhang XK.
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| J Immunol 193(6):2661-8. doi: 10.4049/jimmunol.1302779. Epub 2014 Aug 6.
2014
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| 8 | FLI1
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| Oncogenic Fli-1 is a potential prognostic marker for the progression of epithelial ovarian cancer.
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| Song W, Hu L, Li W, Wang G, Li Y, Yan L, Li A, Cui J.
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| BMC Cancer 14:424. doi: 10.1186/1471-2407-14-424.
2014
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| 9 | ETS1, FLI1
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| Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma.
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| Bonetti P, Testoni M, Scandurra M, Ponzoni M, Piva R, Mensah AA, Rinaldi A, Kwee I, Tibiletti MG, Iqbal J, Greiner TC, Chan WC, Gaidano G, Piris MA, Cavalli F, Zucca E, Inghirami G, Bertoni F.
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| Blood 122(13):2233-41. doi: 10.1182/blood-2013-01-475772. Epub 2013 Aug 7. Erratum in: Blood. 2014 May 8;123(19):3056.
2013
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| 10 | FLI1
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| Fli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma.
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| Smeets MF, Chan AC, Dagger S, Bradley CK, Wei A, Izon DJ.
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| PLoS One 8(5):e62346. doi: 10.1371/journal.pone.0062346. Print 2013.
2013
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| 11 | FLI1
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| The transcription factor Fli-1 regulates monocyte, macrophage and dendritic cell development in mice.
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| Suzuki E, Williams S, Sato S, Gilkeson G, Watson DK, Zhang XK.
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| Immunology 139(3):318-27. doi: 10.1111/imm.12070.
2013
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| 12 | FLI1, KLF1
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| Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q- syndrome and in Diamond-Blackfan anemia.
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| Neuwirtova R, Fuchs O, Holicka M, Vostry M, Kostecka A, Hajkova H, Jonasova A, Cermak J, Cmejla R, Pospisilova D, Belickova M, Siskova M, Hochova I, Vondrakova J, Sponerova D, Kadlckova E, Novakova L, Brezinova J, Michalova K.
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| Ann Hematol 92(1):11-8. doi: 10.1007/s00277-012-1568-1. Epub 2012 Sep 11.
2013
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| 13 | DEL11QD, FLI1
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| SNP array and phenotype correlation shows that FLI1 deletion per se is not responsible for thrombocytopenia development in Jacobsen syndrome.
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| Trkova M, Becvarova V, Hynek M, Hnykova L, Hlavova E, Kreckova G, Kulovany E, Cutka D, Zatloukalova J, Markova K, Sukova M, Horacek J, Stejskal D.
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| Am J Med Genet A 158A(10):2545-50. doi: 10.1002/ajmg.a.35537. Epub 2012 Aug 7.
2012
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| 14 | FLI1, SLC45A3
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| FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer.
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| Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR.
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| Genes Chromosomes Cancer 51(3):240-9. doi: 10.1002/gcc.20948. Epub 2011 Nov 12.
2012
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| 15 | ESR1, FLI1
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| Fli1 is a negative regulator of estrogen receptor α in dermal fibroblasts.
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| Hattori T, Stawski L, Nakerakanti SS, Trojanowska M.
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| J Invest Dermatol 131(7):1469-76. doi: 10.1038/jid.2011.63. Epub 2011 Mar 31.
2011
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| 16 | ELF1, ETS1, ETS2, FLI1
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| The mouse and human Fli1 genes are similarly regulated by Ets factors in T cells.
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| Svenson JL, Chike-Harris K, Amria MY, Nowling TK.
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| Genes Immun 11(2):161-72. Epub 2009 Oct 15.PMID: 19829305 2010
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| 17 | EWSR1, FLI1, FOXO1
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| FOXO1 is a direct target of EWS-Fli1 oncogenic fusion protein in Ewing's sarcoma cells.
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| Yang L, Hu HM, Zielinska-Kwiatkowska A, Chansky HA.
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| Biochem Biophys Res Commun 402(1):129-34. doi: 10.1016/j.bbrc.2010.09.129. Epub 2010 Oct 8.
2010
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| 18 | EWSR1, FLI1, GLI1
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| GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.
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| Beauchamp E, Bulut G, Abaan O, Chen K, Merchant A, Matsui W, Endo Y, Rubin JS, Toretsky J, Uren A.
