Citations for
1FHL2, ROCK2
FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.
Okamoto R, Li Y, Noma K, Hiroi Y, Liu PY, Taniguchi M, Ito M, Liao JK.
FASEB J 27(4):1439-49. doi: 10.1096/fj.12-217018. Epub 2012 Dec 27. 2013
2FHL1, FHL2, FHL3
Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.
Hubbi ME, Gilkes DM, Baek JH, Semenza GL.
J Biol Chem 287(9):6139-49. Epub 2012 Jan 4. 2012
3FHL2
Characterization of human FHL2 transcript variants and gene expression regulation in hepatocellular carcinoma.
Ng CF, Zhou WJ, Ng PK, Li MS, Ng YK, Lai PB, Tsui SK.
Gene 481(1):41-7. Epub 2011 Apr 22. 2011
4FHL2, NR4A1
FHL2 protein is a novel co-repressor of nuclear receptor Nur77.
Kurakula K, van der Wal E, Geerts D, van Tiel CM, de Vries CJ.
J Biol Chem 286(52):44336-43. doi: 10.1074/jbc.M111.308999. Epub 2011 Nov 2. 2011
5CCL19, FHL2
Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration.
König K, Diehl L, Rommerscheidt-Fuss U, Golletz C, Quast T, Kahl P, Kolanus W, Knolle P, Buettner R, Heukamp LC.
J Immunol 185(3):1466-75. Epub 2010 Jun 30. 2010
6FHL2, FOXK1
Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors.
Shi X, Bowlin KM, Garry DJ.
Stem Cells 28(3):462-9. 2010
7FHL2, ID2
FHL2 interacts with and acts as a functional repressor of Id2 in human neuroblastoma cells.
Han W, Wu Z, Zhao Y, Meng Y, Si Y, Yang J, Fu X, Yu L.
Nucleic Acids Res 37(12):3996-4009. Epub 2009 May 5. 2009
8FHL2
FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.
Hayashi H, Nakagami H, Takami Y, Koriyama H, Mori M, Tamai K, Sun J, Nagao K, Morishita R, Kaneda Y.
Arterioscler Thromb Vasc Biol 29(6):909-14. Epub 2009 Mar 26. 2009
9FHL1, FHL2, FHL3
Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.
Ding L, Wang Z, Yan J, Yang X, Liu A, Qiu W, Zhu J, Han J, Zhang H, Lin J, Cheng L, Qin X, Niu C, Yuan B, Wang X, Zhu C, Zhou Y, Li J, Song H, Huang C, Ye Q.
J Clin Invest 119(2):349-61. doi: 10.1172/JCI35930. Epub 2009 Jan 12. 2009
10FHL2, CCND1
The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation.
Labalette C, Nou‘t Y, Sobczak-Thepot J, Armengol C, Levillayer F, Gendron MC, Renard CA, Regnault B, Chen J, Buendia MA, Wei Y.
J Biol Chem 283(22):15201-8. Epub 2008 Mar 31. 2008
11FHL2
Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins.
Park J, Will C, Martin B, Gullotti L, Friedrichs N, Buettner R, Schneider H, Ludwig S, Wixler V.
FASEB J 22(7):2508-20. Epub 2008 Mar 20. 2008
12FHL2, KCNH2
The four and a half LIM domain protein 2 interacts with and regulates the HERG channel.
Lin J, Lin S, Yu X, Choy PC, Shen X, Deng C, Kuang S, Wu J.
FEBS J 275(18):4531-9. Epub 2008 Aug 1. 2008
13TRIM54, FLNC, FHL2
Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction.
Fielitz J, van Rooij E, Spencer JA, Shelton JM, Latif S, van der Nagel R, Bezprozvannaya S, de Windt L, Richardson JA, Bassel-Duby R, Olson EN.
Proc Natl Acad Sci U S A 104(11):4377-82. Epub 2007 Mar 2. 2007
14FHL2, CMD1H
Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy.
Arimura T, Hayashi T, Matsumoto Y, Shibata H, Hiroi S, Nakamura T, Inagaki N, Hinohara K, Takahashi M, Manatsu SI, Sasaoka T, Izumi T, Bonne G, Schwartz K, Kimura A.
Biochem Biophys Res Commun 357(1):162-7. Epub 2007 Mar 30. 2007
15E4F1, FHL2
The LIM-only protein FHL2 is a negative regulator of E4F1.
Paul C, Lacroix M, Iankova I, Julien E, SchŠfer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C.
Oncogene 25(40):5475-84. Epub 2006 May 1. 2006
16FHL2,TNFRSF11A,TRAF6
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL.
J Clin Invest 115(10):2742-51. Epub 2005 Sep 22. 2005
17FHL2, MAPK1
Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.
Purcell NH, Darwis D, Bueno OF, Muller JM, Schule R, Molkentin JD.
Mol Cell Biol 24(3):1081-95. 2004
18FHL2, PIAS1, UBE2I
FHL2, UBC9, and PIAS1 are novel estrogen receptor alpha-interacting proteins.
Kobayashi S, Shibata H, Yokota K, Suda N, Murai A, Kurihara I, Saito I, Saruta T.
Endocr Res 30(4):617-21. 2004
19FHL2, IGFBP5
Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2).
Amaar YG, Thompson GR, Linkhart TA, Chen ST, Baylink DJ, Mohan S.
J Biol Chem 277(14):12053-60. 2002
20FHL2, ZBTB16
The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein.
McLoughlin P, Ehler E, Carlile G, Licht JD, Schafer BW.
J Biol Chem 277(40):37045-53. 2002
21FHL2, ZNF638
Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220.
Ng EK, Chan KK, Wong CH, Tsui SK, Ngai SM, Lee SM, Kotaka M, Lee CY, Waye MM, Fung KP.
J Cell Biochem 84(3):556-66. 2002
22FHL2, TTN
Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.
Lange S, Auerbach D, McLoughlin P, Perriard E, Schafer BW, Perriard JC, Ehler E.
J Cell Sci 115(Pt 24):4925-36. 2002
23FHL2
FHL2, a novel tissue-specific coactivator of the androgen receptor.
Muller JM, Isele U, Metzger E, Rempel A, Moser M, Pscherer A, Breyer T, Holubarsch C, Buettner R, Schule R.
EMBO J 19(3):359-369 2000
24AD4, FHL2, PSEN2
Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein
Tanahashi H, Tabira T.
Hum Mol Genet 9(15):2281-9. 2000
25FHL2
The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.
Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M.
J Biol Chem 275(43):33669-78. 2000
26FHL2
Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart.
Chan KK, et al.
Gene 210 : 345-350. 1998
27FHL2
Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma.
Genini M, et al.
DNA Cell Biol 16 : 433-442. 1997
28FHL2, FHL3
Slim defines a novel family of LIM-proteins expressed in skeletal muscle.
Morgan MJ, Madgwick AJ.
Biochem Biophys Res Commun 225(2):632-8. 1996