| 1 | FHL1, XMPMA
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| A novel single nucleotide splice site mutation in FHL1 confirms an Emery-Dreifuss plus phenotype with pulmonary artery hypoplasia and facial dysmorphology.
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| Pen AE, Nyegaard M, Fang M, Jiang H, Christensen R, Mølgaard H, Andersen H, Ulhøi BP, Østergaard JR, Væth S, Sommerlund M, de Brouwer AP, Zhang X, Jensen UB.
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| Eur J Med Genet ur J Med Genet. 2015 Feb 25. pii: S1769-7212(15)00035-X. doi: 10.1016/j.ejmg.2015.02.003. [Epub ahead of print]
2015
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| 2 | FHL1
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| Estrogen Enhances Activity of Wnt Signaling During Osteogenesis by Inducing Fhl1 Expression.
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| Wu SM, Shih LH, Lee JY, Shen YJ, Lee HH.
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| J Cell Biochem Cell Biochem. 2015 Feb 10. doi: 10.1002/jcb.25102. [Epub ahead of print]
2015
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| 3 | FHL1
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| Fhl1 W122S causes loss of protein function and late-onset mild myopathy.
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| Emmanuele V, Kubota A, Garcia-Diaz B, Garone C, Akman HO, Sánchez-Gutiérrez D, Escudero LM, Kariya S, Homma S, Tanji K, Quinzii CM, Hirano M.
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| Hum Mol Genet 24(3):714-26. doi: 10.1093/hmg/ddu490. Epub 2014 Sep 30.
2015
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| 4 | FHL1, XMPMA
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| A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles.
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| Fujii T, Hayashi S, Kawamura N, Higuchi MA, Tsugawa J, Ohyagi Y, Hayashi YK, Nishino I, Kira J.
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| J Neurol Sci 343(1-2):206-10. doi: 10.1016/j.jns.2014.05.056. Epub 2014 Jun 2.
2014
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| 5 | FHL1, TJP1
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| The LIM domain protein FHL1C interacts with tight junction protein ZO-1 contributing to the epithelial-mesenchymal transition (EMT) of a breast adenocarcinoma cell line.
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| Zhao JL, Liang SQ, Fu W, Zhu BK, Li SZ, Han H, Qin HY.
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| Gene 542(2):182-9. doi: 10.1016/j.gene.2014.03.036. Epub 2014 Mar 19.
2014
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| 6 | FHL1
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| Up-regulated FHL1 expression maybe involved in the prognosis of Hirschsprung's disease.
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| Wang LL, Gu H, Fan Y, Zhang Y, Wu D, Miao JN, Huang TC, Li H, Yuan ZW.
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| Int J Med Sci 11(3):262-7. doi: 10.7150/ijms.7287. eCollection 2014.
2014
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| 7 | FHL1, RBPJ
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| Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling.
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| Collins KJ, Yuan Z, Kovall RA.
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| Structure 22(1):70-81. doi: 10.1016/j.str.2013.10.010. Epub 2013 Nov 27.
2014
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| 8 | FHL1, FHL2, PRKD1
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| Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes.
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| Stathopoulou K, Cuello F, Candasamy AJ, Kemp EM, Ehler E, Haworth RS, Avkiran M.
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| Biochem J 457(3):451-61. doi: 10.1042/BJ20131026.
2014
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| 9 | FHL1, NFATC1, UTRN
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| Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy.
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| D'Arcy CE, Feeney SJ, McLean CA, Gehrig SM, Lynch GS, Smith JE, Cowling BS, Mitchell CA, McGrath MJ.
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| Hum Mol Genet 23(3):618-36. doi: 10.1093/hmg/ddt449. Epub 2013 Sep 18.
2014
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| 10 | FHL1
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| Isolated X-linked hypertrophic cardiomyopathy caused by a novel mutation of the four-and-a-half LIM domain 1 gene.
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| Hartmannova H, Kubanek M, Sramko M, Piherova L, Noskova L, Hodanova K, Stranecky V, Pristoupilova A, Sovova J, Marek T, Maluskova J, Ridzon P, Kautzner J, Hulkova H, Kmoch S.
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| Circ Cardiovasc Genet 6(6):543-51. doi: 10.1161/CIRCGENETICS.113.000245. Epub 2013 Oct 10.
2013
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| 11 | FHL1
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| Left ventricular hypertrophy caused by a novel nonsense mutation in FHL1.
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| Gossios TD, Lopes LR, Elliott PM.
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| Eur J Med Genet 56(5):251-5. doi: 10.1016/j.ejmg.2013.03.001. Epub 2013 Mar 14.
2013
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| 12 | FHL1, SMAD4, VEGFA
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| FHL1 and Smad4 synergistically inhibit vascular endothelial growth factor expression.
