Citations for
1ATF4, EIF2A, FGF21
Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4.
Alonge KM, Meares GP, Hillgartner FB.
J Biol Chem 292(13):5239-5252. doi: 10.1074/jbc.M116.762922. Epub 2017 Feb 10. 2017
2ANGPTL6, FGF21, PPARA
ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21.
Kang SG, Yi HS, Choi MJ, Ryu MJ, Jung S, Chung HK, Chang JY, Kim YK, Lee SE, Kim HW, Choi H, Kim DS, Lee JH, Kim KS, Kim HJ, Lee CH, Oike Y, Shong M.
J Endocrinol 233(1):105-118. doi: 10.1530/JOE-16-0549. Epub 2017 Feb 9. 2017
3BHLHE40, FGF21
Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice.
Fujita Y, Makishima M, Bhawal UK.
Biochem Biophys Res Commun 469(3):477-82. doi: 10.1016/j.bbrc.2015.12.045. Epub 2015 Dec 15. 2016
4FGF21, NR1D1
The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling.
Jager J, Wang F, Fang B, Lim HW, Peed LC, Steger DJ, Won KJ, Kharitonenkov A, Adams AC, Lazar MA.
J Biol Chem 291(20):10867-75. doi: 10.1074/jbc.M116.719120. 2016
5CYP3A4, FGF21, NR1I2
A Fibroblast Growth Factor 21-Pregnane X Receptor Pathway Downregulates Hepatic CYP3A4 in Nonalcoholic Fatty Liver Disease.
Woolsey SJ, Beaton MD, Mansell SE, Leon-Ponte M, Yu J, Pin CL, Adams PC, Kim RB, Tirona RG.
Mol Pharmacol 90(4):437-46. doi: 10.1124/mol.116.104687. Epub 2016 Aug 1. 2016
6FGF21, FGFR1, MAP3K4
MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear.
Haque K, Pandey AK, Zheng HW, Riazuddin S, Sha SH, Puligilla C.
J Neurosci 36(4):1347-61. doi: 10.1523/JNEUROSCI.1853-15.2016. 2016
7FGF21, MTOR
Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.
Guridi M, Tintignac LA, Lin S, Kupr B, Castets P, Rüegg MA.
Sci Signal 8(402):ra113. doi: 10.1126/scisignal.aab3715. 2015
8FGF21, FNDC5
Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans.
Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, Idelson C, Perron RM, Werner CD, Phan GQ, Kammula US, Kebebew E, Pacak K, Chen KY, Celi FS.
Cell Metab 19(2):302-9. doi: 10.1016/j.cmet.2013.12.017. 2014
9FGF21
Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism.
Cyphert HA, Alonge KM, Ippagunta SM, Hillgartner FB.
PLoS One 9(4):e94996. doi: 10.1371/journal.pone.0094996. eCollection 2014. 2014
10FGF21
FGF21-based pharmacotherapy - potential utility for metabolic disorders.
Gimeno RE, Moller DE.
Trends Endocrinol Metab rends Endocrinol Metab. 2014 Apr 4. pii: S1043-2760(14)00043-5. doi: 10.1016/j.tem.2014.03.001. [Epub ahead of print] Review. 2014
11FGF21
Fibroblast growth factor 21: a promising therapeutic target in obesity-related diseases.
Cheung BM, Deng H.
Expert Rev Cardiovasc Ther xpert Rev Cardiovasc Ther. 2014 Apr 3. [Epub ahead of print] 2014
12FGF21
Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue.
Hondares E, Gallego-Escuredo JM, Flachs P, Frontini A, Cereijo R, Goday A, Perugini J, Kopecky P, Giralt M, Cinti S, Kopecky J, Villarroya F.
Metabolism 63(3):312-7. doi: 10.1016/j.metabol.2013.11.014. Epub 2013 Nov 23. 2014
13DDIT3, FGF21
ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress.
Wan XS, Lu XH, Xiao YC, Lin Y, Zhu H, Ding T, Yang Y, Huang Y, Zhang Y, Liu YL, Xu ZM, Xiao J, Li XK.
Biomed Res Int 2014:807874. doi: 10.1155/2014/807874. Epub 2014 May 11. 2014
14DNM2, FGF1, FGF21, FGFR1
FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway.
Yaqoob U, Jagavelu K, Shergill U, de Assuncao T, Cao S, Shah VH.
PLoS One 9(5):e98130. doi: 10.1371/journal.pone.0098130. 2014
15FGF21
Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation.
Kim KH, Jeong YT, Kim SH, Jung HS, Park KS, Lee HY, Lee MS.
