| 1 | CMYA5, FHL2
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| CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes
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| Stathopoulou K, Schnittger J, Raabe J, Fleischer F, Mangels N, Piasecki A, Findlay J, Hartmann K, Krasemann S, Schlossarek S, Uebeler J, Wixler V, Blake DJ, Baillie GS, Carrier L, Ehler E, Cuello F.
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| FEBS J. Aug;289(15):4622-4645. doi: 10.1111/febs.16402. Epub 2022 Feb 27 2022
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| 2 | FHL2
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| How (Epi)Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease
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| Habibe JJ, Clemente-Olivo MP, de Vries CJ.
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| Cells 1;10(10):2611. doi: 10.3390/cells10102611. 2021
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| 3 | FHL2
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| FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply.
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| Basu H, Pekkurnaz G, Falk J, Wei W, Chin M, Steen J, Schwarz TL.
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| J Cell Biol. Oct 4;220(10):e201912077. doi: 10.1083/jcb.201912077. Epub 2021 Aug 3. 2021
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| 4 | FHL2, NFKB1
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| LIM-only protein FHL2 attenuates inflammation in vascular smooth muscle cells through inhibition of the NFκB pathway
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| van de Pol V, Vos M, DeRuiter MC, Goumans MJ, de Vries CJM, Kurakula K.
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| Vascul Pharmacol. Feb-Mar;125-126:106634. doi: 10.1016/j.vph.2019.106634. Epub 2019 Dec 19. 2020
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| 5 | FHL2
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| The role of FHL2 in wound healing and inflammation.
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| Wixler V.
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| FASEB J. Jul;33(7):7799-7809. doi: 10.1096/fj.201802765RR. Epub 2019 Apr 2. 2019
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| 6 | CTNNB1, FHL2
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| FHL2 promotes tubular epithelial-to-mesenchymal transition through modulating β-catenin signalling.
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| Cai T, Sun D, Duan Y, Qiu Y, Dai C, Yang J, He W.
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| J Cell Mol Med. Mar;22(3):1684-1695. doi: 10.1111/jcmm.13446. Epub 2017 Nov 29. 2018
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| 7 | FHL2, TGFB1
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| LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression.
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| Dahan J, Levillayer F, Xia T, Nouët Y, Werts C, Fanton d'Andon M, Adib-Conquy M, Cassard-Doulcier AM, Khanna V, Chen J, Tordjmann T, Buendia MA, Jouvion G, Wei Y.
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| Mol Cell Biol. May 2;37(10):e00636-16. doi: 10.1128/MCB.00636-16 2017
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| 8 | FHL2
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| Protein-protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease
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| Tran MK, Kurakula K, Koenis DS, de Vries CJ.
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| Biochim Biophys Acta. Feb;1863(2):219-28. doi: 10.1016/j.bbamcr.2015.11.002. Epub 2015 Nov 6. 2016
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| 9 | FHL2, FOXK1
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| FOXK1 interaction with FHL2 promotes proliferation, invasion and metastasis in colorectal cance
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| Wu M, Wang J, Tang W, Zhan X, Li Y, Peng Y, Huang X, Bai Y, Zhao J, Li A, Chen C, Chen Y, Peng H, Ren Y, Li G, Liu S, Wang J.
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| Oncogenesis. Nov 28;5(11):e271. doi: 10.1038/oncsis.2016.68. 2016
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| 10 | FHL2
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| The FHL2 regulation in the transcriptional circuitry of human cancers
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| Cao CY, Mok SW, Cheng VW, Tsui SK.
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| Gene. Nov 1;572(1):1-7. doi: 10.1016/j.gene.2015.07.043. Epub 2015 Jul 26. 2015
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| 11 | FHL2
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| FHL2 regulates hematopoietic stem cell functions under stress conditions
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| Hou Y, Wang X, Li L, Fan R, Chen J, Zhu T, Li W, Jiang Y, Mittal N, Wu W, Peace D, Qian Z
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| Leukemia. Mar;29(3):615-24. doi: 10.1038/leu.2014.254. Epub 2014 Sep 2. 2015
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| 12 | FHL1, FHL2, PRKD1
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| Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes.
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| Stathopoulou K, Cuello F, Candasamy AJ, Kemp EM, Ehler E, Haworth RS, Avkiran M.
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| Biochem J 457(3):451-61. doi: 10.1042/BJ20131026.
2014
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| 13 | FHL2
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| FHL2 expression and variants in hypertrophic cardiomyopathy.
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| Friedrich FW, Reischmann S, Schwalm A, Unger A, Ramanujam D, Münch J, Müller OJ, Hengstenberg C, Galve E, Charron P, Linke WA, Engelhardt S, Patten M, Richard P, van der Velden J, Eschenhagen T, Isnard R, Carrier L.
