Citations for
1EXOC4, EXOC5
Disruption of the exocyst induces podocyte loss and dysfunction.
Nihalani D, Solanki AK, Arif E, Srivastava P, Rahman B, Zuo X, Dang Y, Fogelgren B, Fermin D, Gillies CE, Sampson MG, Lipschutz JH.
J Biol Chem 294(26):10104-10119. doi: 10.1074/jbc.RA119.008362. Epub 2019 May 9. 2019
2EPS8L2, EXOC4, EXOC5
Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content
Zuo X, Kwon SH, Janech MG, Dang Y, Lauzon SD, Fogelgren B, Polgar N, Lipschutz JH.
J Biol Chem. Dec 13;294(50):19099-19110. doi: 10.1074/jbc.RA119.009297. Epub 2019 Nov 6. 2019
3CREG1, EXOC4
CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion.
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Stem Cells 36(1):130. doi: 10.1002/stem.2728. Epub 2017 Nov 7. No abstract available. 2018
4CDH2, EXOC4, SMAD3, SMAD4
Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4.
Tanaka T, Goto K, Iino M.
Cell Signal 29:115-126. doi: 10.1016/j.cellsig.2016.10.007. Epub 2016 Oct 18. 2017
5BCL2, EXOC3, EXOC4, MCL1
Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.
Tanaka T, Kikuchi N, Goto K, Iino M.
Apoptosis 21(5):594-608. doi: 10.1007/s10495-016-1230-9. 2016
6CREG1, EXOC4
CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion.
Liu J, Qi Y, Li S, Hsu SC, Saadat S, Hsu J, Rahimi SA, Lee LY, Yan C, Tian X, Han Y.
Stem Cells 34(11):2648-2660. doi: 10.1002/stem.2434. Epub 2016 Jul 8. Erratum in: Stem Cells. 2018 Jan;36(1):130. 2016
7EXOC4
Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.
Torres MJ, Pandita RK, Kulak O, Kumar R, Formstecher E, Horikoshi N, Mujoo K, Hunt CR, Zhao Y, Lum L, Zaman A, Yeaman C, White MA, Pandita TK.
Mol Cell Biol 35(21):3633-45. doi: 10.1128/MCB.00768-15. Epub 2015 Aug 17. 2015
8EXOC4, KRT8
Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways.
Tanaka T, Iino M.
Cell Signal 27(6):1110-9. doi: 10.1016/j.cellsig.2015.02.015. Epub 2015 Feb 26. 2015
9EXOC4
Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.
Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.
J Cancer Res Clin Oncol 139(4):533-42. doi: 10.1007/s00432-012-1356-2. Epub 2012 Dec 4. 2013
10EXOC3L2, EXOC4
Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells.
Barkefors I, Fuchs PF, Heldin J, Bergström T, Forsberg-Nilsson K, Kreuger J.
J Biol Chem 286(27):24189-99. Epub 2011 May 12. 2011
11DLG1, EXOC4, MTMR2
Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination.
Bolis A, Coviello S, Visigalli I, Taveggia C, Bachi A, Chishti AH, Hanada T, Quattrini A, Previtali SC, Biffi A, Bolino A.
J Neurosci 29(27):8858-70.PMID: 19587293 2009
12EXOC4
Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.
Lyons PD, Peck GR, Kettenbach AN, Gerber SA, Roudaia L, Lienhard GE.
Biosci Rep 29(4):229-35.PMID: 19006485 2009
13EXOC1, EXOC4, IQGAP1
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.
Sakurai-Yageta M, Recchi C, Le Dez G, Sibarita JB, Daviet L, Camonis J, D'Souza-Schorey C, Chavrier P.
J Cell Biol 181(6):985-98. Epub 2008 Jun 9.PMID: 18541705 2008
14EXOC2, EXOC3, EXOC4
Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis.
Tsuboi T, Ravier MA, Xie H, Ewart MA, Gould GW, Baldwin SA, Rutter GA.
J Biol Chem 280(27):25565-70. Epub 2005 May 3.PMID: 15878854 2005
15DLG4, EXOC4, PSD95
Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor).
Riefler GM, Balasingam G, Lucas KG, Wang S, Hsu SC, Firestein BL.
Biochem J 373(Pt 1):49-55. 2003
16EXOC1, EXOC3, EXOC4, EXOC7
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.
Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR.
Nature 422(6932):629-33.PMID: 12687004 2003
17EXOC3, EXOC4, EXOC8
Ral GTPases regulate exocyst assembly through dual subunit interactions.
Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA.
J Biol Chem 278(51):51743-8. Epub 2003 Oct 2.PMID: 14525976 2003
18ACAP3, AMBRA1, CMIP, CNTNAP3, CNTNAP4, CPEB4, DAB2IP, DDHD1, DISP2, EEPD1, EXOC4, FAM40A, HELZ2, ITPRIP, KIAA1683, KIAA1712, KIAA1715, KIAA1737, KIAA1751, KIAA1755, KIF21A, MTMR12, PHACTR1, PHF21A, PRDM16, RAPH1, RHOXF1, SEMA4B, SEMA4C, SET7, SH3BP5L, SPHKAP, SSH2, TET1, TEX2, TNKS1BP1, UBE2O, UNC13A, UNK, WNK2, ZCCHC2, ZFHX2, ZNF407, ZNF436
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O.
DNA Res 7(6):347-55. 2000
19EXOC3, EXOC4
Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments.
Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH.
Neuron 20(6):1111-22.PMID: 9655500 1998