1 | ETV4, ETV5, GBX2, TCF15
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| ETS-related Transcription Factors ETV4 and ETV5 Are Involved in Proliferation and Induction of Differentiation-associated Genes in Embryonic Stem (ES) Cells.
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| Akagi T, Kuure S, Uranishi K, Koide H, Costantini F, Yokota T.
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| J Biol Chem 290(37):22460-73. doi: 10.1074/jbc.M115.675595. Epub 2015 Jul 29.
2015
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2 | ACACA, ACLY, ETV4
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| ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.
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| Keenan MM, Liu B, Tang X, Wu J, Cyr D, Stevens RD, Ilkayeva O, Huang Z, Tollini LA, Murphy SK, Lucas J, Muoio DM, Kim SY, Chi JT.
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| PLoS Genet 11(10):e1005599. doi: 10.1371/journal.pgen.1005599. eCollection 2015 Oct.
2015
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3 | ETV4, PANX1
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| Regulation of the pannexin-1 promoter in the rat epididymis.
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| Dufresne J, Cyr DG.
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| Biol Reprod 91(6):143. doi: 10.1095/biolreprod.114.122168. Epub 2014 Nov 5.
2014
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4 | ETV4
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| Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma.
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| Mesci A, Taeb S, Huang X, Jairath R, Sivaloganathan D, Liu SK.
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| World J Gastroenterol 20(46):17376-87. doi: 10.3748/wjg.v20.i46.17376.
2014
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5 | ETV4, POU5F1
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| Transcriptional activation of OCT4 by the ETS transcription factor PEA3 in NCCIT human embryonic carcinoma cells.
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| Park SW, Do HJ, Ha WT, Han MH, Park KH, Song H, Kim NH, Kim JH.
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| FEBS Lett 588(17):3129-36. doi: 10.1016/j.febslet.2014.06.052. Epub 2014 Jun 28.
2014
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6 | CCND2, ETV4
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| Loss of a negative feedback loop involving pea3 and cyclin d2 is required for pea3-induced migration in transformed mammary epithelial cells.
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| Ladam F, Damour I, Dumont P, Kherrouche Z, de Launoit Y, Tulasne D, Chotteau-Lelievre A.
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| Mol Cancer Res 11(11):1412-24. doi: 10.1158/1541-7786.MCR-13-0229. Epub 2013 Aug 29.
2013
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7 | ETV4, PTK2
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| Requirement of PEA3 for transcriptional activation of FAK gene in tumor metastasis.
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| Li S, Huang X, Zhang D, Huang Q, Pei G, Wang L, Jiang W, Hu Q, Tan R, Hua ZC.
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| PLoS One 8(11):e79336. doi: 10.1371/journal.pone.0079336. eCollection 2013.
2013
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8 | ETV4, ETV5
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| Pea3 transcription factor family members Etv4 and Etv5 mediate retrograde signaling and axonal growth of DRG sensory neurons in response to NGF.
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| Fontanet P, Irala D, Alsina FC, Paratcha G, Ledda F.
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| J Neurosci 33(40):15940-51. doi: 10.1523/JNEUROSCI.0928-13.2013.
2013
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9 | ETV4
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| Impaired c-src activation and motility defects in PEA3-null fibroblasts.
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| Chaar ZY, Hastings L, Sriram R, McKay M, Antonova L, Hassell JA, Sabourin LA.
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| Biochim Biophys Acta 1823(12):2237-42. doi: 10.1016/j.bbamcr.2012.09.002. Epub 2012 Sep 12.
2012
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10 | ETV1, ETV4, ETV5
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| ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors.
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| Oh S, Shin S, Janknecht R.
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| Biochim Biophys Acta 1826(1):1-12. doi: 10.1016/j.bbcan.2012.02.002. Epub 2012 Mar 8. Review.
2012
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11 | ETV1, ETV4, ETV5, RFWD2
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| COP1 is a tumour suppressor that causes degradation of ETS transcription factors.
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| Vitari AC, Leong KG, Newton K, Yee C, O'Rourke K, Liu J, Phu L, Vij R, Ferrando R, Couto SS, Mohan S, Pandita A, Hongo JA, Arnott D, Wertz IE, Gao WQ, French DM, Dixit VM.
