| 1 | FGF19, FGFR4
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| Dissecting the Role of the FGF19-FGFR4 Signaling Pathway in Cancer Development and Progression.
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| Liu Y, Cao M, Cai Y, Li X, Zhao C, Cui R.
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| Front Cell Dev Biol 8:95. doi: 10.3389/fcell.2020.00095. eCollection 2020. Review.
2020
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| 2 | FGFR4
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| FGFR4 provides the conduit to facilitate FGF19 signaling in breast cancer progression.
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| Zhao X, Xu F, Dominguez NP, Xiong Y, Xiong Z, Peng H, Shay C, Teng Y.
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| Mol Carcinog 57(11):1616-1625. doi: 10.1002/mc.22884. Epub 2018 Aug 22.
2018
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| 3 | FGFR4, FOXC1, ITGA7
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| Forkhead box C1 promotes colorectal cancer metastasis through transactivating ITGA7 and FGFR4 expression.
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| Liu J, Zhang Z, Li X, Chen J, Wang G, Tian Z, Qian M, Chen Z, Guo H, Tang G, Huang W, Tian D, Wang D, Nie Y, Fan D, Wu K, Xia L.
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| Oncogene 37(41):5477-5491. doi: 10.1038/s41388-018-0355-4. Epub 2018 Jun 8.
2018
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| 4 | FGFR3, FGFR4
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| FGF receptors control alveolar elastogenesis.
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| Li R, Herriges JC, Chen L, Mecham RP, Sun X.
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| Development 144(24):4563-4572. doi: 10.1242/dev.149443. Epub 2017 Nov 9.
2017
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| 5 | FGF23, FGFR4
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| FGF23/FGFR4-mediated left ventricular hypertrophy is reversible.
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| Grabner A, Schramm K, Silswal N, Hendrix M, Yanucil C, Czaya B, Singh S, Wolf M, Hermann S, Stypmann J, Di Marco GS, Brand M, Wacker MJ, Faul C.
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| Sci Rep 7(1):1993. doi: 10.1038/s41598-017-02068-6.
2017
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| 6 | FGF19, FGFR4
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| Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival.
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| Tiong KH, Tan BS, Choo HL, Chung FF, Hii LW, Tan SH, Khor NT, Wong SF, See SJ, Tan YF, Rosli R, Cheong SK, Leong CO.
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| Oncotarget 7(36):57633-57650. doi: 10.18632/oncotarget.9328.
2016
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| 7 | FGF23, FGFR4
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| Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy.
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| Grabner A, Amaral AP, Schramm K, Singh S, Sloan A, Yanucil C, Li J, Shehadeh LA, Hare JM, David V, Martin A, Fornoni A, Di Marco GS, Kentrup D, Reuter S, Mayer AB, Pavenstädt H, Stypmann J, Kuhn C, Hille S, Frey N, Leifheit-Nestler M, Richter B, Haffner D, Abraham R, Bange J, Sperl B, Ullrich A, Brand M, Wolf M, Faul C.
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| Cell Metab 22(6):1020-32. doi: 10.1016/j.cmet.2015.09.002. Epub 2015 Oct 1.
2015
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| 8 | FGFR4
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| Fibroblast growth factor receptor 4 polymorphism is associated with liver cirrhosis in hepatocarcinoma.
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| Sheu MJ, Hsieh MJ, Chiang WL, Yang SF, Lee HL, Lee LM, Yeh CB.
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| PLoS One 10(4):e0122961. doi: 10.1371/journal.pone.0122961. eCollection 2015.
2015
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| 9 | FGFR4
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| Fibroblast growth factor receptor 4 promotes progression and correlates to poor prognosis in cholangiocarcinoma.
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| Xu YF, Yang XQ, Lu XF, Guo S, Liu Y, Iqbal M, Ning SL, Yang H, Suo N, Chen YX.
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| Biochem Biophys Res Commun 446(1):54-60. doi: 10.1016/j.bbrc.2014.02.050. Epub 2014 Feb 22.
