Citations for
1ATF1, EWSR1
Hyalinizing clear cell carcinoma with EWSR1-ATF1 fusion gene: report of three cases with molecular analyses.
Nakano T, Yamamoto H, Nishijima T, Tamiya S, Shiratsuchi H, Nakashima T, Komune S, Oda Y.
Virchows Arch 466(1):37-43. doi: 10.1007/s00428-014-1676-5. Epub 2014 Oct 31. 2015
2EWSR1
The diversity of soft tissue tumours with EWSR1 gene rearrangements: a review.
Fisher C.
Histopathology 64(1):134-50. doi: 10.1111/his.12269. Epub 2013 Nov 6. 2014
3ETV1, EWSR1, FGF10
Etv1 and Ewsr1 cooperatively regulate limb mesenchymal Fgf10 expression in response to apical ectodermal ridge-derived fibroblast growth factor signal.
Yamamoto-Shiraishi Y, Higuchi H, Yamamoto S, Hirano M, Kuroiwa A.
Dev Biol 394(1):181-90. doi: 10.1016/j.ydbio.2014.07.022. Epub 2014 Aug 7. 2014
4EWSR1, FUS
A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins.
Thomsen C, Grundevik P, Elias P, Ståhlberg A, Aman P.
FASEB J 27(12):4965-74. doi: 10.1096/fj.13-234435. Epub 2013 Aug 23. 2013
5EWSR1
A multifunctional protein, EWS, is essential for early brown fat lineage determination.
Park JH, Kang HJ, Kang SI, Lee JE, Hur J, Ge K, Mueller E, Li H, Lee BC, Lee SB.
Dev Cell 26(4):393-404. doi: 10.1016/j.devcel.2013.07.002. 2013
6EWSR1, YY1
RNA sequencing identifies fusion of the EWSR1 and YY1 genes in mesothelioma with t(14;22)(q32;q12).
Panagopoulos I, Thorsen J, Gorunova L, Micci F, Haugom L, Davidson B, Heim S.
Genes Chromosomes Cancer 52(8):733-40. doi: 10.1002/gcc.22068. Epub 2013 Apr 30. 2013
7ATF1, EWSR1
EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice.
Yamada K, Ohno T, Aoki H, Semi K, Watanabe A, Moritake H, Shiozawa S, Kunisada T, Kobayashi Y, Toguchida J, Shimizu K, Hara A, Yamada Y.
J Clin Invest 123(2):600-10. doi: 10.1172/JCI63572. Epub 2013 Jan 2. 2013
8AKT1S1, EWSR1
PRAS40 is a functionally critical target for EWS repression in Ewing sarcoma.
Huang L, Nakai Y, Kuwahara I, Matsumoto K.
Cancer Res 72(5):1260-9. Epub 2012 Jan 12. 2012
9DDIT3, EWSR1
Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells.
Suzuki K, Matsui Y, Higashimoto M, Kawaguchi Y, Seki S, Motomura H, Hori T, Yahara Y, Kanamori M, Kimura T.
PLoS One 7(5):e36682. doi: 10.1371/journal.pone.0036682. Epub 2012 May 3. 2012
10EWSR1
Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.
Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee VM, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD.
Hum Mol Genet 21(13):2899-911. doi: 10.1093/hmg/dds116. Epub 2012 Mar 27. 2012
11EWSR1, FUS, TAF15
mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.
Spitzer JI, Ugras S, Runge S, Decarolis P, Antonescu C, Tuschl T, Singer S.
Genes Chromosomes Cancer 50(5):338-47. doi: 10.1002/gcc.20858. Epub 2011 Feb 22. 2011
12ATF1, EWSR1
EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland.
Antonescu CR, Katabi N, Zhang L, Sung YS, Seethala RR, Jordan RC, Perez-Ordoñez B, Have C, Asa SL, Leong IT, Bradley G, Klieb H, Weinreb I.
Genes Chromosomes Cancer 50(7):559-70. doi: 10.1002/gcc.20881. Epub 2011 Apr 11. 2011
13CREB3L1, EWSR1
A novel EWSR1-CREB3L1 fusion transcript in a case of small cell osteosarcoma.
Debelenko LV, McGregor LM, Shivakumar BR, Dorfman HD, Raimondi SC.
Genes Chromosomes Cancer 50(12):1054-62. doi: 10.1002/gcc.20923. Epub 2011 Aug 24. 2011
14ABL1, CHEK2, EWSR1, MAP4K2
The Ewing sarcoma protein regulates DNA damage-induced alternative splicing.
Paronetto MP, Miñana B, Valcárcel J.
