| 1 | FEN1, WDR4
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| Wuho/WDR4 deficiency inhibits cell proliferation and induces apoptosis via DNA damage in mouse embryonic fibroblasts.
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| Lee CC, Hsieh TS.
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| Cell Signal 47:16-26. doi: 10.1016/j.cellsig.2018.03.007. Epub 2018 Mar 21.
2018
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| 2 | FEN1, WDR4
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| Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1.
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| Cheng IC, Chen BC, Shuai HH, Chien FC, Chen P, Hsieh TS.
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| PLoS Biol 14(1):e1002349. doi: 10.1371/journal.pbio.1002349. eCollection 2016 Jan.
2016
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| 3 | FEN1
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| Rate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences.
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| Tarantino ME, Bilotti K, Huang J, Delaney S.
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| J Biol Chem 290(34):21154-62. doi: 10.1074/jbc.M115.666438. Epub 2015 Jul 9.
2015
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| 4 | FEN1
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| Cohesion establishment factors stimulate endonuclease activity of hFen1 independently and cooperatively.
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| Kim DH, Kim JH, Park BC, Cho S, Park SG.
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| J Microbiol Biotechnol Microbiol Biotechnol. 2015 Jun 2. [Epub ahead of print]
2015
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| 5 | FEN1
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| Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand.
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| Teasley DC, Parajuli S, Nguyen M, Moore HR, Alspach E, Lock YJ, Honaker Y, Saharia A, Piwnica-Worms H, Stewart SA.
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| J Biol Chem 290(24):15133-45. doi: 10.1074/jbc.M115.647388. Epub 2015 Apr 28.
2015
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| 6 | FEN1, RECQL
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| RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.
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| Sami F, Lu X, Parvathaneni S, Roy R, Gary RK, Sharma S.
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| Biochem J 468(2):227-44. doi: 10.1042/BJ20141021.
2015
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| 7 | FEN1
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| Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.
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| Abdel-Fatah TM, Russell R, Albarakati N, Maloney DJ, Dorjsuren D, Rueda OM, Moseley P, Mohan V, Sun H, Abbotts R, Mukherjee A, Agarwal D, Illuzzi JL, Jadhav A, Simeonov A, Ball G, Chan S, Caldas C, Ellis IO, Wilson DM 3rd, Madhusudan S.
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| Mol Oncol 8(7):1326-38. doi: 10.1016/j.molonc.2014.04.009. Epub 2014 May 13.
2014
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| 8 | FEN1
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| Association of functional FEN1 genetic variants and haplotypes and breast cancer risk.
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| Lv Z, Liu W, Li D, Liu L, Wei J, Zhang J, Ge Y, Wang Z, Chen H, Zhou C, Yuan Q, Zhou L, Yang M.
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| Gene 538(1):42-5. doi: 10.1016/j.gene.2014.01.025. Epub 2014 Jan 16.
2014
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| 9 | FANCA, FEN1
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| Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1.
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| Qian L, Yuan F, Rodriguez-Tello P, Padgaonkar S, Zhang Y.
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| PLoS One 8(12):e82666. doi: 10.1371/journal.pone.0082666. eCollection 2013.
2013
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| 10 | FEN1
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| A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties.
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| Kazak L, Reyes A, He J, Wood SR, Brea-Calvo G, Holen TT, Holt IJ.
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| PLoS One 8(5):e62340. doi: 10.1371/journal.pone.0062340. Print 2013.
2013
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| 11 | FEN1
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| Functional FEN1 genetic variants and haplotypes are associated with glioma risk.
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| Chen YD, Zhang X, Qiu XG, Li J, Yuan Q, Jiang T, Yang M.
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| J Neurooncol 111(2):145-51. doi: 10.1007/s11060-012-1007-0. Epub 2012 Nov 27.
2013
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| 12 | FEN1
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| Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression.
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| Guo Z, Kanjanapangka J, Liu N, Liu S, Liu C, Wu Z, Wang Y, Loh T, Kowolik C, Jamsen J, Zhou M, Truong K, Chen Y, Zheng L, Shen B.
