| 1 | EPHA2
|
| EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer.
|
| Martini G, Cardone C, Vitiello PP, Belli V, Napolitano S, Troiani T, Ciardiello D, Della Corte CM, Morgillo F, Matrone N, Sforza V, Papaccio G, Desiderio V, Paul MC, Moreno-Viedma V, Normanno N, Rachiglio AM, Tirino V, Maiello E, Latiano TP, Rizzi D, Signoriello G, Sibilia M, Ciardiello F, Martinelli E.
|
| Mol Cancer Ther. Apr;18(4):845-855. doi: 10.1158/1535-7163.MCT-18-0539. Epub 2019 Mar 1 2019
|
| 2 | EPHA2
|
| EphA2 inhibition suppresses proliferation of small-cell lung cancer cells through inducing cell cycle arrest.
|
| Ishigaki H, Minami T, Morimura O, Kitai H, Horio D, Koda Y, Fujimoto E, Negi Y, Nakajima Y, Niki M, Kanemura S, Shibata E, Mikami K, Takahashi R, Yokoi T, Kuribayashi K, Kijima T.
|
| Biochem Biophys Res Commun. Nov 19;519(4):846-853. doi: 10.1016/j.bbrc.2019.09.076. Epub 2019 Sep 24 2019
|
| 3 | CPP1, EPHA2
|
| A Novel Human Congenital Cataract Mutation in EPHA2 Kinase Domain (p.G668D) Alters Receptor Stability and Function.
|
| Zhai Y, