| 1 | BFPH, FGF8
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| Position effects at the FGF8 locus are associated with femoral hypoplasia.
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| Socha M, Sowińska-Seidler A, Melo US, Kragesteen BK, Franke M, Heinrich V, Schöpflin R, Nagel I, Gruchy N, Mundlos S, Sreenivasan VKA, López C, Vingron M, Bukowska-Olech E, Spielmann M, Jamsheer A.
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| Am J Hum Genet. Sep 2;108(9):1725-1734. doi: 10.1016/j.ajhg.2021.08.001. Epub 2021 Aug 24. 2021
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| 2 | FGF17, FGF18, FGF8
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| The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall. 2020 . PMID:
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| Boylan M, Anderson MJ, Ornitz DM, Lewandoski M.
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| Development Oct 19;147(21):dev189506. doi: 10.1242/dev.189506 2020
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| 3 | FGF8, GLI3, KIF7
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| Altered GLI3 and FGF8 signaling underlies Acrocallosal syndrome phenotypes in Kif7 depleted mice.
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| Putoux A, Baas D, Paschaki M, Morlé L, Maire C, Attié-Bitach T, Thomas S, Durand B.
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| Hum Mol Genet um Mol Genet. 2018 Nov 15. doi: 10.1093/hmg/ddy392. [Epub ahead of print]
2018
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| 4 | CUBN, FGF8
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| Cubilin, the intrinsic factor-vitamin B12 receptor in development and disease.
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| Kozyraki R, Cases O.
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| Curr Med Chem urr Med Chem. 2018 Oct 8. doi: 10.2174/0929867325666181008143945. [Epub ahead of print]
2018
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| 5 | FGF8, SHH
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| FGF8 and Shh promote the survival and maintenance of multipotent neural crest progenitors.
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| da Costa MC, Trentin AG, Calloni GW.
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| Mech Dev 154:251-258. doi: 10.1016/j.mod.2018.07.012. Epub 2018 Aug 1.
2018
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| 6 | FGF8, GMNN
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| Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling.
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| Huang W, Zhang Y, Cao K, Luo L, Huang S.
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| Biomed Res Int 2018:6543196. doi: 10.1155/2018/6543196. eCollection 2018.
2018
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| 7 | FGF8, FGFR3
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| FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease.
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| Liu H, Fang Q, Wang M, Wang W, Zhang M, Zhang D, He Y, Zhang Y, Wang H, Otero M, Ma T, Chen J.
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| Biochem Biophys Res Commun 500(2):184-190. doi: 10.1016/j.bbrc.2018.04.023. Epub 2018 Apr 17.
2018
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| 8 | FGF8
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| Opposing Actions of Fgf8a on Notch Signaling Distinguish Two Muller Glial Cell Populations that Contribute to Retina Growth and Regeneration.
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| Wan J, Goldman D.
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| Cell Rep 19(4):849-862. doi: 10.1016/j.celrep.2017.04.009.
2017
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| 9 | FGF8
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| Fibroblast growth factor-8 inhibits oxidative stress-induced apoptosis in H9c2 cells.
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| Singla RD, Wang J, Singla DK.
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| Mol Cell Biochem 425(1-2):77-84. doi: 10.1007/s11010-016-2863-2. Epub 2016 Nov 1.
2017
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| 10 | FGF8, FLRT3, TBX2
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| Tbx2 regulates anterior neural specification by repressing FGF signaling pathway.
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| Cho GS, Park DS, Choi SC, Han JK.
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| Dev Biol. Jan 15;421(2):183-193. doi: 10.1016/j.ydbio.2016.11.020. Epub 2016 Nov 30 2017
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| 11 | FGF8
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| Fgf8 signaling for development of the midbrain and hindbrain.
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| Harada H, Sato T, Nakamura H.
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| Dev Growth Differ 58(5):437-45. doi: 10.1111/dgd.12293. Epub 2016 Jun 7. Review.
2016
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| 12 | FGF8
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| Fibroblast growth factor 8 regulates postnatal development of paraventricular nucleus neuroendocrine cells.
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| Rodriguez KM, Stevenson EL, Stewart CE, Linscott ML, Chung WC.
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| Behav Brain Funct 11(1):34. doi: 10.1186/s12993-015-0081-9.
2015
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| 13 | FGF8
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| FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis.
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| Atsuta Y, Takahashi Y.
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| Development 142(13):2329-37. doi: 10.1242/dev.122408.
2015
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| 14 | FGF8, TBX1
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| Tbx1 controls the morphogenesis of pharyngeal pouch epithelia through mesodermal Wnt11r and Fgf8a.
|
| Choe CP, Crump JG.
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| Development 141(18):3583-93. doi: 10.1242/dev.111740. Epub 2014 Aug 19.