Biochem Biophys Res Commun 440(1):76-81. doi: 10.1016/j.bbrc.2013.09.026. Epub 2013 Sep 13. 2013
16FGF21
Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease.
Davis RL, Liang C, Edema-Hildebrand F, Riley C, Needham M, Sue CM.
Neurology 81(21):1819-26. doi: 10.1212/01.wnl.0000436068.43384.ef. Epub 2013 Oct 18. 2013
17FGF21
FGF21 regulates metabolism and circadian behavior by acting on the nervous system.
Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, Ding X, Elmquist JK, Takahashi JS, Mangelsdorf DJ, Kliewer SA.
Nat Med 19(9):1147-52. doi: 10.1038/nm.3249. Epub 2013 Aug 11. 2013
18FGF21
Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease.
Davis RL, Liang C, Edema-Hildebrand F, Riley C, Needham M, Sue CM.
Neurology 81(21):1819-26. doi: 10.1212/01.wnl.0000436068.43384.ef. Epub 2013 Oct 18. 2013
19FGF21
FGF21 mediates the lipid metabolism response to amino acid starvation.
De Sousa-Coelho AL, Relat J, Hondares E, Pérez-Martí A, Ribas F, Villarroya F, Marrero PF, Haro D.
J Lipid Res 54(7):1786-97. doi: 10.1194/jlr.M033415. Epub 2013 May 9. 2013
20FGF21
Fibroblast growth factor 21 mediates specific glucagon actions.
Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, DiMarchi RD, Tschöp MH.
Diabetes 62(5):1453-63. doi: 10.2337/db12-1116. Epub 2013 Jan 10. 2013
21FGF21
Fibroblast growth factor 21 is induced by endoplasmic reticulum stress.
Schaap FG, Kremer AE, Lamers WH, Jansen PL, Gaemers IC.
Biochimie 95(4):692-9. doi: 10.1016/j.biochi.2012.10.019. Epub 2012 Nov 2. 2013
22FGF21, LEPROT, LEPROTL1
Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression.
Wu S, Grunwald T, Kharitonenkov A, Dam J, Jockers R, De Luca F.
J Biol Chem 288(38):27375-83. doi: 10.1074/jbc.M113.462218. Epub 2013 Aug 12. 2013
23FGF21, GCG
Fibroblast growth factor 21 mediates specific glucagon actions.
Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, DiMarchi RD, Tschöp MH.
Diabetes 62(5):1453-63. doi: 10.2337/db12-1116. Epub 2013 Jan 10. 2013
24EHMT2, FGF21, NFIL3
Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein.
Tong X, Zhang D, Buelow K, Guha A, Arthurs B, Brady HJ, Yin L.
J Biol Chem 288(8):5417-25. doi: 10.1074/jbc.M112.433482. Epub 2013 Jan 2. 2013
25FGF21
FGF21 and the second coming of PPARγ.
Qiang L, Accili D.
Cell 148(3):397-8. doi: 10.1016/j.cell.2012.01.020. 2012
26FGF21
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.
Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, Mangelsdorf DJ, Kliewer SA.
Cell 148(3):556-67. doi: 10.1016/j.cell.2011.11.062. 2012
27CNPY2, FGF21, LDLR, MYLIP
Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).
Do HT, Tselykh TV, Mäkelä J, Ho TH, Olkkonen VM, Bornhauser BC, Korhonen L, Zelcer N, Lindholm D.
J Biol Chem 287(16):12602-11. doi: 10.1074/jbc.M112.341248. Epub 2012 Feb 29. 2012
28FGF21, FGFR1, FGFR3, MAPK3
Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate.
Wu S, Levenson A, Kharitonenkov A, De Luca F.
J Biol Chem 287(31):26060-7. doi: 10.1074/jbc.M112.343707. Epub 2012 Jun 13. 2012
29FGF21, HMGCS2
Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression in HepG2 cell line.
Vilà-Brau A, De Sousa-Coelho AL, Mayordomo C, Haro D, Marrero PF.
J Biol Chem 286(23):20423-30. Epub 2011 Apr 18. 2011
30FGF21, GH1
Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes.
Chen W, Hoo RL, Konishi M, Itoh N, Lee PC, Ye HY, Lam KS, Xu A.
J Biol Chem 286(40):34559-66. Epub 2011 Aug 17. 2011
31FGF21, KLB, SLC2A1
Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes.
Ge X, Chen C, Hui X, Wang Y, Lam KS, Xu A.
J Biol Chem 286(40):34533-41. Epub 2011 Aug 16. 2011
32FGF19, FGF21, FGF23, FGFR4
FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.
Wu X, Ge H, Lemon B, Vonderfecht S, Weiszmann J, Hecht R, Gupte J, Hager T, Wang Z, Lindberg R, Li Y.