Mol Cell 43(3):353-68. doi: 10.1016/j.molcel.2011.05.035. 2011
15EWSR1
Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence.
Cho J, Shen H, Yu H, Li H, Cheng T, Lee SB, Lee BC.
Blood 117(4):1156-66. doi: 10.1182/blood-2010-04-279349. Epub 2010 Oct 28. 2011
16EWSR1, FLI1, FOXO1
FOXO1 is a direct target of EWS-Fli1 oncogenic fusion protein in Ewing's sarcoma cells.
Yang L, Hu HM, Zielinska-Kwiatkowska A, Chansky HA.
Biochem Biophys Res Commun 402(1):129-34. doi: 10.1016/j.bbrc.2010.09.129. Epub 2010 Oct 8. 2010
17EWSR1, FLI1, GLI1
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.
Beauchamp E, Bulut G, Abaan O, Chen K, Merchant A, Matsui W, Endo Y, Rubin JS, Toretsky J, Uren A.
J Biol Chem 284(14):9074-82. Epub 2009 Feb 3. 2009
18EWSR1, FLI1
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.
Erkizan HV, Kong Y, Merchant M, Schlottmann S, Barber-Rotenberg JS, Yuan L, Abaan OD, Chou TH, Dakshanamurthy S, Brown ML, Uren A, Toretsky JA.
Nat Med 15(7):750-6. Epub 2009 Jul 5. 2009
19EWSR1, ZNF444
t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma.
Brandal P, Panagopoulos I, Bjerkehagen B, Heim S.
Genes Chromosomes Cancer 48(12):1051-6. 2009
20EWSR1, RHBDD3
Bidirectionality and transcriptional activity of the EWSR1 promoter region.
Möller E, Mandahl N, Iliszko M, Mertens F, Panagopoulos I.
Oncol Rep 21(3):641-8. 2009
21EWSR1, PBX1
Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma.
Brandal P, Panagopoulos I, Bjerkehagen B, Gorunova L, Skjeldal S, Micci F, Heim S.
Genes Chromosomes Cancer 47(7):558-64. 2008
22CCNL1, EWSR1, TFIP11
TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization.
Tannukit S, Wen X, Wang H, Paine ML.
Int J Mol Sci 9(8):1504-1514.PMID: 19122807 2008
23EWSR1, CREB1
EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma.
Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD, Ladanyi M.
Genes Chromosomes Cancer 46(12):1051-60. 2007
24EWSR1, POU5F1
The EWS-Oct-4 fusion gene encodes a transforming gene.
Lee J, Kim JY, Kang IY, Kim HK, Han YM, Kim J.
Biochem J 406(3):519-26.PMID: 17564582 2007
25EWSR1
Relevance of translocation type in myxoid liposarcoma and identification of a novel EWSR1-DDIT3 fusion.
Bode-Lesniewska B, Frigerio S, Exner U, Abdou MT, Moch H, Zimmermann DR.
Genes Chromosomes Cancer 46(11):961-71. 2007
26EWSR1
Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein.
Zakaryan RP, Gehring H.
J Mol Biol 363(1):27-38. Epub 2006 Aug 11. 2006
27EWSR1, POU5F1
EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12).
Yamaguchi S, Yamazaki Y, Ishikawa Y, Kawaguchi N, Mukai H, Nakamura T.
Genes Chromosomes Cancer 43(2):217-22. 2005
28ATF1, EWSR1
Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma.
Hallor KH, Mertens F, Jin Y, Meis-Kindblom JM, Kindblom LG, Behrendtz M, Kalen A, Mandahl N, Panagopoulos I.
Genes Chromosomes Cancer 44(1):97-102. 2005
29EWSR1, FLI1
Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells
Taslerova R, Kozubek S, Lukasova E, Jirsova P, Bartova E, Kozubek M.
Hum Genet 112(2):143-55. 2003
30ETS1, EWSR1, TNC
Induction of tenascin-C by tumor-specific EWS-ETS fusion genes.
Watanabe G, Nishimori H, Irifune H, Sasaki Y, Ishida S, Zembutsu H, Tanaka T, Kawaguchi S, Wada T, Hata J, Kusakabe M, Yoshida K, Nakamura Y, Tokino T.
Genes Chromosomes Cancer 36(3):224-32. 2003
31ATF1, EWSR1
Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses.
Panagopoulos I, Mertens F, Debiec-Rychter M, Isaksson M, Limon J, Kardas I, Domanski HA, Sciot R, Perek D, Crnalic S, Larsson O, Mandahl N.