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| Nature 474(7351):403-6. doi: 10.1038/nature10005.
2011
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12 | ETV4
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| PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma.
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| Keld R, Guo B, Downey P, Cummins R, Gulmann C, Ang YS, Sharrocks AD.
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| Br J Cancer 105(1):124-30. doi: 10.1038/bjc.2011.187. Epub 2011 Jun 14.
2011
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13 | ETV4, ETV5
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| The transcription factors Etv4 and Etv5 mediate formation of the ureteric bud tip domain during kidney development.
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| Kuure S, Chi X, Lu B, Costantini F.
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| Development 137(12):1975-9. Epub 2010 May 12.PMID: 20463033 2010
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14 | ETV4, MYOD1
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| Involvement of MyoD and PEA3 in regulation of transcription activity of MDR1 gene.
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| Zhao Y, Liu J, Hong Q, Yang C, Chen L, Chen Y, Wang Q, Zhao K, Jin W.
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| Acta Biochim Biophys Sin (Shanghai) 42(12):900-7. doi: 10.1093/abbs/gmq094. Epub 2010 Oct 27.
2010
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15 | ETV4
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| Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3.
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| Guo B, Sharrocks AD.
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| Mol Cell Biol 29(11):3204-18. Epub 2009 Mar 23.
2009
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16 | ETV4, ETV5
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| Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.
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| Lu BC, Cebrian C, Chi X, Kuure S, Kuo R, Bates CM, Arber S, Hassell J, MacNeil L, Hoshi M, Jain S, Asai N, Takahashi M, Schmidt-Ott KM, Barasch J, D'Agati V, Costantini F.
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| Nat Genet 41(12):1295-302. Epub 2009 Nov 8. Erratum in: Nat Genet. 2010 Apr;42(4):361. PMID: 19898483 2009
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17 | ETV4, ETV5
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| Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb.
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| Mao J, McGlinn E, Huang P, Tabin CJ, McMahon AP.
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| Dev Cell 16(4):600-6.PMID: 19386268 2009
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18 | E2F1, ETV4
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| Identification of E1AF as a target gene of E2F1-induced apoptosis in response to DNA damage.
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| Wei Y, Liu D, Ge Y, Zhou F, Xu J, Chen H, Gu J, Jiang J.
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| J Biochem 144(4):539-46. Epub 2008 Aug 7.
2008
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19 | CANT1, ETV4, KLK2
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| Two unique novel prostate-specific and androgen-regulated fusion partners of ETV4 in prostate cancer.
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| Hermans KG, Bressers AA, van der Korput HA, Dits NF, Jenster G, Trapman J.
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| Cancer Res 68(9):3094-8.
2008
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20 | ETV4, ETV5
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| Reduced tumorigenesis in mouse mammary cancer cells following inhibition of Pea3- or Erm-dependent transcription.
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| Firlej V, Ladam F, Brysbaert G, Dumont P, Fuks F, de Launoit Y, Benecke A, Chotteau-Lelievre A.
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| J Cell Sci 121(Pt 20):3393-402. Epub 2008 Sep 30.PMID: 18827017 2008
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21 | TMPRSS2, ETV1, ETV4
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| Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues.
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| Tu JJ, Rohan S, Kao J, Kitabayashi N, Mathew S, Chen YT.
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| Mod Pathol 20(9):921-8. Epub 2007 Jul 13. 2007
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22 | ETV4, MITF
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| Inhibition of MITF transcriptional activity independent of targeting p300/CBP coactivators.
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| Vachtenheim J, Sestáková B, Tuhácková Z.
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| Pigment Cell Res 20(1):41-51.
2007
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23 | ETV4
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| Association of E1AF mRNA expression with tumor progression and matrilysin in human rectal cancer.
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| Liu HY, Zhou B, Wang L, Li Y, Zhou ZG, Sun XF, Xu B, Zeng YJ, Song JM, Luo HZ, Yang L.
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| Oncology 73(5-6):384-8. Epub 2008 May 30.
2007
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24 | ETV4
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| E1AF promotes breast cancer cell cycle progression via upregulation of Cyclin D3 transcription.
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| Jiang J, Wei Y, Liu D, Zhou J, Shen J, Chen X, Zhang S, Kong X, Gu J.
