1 | EPO, EPOR
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| Alternative Erythropoietin Receptors in the Nervous System.
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| Ostrowski D, Heinrich R.
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| J Clin Med 7(2). pii: E24. doi: 10.3390/jcm7020024. Review.
2018
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2 | EPO, EPOR
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| Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis.
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| Ueda F, Tago K, Tamura H, Funakoshi-Tago M.
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| J Biol Chem 292(5):1826-1846. doi: 10.1074/jbc.M116.749465. Epub 2016 Dec 20.
2017
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3 | EPO, EPOR, FLT1
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| Erythropoietin accelerates tumor growth through increase of erythropoietin receptor (EpoR) as well as by the stimulation of angiogenesis in DLD-1 and Ht-29 xenografts.
|
| Tankiewicz-Kwedlo A, Hermanowicz J, Surażynski A, Rożkiewicz D, Pryczynicz A, Domaniewski T, Pawlak K, Kemona A, Pawlak D.
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| Mol Cell Biochem 421(1-2):1-18. doi: 10.1007/s11010-016-2779-x. Epub 2016 Aug 20.
2016
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4 | EPO, EPOR
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| Erythropoietin increases macrophage-mediated T cell suppression.
|
| Wood MA, Goldman N, DePierri K, Somerville J, Riggs JE.
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| Cell Immunol 306-307:17-24. doi: 10.1016/j.cellimm.2016.05.004. Epub 2016 May 27.
2016
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5 | EPO, EPOR
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| Role of erythropoietin in the angiogenic activity of bone marrow endothelial cells of MGUS and multiple myeloma patients.
|
| Lamanuzzi A, Saltarella I, Ferrucci A, Ria R, Ruggieri S, Racanelli V, Rao L, Annese T, Nico B, Vacca A, Ribatti D.
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| Oncotarget 7(12):14510-21. doi: 10.18632/oncotarget.7587.
2016
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6 | EPO, EPOR
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| Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance.
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| Luo B, Gan W, Liu Z, Shen Z, Wang J, Shi R, Liu Y, Liu Y, Jiang M, Zhang Z, Wu Y.
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| Immunity 44(2):287-302. doi: 10.1016/j.immuni.2016.01.002. Epub 2016 Feb 9.
2016
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7 | ECYT1, EPOR
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| A new point mutation in EPOR inducing a short deletion in congenital erythrocytosis.
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| Chauveau A, Luque Paz D, Lecucq L, Le Gac G, Le Maréchal C, Gueguen P, Berthou C, Ugo V.
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| Br J Haematol 172(3):475-7. doi: 10.1111/bjh.13511. Epub 2015 May 26. No abstract available.
2016
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8 | EPO, EPOR
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| In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain.
|
| Suzuki N, Mukai HY, Yamamoto M.
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| PLoS One 10(3):e0119442. doi: 10.1371/journal.pone.0119442. eCollection 2015.
2015
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9 | CSF2RB, EPOR
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| β Common Receptor Mediates Erythropoietin-Conferred Protection on OxLDL-Induced Lipid Accumulation and Inflammation in Macrophages.
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| Lee TS, Lu KY, Yu YB, Lee HT, Tsai FC.
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| Mediators Inflamm 2015:439759. doi: 10.1155/2015/439759. Epub 2015 May 25.
2015
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10 | EPO, EPOR
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| The erythropoietin receptor is not required for the development, function, and aging of rods and cells in the retinal periphery.
|
| Caprara C, Britschgi C, Samardzija M, Grimm C.
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| Mol Vis 20:307-24. eCollection 2014.
2014
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11 | EPO, EPOR, VEGFA
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| VEGFA activates erythropoietin receptor and enhances VEGFR2-mediated pathological angiogenesis.
|
| Yang Z, Wang H, Jiang Y, Hartnett ME.
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| Am J Pathol 184(4):1230-1239. doi: 10.1016/j.ajpath.2013.12.023. Epub 2014 Mar 12.
2014
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12 | CBL, EPO, EPOR, PIK3R1
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| Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis.
|
| Bulut GB, Sulahian R, Yao H, Huang LJ.
