| 1 | F2RL1, IL8, TMPRSS11D
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| Human airway trypsin-like protease enhances interleukin-8 synthesis in bronchial epithelial cells by activating protease-activated receptor 2.
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| Miki M, Yasuoka S, Tsutsumi R, Nakamura Y, Hajime M, Takeuchi Y, Miki K, Kitada S, Maekura R.
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| Arch Biochem Biophys 664:167-173. doi: 10.1016/j.abb.2019.01.019. Epub 2019 Jan 21.
2019
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| 2 | ELANE, F2RL1, TRPV4
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| Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
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| Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW.
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| J Biol Chem 290(22):13875-87. doi: 10.1074/jbc.M115.642736. Epub 2015 Apr 15.
2015
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| 3 | CTSS, F2RL1
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| Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
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| Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW.
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| J Biol Chem 289(39):27215-34. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12. Erratum in: J Biol Chem. 2014 Dec 26;289(52):35858.
2014
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| 4 | CXCR1, ELANE, F2RL1
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| An interactive network of elastase, secretases, and PAR-2 protein regulates CXCR1 receptor surface expression on neutrophils.
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| Bakele M, Lotz-Havla AS, Jakowetz A, Carevic M, Marcos V, Muntau AC, Gersting SW, Hartl D.
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| J Biol Chem 289(30):20516-25.
2014
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| 5 | F2R, F2RL1, F3
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| Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2.
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| Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW.
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| Am J Respir Cell Mol Biol 48(1):94-104. doi: 10.1165/rcmb.2012-0189OC. Epub 2012 Oct 11.
2013
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| 6 | F2R, F2RL1
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| Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits β-arrestin-mediated endosomal signaling.
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| Lin H, Trejo J.
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| J Biol Chem 288(16):11203-15. doi: 10.1074/jbc.M112.439950. Epub 2013 Mar 8.
2013
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| 7 | F2RL1, TRPV4
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| Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.
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| Poole DP, Amadesi S, Veldhuis NA, Abogadie FC, Lieu T, Darby W, Liedtke W, Lew MJ, McIntyre P, Bunnett NW.
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| J Biol Chem 288(8):5790-802. doi: 10.1074/jbc.M112.438184. Epub 2013 Jan 3.
2013
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| 8 | F2RL1
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| PAR2-induced inflammatory responses in human kidney tubular epithelial cells.
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| Vesey DA, Suen JY, Seow V, Lohman RJ, Liu L, Gobe GC, Johnson DW, Fairlie DP.
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| Am J Physiol Renal Physiol 304(6):F737-50. doi: 10.1152/ajprenal.00540.2012. Epub 2013 Jan 2.
2013
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| 9 | F2RL1, PRSS3
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| Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma.
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| Han S, Lee CW, Trevino JG, Hughes SJ, Sarosi GA Jr.
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| PLoS One 8(10):e76667. doi: 10.1371/journal.pone.0076667. eCollection 2013.
2013
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| 10 | ELANE, F2RL1, MUC5AC
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| Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2.
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| Zhou J, Perelman JM, Kolosov VP, Zhou X.
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| Mol Cell Biochem 377(1-2):75-85. doi: 10.1007/s11010-013-1572-3. Epub 2013 Feb 8.
2013
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| 11 | F2R, F2RL1, KLK6
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| Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity.
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| Yoon H, Radulovic M, Wu J, Blaber SI, Blaber M, Fehlings MG, Scarisbrick IA.
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| J Neurochem 127(2):283-98. doi: 10.1111/jnc.12293. Epub 2013 May 27.
2013
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| 12 | F2R, F2RL1, F3
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| Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling.
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| Reinhardt C, Bergentall M, Greiner TU, Schaffner F, Ostergren-Lundén G, Petersen LC, Ruf W, Bäckhed F.
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| Nature 483(7391):627-31. doi: 10.1038/nature10893.
2012
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| 13 | F2RL1, F3
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| Tissue factor isoforms in cancer and coagulation: may the best isoform win.
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| Kocatürk B, Versteeg HH.
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| Thromb Res 129 Suppl 1:S69-75. doi: 10.1016/S0049-3848(12)70020-8. Review.
2012
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| 14 | F2RL1
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| Protease-activated receptor 2 mediates mucus secretion in the airway submucosal gland.
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| Lee HJ, Yang YM, Kim K, Shin DM, Yoon JH, Cho HJ, Choi JY.
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| PLoS One 7(8):e43188. doi: 10.1371/journal.pone.0043188. Epub 2012 Aug 15.
2012
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| 15 | F2RL1
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| Immunomodulatory role of proteinase-activated receptor-2.
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| Crilly A, Palmer H, Nickdel MB, Dunning L, Lockhart JC, Plevin R, McInnes IB, Ferrell WR.
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| Ann Rheum Dis 71(9):1559-66. doi: 10.1136/annrheumdis-2011-200869. Epub 2012 May 6.
2012
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| 16 | F2RL1
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| Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair.
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| Georgy SR, Pagel CN, Ghasem-Zadeh A, Zebaze RM, Pike RN, Sims NA, Mackie EJ.
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| Bone 50(3):704-12. doi: 10.1016/j.bone.2011.11.023. Epub 2011 Dec 7.