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| Mol Cell 47(3):444-56. doi: 10.1016/j.molcel.2012.05.042. Epub 2012 Jun 30.
2012
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| 13 | EME1, EME2, FEN1, MUS81
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| Human MUS81 complexes stimulate flap endonuclease 1.
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| Shin YK, Amangyeld T, Nguyen TA, Munashingha PR, Seo YS.
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| FEBS J 279(13):2412-30. doi: 10.1111/j.1742-4658.2012.08620.x. Epub 2012 Jun 8.
2012
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| 14 | FEN1, TERT
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| Mapping the FEN1 interaction domain with hTERT.
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| Sampathi S, Chai W.
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| Biochem Biophys Res Commun 407(1):34-8. Epub 2011 Feb 21.
2011
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| 15 | ERCC5, EXO1, FEN1, GEN1
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| Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.
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| Tsutakawa SE, Classen S, Chapados BR, Arvai AS, Finger LD, Guenther G, Tomlinson CG, Thompson P, Sarker AH, Shen B, Cooper PK, Grasby JA, Tainer JA.
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| Cell 145(2):198-211.
2011
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| 16 | FEN1
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| FEN1 ensures telomere stability by facilitating replication fork re-initiation.
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| Saharia A, Teasley DC, Duxin JP, Dao B, Chiappinelli KB, Stewart SA.
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| J Biol Chem 285(35):27057-66. Epub 2010 Jun 15.PMID: 20551483 2010
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| 17 | FEN1
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| FEN1 contributes to telomere stability in ALT-positive tumor cells.
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| Saharia A, Stewart SA.
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| Oncogene 28(8):1162-7. Epub 2009 Jan 12.
2009
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| 18 | FEN1
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| Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance.
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| Sampathi S, Bhusari A, Shen B, Chai W.
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| J Biol Chem. 284(6):3682-90 2009
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| 19 | FEN1, RFC1
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| Human replication factor C stimulates flap endonuclease 1.
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| Cho IT, Kim DH, Kang YH, Lee CH, Amangyelid T, Nguyen TA, Hurwitz J, Seo YS.
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| J Biol Chem 284(16):10387-99. doi: 10.1074/jbc.M808893200. Epub 2009 Feb 9.
2009
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| 20 | FEN1
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| Flap endonuclease 1 contributes to telomere stability.
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| Saharia A, Guittat L, Crocker S, Lim A, Steffen M, Kulkarni S, Stewart SA.
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| Curr. Biol. 18(7):496-500 2008
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| 21 | FEN1, NEIL1
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| Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1.
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| Hegde ML, Theriot CA, Das A, Hegde PM, Guo Z, Gary RK, Hazra TK, Shen B, Mitra S.
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| J Biol Chem 283(40):27028-37. Epub 2008 Jul 28.PMID: 18662981 2008
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| 22 | FEN1
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| Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria.
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| Liu P, Qian L, Sung JS, de Souza-Pinto NC, Zheng L, Bogenhagen DF, Bohr VA, Wilson DM 3rd, Shen B, Demple B.
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| Mol Cell Biol 28(16):4975-87. Epub 2008 Jun 9.
2008
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| 23 | FEN1
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| Fen1 mutations result in autoimmunity, chronic inflammation and cancers.
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| Zheng L, Dai H, Zhou M, Li M, Singh P, Qiu J, Tsark W, Huang Q, Kernstine K, Zhang X, Lin D, Shen B.
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| Nat Med 13(7):812-9. Epub 2007 Jun 24. 2007
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| 24 | FEN1
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| Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks
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| Zheng L, Zhou M, Chai Q, Parrish J, Xue D, Patrick SM, Turchi JJ, Yannone SM, Chen D, Shen B.
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| EMBO Rep. 6(1):83-9 2005
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| 25 | FEN1, PCNA
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| Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.
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| Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA.
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| Cell 116(1):39-50. 2004
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| 26 | WRN, FEN1
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| In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication.
