Citations for
1FBXO45, FBXW7, MYCBP2
FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.
Richter KT, Kschonsak YT, Vodicska B, Hoffmann I.
Cell Death Differ ell Death Differ. 2019 Jul 8. doi: 10.1038/s41418-019-0385-7. [Epub ahead of print] 2019
2FBXW7, MAGEA1, NOTCH1
MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells.
Zhao J, Wang Y, Mu C, Xu Y, Sang J.
Oncogene 36(35):5023-5034. doi: 10.1038/onc.2017.131. Epub 2017 May 1. 2017
3FBXW7, NR1D1
Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.
Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR 3rd, Kay SA, Downes M, Evans RM.
Cell 165(7):1644-57. doi: 10.1016/j.cell.2016.05.012. 2016
4BTRC, FBXL14, FBXL5, FBXO11, FBXO45, FBXW7
F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check.
Díaz VM, de Herreros AG.
Semin Cancer Biol 36:71-9. doi: 10.1016/j.semcancer.2015.10.003. Epub 2015 Nov 11. Review. 2016
5FBXW7, MTOR
Fbxw7 Limits Myelination by Inhibiting mTOR Signaling.
Kearns CA, Ravanelli AM, Cooper K, Appel B.
J Neurosci 35(44):14861-71. doi: 10.1523/JNEUROSCI.4968-14.2015. 2015
6CREB3L1, CREB3L2, FBXW7
F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.
Yumimoto K, Matsumoto M, Onoyama I, Imaizumi K, Nakayama KI.
J Biol Chem 288(40):28488-502. doi: 10.1074/jbc.M113.465179. Epub 2013 Aug 16. 2013
7FAM83D, FBXW7
FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7.
Wang Z, Liu Y, Zhang P, Zhang W, Wang W, Curr K, Wei G, Mao JH.
Oncotarget 4(12):2476-86. 2013
8CDK8, FBXW7, MED13, MED13L
The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.
Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE.
Genes Dev 27(2):151-6. doi: 10.1101/gad.207720.112. Epub 2013 Jan 15. 2013
9FBXW7, KLF2
FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation.
Wang R, Wang Y, Liu N, Ren C, Jiang C, Zhang K, Yu S, Chen Y, Tang H, Deng Q, Fu C, Wang Y, Li R, Liu M, Pan W, Wang P.
Cell Res 23(6):803-19. doi: 10.1038/cr.2013.42. Epub 2013 Mar 19. 2013
10CSF3R, FBXW7, GSK3B
E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation.
Lochab S, Pal P, Kapoor I, Kanaujiya JK, Sanyal S, Behre G, Trivedi AK.
Biochim Biophys Acta 1833(12):2639-52. doi: 10.1016/j.bbamcr.2013.06.018. 2013
11FBXW7, PTEN
Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.
Kwon YW, Kim IJ, Wu D, Lu J, Stock WA Jr, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH.
Mol Cancer Res 10(6):834-44. doi: 10.1158/1541-7786.MCR-12-0025. Epub 2012 Apr 18. 2012
12FBXW7, RICTOR
Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells.
Guo Z, Zhou Y, Evers BM, Wang Q.
Biochem Biophys Res Commun 418(2):426-32. doi: 10.1016/j.bbrc.2012.01.054. Epub 2012 Jan 20. 2012
13FBXW7, NFKB2
SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma.
Busino L, Millman SE, Pagano M.
Sci Signal 5(253):pt14. doi: 10.1126/scisignal.2003408. Review. 2012
14FBXW7, NFKB2
Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.
Arabi A, Ullah K, Branca RM, Johansson J, Bandarra D, Haneklaus M, Fu J, Ariës I, Nilsson P, Den Boer ML, Pokrovskaja K, Grandér D, Xiao G, Rocha S, Lehtiö J, Sangfelt O.
Nat Commun 3:976. doi: 10.1038/ncomms1975. 2012
15FBXW7, USP28
GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.
Flügel D, Görlach A, Kietzmann T.
Blood 119(5):1292-301. doi: 10.1182/blood-2011-08-375014. Epub 2011 Dec 5. 2012
16FBXW7, SYTL1
The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ.
