Citations for
1EZH1, EZH2
Oncogenic roles of enhancer of zeste homolog 1/2 in hematological malignancies.
Nakagawa M, Kitabayashi I.
Cancer Sci 109(8):2342-2348. doi: 10.1111/cas.13655. Epub 2018 Jun 27. Review. 2018
2AKT3, BRWD3, CLOVES, DNMT3A, DNMT3OGS, EZH2, GPC3, HIST1H1E, MCAUTS, MPPH2, MRD35, MRX93, MSMR, MSMS, MTOR, NFIX, NSD1, OGID1, PIK3CA, PPP2R5D, PTEN, SGBS, STOL1, WVSS1, WVSS2
Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability.
Tatton-Brown K, Loveday C, Yost S, Clarke M, Ramsay E, Zachariou A, Elliott A, Wylie H, Ardissone A, Rittinger O, Stewart F, Temple IK, Cole T; Childhood Overgrowth Collaboration, Mahamdallie S, Seal S, Ruark E, Rahman N.
Am J Hum Genet 100(5):725-736. doi: 10.1016/j.ajhg.2017.03.010. 2017
3EZH1, EZH2
Divergent Requirements for EZH1 in Heart Development Versus Regeneration.
Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, Tao G, Li C, Pu WT, He A.
Circ Res 121(2):106-112. doi: 10.1161/CIRCRESAHA.117.311212. Epub 2017 May 16. 2017
4EZH2, MUS81
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Rondinelli B, Gogola E, Yücel H, Duarte AA, van de Ven M, van der Sluijs R, Konstantinopoulos PA, Jonkers J, Ceccaldi R, Rottenberg S, D'Andrea AD.
Nat Cell Biol 19(11):1371-1378. doi: 10.1038/ncb3626. Epub 2017 Oct 16. 2017
5BBC3, EZH2
EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis.
Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, Tan S, Yuan Y, Liu L, Wang J, Zhou X, Yang Y.
Oncotarget 7(35):56338-56354. doi: 10.18632/oncotarget.10841. 2016
6EZH1, EZH2
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy.
Lui JC, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, Jee YH, Landman E, Nilsson O, Barnes KM, Baron J.
Nat Commun 7:13685. doi: 10.1038/ncomms13685. 2016
7EZH2, NOS2
Epigenetic suppression of iNOS expression in human endothelial cells: A potential role of Ezh2-mediated H3K27me3.
Dreger H, Ludwig A, Weller A, Baumann G, Stangl V, Stangl K.
Genomics 107(4):145-9. doi: 10.1016/j.ygeno.2016.02.002. Epub 2016 Feb 4. 2016
8EZH2, MORC2, SORBS2
Microchidia protein 2, MORC2, downregulates the cytoskeleton adapter protein, ArgBP2, via histone methylation in gastric cancer cells.
Tong Y, Li Y, Gu H, Wang C, Liu F, Shao Y, Li J, Cao L, Li F.
Biochem Biophys Res Commun 467(4):821-7. doi: 10.1016/j.bbrc.2015.10.059. Epub 2015 Oct 22. 2015
9EZH1, EZH2
Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.
Mochizuki-Kashio M, Aoyama K, Sashida G, Oshima M, Tomioka T, Muto T, Wang C, Iwama A.
Blood 126(10):1172-83. doi: 10.1182/blood-2015-03-634428. Epub 2015 Jul 28. 2015
10EZH1, EZH2
The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration.
Bae WK, Kang K, Yu JH, Yoo KH, Factor VM, Kaji K, Matter M, Thorgeirsson S, Hennighausen L.
FASEB J 29(5):1653-62. doi: 10.1096/fj.14-261537. Epub 2014 Dec 4. 2015
11EZH2, KDM6A
EZH2 and KDM6A Act as an Epigenetic Switch to Regulate Mesenchymal Stem Cell Lineage Specification.
Hemming S, Cakouros D, Isenmann S, Cooper L, Menicanin D, Zannettino A, Gronthos S.
Stem Cells 32(3):802-15. doi: 10.1002/stem.1573. 2014
12EZH2, NFIB
NFIB-mediated repression of the epigenetic factor Ezh2 regulates cortical development.
Piper M, Barry G, Harvey TJ, McLeay R, Smith AG, Harris L, Mason S, Stringer BW, Day BW, Wray NR, Gronostajski RM, Bailey TL, Boyd AW, Richards LJ.
J Neurosci 34(8):2921-30. doi: 10.1523/JNEUROSCI.2319-13.2014. 2014
13EZH2, POU3F3
Increased levels of the long intergenic non-protein coding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells.