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| Basic Res Cardiol. 109(6):451. doi: 10.1007/s00395-014-0451-8. Epub 2014 Oct 31. 2014
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| 14 | FHL2, ROCK2
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| FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.
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| Okamoto R, Li Y, Noma K, Hiroi Y, Liu PY, Taniguchi M, Ito M, Liao JK.
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| FASEB J 27(4):1439-49. doi: 10.1096/fj.12-217018. Epub 2012 Dec 27.
2013
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| 15 | FHL2, RNF111
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| The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia.
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| Xia T, Lévy L, Levillayer F, Jia B, Li G, Neuveut C, Buendia MA, Lan K, Wei Y.
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| J Biol Chem 288(3):1785-94. doi: 10.1074/jbc.M112.439760. Epub 2012 Dec 4.
2013
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| 16 | FHL2, WNT10B, WNT3A, WNT5A
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| The LIM-only protein FHL2 controls mesenchymal cell osteogenic differentiation and bone formation through Wnt5a and Wnt10b.
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| Brun J, Fromigué O, Dieudonné FX, Marty C, Chen J, Dahan J, Wei Y, Marie PJ.
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| Bone 53(1):6-12. doi: 10.1016/j.bone.2012.11.020. Epub 2012 Nov 29.
2013
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| 17 | FHL2, TRAF6
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| LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis
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| Dahan J, Nouët Y, Jouvion G, Levillayer F, Adib-Conquy M, Cassard-Doulcier AM, Tebbi A, Blanc F, Remy L, Chen J, Cairo S, Werts C, Si-Tahar M, Tordjmann T, Buendia MA, Wei Y.
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| Mol Cell Biol. Aug;33(16):3299-308. doi: 10.1128/MCB.00105-13. Epub 2013 Jun 17. 2013
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| 18 | FHL1, FHL2, FHL3
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| Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.
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| Hubbi ME, Gilkes DM, Baek JH, Semenza GL.
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| J Biol Chem 287(9):6139-49. Epub 2012 Jan 4.
2012
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| 19 | FHL2
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| Characterization of human FHL2 transcript variants and gene expression regulation in hepatocellular carcinoma.
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| Ng CF, Zhou WJ, Ng PK, Li MS, Ng YK, Lai PB, Tsui SK.
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| Gene 481(1):41-7. Epub 2011 Apr 22.
2011
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| 20 | FHL2, NR4A1
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| FHL2 protein is a novel co-repressor of nuclear receptor Nur77.
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| Kurakula K, van der Wal E, Geerts D, van Tiel CM, de Vries CJ.
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| J Biol Chem 286(52):44336-43. doi: 10.1074/jbc.M111.308999. Epub 2011 Nov 2.
2011
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| 21 | CCL19, FHL2
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| Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration.
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| König K, Diehl L, Rommerscheidt-Fuss U, Golletz C, Quast T, Kahl P, Kolanus W, Knolle P, Buettner R, Heukamp LC.
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| J Immunol 185(3):1466-75. Epub 2010 Jun 30.
2010
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| 22 | FHL2, FOXK1
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| Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors.
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| Shi X, Bowlin KM, Garry DJ.
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| Stem Cells 28(3):462-9.
2010
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| 23 | FHL2, ID2
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| FHL2 interacts with and acts as a functional repressor of Id2 in human neuroblastoma cells.
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| Han W, Wu Z, Zhao Y, Meng Y, Si Y, Yang J, Fu X, Yu L.
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| Nucleic Acids Res 37(12):3996-4009. Epub 2009 May 5.
2009
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| 24 | FHL2
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| FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.
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| Hayashi H, Nakagami H, Takami Y, Koriyama H, Mori M, Tamai K, Sun J, Nagao K, Morishita R, Kaneda Y.
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| Arterioscler Thromb Vasc Biol 29(6):909-14. Epub 2009 Mar 26.
2009
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| 25 | FHL1, FHL2, FHL3
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| Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.
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| Ding L, Wang Z, Yan J, Yang X, Liu A, Qiu W, Zhu J, Han J, Zhang H, Lin J, Cheng L, Qin X, Niu C, Yuan B, Wang X, Zhu C, Zhou Y, Li J, Song H, Huang C, Ye Q.
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| J Clin Invest 119(2):349-61. doi: 10.1172/JCI35930. Epub 2009 Jan 12.
2009
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| 26 | FHL2, CCND1
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| The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation.
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| Labalette C, Nou‘t Y, Sobczak-Thepot J, Armengol C, Levillayer F, Gendron MC, Renard CA, Regnault B, Chen J, Buendia MA, Wei Y.