J Biol Chem 285(8):5165-70. Epub 2009 Dec 15. 2010
33FGF21, RORA
Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha.
Wang Y, Solt LA, Burris TP.
J Biol Chem 285(21):15668-73. Epub 2010 Mar 23.PMID: 20332535 2010
34FGF21
Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride.
Li H, Fang Q, Gao F, Fan J, Zhou J, Wang X, Zhang H, Pan X, Bao Y, Xiang K, Xu A, Jia W.
J Hepatol Hepatol. 2010 Jul 17. [Epub ahead of print]PMID: 20675007 2010
35FGF21
FGF21 is dispensable for hypothermia induced by fasting in mice.
Oishi K, Sakamoto K, Konishi M, Murata Y, Itoh N, Sei H.
Neuro Endocrinol Lett 31(2):198-202.PMID: 20424589 2010
36FGF19, FGF21
Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19).
Wu X, Ge H, Lemon B, Vonderfecht S, Baribault H, Weiszmann J, Gupte J, Gardner J, Lindberg R, Wang Z, Li Y.
Proc Natl Acad Sci U S A 107(32):14158-63. Epub 2010 Jul 26.PMID: 20660733 2010
37FGF21, NFIL3
Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding.
Tong X, Muchnik M, Chen Z, Patel M, Wu N, Joshi S, Rui L, Lazar MA, Yin L.
J Biol Chem 285(47):36401-9. Epub 2010 Sep 17. 2010
38FGF21, KLB
FGF21 N- and C-termini play different roles in receptor interaction and activation.
Yie J, Hecht R, Patel J, Stevens J, Wang W, Hawkins N, Steavenson S, Smith S, Winters D, Fisher S, Cai L, Belouski E, Chen C, Michaels ML, Li YS, Lindberg R, Wang M, Véniant M, Xu J.
FEBS Lett 583(1):19-24. Epub 2008 Dec 4. 2009
39FGF21
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis.
Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E.
Endocrinology 150(11):4931-40. Epub 2009 Oct 9.PMID: 19819944 2009
40FGF21
Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia.
Hojman P, Pedersen M, Nielsen AR, Krogh-Madsen R, Yfanti C, Akerstrom T, Nielsen S, Pedersen BK.
Diabetes 58(12):2797-801. Epub 2009 Aug 31.PMID: 19720803 2009
41FGF21
FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity.
Arner P, Pettersson A, Mitchell PJ, Dunbar JD, Kharitonenkov A, RydŽn M.
FEBS Lett 582(12):1725-30. Epub 2008 May 5. 2008
42FGF21, PPARG
Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes.
Wang H, Qiang L, Farmer SR.
Mol Cell Biol 28(1):188-200. Epub 2007 Oct 22.PMID: 17954559 2008
43FGF21
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans.
Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, Wong RL, Chow WS, Tso AW, Lam KS, Xu A.
Diabetes 57(5):1246-53. Epub 2008 Feb 5.PMID: 18252893 2008
44FGF21, KLB
betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c.
Suzuki M, Uehara Y, Motomura-Matsuzaka K, Oki J, Koyama Y, Kimura M, Asada M, Komi-Kuramochi A, Oka S, Imamura T.
Mol Endocrinol 22(4):1006-14. Epub 2008 Jan 10.PMID: 18187602 2008
45FGF21, KLB
BetaKlotho is required for metabolic activity of fibroblast growth factor 21.
Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt KP, Goetz R, Eliseenkova AV, Mohammadi M, Kuro-o M.
Proc Natl Acad Sci U S A 104(18):7432-7. Epub 2007 Apr 23. 2007
46FGF19, FGF21, KLB
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-o M.
J Biol Chem 282(37):26687-95. Epub 2007 Jul 10.PMID: 17623664 2007
47FGF1, FGF18, FGF2, FGF21, FGF22, FGF6, FGF7, FGF9
Fibroblast growth factor expression in the postnatal growth plate.
Lazarus JE, Hegde A, Andrade AC, Nilsson O, Baron J.
Bone 40(3):577-86. Epub 2006 Dec 13. 2007
48FGF21
FGF-21 as a novel metabolic regulator.
Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB.
J Clin Invest 115(6):1627-35. Epub 2005 May 2. 2005
49FGF1, FGF2, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF20, FGF21, FGF22, FGF23
Evolution of the Fgf and Fgfr gene families.
Itoh N, Ornitz DM.
Trends Genet 20(11):563-9. 2004
50FGF21
Identification of a novel FGF, FGF-21, preferentially expressed in the liver.
Nishimura T, Nakatake Y, Konishi M, Itoh N.
Biochim Biophys Acta 1492(1):203-6. 2000