Citations for
1FHIT
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site.
Letessier A, Millot GA, Koundrioukoff S, Lachagès AM, Vogt N, Hansen RS, Malfoy B, Brison O, Debatisse M.
Nature 470(7332):120-3. Epub 2011 Jan 23. 2011
2FHIT
Fhit regulates invasion of lung tumor cells.
Joannes A, Bonnomet A, Bindels S, Polette M, Gilles C, Burlet H, Cutrona J, Zahm JM, Birembaut P, Nawrocki-Raby B.
Oncogene 29(8):1203-13. Epub 2009 Nov 23. 2010
3AGMO, FHIT, RBFOX1, SLC4A10
Strong association of de novo copy number mutations with autism.
Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, Spence SJ, Lee AT, Puura K, Lehtimaki T, Ledbetter D, Gregersen PK, Bregman J, Sutcliffe JS, Jobanputra V, Chung W, Warburton D, King MC, Skuse D, Geschwind DH, Gilliam TC, Ye K, Wigler M.
Science 316(5823):445-9. Epub 2007 Mar 15. 2007
4FHIT
The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.
Weiske J, Albring KF, Huber O.
Proc Natl Acad Sci U S A 104(51):20344-9. Epub 2007 Dec 10. 2007
5FHIT
Different genetic pathways in the development of periocular sebaceous gland carcinomas in presumptive Muir-Torre syndrome patients.
Goldberg M, Rummelt C, Foja S, Holbach LM, Ballhausen WG.
Hum Mutat 27(2):155-62. 2006
6ATP11B, FAM86D, FHIT, FRG2C, OTOL1
The DNA sequence, annotation and analysis of human chromosome 3.
Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA.
Nature 440(7088):1194-8. 2006
7FHIT
FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells.
Bianchi F, Magnifico A, Olgiati C, Zanesi N, Pekarsky Y, Tagliabue E, Croce CM, Menard S, Campiglio M.
Proc Natl Acad Sci U S A 103(50):18981-6. Epub 2006 Dec 1. 2006
8HINT1, HINT2, HINT3, FHIT, GALT
The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity.
Weiske J, Huber O.
J Biol Chem 281(37):27356-66. Epub 2006 Jul 11. 2006
9FHIT
Frequent silencing of fragile histidine triad gene (FHIT) in Burkitt's lymphoma is associated with aberrant hypermethylation.
Hussain A, Gutierrez MI, Timson G, Siraj AK, Deambrogi C, Al-Rasheed M, Gaidano G, Magrath I, Bhatia K.
Genes Chromosomes Cancer 41(4):321-9. 2004
10FHIT, PTPRG
Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic.
Matsuyama A, Shiraishi T, Trapasso F, Kuroki T, Alder H, Mori M, Huebner K, Croce CM.
Proc Natl Acad Sci U S A 100(25):14988-93. Epub 2003 Nov 20. 2003
11RASSF1, FHIT, VHL, FHIT, RARB
Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma.
Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Mori M, Croce CM.
Cancer Res 63(13):3724-8. 2003
12WWOX, FHIT
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.
Ishii H, Vecchione A, Furukawa Y, Sutheesophon K, Han SY, Druck T, Kuroki T, Trapasso F, Nishimura M, Saito Y, Ozawa K, Croce CM, Huebner K, Furukawa Y.
Mol Cancer Res 1(13):940-7. 2003
13FHIT
Direct correlation between FRA3B expression and cigarette smoking.
Stein CK, Glover TW, Palmer JL, Glisson BS.
Genes Chromosomes Cancer 34(3):333-40. 2002
14FHIT
Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene.
Popovici C, Basset C, Bertucci F, Orsetti B, Adelaide J, Mozziconacci MJ, Conte N, Murati A, Ginestier C, Charafe-Jauffret E, Ethier SP, Lafage-Pochitaloff M, Theillet C, Birnbaum D, Chaffanet M.