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| Zhou Z, Lu J, Dou J, Lv Z, Qin X, Lin J.
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| Mol Med Rep 7(2):649-53. doi: 10.3892/mmr.2012.1202. Epub 2012 Nov 26.
2013
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| 13 | FHL1, FHL2, FHL3
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| Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.
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| Hubbi ME, Gilkes DM, Baek JH, Semenza GL.
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| J Biol Chem 287(9):6139-49. Epub 2012 Jan 4.
2012
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| 14 | FHL1
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| Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy.
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| Friedrich FW, Wilding BR, Reischmann S, Crocini C, Lang P, Charron P, Müller OJ, McGrath MJ, Vollert I, Hansen A, Linke WA, Hengstenberg C, Bonne G, Morner S, Wichter T, Madeira H, Arbustini E, Eschenhagen T, Mitchell CA, Isnard R, Carrier L.
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| Hum Mol Genet 21(14):3237-54. doi: 10.1093/hmg/dds157. Epub 2012 Apr 20.
2012
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| 15 | FHL1, TTN
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| A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
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| Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F.
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| J Biol Chem 287(35):29273-84. doi: 10.1074/jbc.M112.372839. Epub 2012 Jul 9.
2012
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| 16 | ACTN1, ACTN4, FHL1, PDLIM1
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| Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein-protein interaction analysis.
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| Sharma P, Shathasivam T, Ignatchenko V, Kislinger T, Gramolini AO.
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| Mol Biosyst 7(4):1185-96. Epub 2011 Jan 18.
2011
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| 17 | FHL1, SPM1, XMPMA
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| Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: a comprehensive review of the clinical, histological and pathological features.
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| Cowling BS, Cottle DL, Wilding BR, D'Arcy CE, Mitchell CA, McGrath MJ.
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| Neuromuscul Disord 21(4):237-51. Review. 2011
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| 18 | FHL1, USP15
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| Transgenic overexpression of USP15 in the heart induces cardiac remodeling in mice.
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| Isumi Y, Hirata T, Saitoh H, Miyakawa T, Murakami K, Kudoh G, Doi H, Ishibashi K, Nakajima H.
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| Biochem Biophys Res Commun 405(2):216-21. doi: 10.1016/j.bbrc.2011.01.012. Epub 2011 Jan 8.
2011
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| 19 | FHL1, KCNA5
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| Four and a half LIM protein 1C (FHL1C): a binding partner for voltage-gated potassium channel K(v1.5).
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| Poparic I, Schreibmayer W, Schoser B, Desoye G, Gorischek A, Miedl H, Hochmeister S, Binder J, Quasthoff S, Wagner K, Windpassinger C, Malle E.
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| PLoS One 6(10):e26524. doi: 10.1371/journal.pone.0026524. Epub 2011 Oct 28.
2011
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| 20 | FHL1
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| LIM domain protein FHL1B interacts with PP2A catalytic β subunit--a novel cell cycle regulatory pathway.
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| Wong CH, Fung YW, Ng EK, Lee SM, Waye MM, Tsui SK.
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| FEBS Lett 584(22):4511-6. Epub 2010 Oct 20.
2010
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| 21 | FHL1, XMPMA
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| Novel FHL1 mutations in fatal and benign reducing body myopathy.
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| Shalaby S, Hayashi YK, Nonaka I, Noguchi S, Nishino I.
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| Neurology 72(4):375-6. No abstract available.
2009
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| 22 | FHL1, SPM1
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| Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy.
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| Gueneau L, Bertrand AT, Jais JP, Salih MA, Stojkovic T, Wehnert M, Hoeltzenbein M, Spuler S, Saitoh S, Verschueren A, Tranchant C, Beuvin M, Lacene E, Romero NB, Heath S, Zelenika D, Voit T, Eymard B, Ben Yaou R, Bonne G.
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| Am J Hum Genet 85(3):338-53. Epub 2009 Aug 27. 2009
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| 23 | FHL1, SIVA1
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| SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis.
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| Cottle DL, McGrath MJ, Wilding BR, Cowling BS, Kane JM, D'Arcy CE, Holdsworth M, Hatzinisiriou I, Prescott M, Brown S, Mitchell CA.
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| J Biol Chem 284(39):26964-77. Epub 2009 Jul 29.
2009
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| 24 | FHL1, FHL2, FHL3
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| Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.
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| Ding L, Wang Z, Yan J, Yang X, Liu A, Qiu W, Zhu J, Han J, Zhang H, Lin J, Cheng L, Qin X, Niu C, Yuan B, Wang X, Zhu C, Zhou Y, Li J, Song H, Huang C, Ye Q.
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| J Clin Invest 119(2):349-61. doi: 10.1172/JCI35930. Epub 2009 Jan 12.