2014
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| 15 | FGF8
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| Heterozygous FGF8 mutations in patients presenting cryptorchidism and multiple VATER/VACTERL features without limb anomalies.
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| Zeidler C, Woelfle J, Draaken M, Mughal SS, Große G, Hilger AC, Dworschak GC, Boemers TM, Jenetzky E, Zwink N, Lacher M, Schmidt D, Schmiedeke E, Grasshoff-Derr S, Märzheuser S, Holland-Cunz S, Schäfer M, Bartels E, Keppler K, Palta M, Leonhardt J, Kujath C, Rißmann A, Nöthen MM, Reutter H, Ludwig M.
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| Birth Defects Res A Clin Mol Teratol 100(10):750-9. doi: 10.1002/bdra.23278. Epub 2014 Aug 8.
2014
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| 16 | FGF8
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| Retinoic acid controls body axis extension by directly repressing Fgf8 transcription.
|
| Kumar S, Duester G.
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| Development 141(15):2972-7. doi: 10.1242/dev.112367.
2014
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| 17 | FGF8
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| Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling.
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| Rengarajan C, Matzke A, Reiner L, Orian-Rousseau V, Scholpp S.
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| PLoS One 9(1):e86373. doi: 10.1371/journal.pone.0086373. eCollection 2014.
2014
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| 18 | FGF8, FOXC1
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| Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of syngnathia.
|
| Inman KE, Purcell P, Kume T, Trainor PA.
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| PLoS Genet 9(12):e1003949. doi: 10.1371/journal.pgen.1003949. Epub 2013 Dec 19.
2013
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| 19 | CDC42, FGF8
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| Regulation of neurogenesis by Fgf8a requires Cdc42 signaling and a novel Cdc42 effector protein.
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| Hulstrand AM, Houston DW.
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| Dev Biol 382(2):385-99. doi: 10.1016/j.ydbio.2013.08.020. Epub 2013 Aug 29.
2013
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| 20 | CUBN, FGF17, FGF18, FGF8
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| Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.
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| Cases O, Perea-Gomez A, Aguiar DP, Nykjaer A, Amsellem S, Chandellier J, Umbhauer M, Cereghini S, Madsen M, Collignon J, Verroust P, Riou JF, Creuzet SE, Kozyraki R.
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| J Biol Chem 288(23):16655-70. doi: 10.1074/jbc.M113.451070. Epub 2013 Apr 16. 2013
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| 21 | FGF8
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| Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules.
|
| Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ.
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| Dev Biol 374(1):185-97. doi: 10.1016/j.ydbio.2012.11.014. Epub 2012 Nov 29.
2013
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| 22 | FGF10, FGF8
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| Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium.
|
| Watanabe Y, Zaffran S, Kuroiwa A, Higuchi H, Ogura T, Harvey RP, Kelly RG, Buckingham M.
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| Proc Natl Acad Sci U S A 109(45):18273-80. doi: 10.1073/pnas.1215360109. Epub 2012 Oct 23.
2012
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| 23 | FGF8, OTX2, SOX2
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| Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation.
|
| Nishihara D, Yajima I, Tabata H, Nakai M, Tsukiji N, Katahira T, Takeda K, Shibahara S, Nakamura H, Yamamoto H.
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| PLoS One 7(11):e48879. doi: 10.1371/journal.pone.0048879. Epub 2012 Nov 8.
2012
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| 24 | FGF8, HTRA1
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| HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8.
|
| Kim GY, Kim HY, Kim HT, Moon JM, Kim CH, Kang S, Rhim H.
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| Mol Cell Biol 32(21):4482-92. doi: 10.1128/MCB.00872-12. Epub 2012 Sep 4.
2012
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| 25 | FGF8, GBX2
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| Gbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary.
|
| Sunmonu NA, Li K, Guo Q, Li JY.
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| Development 138(4):725-34.
2011
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| 26 | FGF4, FGF8
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| FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis.
|
| Naiche LA, Holder N, Lewandoski M.
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| Proc Natl Acad Sci U S A 108(10):4018-23. Epub 2011 Feb 22.
2011
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| 27 | FGF8
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| FGF8 signaling is chemotactic for cardiac neural crest cells.
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| Sato A, Scholl AM, Kuhn EB, Stadt HA, Decker JR, Pegram K, Hutson MR, Kirby ML.
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| Dev Biol 354(1):18-30. Epub 2011 Mar 17.
2011
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| 28 | FGF8
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| Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation.
|
| Sorrell MR, Waxman JS.
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| Dev Biol 358(1):44-55. doi: 10.1016/j.ydbio.2011.07.022. Epub 2011 Jul 22.