Genes Chromosomes Cancer 35(3):204-18. 2002
15FHIT
Alterations of the fragile histidine triad gene, FHIT, and its encoded products contribute to testicular germ cell tumorigenesis.
Kraggerud SM, Aman P, Holm R, Stenwig AE, Fossa SD, Nesland JM, Lothe RA.
Cancer Res 62(2):512-7. 2002
16HINT1, HINT2, HINT3, FHIT, GALT
Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.
Brenner C.
Biochemistry 41(29):9003-14. 2002
17FHIT, RASSF1, ROBO1, VHL
Tumor suppressors on 3p: a neoclassic quartet.
Huebner K.
Proc Natl Acad Sci U S A 98(26):14763-5. No abstract available. 2001
18FHIT
Aberrations in the fragile histidine triad (FHIT) gene in idiopathic pulmonary fibrosis.
Uematsu K, Yoshimura A, Gemma A, Mochimaru H, Hosoya Y, Kunugi S, Matsuda K, Seike M, Kurimoto F, Takenaka K, Koizumi K, Fukuda Y, Tanaka S, Chin K, Jablons DM, Kudoh S.
Cancer Res 61(23):8527-33. 2001
19FHIT
Genomic FHIT analysis in RER(+) and RER(-) adenocarcinomas of the pancreas.
Hilgers W, Koerkamp BG, Geradts J, Tang DJ, Yeo CJ, Hruban RH, Kern SE.
Genes Chromosomes Cancer 27(3):239-243 2000
20FHIT
Abnormalities of the FHIT gene in human oral carcinogenesis.
Tanimoto K, Hayashi S, Tsuchiya E, Tokuchi Y, Kobayashi Y, Yoshiga K, Okui T, Kobayashi M, Ichikawa T.
Br J Cancer 82(4):838-43. 2000
21FHIT
The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma.
Gatalica Z, Lele SM, Rampy BA, Norris BA.
Cancer 88(6):1378-83. 2000
22FHIT
Anomalous transcripts and allelic deletions of the FHIT gene in human esophageal cancer.
Menin C, Santacatterina M, Zambon A, Montagna M, Parenti A, Ruol A, D'Andrea E.
Cancer Genet Cytogenet 119(1):56-61. 2000
23FHIT
Frequent altered expression of fragile histidine triad protein in human colorectal adenomas.
Morikawa H, Nakagawa Y, Hashimoto K, Niki M, Egashira Y, Hirata I, Katsu K, Akao Y.
Biochem Biophys Res Commun 278(1):205-10. 2000
24FHIT, UBE2I
Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9.
Shi Y, Zou M, Farid NR, Paterson MC.
Biochem J 352 Pt 2:443-8. 2000
25FHIT
Abnormal FHIT transcripts found in both lung cancer and normal lung tissue.
Tokuchi Y, et al.
Genes Chromosomes Cancer 24 : 105-111. 1999
26FHIT
The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control.
Sard L, et al.
Proc Natl Acad Sci U S A 96(15):8489-92. 1999
27DLEC1, FHIT
Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.
Mimori K, et al.
Proc Natl Acad Sci U S A 96(13):7456-61. 1999
28FHIT
Reduced Fhit expression in sporadic and BRCA2-linked breast carcinomas.
Ingvarsson S, et al.
Cancer Res 59(11):2682-9. 1999
29FHIT
FHIT loss of function in human primary breast cancer correlates with advanced stage of the disease.
Campiglio M, Pekarsky Y, Menard S, Tagliabue E, Pilotti S, Croce CM.
Cancer Res 59(16):3866-9 1999
30FHIT
The tumor suppressor protein Fhit. A novel interaction with tubulin.
Chaudhuri AR, Khan IA, Prasad V, Robinson AK, Luduena RF, Barnes LD.
J Biol Chem 274(34):24378-82 1999
31FHIT
Frequent homozygous deletions in the FRA3B region in tumor cell lines still leave the FHIT exons intact.
Wang L, et al.