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| arma S, Sommers JA, Brosh RM Jr.
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| Hum Mol Genet 13(19):2247-61. Epub 2004 Jul 28. 2004
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| 27 | FEN1
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| In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication
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| Sharma, S.; Sommers, J. A.; Brosh, R. M., Jr.
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| Hum. Molec. Genet. 13: 2247-2261 2004
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| 28 | FEN1, FENL1
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| Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer.
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| Sato M, Girard L, Sekine I, Sunaga N, Ramirez RD, Kamibayashi C, Minna JD.
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| Oncogene 22(46):7243-6. 2003
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| 29 | CSB, ERCC5, ERCC6, FEN1, XPG
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| Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription. implications for Cockayne syndrome.
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| Lee SK, Yu SL, Prakash L, Prakash S.
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| Cell 109(7):823-34. 2002
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| 30 | APEX1, FEN1
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| AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair.
|
| Ranalli TA, Tom S, Bambara RA.
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| J Biol Chem 277(44):41715-24. 2002
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| 31 | FEN1
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| The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.
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| Storici F, Henneke G, Ferrari E, Gordenin DA, Hubscher U, Resnick MA.
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| EMBO J 21(21):5930-42. 2002
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| 32 | WRN, FEN1
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| Biochemical characterization of the WRN-FEN-1 functional interaction.
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| Brosh RM Jr, Driscoll HC, Dianov GL, Sommers JA.
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| Biochemistry 41(40):12204-16. 2002
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| 33 | FEN1
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| Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.
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| Kucherlapati, M.; Yang, K.; Kuraguchi, M.; Zhao, J.; Lia, M.; Heyer, J.; Kane, M. F.; Fan, K.; Russell, R.; Brown, A. M. C.; Kneitz, B.; Edelmann, W.; Kolodner, R. D.; Lipkin, M.; Kucherlapati, R.
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| Proc. Nat. Acad. Sci 99: 9924-9929 2002
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| 34 | EP300, FEN1
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| Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.
|
| Hasan S, Stucki M, Hassa PO, Imhof R, Gehrig P, Hunziker P, Hubscher U, Hottiger MO.
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| Mol Cell 7(6):1221-31. 2001
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| 35 | FEN1, WRN
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| Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
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| Brosh RM Jr, von Kobbe C, Sommers JA, Karmakar P, Opresko PL, Piotrowski J, Dianova I, Dianov GL, Bohr VA.
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| EMBO J 20(20):5791-801. 2001
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| 36 | FEN1
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| Toward a survey of somatic mutation of the NF1 gene in benign neurofibromas of patients with neurofibromatosis type 1.
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| Eisenbarth I, Beyer K, Krone W, Assum G.
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| Am J Hum Genet 66(2):393-401. 2000
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| 37 | FEN1, PCNA
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| Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1.
|
| Tom S, Henricksen LA, Bambara RA.
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| J Biol Chem 275(14):10498-505. 2000
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| 38 | FEN1
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| Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability.
|
| Greene AL, et al.
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| Hum Mol Genet 8(12):2263-2273 1999
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| 39 | CD6, FEN1, BEST1, SYT7
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| Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes.
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| Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB.
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| Genomics 49(3):419-29. 1998
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| 40 | FEN1, FENL1
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| Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
|
| Hosfield DJ, Mol CD, Shen B, Tainer JA.
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| Cell 95(1):135-46. 1998
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| 41 | GADD45A, FEN1, PCNA, POLD1, POLE, RFC1
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| Proliferating cell nuclear antigen : more than a clamp for DNA polymerases.
|
| Jonsson ZO, Hubscher U.
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| BioEssays 19(11):967-75. 1997
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| 42 | FENL1, FEN1
|
| Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human.
|
| Hiraoka LR, et al.
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| Genomics 25(1):220-5. 1995
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| 43 | FEN1, FENL1
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| The characterization of a mammalian DNA structure-specific endonuclease.
|
| Harrington JJ, et al.
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| EMBO J 13(5):1235-46. 1994
|