Int J Cancer 99(4):560-7. 2002
32COL1A1, DDIT3, EWSR1, SUZ12, JAZF1, NR4A3, WT1
Cytogenetics and molecular genetics of bone and soft-tissue tumors.
Sandberg AA.
Am J Med Genet 115(3):189-93. 2002
33EWSR1, NR4A3, TAF15
Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma.
Panagopoulos I, Mertens F, Isaksson M, Domanski HA, Brosjo O, Heim S, Bjerkehagen B, Sciot R, Dal Cin P, Fletcher JA, Fletcher CD, Mandahl N.
Genes Chromosomes Cancer 35(4):340-52. 2002
34EWSR1, NR4A3
The EWS/NOR1 fusion gene product gains a novel activity affecting pre-mRNA splicing.
Ohkura N, Yaguchi H, Tsukada T, Yamaguchi K.
J Biol Chem 277(1):535-43. Epub 2001 Oct 22. 2002
35ID2, EWSR1, FLI1, ERG
The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.
Nishimori H, Sasaki Y, Yoshida K, Irifune H, Zembutsu H, Tanaka T, Aoyama T, Hosaka T, Kawaguchi S, Wada T, Hata J, Toguchida J, Nakamura Y, Tokino T.
Oncogene 21(54):8302-9. 2002
36EWSR1, TAF15, ZNF384
Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia.
Martini A, La Starza R, Janssen H, Bilhou-Nabera C, Corveleyn A, Somers R, Aventin A, Foà R, Hagemeijer A, Mecucci C, Marynen P.
Cancer Res 62(19):5408-12. 2002
37ERG, EWSR1
Fine-mapping of cytogenetically undetectable EWS/ERG fusions on DNA fibers of Ewing tumors.
Hattinger CM, Rumpler S, Kovar H, Ambros PF.
Cytogenet Cell Genet 93(1-2):29-35. 2001
38EWSR1, FEV, PATZ1
A novel zinc finger gene is fused to EWS in small round cell tumor.
Mastrangelo T, Modena P, Tornielli S, Bullrich F, Testi MA, Mezzelani A, Radice P, Azzarelli A, Pilotti S, Croce CM, Pierotti MA, Sozzi G.
Oncogene 19(33):3799-804. 2000
39NR4A3, EWSR1
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
Unger T, et al.
Oncogene 18(21):3205-12. 1999
40TGFBR2, EWSR1, FLI1
Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein.
Hahm KB, et al.
Nat Genet 23(2):222-7 1999
41EWSR1, EWSR1
Cryptic exons as a source of increased diversity of ewing tumor-associated EWS-FLI1 chimeric products.
Kovar H, et al.
Genomics 60(3):371-4 1999
42ATF1, EWSR1, EWSR1
New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts).
Pellin A, et al.
Genes Chromosomes Cancer 23 : 358-360. 1998
43ETV4, EWSR1, EWSR1
The genomic breakpoint and chimeric transcripts in the EWSR1-ETV4/E1AF gene fusion in Ewing sarcoma.
Ishida S, et al.
Cytogenet Cell Genet 82 : 278-283. 1998
44EWSR1, TAF15
EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes.
Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L.
Mol Cell Biol 18(3):1489-97. 1998
45ERG, EWSR1, EWSR1
EWS-ERG fusion transcript produced by chromosomal insertion in a Ewing sarcoma.
Kaneko Y, et al.
Genes Chromosomes Cancer 18 : 228-231. 1997
46DDIT3, ERG, EWSR1, FUS
Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia.
Panagopoulos I, Lassen C, Isaksson M, Mitelman F, Mandahl N, Aman P.
Oncogene 15(11):1357-62. 1997
47EWSR1
The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour.
Lee SB, et al.
Nat Genet 17 : 309-313. 1997
48EWSR1, NR4A3, MCHS
Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma.
Clark J, et al.
Oncogene 12 : 229-235. 1996
49EWSR1, FUS
Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.
Aman P, et al.
Genomics 37 : 1-8. 1996
50DSRCT, EWSR1, WT1
Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell Tumor.
Gerald WL, et al.
Proc Natl Acad Sci U S A 92 : 1028-1032. 1995
51NR4A3, EWSR1, MCHS
Fusion of the EWS gene to a DNA segment from 9q22-31 in a human myxoid chondrosarcoma.
Gill S, et al.
Genes Chromosomes Cancer 12 : 307-310. 1995
52EWSR1, FLI1
Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene.
Sorensen PH, et al.
Cancer Res 55 : 1385-1392. 1995
53ERG, EWSR1, EWSR1, FLI1
A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG.
Sorensen PHB, et al.
Nat Genet 6 : 146-151. 1994
54EWSR1, FLI1
DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma.
