1 | FBXO45, FBXW7, MYCBP2
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| FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.
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| Richter KT, Kschonsak YT, Vodicska B, Hoffmann I.
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| Cell Death Differ ell Death Differ. 2019 Jul 8. doi: 10.1038/s41418-019-0385-7. [Epub ahead of print]
2019
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2 | FBXW7, MAGEA1, NOTCH1
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| MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells.
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| Zhao J, Wang Y, Mu C, Xu Y, Sang J.
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| Oncogene 36(35):5023-5034. doi: 10.1038/onc.2017.131. Epub 2017 May 1.
2017
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3 | FBXW7, NR1D1
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| Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.
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| Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR 3rd, Kay SA, Downes M, Evans RM.
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| Cell 165(7):1644-57. doi: 10.1016/j.cell.2016.05.012.
2016
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4 | BTRC, FBXL14, FBXL5, FBXO11, FBXO45, FBXW7
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| F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check.
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| Díaz VM, de Herreros AG.
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| Semin Cancer Biol 36:71-9. doi: 10.1016/j.semcancer.2015.10.003. Epub 2015 Nov 11. Review.
2016
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5 | FBXW7, MTOR
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| Fbxw7 Limits Myelination by Inhibiting mTOR Signaling.
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| Kearns CA, Ravanelli AM, Cooper K, Appel B.
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| J Neurosci 35(44):14861-71. doi: 10.1523/JNEUROSCI.4968-14.2015.
2015
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6 | CREB3L1, CREB3L2, FBXW7
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| F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.
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| Yumimoto K, Matsumoto M, Onoyama I, Imaizumi K, Nakayama KI.
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| J Biol Chem 288(40):28488-502. doi: 10.1074/jbc.M113.465179. Epub 2013 Aug 16.
2013
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7 | FAM83D, FBXW7
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| FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7.
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| Wang Z, Liu Y, Zhang P, Zhang W, Wang W, Curr K, Wei G, Mao JH.
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| Oncotarget 4(12):2476-86.
2013
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8 | CDK8, FBXW7, MED13, MED13L
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| The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.
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| Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE.
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| Genes Dev 27(2):151-6. doi: 10.1101/gad.207720.112. Epub 2013 Jan 15.
2013
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9 | FBXW7, KLF2
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| FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation.
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| Wang R, Wang Y, Liu N, Ren C, Jiang C, Zhang K, Yu S, Chen Y, Tang H, Deng Q, Fu C, Wang Y, Li R, Liu M, Pan W, Wang P.
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| Cell Res 23(6):803-19. doi: 10.1038/cr.2013.42. Epub 2013 Mar 19.
2013
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10 | CSF3R, FBXW7, GSK3B
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| E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation.
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| Lochab S, Pal P, Kapoor I, Kanaujiya JK, Sanyal S, Behre G, Trivedi AK.
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| Biochim Biophys Acta 1833(12):2639-52. doi: 10.1016/j.bbamcr.2013.06.018.
2013
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11 | FBXW7, PTEN
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| Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.
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| Kwon YW, Kim IJ, Wu D, Lu J, Stock WA Jr, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH.
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| Mol Cancer Res 10(6):834-44. doi: 10.1158/1541-7786.MCR-12-0025. Epub 2012 Apr 18.
2012
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12 | FBXW7, RICTOR
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| Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells.
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| Guo Z, Zhou Y, Evers BM, Wang Q.
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| Biochem Biophys Res Commun 418(2):426-32. doi: 10.1016/j.bbrc.2012.01.054. Epub 2012 Jan 20.
2012
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13 | FBXW7, NFKB2
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| SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma.
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| Busino L, Millman SE, Pagano M.
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| Sci Signal 5(253):pt14. doi: 10.1126/scisignal.2003408. Review.
2012
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14 | FBXW7, NFKB2
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| Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.
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| Arabi A, Ullah K, Branca RM, Johansson J, Bandarra D, Haneklaus M, Fu J, Ariës I, Nilsson P, Den Boer ML, Pokrovskaja K, Grandér D, Xiao G, Rocha S, Lehtiö J, Sangfelt O.
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| Nat Commun 3:976. doi: 10.1038/ncomms1975.
2012
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15 | FBXW7, USP28
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| GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.
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| Flügel D, Görlach A, Kietzmann T.
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| Blood 119(5):1292-301. doi: 10.1182/blood-2011-08-375014. Epub 2011 Dec 5.
2012
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16 | FBXW7, SYTL1
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| The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ.
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| Zhang W, MacDonald EM, Koepp DM.