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| J Biol Chem 283(22):15201-8. Epub 2008 Mar 31. 2008
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| 27 | FHL2
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| Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins.
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| Park J, Will C, Martin B, Gullotti L, Friedrichs N, Buettner R, Schneider H, Ludwig S, Wixler V.
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| FASEB J 22(7):2508-20. Epub 2008 Mar 20.
2008
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| 28 | FHL2, KCNH2
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| The four and a half LIM domain protein 2 interacts with and regulates the HERG channel.
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| Lin J, Lin S, Yu X, Choy PC, Shen X, Deng C, Kuang S, Wu J.
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| FEBS J 275(18):4531-9. Epub 2008 Aug 1.
2008
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| 29 | TRIM54, FLNC, FHL2
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| Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction.
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| Fielitz J, van Rooij E, Spencer JA, Shelton JM, Latif S, van der Nagel R, Bezprozvannaya S, de Windt L, Richardson JA, Bassel-Duby R, Olson EN.
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| Proc Natl Acad Sci U S A 104(11):4377-82. Epub 2007 Mar 2. 2007
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| 30 | FHL2, CMD1H
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| Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy.
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| Arimura T, Hayashi T, Matsumoto Y, Shibata H, Hiroi S, Nakamura T, Inagaki N, Hinohara K, Takahashi M, Manatsu SI, Sasaoka T, Izumi T, Bonne G, Schwartz K, Kimura A.
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| Biochem Biophys Res Commun 357(1):162-7. Epub 2007 Mar 30. 2007
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| 31 | E4F1, FHL2
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| The LIM-only protein FHL2 is a negative regulator of E4F1.
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| Paul C, Lacroix M, Iankova I, Julien E, SchŠfer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C.
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| Oncogene 25(40):5475-84. Epub 2006 May 1. 2006
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| 32 | FHL2,TNFRSF11A,TRAF6
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| FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
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| Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL.
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| J Clin Invest 115(10):2742-51. Epub 2005 Sep 22. 2005
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| 33 | FHL2, MAPK1
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| Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.
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| Purcell NH, Darwis D, Bueno OF, Muller JM, Schule R, Molkentin JD.
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| Mol Cell Biol 24(3):1081-95. 2004
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| 34 | FHL2, PIAS1, UBE2I
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| FHL2, UBC9, and PIAS1 are novel estrogen receptor alpha-interacting proteins.
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| Kobayashi S, Shibata H, Yokota K, Suda N, Murai A, Kurihara I, Saito I, Saruta T.
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| Endocr Res 30(4):617-21. 2004
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| 35 | FHL2, IGFBP5
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| Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2).
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| Amaar YG, Thompson GR, Linkhart TA, Chen ST, Baylink DJ, Mohan S.
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| J Biol Chem 277(14):12053-60. 2002
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| 36 | FHL2, ZBTB16
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| The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein.
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| McLoughlin P, Ehler E, Carlile G, Licht JD, Schafer BW.
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| J Biol Chem 277(40):37045-53. 2002
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| 37 | FHL2, ZNF638
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| Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220.
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| Ng EK, Chan KK, Wong CH, Tsui SK, Ngai SM, Lee SM, Kotaka M, Lee CY, Waye MM, Fung KP.
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| J Cell Biochem 84(3):556-66. 2002
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| 38 | FHL2, TTN
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| Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.
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| Lange S, Auerbach D, McLoughlin P, Perriard E, Schafer BW, Perriard JC, Ehler E.
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| J Cell Sci 115(Pt 24):4925-36. 2002
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| 39 | FHL2
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| FHL2, a novel tissue-specific coactivator of the androgen receptor.
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| Muller JM, Isele U, Metzger E, Rempel A, Moser M, Pscherer A, Breyer T, Holubarsch C, Buettner R, Schule R.
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| EMBO J 19(3):359-369 2000
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| 40 | AD4, FHL2, PSEN2
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| Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein
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| Tanahashi H, Tabira T.
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| Hum Mol Genet 9(15):2281-9. 2000
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| 41 | FHL2
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| The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.
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| Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M.
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| J Biol Chem 275(43):33669-78. 2000
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| 42 | FHL2
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| Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart.
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| Chan KK, et al.
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| Gene 210 : 345-350. 1998
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| 43 | FHL2
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| Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma.
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| Genini M, et al.
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| DNA Cell Biol 16 : 433-442. 1997
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| 44 | FHL2, FHL3
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| Slim defines a novel family of LIM-proteins expressed in skeletal muscle.
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| Morgan MJ, Madgwick AJ.
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| Biochem Biophys Res Commun 225(2):632-8. 1996
|