Li W, Zheng J, Deng J, You Y, Wu H, Li N, Lu J, Zhou Y.
Gastroenterology 146(7):1714-26.e5. doi: 10.1053/j.gastro.2014.03.002. Epub 2014 Mar 12. 2014
14EZH2, MST1, SAFB
Scaffold attachment factor B1 regulates the androgen receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2.
Mukhopadhyay NK, Kim J, You S, Morello M, Hager MH, Huang WC, Ramachandran A, Yang J, Cinar B, Rubin MA, Adam RM, Oesterreich S, Di Vizio D, Freeman MR.
Oncogene ncogene. 2013 Jul 29. doi: 10.1038/onc.2013.294. [Epub ahead of print] 2013
15EZH2, WHSC1
Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer.
Asangani IA, Ateeq B, Cao Q, Dodson L, Pandhi M, Kunju LP, Mehra R, Lonigro RJ, Siddiqui J, Palanisamy N, Wu YM, Cao X, Kim JH, Zhao M, Qin ZS, Iyer MK, Maher CA, Kumar-Sinha C, Varambally S, Chinnaiyan AM.
Mol Cell 49(1):80-93. doi: 10.1016/j.molcel.2012.10.008. Epub 2012 Nov 15. 2013
16EZH2, SOX4
Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming.
Tiwari N, Tiwari VK, Waldmeier L, Balwierz PJ, Arnold P, Pachkov M, Meyer-Schaller N, Schübeler D, van Nimwegen E, Christofori G.
Cancer Cell 23(6):768-83. doi: 10.1016/j.ccr.2013.04.020. 2013
17EZH1, EZH2
Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin.
Son J, Shen SS, Margueron R, Reinberg D.
Genes Dev 27(24):2663-77. doi: 10.1101/gad.225888.113. Erratum in: Genes Dev. 2014 Apr 15;28(8):921. 2013
18EZH2, WVSS2
Mutations in EZH2 Cause Weaver Syndrome.
Gibson WT, Hood RL, Zhan SH, Bulman DE, Fejes AP, Moore R, Mungall AJ, Eydoux P, Babul-Hirji R, An J, Marra MA; FORGE Canada Consortium, Chitayat D, Boycott KM, Weaver DD, Jones SJ.
Am J Hum Genet 90(1):110-8. Epub 2011 Dec 15. 2012
19EZH2, GATA1, HES1
GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis.
Ross J, Mavoungou L, Bresnick EH, Milot E.
Mol Cell Biol 32(18):3624-38. doi: 10.1128/MCB.00163-12. Epub 2012 Jul 9. 2012
20EZH2, SIX1
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG.
Nat Genet 44(3):343-7. doi: 10.1038/ng.1068. 2012
21EZH2
RAS oncogenic signal upregulates EZH2 in pancreatic cancer.
Fujii S, Fukamachi K, Tsuda H, Ito K, Ito Y, Ochiai A.
Biochem Biophys Res Commun 417(3):1074-9. doi: 10.1016/j.bbrc.2011.12.099. Epub 2011 Dec 26. 2012
22EZH1, EZH2
Polycomb protein Ezh1 promotes RNA polymerase II elongation.
Mousavi K, Zare H, Wang AH, Sartorelli V.
Mol Cell 45(2):255-62. doi: 10.1016/j.molcel.2011.11.019. Epub 2011 Dec 22. 2012
23EZH2, KLF2
Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer.
Taniguchi H, Jacinto FV, Villanueva A, Fernandez AF, Yamamoto H, Carmona FJ, Puertas S, Marquez VE, Shinomura Y, Imai K, Esteller M.
Oncogene 31(15):1988-94. doi: 10.1038/onc.2011.387. Epub 2011 Sep 5. 2012
24EZH2, SUV39H1, UHRF1
The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression.
Babbio F, Pistore C, Curti L, Castiglioni I, Kunderfranco P, Brino L, Oudet P, Seiler R, Thalman GN, Roggero E, Sarti M, Pinton S, Mello-Grand M, Chiorino G, Catapano CV, Carbone GM, Bonapace IM.
Oncogene 31(46):4878-87. doi: 10.1038/onc.2011.641. Epub 2012 Feb 13. 2012
25EZH2
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.
McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS, Liu Y, Graves AP, Della Pietra A 3rd, Diaz E, LaFrance LV, Mellinger M, Duquenne C, Tian X, Kruger RG, McHugh CF, Brandt M, Miller WH, Dhanak D, Verma SK, Tummino PJ, Creasy CL.