Oncogene 16 : 635-642. 1998
32FHIT
Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction : implications for the mechanism of fragile site induction.
Le Beau MM, et al.
Hum Mol Genet 7 : 755-761. 1998
33DLEC1, FHIT
An FHIT tumor suppressor gene?
Le Beau MM, et al.
Genes Chromosomes Cancer 21 : 281-289. 1998
34FHIT, TSG3G
Chromosome 3p14 alterations in lung cancer : evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos.
Nelson HH, et al.
Cancer Res 58 : 1804-1807. 1998
35CRCC, FHIT, RCC3, RNF139
The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.
Gemmill RM, et al.
Proc Natl Acad Sci U S A 95 : 9572-9577. 1998
36FHIT
Study of FHIT transcripts in normal and malignant breast tissue.
Biche I, et al.
Genes Chromosomes Cancer 23 : 292-299. 1998
37FHIT, DLEC1
Loss of FHIT expression in gastric carcinoma.
Baffa R, Veronese ML, Santoro R, Mandes B, Palazzo JP, Rugge M, Santoro E, Croce CM, Huebner K.
Cancer Res 58 : 4708-4714. 1998
38FHIT
Frequent aberration of FHIT gene expression in acute leukemias.
Iwai T, et al.
Cancer Res 58 : 5182-5187. 1998
39FHIT, DLEC1
Loss of FHIT function in lung cancer and preinvasive bronchial lesions.
Sozzi G, et al.
Cancer Res 58 : 5032-5037. 1998
40FHIT
The role of the FHIT/FRA3B locus in cancer.
Huebner K, et al.
Annu Rev Genet 32:7-31. Review. 1998
41DLEC1, FHIT
Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B.
Boldog F, et al.
Hum Mol Genet 6 : 193-203. 1997
42FHIT, HPV16I1
Human papillomavirus (HPV) in head and neck cancer. An association of HPV 16 with squamous cell carcinoma of Waldeyer's tonsillar ring.
Paz IB, et al.
Cancer 79 : 595-604. 1997
43FHIT
Frequent breakpoints in the region surrounding FRA3B in sporadic renal cell carcinomas.
Shridhar V, Wang L, Rosati R, Paradee W, Shridhar R, Mullins C, Sakr W, Grignon D, Miller OJ, Sun QC, Petros J, Smith DI.
Oncogene 14(11):1269-77. 1997
44FHIT
Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.
Zimonjic DB, et al.
Cancer Res 57 : 1166-1170. 1997
45FHIT
Aphidicolin-induced FRA3B breakpoints cluster in two distinct regions.
Wang L, Paradee W, Mullins C, Shridhar R, Rosati R, Wilke CM, Glover TW, Smith DI.
Genomics 41(3):485-8. 1997
46FHIT
FHIT mutations in human primary gastric cancer.
Gemma A, et al.
Cancer Res 57 : 1435-1437. 1997
47 FHIT, RCC3, DLEC1, CRCC
Identification of novel 'expressed sequence tags' within the FHIT gene locus in human chromosome region 3p14.2.
Lux A, Bardenheuer W, Michael D, Brocker F, Julicher K, Vieten L, Michaelis S, Seeber S, Opalka B, Schutte J.
Hum Genet 100(1):90-5. 1997
48FHIT, TSG3B
FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.
Fong KM, Biesterveld EJ, Virmani A, Wistuba I, Sekido Y, Bader SA, Ahmadian M, Ong ST, Rassool FV, Zimmerman PV, Giaccone G, Gazdar AF, Minna JD.
Cancer Res 57(11):2256-67. 1997
49FHIT
Variable FHIT transcripts in non-neoplastic tissues.
Panagopoulos I, Thelin S, Mertens F, Mitelman F, Aman P.
Genes Chromosomes Cancer 19(4):215-9. 1997
50FHIT, RCC3, CRCC
Normal FHIT transcripts in renal cell cancer- and lung cancer -derived cell lines, including a cell line with a homozygous deletion in the FRA3B region.
van den Berg A, Draaijers TG, Kok K, Timmer T, Van der Veen AY, Veldhuis PM, de Leij L, Gerhartz CD, Naylor SL, Smith DI, Buys CH.