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| J Biol Chem 284(14):9074-82. Epub 2009 Feb 3. 2009
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| 19 | EWSR1, FLI1
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| A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.
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| Erkizan HV, Kong Y, Merchant M, Schlottmann S, Barber-Rotenberg JS, Yuan L, Abaan OD, Chou TH, Dakshanamurthy S, Brown ML, Uren A, Toretsky JA.
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| Nat Med 15(7):750-6. Epub 2009 Jul 5.
2009
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| 20 | DEL11QD, FLI1, TCDM
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| Clinical and molecular-cytogenetic evaluation of a family with partial Jacobsen syndrome without thrombocytopenia caused by an approximately 5 Mb deletion del(11)(q24.3).
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| Bernaciak J, Szcza³uba K, Derwiñska K, Wiœniowiecka-Kowalnik B, Bocian E, Sasiadek MM, Makowska I, Stankiewicz P, Smigiel R.
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| Am J Med Genet A 146A(19):2449-54. 2008
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| 21 | FLI1
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| Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
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| Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T.
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| Rheumatology (Oxford) 47(2):158-64. Epub 2008 Jan 3.PMID: 18174230 2008
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| 22 | FLI1
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| Fli-1 expression in malignant melanoma.
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| Torlakovic EE, Slipicevic A, Flørenes VA, Chibbar R, DeCoteau JF, Bilalovic N.
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| Histol Histopathol 23(11):1309-14.PMID: 18785112 2008
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| 23 | ELF1, FLI1
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| Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes.
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| Nowling TK, Fulton JD, Chike-Harris K, Gilkeson GS.
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| Mol Immunol 45(1):1-12. Epub 2007 Jul 2.PMID: 17606295 2008
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| 24 | FLI1
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| Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy.
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| Sakurai T, Kondoh N, Arai M, Hamada J, Yamada T, Kihara-Negishi F, Izawa T, Ohno H, Yamamoto M, Oikawa T.
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| Cancer Sci 98(11):1775-84.PMID: 17727680 2007
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| 25 | FLI1, GATA2
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| Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.
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| Pimanda JE, Ottersbach K, Knezevic K, Kinston S, Chan WY, Wilson NK, Landry JR, Wood AD, Kolb-Kokocinski A, Green AR, Tannahill D, Lacaud G, Kouskoff V, Göttgens B.
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| Proc Natl Acad Sci U S A 104(45):17692-7. Epub 2007 Oct 25.PMID: 17962413 2007
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| 26 | FLI1, NFRKB, SNX19
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| Amplified, lost, and fused genes in 11q23-25 amplicon in acute myeloid leukemia, an array-CGH study.
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| Tyybakinoja A, Saarinen-Pihkala U, Elonen E, Knuutila S.
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| Genes Chromosomes Cancer 45(3):257-64. 2006
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| 27 | FLI1
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| Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts.
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| Wang Y, Fan PS, Kahaleh B.
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| Arthritis Rheum 54(7):2271-9. 2006
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| 28 | GATA1, FLI1, ITGA2B, GP9
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| Ets-dependent regulation of target gene expression during megakaryopoiesis.
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| Jackers P, Szalai G, Moussa O, Watson DK.
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| J Biol Chem 279(50):52183-90. Epub 2004 Oct 5. Erratum in: J Biol Chem. 2005 Jul 1;280(26):25304. 2004
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| 29 | FLI1, TCDM, DEL11QD
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| FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia.
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| Raslova H, Komura E, Le Couedic JP, Larbret F, Debili N, Feunteun J, Danos O, Albagli O, Vainchenker W, Favier R.
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| J Clin Invest 114(1):77-84. 2004
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| 30 | EWSR1, FLI1
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| Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells
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| Taslerova R, Kozubek S, Lukasova E, Jirsova P, Bartova E, Kozubek M.
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| Hum Genet 112(2):143-55. 2003
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| 31 | FLI1, TBX1, GP6, SPI1
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| Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1.
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| Holmes ML, Bartle N, Eisbacher M, Chong BH.
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| J Biol Chem 277(50):48333-41. 2002
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| 32 | ID2, EWSR1, FLI1, ERG
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| The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.
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| Nishimori H, Sasaki Y, Yoshida K, Irifune H, Zembutsu H, Tanaka T, Aoyama T, Hosaka T, Kawaguchi S, Wada T, Hata J, Toguchida J, Nakamura Y, Tokino T.