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| Blood 122(24):3964-72. doi: 10.1182/blood-2013-05-506212. Epub 2013 Oct 10.
2013
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13 | EPO, EPOR
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| Erythropoietin (EPO) increases myelin gene expression in CG4 oligodendrocyte cells through the classical EPO receptor.
|
| Cervellini I, Annenkov A, Brenton T, Chernajovsky Y, Ghezzi P, Mengozzi M.
|
| Mol Med 19:223-9. doi: 10.2119/molmed.2013.00013.
2013
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14 | EPOR, SP1
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| Changes in the Expression of Transcription Factors Involved in Modulating the Expression of EPO-R in Activated Human CD4-Positive Lymphocytes.
|
| Lisowska KA, Frackowiak JE, Mikosik A, Witkowski JM.
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| PLoS One 8(4):e60326. doi: 10.1371/journal.pone.0060326. Epub 2013 Apr 5.
2013
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15 | EPO, EPOR, JAK2, SH2B1
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| The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor.
|
| Javadi M, Hofstätter E, Stickle N, Beattie BK, Jaster R, Carter-Su C, Barber DL.
|
| J Biol Chem 287(31):26223-34. doi: 10.1074/jbc.M112.382721. Epub 2012 Jun 5.
2012
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16 | EPOR, GATA1, GATA2, LDB1, TAL1
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| T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis.
|
| Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT.
|
| J Biol Chem 287(44):36720-31. doi: 10.1074/jbc.M112.378398. Epub 2012 Sep 16.
2012
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17 | EPO, EPOR
|
| Emergence of the Erythropoietin/Erythropoietin Receptor System as a Novel Cardiovascular Therapeutic Target.
|
| Satoh K, Fukumoto Y, Nakano M, Kagaya Y, Shimokawa H.
|
| J Cardiovasc Pharmacol Cardiovasc Pharmacol. 2011 Sep 20. [Epub ahead of print]
2011
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18 | EPO, EPOR
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| Erythropoietin receptor contributes to melanoma cell survival in vivo.
|
| Kumar SM, Zhang G, Bastian BC, Arcasoy MO, Karande P, Pushparajan A, Acs G, Xu X.
|
| Oncogene ncogene. 2011 Aug 22. doi: 10.1038/onc.2011.366. [Epub ahead of print]
2011
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19 | EPO, EPOR
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| The role of erythropoietin and erythropoiesis-stimulating agents in tumor progression.
|
| Hedley BD, Allan AL, Xenocostas A.
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| Clin Cancer Res 17(20):6373-80. Epub 2011 Jul 12.
2011
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20 | EPO, EPOR
|
| Erythropoietin: a hormone with multiple functions.
|
| Lombardero M, Kovacs K, Scheithauer BW.
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| Pathobiology 78(1):41-53. Epub 2011 Apr 5. Review.
2011
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21 | EPOR
|
| Erythropoietin receptor is detectable on peripheral blood lymphocytes and its expression increases in activated T lymphocytes.
|
| Lisowska KA, Bryl E, Witkowski JM.
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| Haematologica 96(3):e12-3; author reply e14. No abstract available.
2011
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22 | EPOR, GATA4
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| Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes.
|
| Salisch S, Klar M, Thurisch B, Bungert J, Dame C.
|
| J Cell Mol Med 15(9):1963-72. doi: 10.1111/j.1582-4934.2010.01193.x.
2011
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23 | EPOR
|
| Cytosolic lysine residues enhance anterograde transport and activation of the erythropoietin receptor.
|
| Yosha L, Ravid O, Ben-Califa N, Neumann D.
|
| Biochem J 435(2):509-18.
2011
|
24 | EPO, EPOR, GDF15, TFR2
|
| Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis.
|
| Forejtnikovà H, Vieillevoye M, Zermati Y, Lambert M, Pellegrino RM, Guihard S, Gaudry M, Camaschella C, Lacombe C, Roetto A, Mayeux P, Verdier F.
|
| Blood 116(24):5357-67. Epub 2010 Sep 8.
