| 1 | F2, MMP9
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| Thrombin regulates matrix metalloproteinase-9 expression in human monocytes.
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| Chang CJ, Hsu LA, Ko YH, Chen PL, Chuang YT, Lin CY, Liao CH, Pang JH.
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| Biochem Biophys Res Commun 385(2):241-6. Epub 2009 May 18. 2009
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| 2 | F2, F5
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| Prothrombin and risk of venous thromboembolism, ischemic heart disease and ischemic cerebrovascular disease in the general population.
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| Weischer M, Juul K, Zacho J, Jensen GB, Steffensen R, Schroeder TV, Tybjærg-Hansen A, Nordestgaard BG.
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| Atherosclerosis therosclerosis. 2009 May 21. [Epub ahead of print]
2009
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| 3 | F2, F2D
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| True congenital prothrombin deficiency due to a 'new' mutation in the pre-propeptide (ARG-39 GLN).
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| Girolami A, Santarossa L, Scarparo P, Candeo N, Girolami B.
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| Acta Haematol 120(2):82-6. Epub 2008 Oct 14. No abstract available. 2008
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| 4 | F2, KLKB1
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| Kallikrein activates prothrombin.
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| Stief TW.
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| Clin Appl Thromb Hemost 14(1):97-8. Epub 2007 Dec 26.
2008
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| 5 | F2
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| Thrombin regulates the function of human blood dendritic cells.
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| Yanagita M, Kobayashi R, Kashiwagi Y, Shimabukuro Y, Murakami S.
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| Biochem Biophys Res Commun 364(2):318-24. Epub 2007 Oct 11. 2007
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| 6 | F2, MTHFR
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| Molecular analysis of factor V Leiden, factor V Hong Kong, factor II G20210A, methylenetetrahydrofolate reductase C677T, and A1298C mutations related to Turkish thrombosis patients.
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| Dšlek B, Eraslan S, EroÀlu S, Kesim BE, Ulutin T, Yaliner A, Laleli YR, GšzŸkirmizi N.
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| Clin Appl Thromb Hemost 13(4):435-8. 2007
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| 7 | F2
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| Severe prothrombin deficiency caused by prothrombin-Edmonton (R-4Q) combined with a previously undetected deletion.
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| Wong AY, Hewitt J, Clarke BJ, Hudson DM, Krisinger MJ, Dower NA, MacGillivray RT.
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| J Thromb Haemost 4(12):2623-8. Epub 2006 Sep 26.
2006
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| 8 | F2, F2D
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| Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype.
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| Akhavan S, De Cristofaro R, Peyvandi F, Lavoretano S, Landolfi R, Mannucci PM.
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| Blood 100(4):1347-53. 2002
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| 9 | F2
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| Role of thrombin signalling in platelets in haemostasis and thrombosis.
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| Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR.
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| Nature 413(6851):74-8. 2001
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| 10 | F2
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| The G20210A mutation of the prothrombin gene in patients with previous first episodes of deep-vein thrombosis : prevalence and association with factor V G1691A, methylenetetrahydrofolate reductase C677T and plasma prothrombin levels.
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| Cattaneo M, et al.
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| Thromb Res 93 : 1-8. 1999
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| 11 | F2
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| Frequent factor II G20210A mutation in idiopathic portal vein thrombosis.
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| Chamouard P, et al.
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| Gastroenterology 116(1):144-8. 1999
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| 12 | F2, F5TPH
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| The factor II G20210A and factor V G1691A gene transitions and coronary heart disease.
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| Gardemann A, et al.
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| Thromb Haemost 81(2):208-13. 1999
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| 13 | F2
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| Familial thrombophilia and the prothrombin 20210A mutation: association with increased thrombin generation and unusual thrombosis.
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| Eikelboom JW, et al.
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| Blood Coagul Fibrinolysis 10(1):1-5. 1999
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| 14 | F2, F5TPH
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| The prothrombin 20210A allele and the factor V Leiden are associated with venous thrombosis but not with early coronary artery disease.