Zhang W, MacDonald EM, Koepp DM.
PLoS One 7(10):e47736. doi: 10.1371/journal.pone.0047736. Epub 2012 Oct 17. 2012
17FBXW7, GLMN, RBX1
The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.
Tron AE, Arai T, Duda DM, Kuwabara H, Olszewski JL, Fujiwara Y, Bahamon BN, Signoretti S, Schulman BA, DeCaprio JA.
Mol Cell 46(1):67-78. doi: 10.1016/j.molcel.2012.02.005. Epub 2012 Mar 8. 2012
18BMI1, CCNE1, FBXW7
Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression.
Mao L, Ding J, Perdue A, Yang L, Zha Y, Ren M, Huang S, Cui H, Ding HF.
Oncogene 31(33):3785-95. doi: 10.1038/onc.2011.536. Epub 2011 Nov 28. 2012
19FBXW7, PIN1
Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.
Min SH, Lau AW, Lee TH, Inuzuka H, Wei S, Huang P, Shaik S, Lee DY, Finn G, Balastik M, Chen CH, Luo M, Tron AE, Decaprio JA, Zhou XZ, Wei W, Lu KP.
Mol Cell 46(6):771-83. doi: 10.1016/j.molcel.2012.04.012. Epub 2012 May 17. 2012
20EBNA1BP2, FBXW7
Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.
Welcker M, Larimore EA, Frappier L, Clurman BE.
Mol Cell Biol 31(6):1214-24. Epub 2011 Jan 10. 2011
21FBXW7
Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.
Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI.
J Biol Chem 286(15):13754-64. Epub 2011 Feb 24. 2011
22FBXW7, NFE2L1
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.
Biswas M, Phan D, Watanabe M, Chan JY.
J Biol Chem 286(45):39282-9. doi: 10.1074/jbc.M111.253807. Epub 2011 Sep 27. 2011
23FBXW7
The F-box protein Fbw7 is required for cerebellar development.
Jandke A, Da Costa C, Sancho R, Nye E, Spencer-Dene B, Behrens A.
Dev Biol 358(1):201-12. doi: 10.1016/j.ydbio.2011.07.030. Epub 2011 Jul 29. 2011
24FBXW7, MYCN
Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.
Williams RD, Al-Saadi R, Chagtai T, Popov S, Messahel B, Sebire N, Gessler M, Wegert J, Graf N, Leuschner I, Hubank M, Jones C, Vujanic G, Pritchard-Jones K; Children's Cancer and Leukaemia Group; SIOP Wilms' Tumour Biology Group.
Clin Cancer Res 16(7):2036-45. Epub 2010 Mar 23.PMID: 20332316 2010
25CEBPA, FBXW7
The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation.
Bengoechea-Alonso MT, Ericsson J.
Proc Natl Acad Sci U S A 107(26):11817-22. Epub 2010 Jun 1.PMID: 20534483 2010
26FBXW7, TGIF1
Tumor suppressor Fbxw7 regulates TGFâ signaling by targeting TGIF1 for degradation.
Bengoechea-Alonso MT, Ericsson J.
Oncogene 29(38):5322-8. Epub 2010 Jul 12. 2010
27FBXW7
Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.
Hoeck JD, Jandke A, Blake SM, Nye E, Spencer-Dene B, Brandner S, Behrens A.
Nat Neurosci. 13(11):1365-72. 2010
28FBXW7, IKBKG, MYC
NEMO stabilizes c-Myc through direct interaction in the nucleus.
Kim BY, Yang JS, Kwak SY, Zhang XK, Han YH.
FEBS Lett 584(22):4524-30. Epub 2010 Oct 21. 2010
29FBXW7, KLF5
The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation.
Zhao D, Zheng HQ, Zhou Z, Chen C.
Cancer Res 70(11):4728-38. Epub 2010 May 18. 2010
30FBXW7, MYB, NLK
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.
Kanei-Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama KI, Ishii S.
J Biol Chem 283(45):30540-8. Epub 2008 Sep 2. 2008
31FBXW7, MTOR, PTEN
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A.
Science 321(5895):1499-502. 2008
32FBXW7
The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma.
