| 1 | FFAR3, RGS4
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| Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling
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| Carbone AM, Borges JI, Suster MS, Sizova A, Cora N, Desimine VL, Lymperopoulos A.
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| Int J Mol Sci. May 22;23(10):5803. doi: 10.3390/ijms23105803. 2022
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| 2 | FFAR2, FFAR3
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| Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells.
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| Kobayashi M, Mikami D, Kimura H, Kamiyama K, Morikawa Y, Yokoi S, Kasuno K, Takahashi N, Taniguchi T, Iwano M.
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| Biochem Biophys Res Commun 486(2):499-505. doi: 10.1016/j.bbrc.2017.03.071. Epub 2017 Mar 18.
2017
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| 3 | FFAR3
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| GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.
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| Veprik A, Laufer D, Weiss S, Rubins N, Walker MD.
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| FASEB J 30(11):3860-3869. Epub 2016 Aug 22.
2016
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| 4 | FFAR3
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| FFAR3 modulates insulin secretion and global gene expression in mouse islets.
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| Priyadarshini M, Layden BT.
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| Islets 7(2):e1045182. doi: 10.1080/19382014.2015.1045182. Epub 2015 Jun 19.
2015
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| 5 | FFAR1, FFAR2, FFAR3, FFAR4
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| A novel antidiabetic therapy: free fatty acid receptors as potential drug target.
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| Sekiguchi H, Kasubuchi M, Hasegawa S, Pelisch N, Kimura I, Ichimura A.
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| Curr Diabetes Rev 11(2):107-15. Review.
2015
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| 6 | FFAR3
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| Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.
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| Nøhr MK, Egerod KL, Christiansen SH, Gille A, Offermanns S, Schwartz TW, Møller M.
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| Neuroscience 290:126-37. doi: 10.1016/j.neuroscience.2015.01.040. Epub 2015 Jan 28.
2015
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| 7 | FFAR2, FFAR3
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| Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.
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| Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S.
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| Nat Med 21(2):173-7. doi: 10.1038/nm.3779. Epub 2015 Jan 12.
2015
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| 8 | FFAR3
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| Regulation of Energy Homeostasis by GPR41.
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| Inoue D, Tsujimoto G, Kimura I.
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| Front Endocrinol (Lausanne) 5:81. doi: 10.3389/fendo.2014.00081. eCollection 2014. Review.
2014
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| 9 | FFAR3
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| Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity.
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| Remely M, Aumueller E, Merold C, Dworzak S, Hippe B, Zanner J, Pointner A, Brath H, Haslberger AG.
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| Gene 537(1):85-92. doi: 10.1016/j.gene.2013.11.081. Epub 2013 Dec 8.
2014
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| 10 | FFAR2, FFAR3
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| Free fatty acid receptors and their role in regulation of energy metabolism.
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| Hara T, Kimura I, Inoue D, Ichimura A, Hirasawa A.
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| Rev Physiol Biochem Pharmacol 164:77-116. doi: 10.1007/112_2013_13. Review.
2013
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| 11 | FFAR1, FFAR3
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| GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.
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| Bahar Halpern K, Veprik A, Rubins N, Naaman O, Walker MD.
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| J Biol Chem 287(24):20154-63. doi: 10.1074/jbc.M112.358887. Epub 2012 Apr 9.
2012
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| 12 | FFAR3
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| Butyrate-induced GPR41 activation inhibits histone acetylation and cell growth.
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| Wu J, Zhou Z, Hu Y, Dong S.
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| J Genet Genomics 39(8):375-84. doi: 10.1016/j.jgg.2012.05.008. Epub 2012 Jul 13.
2012
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| 13 | FFAR2, FFAR3
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| Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.
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| Tolhurst G, Heffron H, Lam YS, Parker HE, Habib AM, Diakogiannaki E, Cameron J, Grosse J, Reimann F, Gribble FM.
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| Diabetes 61(2):364-71. doi: 10.2337/db11-1019. Epub 2011 Dec 21.
2012
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| 14 | FFAR3
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| Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).
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| Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G.
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| Proc Natl Acad Sci U S A 108(19):8030-5. Epub 2011 Apr 25.
2011
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| 15 | FFAR2, FFAR3
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| Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.
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| Zaibi MS, Stocker CJ, O'Dowd J, Davies A, Bellahcene M, Cawthorne MA, Brown AJ, Smith DM, Arch JR.
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| FEBS Lett 584(11):2381-6. Epub 2010 Apr 20.PMID: 20399779 2010
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| 16 | FFAR1, FFAR3, GPR42
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| Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.
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| Liaw CW, Connolly DT.
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| DNA Cell Biol 28(11):555-60. 2009
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| 17 | FFAR3
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| Expression of short-chain fatty acid receptor GPR41 in the human colon.
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| Tazoe H, Otomo Y, Karaki S, Kato I, Fukami Y, Terasaki M, Kuwahara A.
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| Biomed Res 30(3):149-56.
2009
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| 18 | FFAR3
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| Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.
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| Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, Hammer RE, Williams SC, Crowley J, Yanagisawa M, Gordon JI.
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| Proc Natl Acad Sci U S A 105(43):16767-72. Epub 2008 Oct 17.
2008
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| 19 | FFAR2, FFAR3
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| Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line.
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| Yonezawa T, Kobayashi Y, Obara Y.
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| Cell Signal 19(1):185-93. Epub 2006 Aug 2. 2007
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| 20 | FFAR1,FFAR3
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| A family of fatty acid binding receptors.
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| Brown AJ, Jupe S, Briscoe CP.
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| DNA Cell Biol 24(1):54-61. Review. 2005
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| 21 | FFAR3
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| Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.
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| Xiong Y, Miyamoto N, Shibata K, Valasek MA, Motoike T, Kedzierski RM, Yanagisawa M.
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| Proc Natl Acad Sci U S A 101(4):1045-50. Epub 2004 Jan 13. 2004
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| 22 | FFAR3, FFAR2
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| Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
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| Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van Damme J, Parmentier M, Detheux M.
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| J Biol Chem 278(28):25481-9. Epub 2003 Apr 23. 2003
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| 23 | FFAR2, FFAR3, GPR42
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| The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
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| Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ.
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| J Biol Chem. 278(13):11312-9. 2003
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| 24 | FFAR1, FFAR3, GPR42, FFAR2
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| A cluster of four novel human G protein-coupled receptor genes occuring in close proximity to CD22 gene on chromosome 19q13.1.
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| Sawzdargo M, George SR, Nguyen T, Xu S, Kolakowski LF, O'Dowd BF.
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| Biochem Biophys Res Commun 239(2):543-7. 1997
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