2009
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| 25 | XMPMA, FHL1
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| An X-Linked Myopathy with Postural Muscle Atrophy and Generalized Hypertrophy, Termed XMPMA, Is Caused by Mutations in FHL1.
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| Windpassinger C, Schoser B, Straub V, Hochmeister S, Noor A, Lohberger B, Farra N, Petek E, Schwarzbraun T, Ofner L, Lšscher WN, Wagner K, LochmŸller H, Vincent JB, Quasthoff S.
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| Am J Hum Genet 82(1):88-99. 2008
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| 26 | FHL1, XMPMA
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| X-linked dominant scapuloperoneal myopathy is due to a mutation in the gene encoding four-and-a-half-LIM protein 1.
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| Quinzii CM, Vu TH, Min KC, Tanji K, Barral S, Grewal RP, Kattah A, Cama–o P, Otaegui D, Kunimatsu T, Blake DM, Wilhelmsen KC, Rowland LP, Hays AP, Bonilla E, Hirano M.
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| Am J Hum Genet 82(1):208-13. 2008
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| 27 | FHL1, TLX1
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| Transcriptional regulation of FHL1 by TLX1/HOX11 is dosage, cell-type and promoter context-dependent.
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| Rice KL, Kees UR, Greene WK.
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| Biochem Biophys Res Commun 367(3):707-13. Epub 2007 Dec 10.
2008
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| 28 | FHL1
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| Fhl-1, a new key protein in pulmonary hypertension.
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| Kwapiszewska G, Wygrecka M, Marsh LM, Schmitt S, Trösser R, Wilhelm J, Helmus K, Eul B, Zakrzewicz A, Ghofrani HA, Schermuly RT, Bohle RM, Grimminger F, Seeger W, Eickelberg O, Fink L, Weissmann N.
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| Circulation 118(11):1183-94. Epub 2008 Aug 25.
2008
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| 29 | FHL1
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| Variations in the four and a half LIM domains 1 gene (FHL1) are associated with fasting insulin and insulin sensitivity responses to regular exercise.
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| Teran-Garcia M, Rankinen T, Rice T, Leon AS, Rao DC, Skinner JS, Bouchard C.
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| Diabetologia 50(9):1858-66. Epub 2007 Jun 23. 2007
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| 30 | MYBPC1, FHL1
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| Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.
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| McGrath MJ, Cottle DL, Nguyen MA, Dyson JM, Coghill ID, Robinson PA, Holdsworth M, Cowling BS, Hardeman EC, Mitchell CA, Brown S.
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| J Biol Chem 281(11):7666-83. Epub 2006 Jan 9. 2006
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| 31 | CBX4, FHL1
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| The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2.
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| Qin H, Du D, Zhu Y, Li J, Feng L, Liang Y, Han H.
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| FEBS Lett 579(5):1220-6. Epub 2005 Jan 26.
2005
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| 32 | FHL1, HIPK3, MTOR
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| TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1.
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| Martin DE, Soulard A, Hall MN.
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| Cell 119(7):969-79. 2004
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| 33 | FHL1
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| Characterization of tissue-specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM-only protein (FHL1).
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| Ng EK, Lee SM, Li HY, Ngai SM, Tsui SK, Waye MM, Lee CY, Fung KP.
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| J Cell Biochem 82(1):1-10. 2001
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| 34 | FHL1, FHL3
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| The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle.
|
| Morgan MJ, et al.
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| Biochem Biophys Res Commun 255(2):245-50. 1999
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| 35 | FHL1
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| Genomic structure, tissue expression and chromosomal location of the LIM-only gene, SLIM1.
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| Greene WK, et al.
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| Gene 232(2):203-7. 1999
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| 36 | FHL1
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| Characterization of a brain-specific nuclear LIM domain protein (FHL1B) which is an alternatively spliced variant of FHL1.
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| Lee SM, Li HY, Ng EK, Or SM, Chan KK, Kotaka M, Chim SS, Tsui SK, Waye MM, Fung KP, Lee CY.
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| Gene 237(1):253-63 1999
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| 37 | FHL1
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| Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nuclear-cytoplasmic communication.
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| Brown S, McGrath MJ, Ooms LM, Gurung R, Maimone MM, Mitchell CA.
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| J Biol Chem 274(38):27083-91 1999
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| 38 | RBPJL, FHL1
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| Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L.
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| Tani S, Taniwaki M, Taniguchi Y, Minoguchi S, Kuroda K, Han H, Aoki T, Miyatake S, Hashimoto N, Honjo T.
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| J Hum Genet 44(1):73-5. 1999
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| 39 | FHL1
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| Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1).
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| Lee SM, Tsui SK, Chan KK, Garcia-Barcelo M, Waye MM, Fung KP, Liew CC, Lee CY.
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| Gene 216 : 163-170. 1998
|