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| Vargas M, et al.
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| Blood Coagul Fibrinolysis 10(1):39-41. 1999
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| 15 | F2
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| The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation.
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| De Stefano V, et al.
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| N Engl J Med 341(11):801-6. 1999
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| 16 | F2, F5TPH
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| The A20210 allele of the prothrombin gene is frequently associated with the factor V Arg 506 to Gln mutation but not with protein S deficiency in thrombophilic families.
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| Zšller B, et al.
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| Blood 91 : 2210-2211. 1998
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| 17 | F2, F5TPH
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| High risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives.
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| Martinelli I, et al.
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| N Engl J Med 338 : 1793-1797. 1998
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| 18 | F2
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| Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients.
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| De Stefano V, et al.
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| Blood 91 : 3562-3665. 1998
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| 19 | F2
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| Two novel mutations in the prothrombin gene cause severe bleeding in a compound heterozygous patient.
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| Poort SR, et al.
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| Blood Coagul Fibrinolysis 9(8):761-4. 1998
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| 20 | F2, PROC
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| Ischemic stroke in a young patient with protein C deficiency and prothrombin gene mutation G20210A.
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| Arkel YS, et al.
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| Blood Coagul Fibrinolysis 9(8):757-60. 1998
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| 21 | F2
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| A patient homozygous for a mutation in the prothrombin gene 3'-untranslated region associated with massive thrombosis.
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| Howard TE, Marusa M, Channell C, Duncan A.
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| Blood Coagul Fibrinolysis 8(5):316-9. 1997
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| 22 | F2
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| Genetic analysis and functional characterization of prothrombins Corpus Christi (Arg382-Cys), Dhahran (Arg271-His), and hypoprothrombinemia.
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| O'Marcaigh AS, et al.
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| Blood 88 : 2611-2618. 1996
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| 23 | F2
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| A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.
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| Poort SR, et al.
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| Blood 88 : 3698-3703. 1996
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| 24 | F2
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| Highly polymorphic region of the human prothrombin (F2) gene.
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| Iwahana H, et al.
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| Hum Genet 89 : 123-124. 1992
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| 25 | F2
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| Detection of a new polymorphism of the human prothrombin (F2) gene by combination of PASA and mutated primer-mediated PCR-RFLP.
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| Iwahana H, et al.
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| Hum Genet 90 : 325-326. 1992
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| 26 | F2
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| Prothrombin Himi : a compound heterozygote for two dysfunctional prothrombin molecules (Met-337--Thr and Arg-388--His).
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| Morishita E, et al.
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| Blood 80 : 2275-2280. 1992
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| 27 | F2
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| NcoI RFLP in the human prothrombin (F2) gene.
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| Iwahana H, et al.
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| Nucleic Acids Res 19 : 4309. 1991
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| 28 | F2
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| Polymorphism detected by multiple RENS in the human coagulation factor II (F2) gene.
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| McAlpine PJ, et al.
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| Nucleic Acids Res 19 : 193. 1991
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| 29 | F2
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| RFLP for the human prothrombin (F2) gene.
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| de Vetten M, et al.
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| Nucleic Acids Res 18 : 5917. 1990
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| 30 | CP, CPP, F2, F5TPH, F12
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| Regional assignment for the human genes encoding FII, FV, FXII, ceruloplasmin and pseudoceruloplasmin.
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| Riddell DC, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 682. 1987
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| 31 | F2, CP, CPL1
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| Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively.
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| Royle NJ, et al.
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| Somat Cell Mol Genet 13 : 285-292. 1987
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| 32 | F2, F5TPH, F7, VWF, F10, F11, F12, F13A1, F13B, FG@
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| The genetics of blood coagulation.
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| Graham JB, et al.
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| Adv Hum Genet 13 : 1-65. 1983
|