Nature 492(7427):108-12. doi: 10.1038/nature11606. Epub 2012 Oct 10. 2012
26EZH2
MEK-ERK pathway regulates EZH2 overexpression in association with aggressive breast cancer subtypes.
Fujii S, Tokita K, Wada N, Ito K, Yamauchi C, Ito Y, Ochiai A.
Oncogene 30(39):4118-28. doi: 10.1038/onc.2011.118. Epub 2011 Apr 18. 2011
27EZH2, PIP5K1C
EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling.
Yu YL, Chou RH, Chen LT, Shyu WC, Hsieh SC, Wu CS, Zeng HJ, Yeh SP, Yang DM, Hung SC, Hung MC.
J Biol Chem 286(11):9657-67. Epub 2011 Jan 7. 2011
28EZH2, MKI67
Enhancer of zeste homologue 2 expression in breast carcinoma smears in relationship with p53, Ki-67 and other prognostic parameters.
Athanassiadou AM, Tsipis A, Patsouris E, Gonidi M, Nicolopoulou-Stamati P, Chelidonis G, Athanassiadou P.
Acta Cytol 55(2):180-6. Epub 2011 Feb 15. 2011
29EZH1, EZH2
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.
Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E.
Genes Dev 25(5):485-98. Epub 2011 Feb 11. 2011
30EZH2
Enhancer of zeste homolog 2: A potential target for tumor therapy.
Xiao Y.
Int J Biochem Cell Biol 43(4):474-7. Epub 2011 Jan 15. Review. 2011
31EZH2, FGF2, KDM2B
FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway.
Kottakis F, Polytarchou C, Foltopoulou P, Sanidas I, Kampranis SC, Tsichlis PN.
Mol Cell 43(2):285-98. 2011
32EZH2
Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.
Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S.
Development. 138(17):3759-67. 2011
33CDKN2A, EZH2, PDGFA, PDGFRA, PDGFRB
PDGF signalling controls age-dependent proliferation in pancreatic β-cells.
Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, Schorle H, Sage J, Kim SK.
Nature 478(7369):349-55. doi: 10.1038/nature10502. 2011
34CDKN1C, EZH2
EZH2 regulates expression of p57 and contributes to progression of ovarian cancer in vitro and in vivo.
Guo J, Cai J, Yu L, Tang H, Chen C, Wang Z.
Cancer Sci 102(3):530-9. doi: 10.1111/j.1349-7006.2010.01836.x. Epub 2011 Jan 18. 2011
35EZH2
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states.
Wigle TJ, Knutson SK, Jin L, Kuntz KW, Pollock RM, Richon VM, Copeland RA, Scott MP.
FEBS Lett 585(19):3011-4. doi: 10.1016/j.febslet.2011.08.018. Epub 2011 Aug 17. 2011
36EZH2
EZH2 mutational status predicts poor survival in myelofibrosis.
Guglielmelli P, Biamonte F, Score J, Hidalgo-Curtis C, Cervantes F, Maffioli M, Fanelli T, Ernst T, Winkelman N, Jones AV, Zoi K, Reiter A, Duncombe A, Villani L, Bosi A, Barosi G, Cross NC, Vannucchi AM.
Blood 118(19):5227-34. doi: 10.1182/blood-2011-06-363424. Epub 2011 Sep 14. 2011
37DNMT3A, EZH2, KDM6A
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.
Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F, Visconte V, Sugimoto Y, Prince C, O'Keefe C, Hsi ED, List A, Sekeres MA, Rao A, McDevitt MA, Maciejewski JP.
Blood 118(14):3932-41. doi: 10.1182/blood-2010-10-311019. Epub 2011 Aug 9. 2011
38EZH2
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.
Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, Paul JE, Boyle M, Woolcock BW, Kuchenbauer F, Yap D, Humphries RK, Griffith OL, Shah S, Zhu H, Kimbara M, Shashkin P, Charlot JF, Tcherpakov M, Corbett R, Tam A, Varhol R, Smailus D, Moksa M, Zhao Y, Delaney A, Qian H, Birol I, Schein J, Moore R, Holt R, Horsman DE, Connors JM, Jones S, Aparicio S, Hirst M, Gascoyne RD, Marra MA.
Nat Genet 42(2):181-5. Epub 2010 Jan 17. 2010
39CDK1, CDK2, EZH2
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.
Chen S, Bohrer LR, Rai AN, Pan Y, Gan L, Zhou X, Bagchi A, Simon JA, Huang H.
Nat Cell Biol 2010 Oct 10. [Epub ahead of print]PMID: 20935635 2010
40EZH2
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.