2010
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25 | EPO, EPOR
|
| Up-regulation of erythropoietin receptor by nitric oxide mediates hypoxia preconditioning.
|
| Chen ZY, Wang L, Asavaritkrai P, Noguchi CT.
|
| J Neurosci Res 88(14):3180-8.
2010
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26 | EPO, EPOR
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| Erythropoietin Receptor Signaling Through STAT3 Is Required For Glioma Stem Cell Maintenance.
|
| Cao Y, Lathia JD, Eyler CE, Wu Q, Li Z, Wang H, McLendon RE, Hjelmeland AB, Rich JN.
|
| Genes Cancer 1(1):50-61.
2010
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27 | EPO, EPOR
|
| Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease.
|
| Khankin EV, Mutter WP, Tamez H, Yuan HT, Karumanchi SA, Thadhani R.
|
| PLoS One 5(2):e9246.
2010
|
28 | EPO, EPOR
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| Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo.
|
| Huang X, Pierce LJ, Chen GL, Chang KT, Spangrude GJ, Prchal JT.
|
| Blood Cells Mol Dis 44(1):1-6. Epub 2009 Oct 17.
2010
|
29 | ECYT1, ECYT2, ECYT3, ECYT4, EGLN1, EPAS1, EPOR, VHL
|
| Genetic origins and clinical phenotype of familial and acquired erythrocytosis and thrombocytosis.
|
| Percy MJ, Rumi E.
|
| Am J Hematol 84(1):46-54. Review. 2009
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30 | EPO, EPOR
|
| Molecular basis of cardioprotection by erythropoietin.
|
| Burger D, Xenocostas A, Feng QP.
|
| Curr Mol Pharmacol 2(1):56-69. Review.
2009
|
31 | EPO, EPOR, VEGFA
|
| Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear.
|
| Monge Naldi A, Gassmann M, Bodmer D.
|
| Cell Mol Life Sci 66(22):3595-9. Epub 2009 Sep 10. Review.
2009
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32 | ECYT1, ECYT2, ECYT3, ECYT4, EGLN1, EPAS1, EPOR, VHL
|
| A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene.
|
| Al-Sheikh M, Mazurier E, Gardie B, Casadevall N, Galactéros F, Goossens M, Wajcman H, Préhu C, Ugo V.
|
| Haematologica 93(7):1072-5. Epub 2008 May 19. 2008
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33 | CALM1, EPOR, JAK2
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| Calmodulin physically interacts with the erythropoietin receptor and enhances Jak2-mediated signaling.
|
| Kakihana K, Yamamoto M, Iiyama M, Miura O.
|
| Biochem Biophys Res Commun 335(2):424-31. 2005
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34 | MST1R, EPOR
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| Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors.
|
| van den Akker E, van Dijk T, Parren-van Amelsvoort M, Grossmann KS, Schaeper U, Toney-Earley K, Waltz SE, Lowenberg B, von Lindern M.
|
| Blood 103(12):4457-65. Epub 2004 Feb 24. 2004
|
35 | EPOR, STAT1, STAT3, STAT5A
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| Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation.
|
| Kirito K, Nakajima K, Watanabe T, Uchida M, Tanaka M, Ozawa K, Komatsu N.
|
| Blood 99(1):102-10. 2002
|
36 | EPOR, SOCS3
|
| A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
|
| Hortner M, Nielsch U, Mayr LM, Heinrich PC, Haan S.
|
| Eur J Biochem 269(10):2516-26. 2002
|
37 | EPOR
|
| Erythropoietin and erythropoietin receptor expression in human endometrium throughout the menstrual cycle.
|
| Yokomizo R, Matsuzaki S, Uehara S, Murakami T, Yaegashi N, Okamura K.
|
| Mol Hum Reprod 8(5):441-6. 2002
|
38 | EPOR
|
| A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation.
|
| Arcasoy MO, et al.
|
| Exp Hematol 27(1):63-74. 1999
|
39 | EPO, EPOR
|
| Human, rat, and mouse kidney cells express functional erythropoietin receptors.
|
| Westenfelder C, et al.