2014
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| 10 | FGFR4
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| Fibroblast growth factor receptor 4 as a potential prognostic and therapeutic marker in colorectal cancer.
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| Li CS, Zhang SX, Liu HJ, Shi YL, Li LP, Guo XB, Zhang ZH.
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| Biomarkers 19(1):81-5. doi: 10.3109/1354750X.2013.876555. Epub 2014 Jan 13.
2014
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| 11 | DUP5QD, FGFR4
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| Bilateral radial agenesis with absent thumbs, complex heart defect, short stature, and facial dysmorphism in a patient with pure distal microduplication of 5q35.2-5q35.3.
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| Jamsheer A, Sowińska A, Simon D, Jamsheer-Bratkowska M, Trzeciak T, Latos-Bieleńska A.
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| BMC Med Genet 14:13. doi: 10.1186/1471-2350-14-13.
2013
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| 12 | FGFR4
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| FGFR4 promotes stroma-induced epithelial-to-mesenchymal transition in colorectal cancer.
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| Liu R, Li J, Xie K, Zhang T, Lei Y, Chen Y, Zhang L, Huang K, Wang K, Wu H, Wu M, Nice EC, Huang C, Wei Y.
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| Cancer Res 73(19):5926-35. doi: 10.1158/0008-5472.CAN-12-4718. Epub 2013 Aug 13.
2013
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| 13 | FGFR4
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| Association between fibroblast growth factor receptor 4 polymorphisms and risk of hepatocellular carcinoma.
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| Yang Y, Zhou Y, Lu M, An Y, Li R, Chen Y, Lu DR, Jin L, Zhou WP, Qian J, Wang HY.
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| Mol Carcinog 51(7):515-21. doi: 10.1002/mc.20805. Epub 2011 Jun 7.
2012
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| 14 | FGF19, FGFR4
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| Soluble FGFR4 extracellular domain inhibits FGF19-induced activation of FGFR4 signaling and prevents nonalcoholic fatty liver disease.
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| Chen Q, Jiang Y, An Y, Zhao N, Zhao Y, Yu C.
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| Biochem Biophys Res Commun 409(4):651-6. Epub 2011 May 17.
2011
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| 15 | FGF19, FGF21, FGF23, FGFR4
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| FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.
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| Wu X, Ge H, Lemon B, Vonderfecht S, Weiszmann J, Hecht R, Gupte J, Hager T, Wang Z, Lindberg R, Li Y.
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| J Biol Chem 285(8):5165-70. Epub 2009 Dec 15. 2010
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| 16 | FGFR4, MMP14
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| FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.
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| Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K.
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| Proc Natl Acad Sci U S A 107(36):15786-91. Epub 2010 Aug 23.PMID: 20798051 2010
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| 17 | FGFR4, KLB
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| Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation.
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| Luo Y, Yang C, Lu W, Xie R, Jin C, Huang P, Wang F, McKeehan WL.
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| J Biol Chem 285(39):30069-78. Epub 2010 Jul 23.PMID: 20657013 2010
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| 18 | FGFR4
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| FGFR4 transmembrane domain polymorphism and cancer risk: A meta-analysis including 8555 subjects.
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| Xu W, Li Y, Wang X, Chen B, Wang Y, Liu S, Xu J, Zhao W, Wu J.
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| Eur J Cancer ur J Cancer. 2010 Jul 16. [Epub ahead of print]PMID: 20638838 2010
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| 19 | FGFR4, FOXO1
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| FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action.
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| Shin DJ, Osborne TF.
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| J Biol Chem 284(17):11110-20. Epub 2009 Feb 23.
2009
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| 20 | FGFR4
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| Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention.
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| Ho HK, Pok S, Streit S, Ruhe JE, Hart S, Lim KS, Loo HL, Aung MO, Lim SG, Ullrich A.
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| J Hepatol 50(1):118-27. Epub 2008 Oct 12.PMID: 19008009 2009
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| 21 | APC, ATM, EPHA3, ERBB2, ERBB4, FGFR4
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| Somatic mutations affect key pathways in lung adenocarcinoma.