Nikoloski G, Langemeijer SM, Kuiper RP, Knops R, Massop M, Tönnissen ER, van der Heijden A, Scheele TN, Vandenberghe P, de Witte T, van der Reijden BA, Jansen JH.
Nat Genet 42(8):665-7. Epub 2010 Jul 4.PMID: 20601954 2010
41EED, EZH2, RBBP4, SUZ12
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.
Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, Waghorn K, Zoi K, Ross FM, Reiter A, Hochhaus A, Drexler HG, Duncombe A, Cervantes F, Oscier D, Boultwood J, Grand FH, Cross NC.
Nat Genet 42(8):722-6. Epub 2010 Jul 4.PMID: 20601953 2010
42EZH2, SLIT2
The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer.
Yu J, Cao Q, Yu J, Wu L, Dallol A, Li J, Chen G, Grasso C, Cao X, Lonigro RJ, Varambally S, Mehra R, Palanisamy N, Wu JY, Latif F, Chinnaiyan AM.
Oncogene 29(39):5370-80. Epub 2010 Jul 12. 2010
43EZH2
Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.
Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ.
Proc Natl Acad Sci U S A 107(36):15957-62. Epub 2010 Aug 23.PMID: 20798045 2010
44EED, EZH2, RBBP7, SUZ12
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, MacKenzie F, Pan P, Li SS, Wang H, Min J.
Proc Natl Acad Sci U S A 107(45):19266-71. Epub 2010 Oct 25. 2010
45EZH2
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.
Velichutina I, Shaknovich R, Geng H, Johnson NA, Gascoyne RD, Melnick AM, Elemento O.
Blood 116(24):5247-55. Epub 2010 Aug 24. 2010
46EZH2
EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation.
Richter GH, Plehm S, Fasan A, Rössler S, Unland R, Bennani-Baiti IM, Hotfilder M, Löwel D, von Luettichau I, Mossbrugger I, Quintanilla-Martinez L, Kovar H, Staege MS, Müller-Tidow C, Burdach S.
Proc Natl Acad Sci U S A 106(13):5324-9. Epub 2009 Mar 16. 2009
47BRCA1, EZH2
Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1.
Gonzalez ME, Li X, Toy K, DuPrie M, Ventura AC, Banerjee M, Ljungman M, Merajver SD, Kleer CG.
Oncogene 28(6):843-53. Epub 2008 Dec 15. 2009
48BRDT, EZH2, MBD1, MBD2, MBD3L1, PWRN1, PWRN2, SUV39H2
Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis.
Wawrzik M, Spiess AN, Herrmann R, Buiting K, Horsthemke B.
Eur J Hum Genet 17(11):1463-70. Epub 2009 May 27.PMID: 19471314 2009
49EZH2
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.
Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN.
Proc Natl Acad Sci U S A. 106(8):2641-6. 2009
50EZH2
Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia.
Li X, Gonzalez ME, Toy K, Filzen T, Merajver SD, Kleer CG.
Am J Pathol. 175(3):1246-54. 2009
51EZH2
Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.
Chen H, Gu X, Su IH, Bottino R, Contreras JL, Tarakhovsky A, Kim SK.
Genes Dev. 23(8):975-85. 2009
52EZH2, RUNX3
Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation.
Fujii S, Ito K, Ito Y, Ochiai A.
J Biol Chem 283(25):17324-32. Epub 2008 Apr 22. 2008
53EED, EZH2, PHF1
Role of hPHF1 in H3K27 methylation and Hox gene silencing.
Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, Zhang Y.
Mol Cell Biol 28(5):1862-72. Epub 2007 Dec 17.PMID: 18086877 2008
54EZH2
EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor.
Hwang C, Giri VN, Wilkinson JC, Wright CW, Wilkinson AS, Cooney KA, Duckett CS.
Breast Cancer Res Treat. 107(2):235-42. 2008
55EZH1, EZH2
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.
Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL, Dynlacht BD, Reinberg D.
Mol Cell 32(4):503-18. 2008
56EZH2, MSMB
The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2.
Beke L, Nuytten M, Van Eynde A, Beullens M, Bollen M.
Oncogene 26(31):4590-5. Epub 2007 Jan 22. 2007
57EZH2
The transcriptional repression by NIPP1 is mediated by Polycomb group proteins.
Roy N, Van Eynde A, Beke L, Nuytten M, Bollen M.
Biochim Biophys Acta. 1769(9-10):541-5. 2007
58EZH2
The Polycomb group protein EZH2 directly controls DNA methylation.
Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y, Fuks F.