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| Oncogene 21(54):8302-9. 2002
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| 33 | FLI1
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| Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor.
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| Spyropoulos DD, Pharr PN, Lavenburg KR, Jackers P, Papas TS, Ogawa M, Watson DK.
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| Mol Cell Biol 20(15):5643-52. 2000
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| 34 | FLI1
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| Translocation of chromosomes 11 and 22 in choroidal metastatic Ewing sarcoma detected by fluorescent in situ hybridization.
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| Chan CC, et al.
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| Am J Ophthalmol 127(2):226-8. 1999
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| 35 | FLI1
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| Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains.
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| Goshima M, et al.
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| Biochem Biophys Res Commun 257(1):111-6. 1999
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| 36 | TGFBR2, EWSR1, FLI1
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| Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein.
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| Hahm KB, et al.
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| Nat Genet 23(2):222-7 1999
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| 37 | EWSR1, FLI1
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| Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene.
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| Sorensen PH, et al.
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| Cancer Res 55 : 1385-1392. 1995
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| 38 | FLI1
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| High-resolution physical mapping of a 250-kb region of human chromosome 11q24 by genomic sequence sampling (GSS).
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| Selleri L, et al.
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| Genomics 26 : 489-501. 1995
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| 39 | ERG, EWSR1, EWSR1, FLI1
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| A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG.
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| Sorensen PHB, et al.
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| Nat Genet 6 : 146-151. 1994
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| 40 | FLI1
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| Cloning of the entire FLI1 gene, disrupted by the Ewing's Sarcoma translocation breakpoint on 11q24, in a yeast artificial chromosome.
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| Selleri L, et al.
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| Cytogenet Cell Genet 67 : 129-136. 1994
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| 41 | FLI1
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| Yeast artificial chromosome cloning of 3.2 megabases within chromosomal band 11q24 closely linking c-ets 1 and Fli-1 and encompassing the Ewing sarcoma breakpoint.
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| Selleri L, et al.
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| Genomics 22 : 137-147. 1994
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| 42 | EWSR1, FLI1
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| DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma.
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| Bailly RA, et al.
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| Mol Cell Biol 14 : 3230-3241. 1994
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| 43 | EWSR1, FLI1
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| EWS/FLi-1 chimeric protein is a transcriptional activator.
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| Ohno T, et al.
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| Cancer Res 53 : 5859-5863. 1993
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| 44 | FLI1
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| Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma.
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| Hromas R, et al.
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| Biochim Biophys Acta 1172 : 155-158. 1993
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| 45 | EWSR1, FLI1
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| Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.
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| May WA, et al.
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| Proc Natl Acad Sci U S A 90 : 5752-5756. 1993
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| 46 | EWSR1, EWSR1, FLI1
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| Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.
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| Delattre O, et al.
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| Nature 359 : 162-166. 1992
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| 47 | EWSR1, FLI1
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| Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints.
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| Zucman J, et al.
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| Genes Chromosomes Cancer 5 : 271-277. 1992
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| 48 | FLI1
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| The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24.
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| Baud V, et al.
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| Genomics 11 : 223-224. 1991
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| 49 | EWSR1, FLI1, CBL, LIF
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| Molecular localization of the t(11;22)(q24;q12) translocation of Ewing sarcoma by chromosomal in situ suppression hybridization.
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| Selleri L, et al.
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| Proc Natl Acad Sci U S A 88 : 887-891. 1991
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| 50 | EWSR1, FLI1
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| Chromosomes in Ewing's sarcoma. I.An evaluation of 85 cases and remarkable consistency of t(11;22)(q24;q12).
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| Turc-Carel C, et al.
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| Cancer Genet Cytogenet 32 : 229-238. 1988
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| 51 | EWSR1, FLI1
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| Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12).
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| Turc-Carel C, et al.
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| Cancer Genet Cytogenet 12 : 1-19. 1984
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| 52 | EWSR1, FLI1
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| Chromosome translocation in peripheral neuroepithelioma.
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| Whang-Peng J, et al.
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| N Engl J Med 311 : 584-585. 1984
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| 53 | EWSR1, FLI1
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| Chromosomal translocations in Ewing's sarcoma.
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| Turc-Carel C, et al.
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| N Engl J Med 309 : 497-498. 1983
|