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| PLoS One 7(10):e47736. doi: 10.1371/journal.pone.0047736. Epub 2012 Oct 17.
2012
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17 | FBXW7, GLMN, RBX1
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| The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.
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| Tron AE, Arai T, Duda DM, Kuwabara H, Olszewski JL, Fujiwara Y, Bahamon BN, Signoretti S, Schulman BA, DeCaprio JA.
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| Mol Cell 46(1):67-78. doi: 10.1016/j.molcel.2012.02.005. Epub 2012 Mar 8.
2012
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18 | BMI1, CCNE1, FBXW7
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| Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression.
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| Mao L, Ding J, Perdue A, Yang L, Zha Y, Ren M, Huang S, Cui H, Ding HF.
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| Oncogene 31(33):3785-95. doi: 10.1038/onc.2011.536. Epub 2011 Nov 28.
2012
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19 | FBXW7, PIN1
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| Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.
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| Min SH, Lau AW, Lee TH, Inuzuka H, Wei S, Huang P, Shaik S, Lee DY, Finn G, Balastik M, Chen CH, Luo M, Tron AE, Decaprio JA, Zhou XZ, Wei W, Lu KP.
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| Mol Cell 46(6):771-83. doi: 10.1016/j.molcel.2012.04.012. Epub 2012 May 17.
2012
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20 | EBNA1BP2, FBXW7
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| Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.
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| Welcker M, Larimore EA, Frappier L, Clurman BE.
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| Mol Cell Biol 31(6):1214-24. Epub 2011 Jan 10.
2011
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21 | FBXW7
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| Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.
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| Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI.
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| J Biol Chem 286(15):13754-64. Epub 2011 Feb 24.
2011
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22 | FBXW7, NFE2L1
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| The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.
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| Biswas M, Phan D, Watanabe M, Chan JY.
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| J Biol Chem 286(45):39282-9. doi: 10.1074/jbc.M111.253807. Epub 2011 Sep 27.
2011
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23 | FBXW7
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| The F-box protein Fbw7 is required for cerebellar development.
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| Jandke A, Da Costa C, Sancho R, Nye E, Spencer-Dene B, Behrens A.
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| Dev Biol 358(1):201-12. doi: 10.1016/j.ydbio.2011.07.030. Epub 2011 Jul 29.
2011
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24 | FBXW7, MYCN
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| Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.
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| Williams RD, Al-Saadi R, Chagtai T, Popov S, Messahel B, Sebire N, Gessler M, Wegert J, Graf N, Leuschner I, Hubank M, Jones C, Vujanic G, Pritchard-Jones K; Children's Cancer and Leukaemia Group; SIOP Wilms' Tumour Biology Group.
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| Clin Cancer Res 16(7):2036-45. Epub 2010 Mar 23.PMID: 20332316 2010
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25 | CEBPA, FBXW7
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| The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation.
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| Bengoechea-Alonso MT, Ericsson J.
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| Proc Natl Acad Sci U S A 107(26):11817-22. Epub 2010 Jun 1.PMID: 20534483 2010
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26 | FBXW7, TGIF1
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| Tumor suppressor Fbxw7 regulates TGFâ signaling by targeting TGIF1 for degradation.
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| Bengoechea-Alonso MT, Ericsson J.
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| Oncogene 29(38):5322-8. Epub 2010 Jul 12.
2010
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27 | FBXW7
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| Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.
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| Hoeck JD, Jandke A, Blake SM, Nye E, Spencer-Dene B, Brandner S, Behrens A.
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| Nat Neurosci. 13(11):1365-72. 2010
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28 | FBXW7, IKBKG, MYC
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| NEMO stabilizes c-Myc through direct interaction in the nucleus.
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| Kim BY, Yang JS, Kwak SY, Zhang XK, Han YH.
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| FEBS Lett 584(22):4524-30. Epub 2010 Oct 21.
2010
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29 | FBXW7, KLF5
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| The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation.
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| Zhao D, Zheng HQ, Zhou Z, Chen C.
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| Cancer Res 70(11):4728-38. Epub 2010 May 18.
2010
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30 | FBXW7, MYB, NLK
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| Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.
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| Kanei-Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama KI, Ishii S.
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| J Biol Chem 283(45):30540-8. Epub 2008 Sep 2.
2008
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31 | FBXW7, MTOR, PTEN
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| FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
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| Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A.
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| Science 321(5895):1499-502. 2008
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32 | FBXW7
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| The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma.
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| Gu Z, Mitsui H, Inomata K, Honda M, Endo C, Sakurada A, Sato M, Okada Y, Kondo T, Horii A.