Nature 439(7078):871-4. Epub 2005 Dec 14. 2006
59EZH2
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast.
Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA, Salvesen HB, Otte AP, Akslen LA.
J Clin Oncol 24(2):268-73. Epub 2005 Dec 5. 2006
60EZH2
Polycomb group protein ezh2 controls actin polymerization and cell signaling.
Su IH, Dobenecker MW, Dickinson E, Oser M, Basavaraj A, Marqueron R, Viale A, Reinberg D, Wulfing C, Tarakhovsky A.
Cell 121(3):425-36. 2005
61EZH2, AKT1
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC.
Science 310(5746):306-10. 2005
62EZH2
Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancer.
Bachmann N, Hoegel J, Haeusler J, Kuefer R, Herkommer K, Paiss T, Vogel W, Maier C.
Prostate 65(3):252-9. 2005
63EZH2
Polycomb group protein ezh2 controls actin polymerization and cell signaling.
Su IH, Dobenecker MW, Dickinson E, Oser M, Basavaraj A, Marqueron R, Viale A, Reinberg D, Wülfing C, Tarakhovsky A.
Cell. 121(3):425-36. 2005
64E2F6, EPC1, EZH2
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.
Attwooll C, Oddi S, Cartwright P, Prosperini E, Agger K, Steensgaard P, Wagener C, Sardet C, Moroni MC, Helin K.
J Biol Chem 280(2):1199-208. Epub 2004 Nov 8.PMID: 15536069 2005
65EZH2
Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A.
Tonini T, Bagella L, D'Andrilli G, Claudio PP, Giordano A.
Oncogene. 23(28):4930-7. 2004
66EZH2
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.
Cao R, Zhang Y.
Mol Cell. 15(1):57-67. 2004
67EZH2
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.
Caretti G, Di Padova M, Micales B, Lyons GE, Sartorelli V.
Genes Dev. 18(21):2627-38. 2004
68EZH2
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells.
Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, Ghosh D, Sewalt RG, Otte AP, Hayes DF, Sabel MS, Livant D, Weiss SJ, Rubin MA, Chinnaiyan AM.
Proc Natl Acad Sci U S A 100(20):11606-11. Epub 2003 Sep 19. 2003
69EZH2
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.
Su IH, Basavaraj A, Krutchinsky AN, Hobert O, Ullrich A, Chait BT, Tarakhovsky A.
Nat Immunol. 4(2):124-31 2003
70EZH2
Cancer: The silence of the genes.
Zetter BR, Banyard J.
Nature 419(6907):572-3. No abstract available. 2002
71EZH2
The polycomb group protein EZH2 is involved in progression of prostate cancer.
Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM.
Nature 419(6907):624-9. 2002
72EZH2
The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma.
Visser HP, Gunster MJ, Kluin-Nelemans HC, Manders EM, Raaphorst FM, Meijer CJ, Willemze R, Otte AP.
Br J Haematol 112(4):950-8. 2001
73EZH2
Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein.
O'Connell S, Wang L, Robert S, Jones CA, Saint R, Jones RS.
J Biol Chem. 276(46):43065-73. 2001
74EZH2, EZH2P
The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders.
Cardoso C, Mignon C, Hetet G, Grandchamps B, Fontes M, Colleaux L.
Eur J Hum Genet 8(3):174-80. 2000
75EZH2, ATRX
Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.
Cardoso C, et al.
Hum Mol Genet 7 : 679-684. 1998
76EZH2
Cloning and expression of a human/mouse polycomb group gene, ENX-2/Enx-2.
Ogawa M, Hiraoka Y, Taniguchi K, Aiso S.
Biochim Biophys Acta 1395(2):151-8. 1998
77EED, EZH2
Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.
Sewalt RG, van der Vlag J, Gunster MJ, Hamer KM, den Blaauwen JL, Satijn DP, Hendrix T, van Driel R, Otte AP.
Mol Cell Biol 18(6):3586-95. 1998
78ATP5O, EZH2, HLCS, LSS, NCAM2, PCNT, PWP2, U2AF1
Characterization of chromosome 21 genes; progress report. (abstr)
Antonarakis SE, et al.
Cytogenet Cell Genet 79 : 40. 1997
79EZH1, EZH2
Characterization of EZH1, a human homolog of Drosophila enhancer of zeste near BRCA1.
Abel KJ, et al.
Genomics 37 : 161-171. 1996
80EZH2
Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2.
Chen H, et al.
Genomics 38 : 30-37. 1996
81EZH2
Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.
Hobert O, Jallal B, Ullrich A.
Mol Cell Biol. 16(6):3066-73. 1996