Genes Chromosomes Cancer 19(4):220-7. 1997
51FHIT, DLEC1
The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B.
Huebner K, Hadaczek P, Siprashvili Z, Druck T, Croce CM.
Biochim Biophys Acta 1332(3):M65-70. 1997
52FHIT, DLEC1
The putative tumor suppressor gene FHIT at 3p14.2 is rarely affected by loss of heterozygosity in primary human brain tumors.
Frank S, Muller J, Plaschke J, Hahn M, Hampl J, Hampl M, Pistorius S, Schackert G, Schackert HK.
Cancer Res 57(13):2638-41. 1997
53FHIT
FHIT gene alterations in esophageal cancer and ulcerative colitis (UC).
Zou TT, Lei J, Shi YQ, Yin J, Wang S, Souza RF, Kong D, Shimada Y, Smolinski KN, Greenwald BD, Abraham JM, Harpaz N, Meltzer SJ.
Oncogene 15(1):101-5. 1997
54FHIT, TSG3G
Analysis of the fragile histidine triad gene in primary gastric carcinomas and gastric carcinoma cell lines.
Tamura G, Sakata K, Nishizuka S, Maesawa C, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R.
Genes Chromosomes Cancer 20(1):98-102. 1997
55FHIT
The FHIT gene is alternatively spliced in normal kidney and renal cell carcinoma.
Luan X, Shi G, Zohouri M, Paradee W, Smith DI, Decker HJ, Cannizzaro LA.
Oncogene 15(1):79-86. 1997
56DLEC1, FHIT
Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines.
Ong ST, Fong KM, Bader SA, Minna JD, Le Beau MM, McKeithan TW, Rassool FV.
Genes Chromosomes Cancer 20(1):16-23. 1997
57FHIT, TSG3G
Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas.
Michael D, Beer DG, Wilke CW, Miller DE, Glover TW.
Oncogene 15(14):1653-9. 1997
58FHIT, TSG101
Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours.
Gayther SA, Barski P, Batley SJ, Li L, de Foy KA, Cohen SN, Ponder BA, Caldas C.
Oncogene 15(17):2119-26. 1997
59FHIT, TSG3G
Replacement of Fhit in cancer cells suppresses tumorigenicity.
Siprashvili Z, Sozzi G, Barnes LD, McCue P, Robinson AK, Eryomin V, Sard L, Tagliabue E, Greco A, Fusetti L, Schwartz G, Pierotti MA, Croce CM, Huebner K.
Proc Natl Acad Sci U S A 94(25):13771-6. 1997
60FHIT, MTERFL
Sequence of the FRA3B common fragile region : implications for the mechanism of FHIT deletion.
Inoue H, Ishii H, Alder H, Snyder E, Druck T, Huebner K, Croce CM.
Proc Natl Acad Sci U S A 94(26):14584-9. 1997
61CRCC, FHIT, RCC3
FHIT gene and the FRA3B region are not involved in the genetics of renal cell carcinomas.
Bugert P, Wilhelm M, Kovacs G.
Genes Chromosomes Cancer 20(1):9-15. 1997
62CRCC, FHIT, HPV16I1, PPIAP, RCC3
FRA3B extends over a broad region and contains a spontaneous HPV16 integration site : direct evidence for the coincidence of viral integration sites and fragile sites.
Wilke CM, et al.
Hum Mol Genet 5 : 187-195. 1996
63FHIT, RCC3
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3.8) breakpoint, is abnormal in digestive tract cancers.
Ohta M, et al.
Cell 84 : 587-597. 1996
64FHIT, HPV16I1, RCC3
A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints.
Paradee W, et al.
Genomics 35 : 87-93. 1996
65FHIT
Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2.
Rassol FV, et al.