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| Biochem Biophys Res Commun 377(2):685-8. Epub 2008 Oct 18.
2008
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33 | FBXW7
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| Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
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| Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T.
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| Genes Dev 22(8):986-91. Epub 2008 Mar 26.
2008
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34 | CUL7, FBXW7
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| Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.
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| Tsutsumi T, Kuwabara H, Arai T, Xiao Y, Decaprio JA.
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| Mol Cell Biol 28(2):743-51. Epub 2007 Nov 12.PMID: 17998335 2008
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35 | FBXW7
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| FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.
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| Welcker M, Clurman BE.
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| Nat Rev Cancer 8(2):83-93. Review.PMID: 18094723 2008
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36 | FBXW7
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| Low frequency of hCDC4 mutations in human primary ovarian cancer.
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| Sgambato A, Cittadini A, Masciullo V, Di Salvatore M, Graziani C, Rettino A, Valdivieso P, Scambia G, Bianchino G, Zupa A, Improta G, Cifarelli RA.
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| Gynecol Oncol 105(2):553-5. Epub 2007 Feb 23. No abstract available. 2007
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37 | USP28, FBXW7, MYC
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| The ubiquitin-specific protease USP28 is required for MYC stability.
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| Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M.
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| Nat Cell Biol 9(7):765-74. Epub 2007 Jun 10. 2007
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38 | FBXW7
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| The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.
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| Malyukova A, Dohda T, von der Lehr N, Akhoondi S, Corcoran M, Heyman M, Spruck C, Grandér D, Lendahl U, Sangfelt O.
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| Cancer Res 67(12):5611-6. Erratum in: Cancer Res. 2008 Mar 15;68(6):2051. Akhondi, Shahab [corrected to Akhoondi, Shahab].
2007
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39 | FBXW7
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| Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.
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| Hao B, Oehlmann S, Sowa ME, Harper JW, Pavletich NP.
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| 26(1):131-43. 26(1):131-43. 2007
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40 | FBXW7
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| CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability.
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| Kemp Z, Rowan A, Chambers W, Wortham N, Halford S, Sieber O, Mortensen N, von Herbay A, Gunther T, Ilyas M, Tomlinson I.
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| Cancer Res 65(24):11361-6. 2005
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41 | FBXW7
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| Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).
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| Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, Ericsson J.
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| Cell Metab. 1(6):379-91. 2005
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42 | FBXW7, CCNE1
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| Inactivation of hCDC4 can cause chromosomal instability.
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| Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C.
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| Nature 428(6978):77-81. 2004
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43 | FBXW7
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| Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
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| Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, Imaki H, Ishida N, Okumura F, Nakayama K, Nakayama KI.
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| EMBO J. 23(10):2116-25. 2004
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44 | FBXW7
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| Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.
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| Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ.
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| Proc Natl Acad Sci U S A. 101(10):3338-45. 2004
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45 | FBXW7
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| Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.
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| Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, Brown K, Bryson S, Balmain A.
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| Nature. 432(7018):775-9. 2004
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46 | FBXW7
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| Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity.
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| Staropoli JF, McDermott C, Martinat C, Schulman B, Demireva E, Abeliovich A.
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| Neuron. 37(5):735-49. 2003
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47 | FBXW7
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| hCDC4 gene mutations in endometrial cancer.
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| Spruck CH, Strohmaier H, Sangfelt O, Muller HM, Hubalek M, Muller-Holzner E, Marth C, Widschwendter M, Reed SI.
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| Cancer Res 62(16):4535-9. 2002
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48 | FBXW7, PSEN1
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| SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production.
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| Li J, Pauley AM, Myers RL, Shuang R, Brashler JR, Yan R, Buhl AE, Ruble C, Gurney ME.
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| J Neurochem. 82(6):1540-8. 2002
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49 | FBXW7
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| Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines.
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| Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK.
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| Nature 413(6853):311-6. 2001
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50 | FBXW7
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| Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.
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| Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI.
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| Nature 413(6853):316-22. 2001
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51 | FBXW7
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| Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.
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| Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, Ciechanover A, Israel A.
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| J Biol Chem 276(37):34371-8. 2001
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52 | FBXW7, CCNE1
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| Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
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| Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ.
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| Science 294(5540):173-7. 2001
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53 | CCNF, FBXL12, FBXL6, FBXO10, FBXO11, FBXO18, FBXO2, FBXO3, FBXO4, FBXO8, FBXW5, FBXW5, FBXW7, FBXW8, KDM2A, SHFM3P1, SKP1, TSPAN17
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| A family of mammalian F-box proteins.
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| Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW.
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| Curr Biol 9(20):1180-2. 1999
|