Gu Z, Mitsui H, Inomata K, Honda M, Endo C, Sakurada A, Sato M, Okada Y, Kondo T, Horii A.
Biochem Biophys Res Commun 377(2):685-8. Epub 2008 Oct 18. 2008
33FBXW7
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T.
Genes Dev 22(8):986-91. Epub 2008 Mar 26. 2008
34CUL7, FBXW7
Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.
Tsutsumi T, Kuwabara H, Arai T, Xiao Y, Decaprio JA.
Mol Cell Biol 28(2):743-51. Epub 2007 Nov 12.PMID: 17998335 2008
35FBXW7
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.
Welcker M, Clurman BE.
Nat Rev Cancer 8(2):83-93. Review.PMID: 18094723 2008
36FBXW7
Low frequency of hCDC4 mutations in human primary ovarian cancer.
Sgambato A, Cittadini A, Masciullo V, Di Salvatore M, Graziani C, Rettino A, Valdivieso P, Scambia G, Bianchino G, Zupa A, Improta G, Cifarelli RA.
Gynecol Oncol 105(2):553-5. Epub 2007 Feb 23. No abstract available. 2007
37USP28, FBXW7, MYC
The ubiquitin-specific protease USP28 is required for MYC stability.
Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M.
Nat Cell Biol 9(7):765-74. Epub 2007 Jun 10. 2007
38FBXW7
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.
Malyukova A, Dohda T, von der Lehr N, Akhoondi S, Corcoran M, Heyman M, Spruck C, Grandér D, Lendahl U, Sangfelt O.
Cancer Res 67(12):5611-6. Erratum in: Cancer Res. 2008 Mar 15;68(6):2051. Akhondi, Shahab [corrected to Akhoondi, Shahab]. 2007
39FBXW7
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.
Hao B, Oehlmann S, Sowa ME, Harper JW, Pavletich NP.
26(1):131-43. 26(1):131-43. 2007
40FBXW7
CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability.
Kemp Z, Rowan A, Chambers W, Wortham N, Halford S, Sieber O, Mortensen N, von Herbay A, Gunther T, Ilyas M, Tomlinson I.
Cancer Res 65(24):11361-6. 2005
41FBXW7
Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).
Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, Ericsson J.
Cell Metab. 1(6):379-91. 2005
42FBXW7, CCNE1
Inactivation of hCDC4 can cause chromosomal instability.
Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C.
Nature 428(6978):77-81. 2004
43FBXW7
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, Imaki H, Ishida N, Okumura F, Nakayama K, Nakayama KI.
EMBO J. 23(10):2116-25. 2004
44FBXW7
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.
Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ.
Proc Natl Acad Sci U S A. 101(10):3338-45. 2004
45FBXW7
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.
Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, Brown K, Bryson S, Balmain A.
Nature. 432(7018):775-9. 2004
46FBXW7
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity.
Staropoli JF, McDermott C, Martinat C, Schulman B, Demireva E, Abeliovich A.
Neuron. 37(5):735-49. 2003
47FBXW7
hCDC4 gene mutations in endometrial cancer.
Spruck CH, Strohmaier H, Sangfelt O, Muller HM, Hubalek M, Muller-Holzner E, Marth C, Widschwendter M, Reed SI.
Cancer Res 62(16):4535-9. 2002
48FBXW7, PSEN1
SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production.
Li J, Pauley AM, Myers RL, Shuang R, Brashler JR, Yan R, Buhl AE, Ruble C, Gurney ME.
J Neurochem. 82(6):1540-8. 2002
49FBXW7
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines.
Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK.
Nature 413(6853):311-6. 2001
50FBXW7
Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.
Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI.
Nature 413(6853):316-22. 2001
51FBXW7
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.
Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, Ciechanover A, Israel A.
J Biol Chem 276(37):34371-8. 2001
52FBXW7, CCNE1
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ.
Science 294(5540):173-7. 2001
53CCNF, FBXL12, FBXL6, FBXO10, FBXO11, FBXO18, FBXO2, FBXO3, FBXO4, FBXO8, FBXW5, FBXW5, FBXW7, FBXW8, KDM2A, SHFM3P1, SKP1, TSPAN17
A family of mammalian F-box proteins.
Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW.
Curr Biol 9(20):1180-2. 1999