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| Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good PJ, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK.
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| Nature 455(7216):1069-75.
2008
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| 22 | FGFR4
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| FGFR4 and its novel splice form in myogenic cells: Interplay of glycosylation and tyrosine phosphorylation.
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| Kwiatkowski BA, Kirillova I, Richard RE, Israeli D, Yablonka-Reuveni Z.
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| J Cell Physiol 215(3):803-17.PMID: 18186042 2008
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| 23 | FGF23, FGFR3, FGFR4
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| FGFR3 and FGFR4 do not mediate renal effects of FGF23.
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| Liu S, Vierthaler L, Tang W, Zhou J, Quarles LD.
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| J Am Soc Nephrol 19(12):2342-50. Epub 2008 Aug 27.PMID: 18753255 2008
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| 24 | FGFR4, KLB
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| Liver-specific activities of FGF19 require Klotho beta.
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| Lin BC, Wang M, Blackmore C, Desnoyers LR.
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| J Biol Chem 282(37):27277-84. Epub 2007 Jul 11.PMID: 17627937 2007
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| 25 | FGFR4
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| Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis.
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| Matakidou A, El Galta R, Rudd MF, Webb EL, Bridle H, Eisen T, Houlston RS.
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| Br J Cancer 96(12):1904-7. Epub 2007 May 22. 2007
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| 26 | FGFR4, MYOD1, TEAD2
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| Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway.
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| Zhao P, Caretti G, Mitchell S, McKeehan WL, Boskey AL, Pachman LM, Sartorelli V, Hoffman EP.
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| J Biol Chem 281(1):429-38. Epub 2005 Nov 2. 2006
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| 27 | FGFR4, CYP7A1
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| Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids.
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| Yu C, Wang F, Jin C, Huang X, McKeehan WL.
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| J Biol Chem 280(18):17707-14. Epub 2005 Mar 4. 2005
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| 28 | FGFR4
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| FGFR4 signaling is a necessary step in limb muscle differentiation.
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| Marics I, Padilla F, Guillemot JF, Scaal M, Marcelle C.
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| Development 129(19):4559-69. 2002
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| 29 | HNF1A, FGFR4
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| FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1alpha.
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| Shah RN, Ibbitt JC, Alitalo K, Hurst HC.
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| Oncogene 21(54):8251-61. 2002
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| 30 | FGFR4
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| Identification of a novel alternative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells.
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| Takaishi S, Sawada M, Morita Y, Seno H, Fukuzawa H, Chiba T.
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| Biochem Biophys Res Commun 267(2):658-62. 2000
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| 31 | FGFR4
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| Fibroblast growth factor receptor 4 (FGFR4) is expressed in adult rat and human retinal photoreceptors and neurons.
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| Fuhrmann V, Kinkl N, Leveillard T, Sahel J, Hicks D.
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| J Mol Neurosci 13(1-2):187-97. 1999
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| 32 | FGFR4
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| Genomic structure and complete sequence of the human FGFR4 gene.
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| Kostrzewa M, Muller U.
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| Mamm Genome 9(2):131-5. 1998
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| 33 | FGFR4
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| Analysis of patients with craniosynostosis syndromes for a pro246Arg mutation of FGFR4.
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| Gaudenz K, et al.
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| Mol Genet Metab 64 : 76-79. 1998
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| 34 | FLT4, FGFR4
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| Localization of two tyrosine kinase receptor genes with respect to the 5q35 chromosomal breakpoint of Ki-I lymphoma cell lines.
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| Pbusque MJ, et al.
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| Genes Chromosomes Cancer 8 : 119-126. 1993
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| 35 | FGFR4
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| Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter.
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| Armstrong E, et al.
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| Genes Chromosomes Cancer 4 : 94-98. 1992
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| 36 | FGFR4
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| RFLPs in the fibroblast growth factor receptor-4 locus (FGFR4) in 5q33-qter.
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| Armstrong E, et al.
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| Nucleic Acids Res 19 : 5096. 1991
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