2011
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| 29 | FGF17, FGF8
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| FGF17, a gene involved in cerebellar development, is downregulated in a patient with Dandy-Walker malformation carrying a de novo 8p deletion.
|
| Zanni G, Barresi S, Travaglini L, Bernardini L, Rizza T, Digilio MC, Mercuri E, Cianfarani S, Valeriani M, Ferraris A, Da Sacco L, Novelli A, Valente EM, Dallapiccola B, Bertini ES.
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| Neurogenetics 12(3):241-5. doi: 10.1007/s10048-011-0283-8. Epub 2011 Apr 12.
2011
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| 30 | FGF8, SETX
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| Senataxin modulates neurite growth through fibroblast growth factor 8 signalling.
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| Vantaggiato C, Bondioni S, Airoldi G, Bozzato A, Borsani G, Rugarli EI, Bresolin N, Clementi E, Bassi MT.
|
| Brain 134(Pt 6):1808-28. doi: 10.1093/brain/awr084. Epub 2011 May 15.
2011
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| 31 | FGF8, FGFR1, KAL6, NIHH
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| Nonsense mutations in FGF8 gene causing different degrees of human gonadotropin-releasing deficiency.
|
| Trarbach EB, Abreu AP, Silveira LF, Garmes HM, Baptista MT, Teles MG, Costa EM, Mohammadi M, Pitteloud N, Mendonca BB, Latronico AC.
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| J Clin Endocrinol Metab 95(7):3491-6. Epub 2010 May 12.
2010
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| 32 | CDH7, FGF8, FGFR1, GNRHR, IHH1, IHH2GNRH1, KAL1, KAL1, KAL2, KAL3, KAL4, KISS1R, PCC, PROK2, PROKR2, TAC3, TACR3
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| Genetics basis for GnRH-dependent pubertal disorders in humans.
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| Silveira LF, Trarbach EB, Latronico AC.
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| Mol Cell Endocrinol 324(1-2):30-8. Epub 2010 Feb 25. Review.PMID: 20188792 2010
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| 33 | FGF8
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| Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum.
|
| Guo Q, Li K, Sunmonu NA, Li JY.
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| Dev Biol 338(2):183-92. Epub 2009 Dec 5.PMID: 19968985 2010
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| 34 | FGF8
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| Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells.
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| Zimmer C, Lee J, Griveau A, Arber S, Pierani A, Garel S, Guillemot F.
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| Development 137(2):293-302.PMID: 20040495 2010
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| 35 | FGF8
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| The development of the thalamic motor learning area is regulated by Fgf8 expression.
|
| Martinez-Ferre A, Martinez S.
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| J Neurosci 29(42):13389-400.PMID: 19846726 2009
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| 36 | FGF8
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| Tissue-specific requirements for FGF8 during early inner ear development.
|
| Domínguez-Frutos E, Vendrell V, Alvarez Y, Zelarayan LC, López-Hernández I, Ros M, Schimmang T.
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| Mech Dev 126(10):873-81. Epub 2009 Jul 18.PMID: 19619645 2009
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| 37 | FGF8
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| Actions of fibroblast growth factor-8 in bone cells in vitro.
|
| Lin JM, Callon KE, Lin JS, Watson M, Empson V, Tong PC, Grey A, Naot D, Green CR, Reid IR, Cornish J.
|
| Am J Physiol Endocrinol Metab 297(1):E142-50. Epub 2009 Apr 21.PMID: 19383871 2009
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| 38 | FGF8, RUNX2
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| FGF8 regulates myogenesis and induces Runx2 expression and osteoblast differentiation in cultured cells.
|
| Omoteyama K, Takagi M.
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| J Cell Biochem 106(4):546-52.PMID: 19170063 2009
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| 39 | FGF8, KAL6
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| Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice.
|
| Falardeau J, Chung WC, Beenken A, Raivio T, Plummer L, Sidis Y, Jacobson-Dickman EE, Eliseenkova AV, Ma J, Dwyer A, Quinton R, Na S, Hall JE, Huot C, Alois N, Pearce SH, Cole LW, Hughes V, Mohammadi M, Tsai P, Pitteloud N.
|
| J Clin Invest 118(8):2822-31.
2008
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| 40 | FGF8, FGFR1, KAL2, KAL4
|
| Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons.
|
| Chung WC, Moyle SS, Tsai PS.
|
| Endocrinology 149(10):4997-5003. Epub 2008 Jun 19.
2008
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| 41 | FGF8
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| Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis.
|
| Uchii M, Tamura T, Suda T, Kakuni M, Tanaka A, Miki I.
|
| Arthritis Res Ther 10(4):R90. Epub 2008 Aug 12.PMID: 18699993 2008
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| 42 | FGF8
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| Fgf8 controls regional identity in the developing thalamus.
|
| Kataoka A, Shimogori T.