Bailly RA, et al.
Mol Cell Biol 14 : 3230-3241. 1994
55EWSR1, WT1
Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor.
Ladanyi M, et al.
Cancer Res 54 : 2837-2840. 1994
56EWSR1
The Ewing family of tumors - a subgroup of small-round-cell tumors defined by specific chimeric transcripts.
Delattre O, et al.
N Engl J Med 331 : 294-299. 1994
57EWSR1
The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains.
Ohno T, et al.
Oncogene 9 : 3087-3097. 1994
58EWSR1, FMR1, FXR1, FXR2, FYN, GRB2, HDLBP, HNRNPA1, HNRNPA2B1, NCL, PTBP1, RBMXP1, RBMY1A1, RBMY1A2, RBM3, SF1
Conserved structures and diversity of functions of RNA-binding proteins.
Burd CG, et al.
Science 265 : 615-621. 1994
59EWSR1
Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation.
Plougastel B, et al.
Genomics 18 : 609-615. 1993
60EWSR1, FLI1
EWS/FLi-1 chimeric protein is a transcriptional activator.
Ohno T, et al.
Cancer Res 53 : 5859-5863. 1993
61EWSR1, FLI1
Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.
May WA, et al.
Proc Natl Acad Sci U S A 90 : 5752-5756. 1993
62EWSR1, ATF1
Reciprocal translocation t(12;22)(q13;q13) in clear-cell sarcoma of tendons and aponeuroses.
Stenman G, et al.
Genes Chromosomes Cancer 4 : 122-127. 1993
63EWSR1, EWSR1, ATF1
EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts.
Zucman J, et al.
Nat Genet 4 : 341-345. 1993
64EWSR1
Ordering of probes surrounding the Ewing's sarcoma breakpoint on chromosome 22 using fluorescent in situ hybridization to interphase nuclei.
Giovannini M, et al.
Cytogenet Cell Genet 64 : 233-239. 1993
65EWSR1
Long-range restriction map of human chromosome 22q11-22q12 between the lambda immunoglobulin locus and the ewing sarcoma breakpoint.
McDermid HE, et al.
Genomics 18 : 308-318. 1993
66EWSR1, EWSR1, FLI1
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.
Delattre O, et al.
Nature 359 : 162-166. 1992
67EWSR1, FLI1
Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints.
Zucman J, et al.
Genes Chromosomes Cancer 5 : 271-277. 1992
68ATF1, EWSR1
Translocation (12;22) (q13-14;q12) is a nonrandom aberration in soft-tissue clear-cell sarcoma.
Fletcher JA.
Genes Chromosomes Cancer 5 : 184. 1992
69D22S165, D22S166, D22S167, D22S168, D22S169, EWSR1
New markers for the neurofibromatosis-2 region generated by microdissection of chromosome 22.
Fiedler W, et al.
Genomics 10 : 786-791. 1991
70EWSR1
Isolation and characterisation of YAC clones surrounding the Ewing's sarcoma translocation breakpoint on chromosome 22.
Patel K, et al.
(HGM11) Cytogenet Cell Genet 58 : 2050. 1991
71EWSR1
Cloning and mapping rare cutting sites surrounding the Ewing's sarcoma translocation breakpoint region on chromosome 22.
Shipley JM, et al.
(HGM11) Cytogenet Cell Genet 58 : 2051. 1991
72EWSR1
Cytogenetic analysis of primitive neuroectodermal tumours. Absence of the t(11;22) in two of three cases and a review of the literature.
Gorman PA, et al.
Cancer Genet Cytogenet 51 : 13-22. 1991
73EWSR1, FLI1, CBL, LIF
Molecular localization of the t(11;22)(q24;q12) translocation of Ewing sarcoma by chromosomal in situ suppression hybridization.
Selleri L, et al.
Proc Natl Acad Sci U S A 88 : 887-891. 1991
74EWSR1, FLI1
Chromosomes in Ewing's sarcoma. I.An evaluation of 85 cases and remarkable consistency of t(11;22)(q24;q12).
Turc-Carel C, et al.
Cancer Genet Cytogenet 32 : 229-238. 1988
75EWSR1, FLI1
Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12).
Turc-Carel C, et al.
Cancer Genet Cytogenet 12 : 1-19. 1984
76EWSR1, FLI1
Chromosome translocation in peripheral neuroepithelioma.
Whang-Peng J, et al.
N Engl J Med 311 : 584-585. 1984
77EWSR1, FLI1
Chromosomal translocations in Ewing's sarcoma.
Turc-Carel C, et al.
N Engl J Med 309 : 497-498. 1983