|
| Kidney Int 55(3):808-20. 1999
|
40 | EPOR, EPO
|
| Identification of the erythropoietin receptor domain required for calcium channel activation.
|
| Miller BA, et al.
|
| J Biol Chem 274(29):20465-72 1999
|
41 | ECYT1, EPOR
|
| Erythrocytosis due to a mutation in the erythropoietin receptor gene.
|
| Percy MJ, McMullin MF, Roques AW, Westwood NB, Acharya J, Hughes AE, Lappin TR, Pearson TC.
|
| Br J Haematol 100(2):407-10. 1998
|
42 | ECYT1, EPOR
|
| Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia.
|
| Kralovics R, et al.
|
| J Clin Invest 102 : 124-129. 1998
|
43 | ECYT1, EPOR
|
| Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene.
|
| Arcasoy MO, Degar BA, Harris KW, Forget BG.
|
| Blood 89(12):4628-35. 1997
|
44 | ECYT1, EPOR
|
| Two new EPO receptor mutations: truncated EPO receptors are most frequently associated with primary familial and congenital polycythemias.
|
| Kralovics R, Indrak K, Stopka T, Berman BW, Prchal JF, Prchal JT.
|
| Blood 90(5):2057-61. 1997
|
45 | ECYT1, EPOR
|
| Primary familial polycythaemia associated with a novel point mutation in the erythropoietin receptor.
|
| Furukawa T, et al.
|
| Br J Haematol 99 : 222-227. 1997
|
46 | CYP2B, CYP2B6, CYP2B7P1, CYP2F1, EPOR, HERVK10T, JAK3, RRAS, ZNF134, ZNF14, ZNF44, ZNF91, ZNF97
|
| Positioning of 72 potentially full size LTRs of human endogenous retroviruses HERV-K on the human chromosome 19 map. Occurrences of the LTRs in human gene sites.
|
| Vinogradova T, Volik S, Lebedev Y, Shevchenko Y, Lavrentyeva I, Khil P, Grzeschik KH, Ashworth LK, Sverdlov E.
|
| Gene 199(1-2):255-64. 1997
|
47 | EPOR
|
| Mutations in the erythropoietin receptor gene are not a common cause of Diamond-Blackfan anemia.
|
| Dianzani I, et al.
|
| Blood 87 : 2568-2572. 1996
|
48 | ECYT1, EPOR
|
| Primary familial polycythemia : a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin.
|
| Sikol L, et al.
|
| Blood 86 : 15-22. 1995
|
49 | EPOR
|
| Two microsatellite repeat polymorphisms in the EPO gene.
|
| Sokol L, et al.
|
| Hum Mol Genet 3 : 219. 1994
|
50 | EPOR
|
| Dinucleotide repeat polymorphism at the human erythropoietin receptor locus (EPOR) at 19p13.
|
| McDonald MT, et al.
|
| Hum Mol Genet 2 : 619. 1993
|
51 | ECYT1, EPOR
|
| Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis.
|
| de la Chapelle A, et al.
|
| Proc Natl Acad Sci U S A 90 : 4495-4499. 1993
|
52 | EPOR
|
| Genetic mapping of the erythropoietin receptor gene.
|
| Sistonen P, et al.
|
| Hum Genet 92 : 299-301. 1993
|
53 | ECYT1, EPOR
|
| Familial erythrocytosis genetically linked to erythropoietin receptor gene.
|
| de La Chapelle A, et al.
|
| Lancet 341 : 82-84. 1993
|
54 | EPOR
|
| Autosomal dominant erythrocytosis caused by increased sensitivity to erythropoietin.
|
| Juvonen E, et al.
|
| Blood 78 : 3066-3069. 1991
|
55 | EPOR
|
| Human erythropoietin receptor : cloning, expression, and biologic characterization.
|
| Jones SS, et al.
|
| Blood 76 : 31-35. 1990
|
56 | EPOR
|
| The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p.
|
| Winkelmann JC, et al.
|
| Blood 76 : 24-30. 1990
|
57 | EPOR
|
| Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity.
|
| Yoshimura A, et al.
|
| Nature 348 : 647-649. 1990
|