Genomics 35 : 109-117. 1996
66FHIT, DLEC1
The FHIT gene at 3p14.2 is abnormal in breast carcinomas.
Negrini M, et al.
Cancer Res 56 : 3173-3179. 1996
67FHIT
FHIT gene alterations in head and neck squamous cell carcinomas.
Virgilio L, et al.
Proc Natl Acad Sci U S A 93 : 9770-9775. 1996
68FHIT, PTPRG
The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14.
Panagopoulos I, et al.
Cancer Res 56 : 4871-4875. 1996
69FHIT
Frequent breakpoints in the 3p14.2 fragile site, FRA3B, in pancreatic tumors.
Shridhar R, et al.
Cancer Res 56 : 4347-4350. 1996
70ATM, FHIT, DLEC1, ST3
High levels of allele loss at the FHIT and ATM genes in non-comedo ductal carcinoma in situ and grade I tubular invasive breast cancers.
Man S, et al.
Cancer Res 56 : 5484-5489. 1996
71FHIT
Molecular analysis of the FHIT gene at 3p14.2 in lung cancer cell lines.
Yanagisawa K, et al.
Cancer Res 56 : 5579-5582. 1996
72FHIT
The FHIT gene at 3p14.2 is abnormal in lung cancer.
Sozzi G, et al.
Cell 85 : 17-26. 1996
73FHIT
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5'''-P1,P3-triphosphate hydrolase.
Barnes LD, et al.
Biochemistry 35 : 11529-11535. 1996
74DLEC1, FHIT
Precise localization of aphidicolin-induced breakpoints on the short arm of human chromosome 3.
Paradee W, et al.
Genomics 27 : 358-361. 1995
75FHIT, RCC3
Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma.
Wilke CM, et al.
Genomics 22 : 319-326. 1994
76FHIT, RCC3
Integrated YAC contig containing the 3p14.2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B.
Boldog FL, et al.
Genes Chromosomes Cancer 11 : 216-221. 1994
77FHIT, RCC3
Detailed mapping around the breakpoint of (3;8) translocation in familial renal cell carcinoma and FRA3B.
Yamakawa K, et al.
Genomics 14 : 412-416. 1992
78FHIT
Preferential integration of marker DNA into the chromosomal fragile site at 3p14 : an approach to cloning fragile sites.
Rassool FV, et al.
Proc Natl Acad Sci U S A 88 : 6657-6661. 1991
79FHIT, FRA14C, FRA1C, FRA1E, FRA1F, FRA1G, FRA1I, FRA1K, FRA20B, FRA2C, FRA2F, FRA2H, FRA4A, FRA4C, FRA6B, FRA7C, FRA7F, WWOX
Common fragile sites : their prevalence in subjects with constitutional and acquired chromosomal instability.
Tedeschi B, et al.
Am J Med Genet 27 : 471-482. 1987
80FHIT, FRA10D, FRA10E, FRA10F, FRA11C, FRA11D, FRA11F, FRA11G, FRA12B, FRA13A, FRA13C, FRA14B, FRA14C, FRA16C, FRA17B, FRA18A, FRA18B, FRA18C, FRA1C, FRA1E, FRA1F, FRA1G, FRA1I, FRA20B, FRA22B, FRA2C, FRA2D, FRA2E, FRA2F, FRA2H, FRA2J, FRA3A, FRA3C, FRA4A, FRA4C, FRA5C, FRA6B, FRA6C, FRA7B, FRA7C, FRA7E, FRA7G, FRA7H, FRA8B, FRA8C, FRA8D, FRA9D, FRAXB, FRAXC, WWOX
Constitutive fragile sites and cancer.
Yunis JJ, et al.
Science 226 : 1199-1204. 1984
81FHIT, FRA10A, FRA11A, FRA11B, FRA12A, FRA7A
Report of the committee on chomosome rearrangements in neoplasia and on fragile sites.
de La Chapelle A, et al.
(HGM7) Cytogenet Cell Genet 37 : 274-311. 1984