1 | EXOC4, EXOC5
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| Disruption of the exocyst induces podocyte loss and dysfunction.
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| Nihalani D, Solanki AK, Arif E, Srivastava P, Rahman B, Zuo X, Dang Y, Fogelgren B, Fermin D, Gillies CE, Sampson MG, Lipschutz JH.
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| J Biol Chem 294(26):10104-10119. doi: 10.1074/jbc.RA119.008362. Epub 2019 May 9.
2019
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2 | EPS8L2, EXOC4, EXOC5
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| Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content
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| Zuo X, Kwon SH, Janech MG, Dang Y, Lauzon SD, Fogelgren B, Polgar N, Lipschutz JH.
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| J Biol Chem. Dec 13;294(50):19099-19110. doi: 10.1074/jbc.RA119.009297. Epub 2019 Nov 6. 2019
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3 | CREG1, EXOC4
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| CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion.
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| [
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| Stem Cells 36(1):130. doi: 10.1002/stem.2728. Epub 2017 Nov 7. No abstract available.
2018
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4 | CDH2, EXOC4, SMAD3, SMAD4
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| Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4.
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| Tanaka T, Goto K, Iino M.
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| Cell Signal 29:115-126. doi: 10.1016/j.cellsig.2016.10.007. Epub 2016 Oct 18.
2017
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5 | BCL2, EXOC3, EXOC4, MCL1
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| Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.
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| Tanaka T, Kikuchi N, Goto K, Iino M.
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| Apoptosis 21(5):594-608. doi: 10.1007/s10495-016-1230-9.
2016
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6 | CREG1, EXOC4
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| CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion.
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| Liu J, Qi Y, Li S, Hsu SC, Saadat S, Hsu J, Rahimi SA, Lee LY, Yan C, Tian X, Han Y.
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| Stem Cells 34(11):2648-2660. doi: 10.1002/stem.2434. Epub 2016 Jul 8. Erratum in: Stem Cells. 2018 Jan;36(1):130.
2016
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7 | EXOC4
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| Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.
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| Torres MJ, Pandita RK, Kulak O, Kumar R, Formstecher E, Horikoshi N, Mujoo K, Hunt CR, Zhao Y, Lum L, Zaman A, Yeaman C, White MA, Pandita TK.
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| Mol Cell Biol 35(21):3633-45. doi: 10.1128/MCB.00768-15. Epub 2015 Aug 17.
2015
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8 | EXOC4, KRT8
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| Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways.
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| Tanaka T, Iino M.
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| Cell Signal 27(6):1110-9. doi: 10.1016/j.cellsig.2015.02.015. Epub 2015 Feb 26.
2015
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9 | EXOC4
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| Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.
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| Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.
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| J Cancer Res Clin Oncol 139(4):533-42. doi: 10.1007/s00432-012-1356-2. Epub 2012 Dec 4.
2013
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10 | EXOC3L2, EXOC4
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| Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells.
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| Barkefors I, Fuchs PF, Heldin J, Bergström T, Forsberg-Nilsson K, Kreuger J.
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| J Biol Chem 286(27):24189-99. Epub 2011 May 12.
2011
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11 | DLG1, EXOC4, MTMR2
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| Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination.
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| Bolis A, Coviello S, Visigalli I, Taveggia C, Bachi A, Chishti AH, Hanada T, Quattrini A, Previtali SC, Biffi A, Bolino A.
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| J Neurosci 29(27):8858-70.PMID: 19587293 2009
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12 | EXOC4
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| Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.
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| Lyons PD, Peck GR, Kettenbach AN, Gerber SA, Roudaia L, Lienhard GE.
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| Biosci Rep 29(4):229-35.PMID: 19006485 2009
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13 | EXOC1, EXOC4, IQGAP1
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| The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.
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| Sakurai-Yageta M, Recchi C, Le Dez G, Sibarita JB, Daviet L, Camonis J, D'Souza-Schorey C, Chavrier P.
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| J Cell Biol 181(6):985-98. Epub 2008 Jun 9.PMID: 18541705 2008
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14 | EXOC2, EXOC3, EXOC4
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| Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis.
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| Tsuboi T, Ravier MA, Xie H, Ewart MA, Gould GW, Baldwin SA, Rutter GA.
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| J Biol Chem 280(27):25565-70. Epub 2005 May 3.PMID: 15878854 2005
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15 | DLG4, EXOC4, PSD95
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| Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor).
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| Riefler GM, Balasingam G, Lucas KG, Wang S, Hsu SC, Firestein BL.
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| Biochem J 373(Pt 1):49-55. 2003
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16 | EXOC1, EXOC3, EXOC4, EXOC7
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| The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.
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| Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR.
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| Nature 422(6932):629-33.PMID: 12687004 2003
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17 | EXOC3, EXOC4, EXOC8
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| Ral GTPases regulate exocyst assembly through dual subunit interactions.
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| Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA.
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| J Biol Chem 278(51):51743-8. Epub 2003 Oct 2.PMID: 14525976 2003
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18 | ACAP3, AMBRA1, CMIP, CNTNAP3, CNTNAP4, CPEB4, DAB2IP, DDHD1, DISP2, EEPD1, EXOC4, FAM40A, HELZ2, ITPRIP, KIAA1683, KIAA1712, KIAA1715, KIAA1737, KIAA1751, KIAA1755, KIF21A, MTMR12, PHACTR1, PHF21A, PRDM16, RAPH1, RHOXF1, SEMA4B, SEMA4C, SET7, SH3BP5L, SPHKAP, SSH2, TET1, TEX2, TNKS1BP1, UBE2O, UNC13A, UNK, WNK2, ZCCHC2, ZFHX2, ZNF407, ZNF436
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| Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
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| Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O.
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| DNA Res 7(6):347-55. 2000
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19 | EXOC3, EXOC4
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| Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments.
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| Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH.
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| Neuron 20(6):1111-22.PMID: 9655500 1998
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