2012
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| 17 | F2RL1, KLK14
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| Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.
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| Chung H, Hamza M, Oikonomopoulou K, Gratio V, Saifeddine M, Virca GD, Diamandis EP, Hollenberg MD, Darmoul D.
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| Biol Chem 393(5):413-20. doi: 10.1515/bc-2011-231.
2012
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| 18 | F2R, F2RL1
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| Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia.
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| Sevigny LM, Austin KM, Zhang P, Kasuda S, Koukos G, Sharifi S, Covic L, Kuliopulos A.
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| Arterioscler Thromb Vasc Biol 31(12):e100-6. Epub 2011 Sep 22.
2011
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| 19 | F2RL1
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| Redox regulation of human protease-activated receptor-2 by activated factor X.
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| Jobi K, Rauch BH, Dangwal S, Freidel K, Doller A, Eberhardt W, Fischer JW, Schrör K, Rosenkranz AC.
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| Free Radic Biol Med 51(9):1758-64. doi: 10.1016/j.freeradbiomed.2011.08.003. Epub 2011 Aug 12.
2011
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| 20 | F2RL1, PRTN3
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| Membrane-bound proteinase 3 and PAR2 mediate phagocytosis of non-opsonized bacteria in human neutrophils.
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| Kim YC, Shin JE, Lee SH, Chung WJ, Lee YS, Choi BK, Choi Y.
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| Mol Immunol 48(15-16):1966-74. doi: 10.1016/j.molimm.2011.05.026. Epub 2011 Jun 22.
2011
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| 21 | F2RL1
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| Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development.
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| Schaffner F, Versteeg HH, Schillert A, Yokota N, Petersen LC, Mueller BM, Ruf W.
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| Blood 116(26):6106-13. doi: 10.1182/blood-2010-06-289314. Epub 2010 Sep 22.
2010
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| 22 | F2RL1, STAMBP, USP8
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| Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.
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| Hasdemir B, Murphy JE, Cottrell GS, Bunnett NW.
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| J Biol Chem 284(41):28453-66. Epub 2009 Aug 14.PMID: 19684015 2009
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| 23 | F2R, F2RL1
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| Distinct roles of protease-activated receptors in signal transduction regulation of endothelial nitric oxide synthase.
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| Suzuki H, Motley ED, Eguchi K, Hinoki A, Shirai H, Watts V, Stemmle LN, Fields TA, Eguchi S.
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| Hypertension 53(2):182-8. Epub 2008 Dec 8.
2009
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| 24 | F2RL1
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| Signal transduction for formation/release of interleukin-8 caused by a PAR2-activating peptide in human lung epithelial cells.
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| Moriyuki K, Nagataki M, Sekiguchi F, Nishikawa H, Kawabata A.
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| Regul Pept 145(1-3):42-8. Epub 2007 Aug 16. 2008
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| 25 | F2RL1, TMED2
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| p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking.
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| Luo W, Wang Y, Reiser G.
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| J Biol Chem 282(41):30246-55. Epub 2007 Aug 10.
2007
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| 26 | COPS5, F2RL1
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| Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1.
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| Luo W, Wang Y, Hanck T, Stricker R, Reiser G.
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| J Biol Chem 281(12):7927-36. Epub 2006 Jan 12. 2006
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| 27 | F2RL1
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| Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells.
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| Moormann C, Artuc M, Pohl E, Varga G, Buddenkotte J, Vergnolle N, Brehler R, Henz BM, Schneider SW, Luger TA, Steinhoff M.
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| J Invest Dermatol 126(4):746-55. 2006
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| 28 | TMPRSS2, F2RL1
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| The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.
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| Wilson S, Greer B, Hooper J, Zijlstra A, Walker B, Quigley J, Hawthorne S.
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| Biochem J 388(Pt 3):967-72. 2005
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| 29 | TMPRSS11D, F2RL1, IL8
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| Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris.
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| Iwakiri K, Ghazizadeh M, Jin E, Fujiwara M, Takemura T, Takezaki S, Kawana S, Yasuoka S, Kawanami O.
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| J Invest Dermatol 122(4):937-44. 2004
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| 30 | F2RL1
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| Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes.
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| Smith R, Jenkins A, Lourbakos A, Thompson P, Ramakrishnan V, Tomlinson J, Deshpande U, Johnson DA, Jones R, Mackie EJ, Pike RN.
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| FEBS Lett 484(3):285-90. 2000
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| 31 | F2R, F2RL1, F2RL2
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| Protease-activated receptor genes are clustered on 5q13.
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| Guyonnet Duperat V, et al.
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| Blood 92 : 25-31. 1998
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| 32 | F2R, F2RL1, F2RL2
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| Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.
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| Kahn ML, et al.
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| J Biol Chem 273 : 23290-23296. 1998
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| 33 | F2R, F2RL1
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| The human thrombin receptor and proteinase activated receptor-2 genes are tightly linked on chromosome 5q13.
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| Schmidt VA, Nierman WC, Feldblyum TV, Maglott DR, Bahou WF.
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| Br J Haematol 97(3):523-9. 1997
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| 34 | F2RL1
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| Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2.
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| Nystedt S, et al.
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| Eur J Biochem 232 : 84-89. 1995
|