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| Development 135(17):2873-81. Epub 2008 Jul 24.PMID: 1865356 2008
|
| 43 | FGF8
|
| FGF-8 is involved in bone metastasis of prostate cancer.
|
| Valta MP, Tuomela J, Bjartell A, Valve E, Väänänen HK, Härkönen P.
|
| Int J Cancer 123(1):22-31.PMID: 18386787 2008
|
| 44 | EMX2, FGF17, FGF8
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| Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2.
|
| Cholfin JA, Rubenstein JL.
|
| J Comp Neurol 509(2):144-55. doi: 10.1002/cne.21709.
2008
|
| 45 | IHH, FGF8
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| IHH and FGF8 coregulate elongation of digit primordia.
|
| Zhou J, Meng J, Guo S, Gao B, Ma G, Zhu X, Hu J, Xiao Y, Lin C, Wang H, Ding L, Feng G, Guo X, He L.
|
| Biochem Biophys Res Commun 363(3):513-8. Epub 2007 Sep 17. 2007
|
| 46 | FGF8
|
| fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo.
|
| Dubrulle J, Pourquie O.
|
| Nature 427(6973):419-22. 2004
|
| 47 | FGF1, FGF2, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF20, FGF21, FGF22, FGF23
|
| Evolution of the Fgf and Fgfr gene families.
|
| Itoh N, Ornitz DM.
|
| Trends Genet 20(11):563-9. 2004
|
| 48 | FGF8
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| FGF8 isoform b expression in human prostate cancer.
|
| Gnanapragasam VJ, Robinson MC, Marsh C, Robson CN, Hamdy FC, Leung HY.
|
| Br J Cancer 88(9):1432-8. 2003
|
| 49 | BARHL1, EN1, EN2, FGF8, JBTS1, WNT1
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| Search for genes involved in Joubert syndrome: evidence that one or more major loci are yet to be identified and exclusion of candidate genes EN1, EN2, FGF8, and BARHL1.
|
| Blair IP, Gibson RR, Bennett CL, Chance PF.
|
| Am J Med Genet 107(3):190-6. 2002
|
| 50 | FGF8
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| Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer.
|
| Zammit C, Coope R, Gomm JJ, Shousha S, Johnston CL, Coombes RC.
|
| Br J Cancer 86(7):1097-103. 2002
|
| 51 | FGF8
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| Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.
|
| Trainor PA, Ariza-McNaughton L, Krumlauf R.
|
| Science 295(5558):1288-91. 2002
|
| 52 | FGF8
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| Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8.
|
| Ye W, Bouchard M, Stone D, Liu X, Vella F, Lee J, Nakamura H, Ang SL, Busslinger M, Rosenthal A.
|
| Nat Neurosci 4(12):1175-81. 2001
|
| 53 | FGF8, SPRY1, SPRY2
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| Regulation and function of FGF8 in patterning of midbrain and anterior hindbrain.
|
| Mason I, Chambers D, Shamim H, Walshe J, Irving C.
|
| Biochem Cell Biol 78(5):577-84. 2000
|
| 54 | FGF8,TP63
|
| p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development.
|
| Yang A, et al.
|
| Nature 398(6729):714-8 1999
|
| 55 | FGF2, FGF8, FGF10
|
| Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.
|
| Xu X, et al.
|
| Development 125(4):753-65. 1998
|
| 56 | FGF8
|
| Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes.
|
| Yoshiura K, Leysens NJ, Chang J, Ward D, Murray JC, Muenke M.
|
| Am J Med Genet 72(3):354-62. 1997
|
| 57 | FGF8, FGF10
|
| The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor.
|
| Ohuchi H, et al.
|
| Development 124 : 2235-2244. 1997
|
| 58 | FGF8
|
| Structure and sequence of human FGF8.
|
| Gemel J, et al.
|
| Genomics 35 : 253-257. 1996
|
| 59 | FGF8
|
| The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells.
|
| Payson RA, et al.
|
| Oncogene 13 : 47-53. 1996
|
| 60 | FGF8
|
| Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb.
|
| Vogel A, et al.
|
| Development 122(6):1737-50 1996
|
| 61 | FGF8
|
| Assignment of FGF8 to human chromosome 10q25-q26 : mutations in FGF8 maybe responsible for some types of acrocephalosyndactyly linked to this region.
|
| White RA, et al.
|
| Genomics 30 : 109-111. 1995
|
| 62 | FGF8
|
| Expression cloning, developmental expression and chromosomal localization of fibroblast growth factor-8.
|
| Lorenzi MV, et al.
|
| Oncogene 10 : 2051-2055. 1995
|
| 63 | FGF7, FGF8
|
| Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively.
|
| Mattei MG, et al.
|
| Mamm Genome 6 : 196-197. 1995
|
| 64 | FGF8
|
| Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.
|
| Tanaka A, et al.
|
| Proc Natl Acad Sci U S A 89 : 8928-8932. 1992
|