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| Biochem Biophys Res Commun 358(1):53-8. Epub 2007 Apr 18.
2007
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25 | ETV4, PIAS4
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| Repression of E1AF transcriptional activity by sumoylation and PIASy.
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| Nishida T, Terashima M, Fukami K, Yamada Y.
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| Biochem Biophys Res Commun 360(1):226-32. Epub 2007 Jun 14.
2007
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26 | ETV4
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| Genomic structure and promoter activity of the E1AF gene, a member of the ETS oncogene family.
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| Ishida S, Higashino F, Aoyagi M, Takahashi A, Suzuki T, Shindoh M, Fujinaga K, Yoshida K.
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| Biochem Biophys Res Commun 339(1):325-30. Epub 2005 Nov 15. 2006
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27 | TMPRSS2, ETV4, ETV1
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| TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer.
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| Tomlins SA, Mehra R, Rhodes DR, Smith LR, Roulston D, Helgeson BE, Cao X, Wei JT, Rubin MA, Shah RB, Chinnaiyan AM.
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| Cancer Res 66(7):3396-400. 2006
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28 | MUC4, ETV4, ERBB2
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| The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells.
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| Fauquette V, Perrais M, Cerulis S, Jonckheere N, Ducourouble MP, Aubert JP, Pigny P, Van Seuningen I.
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| Biochem J 386(Pt 1):35-45. 2005
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29 | WT1, ETV4
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| Activation of the WT1 tumor suppressor gene promoter by Pea3.
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| Discenza MT, Vaz D, Hassell JA, Pelletier J.
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| FEBS Lett 560(1-3):183-91. 2004
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30 | ETV4, JUN, SPP1, CTNNB1
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| Ets gene PEA3 cooperates with beta-catenin-Lef-1 and c-Jun in regulation of osteopontin transcription.
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| El-Tanani M, Platt-Higgins A, Rudland PS, Campbell FC.
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| J Biol Chem 279(20):20794-806. Epub 2004 Feb 27. 2004
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31 | ETV4
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| Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.
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| Kurpios NA, Sabolic NA, Shepherd TG, Fidalgo GM, Hassell JA.
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| J Mammary Gland Biol Neoplasia 8(2):177-90. Review. 2003
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32 | ETV4
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| Genomic organization of the human e1af gene,a member of Ets transcription factors.
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| Coutte L, Monte D, Baert J, de Launoit Y.
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| Gene 240(1):201-7. 1999
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33 | ETV4, EWSR1, EWSR1
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| The genomic breakpoint and chimeric transcripts in the EWSR1-ETV4/E1AF gene fusion in Ewing sarcoma.
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| Ishida S, et al.
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| Cytogenet Cell Genet 82 : 278-283. 1998
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34 | ETV4, EWSR1
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| Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy.
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| Kaneko Y, et al.
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| Genes Chromosomes Cancer 15 : 115-121. 1996
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35 | ETV1, ETV5, ETV4
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| Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors.
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| Mont D, et al.
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| Genomics 35 : 236-240. 1996
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36 | AOC3P,BRCA1,ETV4,EZH1,GSD1A,HSD17B2,NBR1
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| Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21.
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| Osborne-Lawrence S, et al.
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| Genomics 25 : 248-255. 1995
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37 | AOC3P,ATP6V0A1,BRCA1,DDX5,ETV4,EZH1,FLT4R,GSD1A,HMG17P1,HSD17B1,NRXN3,RPL27,TUBG1
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| Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17.
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| Brody LC, et al.
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| Genomics 25 : 238-247. 1995
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38 | ETV4
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| Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21.
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| Isobe M, et al.
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| Genomics 28 : 357-359. 1995
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39 | ETV4
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| Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters.
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| Higashino F, Yoshida K, Noumi T, Seiki M, Fujinaga K.
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| Oncogene 10(7):1461-3 1995
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40 | ETV1, ETV5, ETV4
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| Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors.
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| Mont D, et al.
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| Oncogene 9 : 1397-1406. 1994
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41 | ETV4
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| Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein : a new human member of the ets oncogene family.
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| Higashino F, et al.
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| Nucleic Acids Res 21 : 547-553. 1993
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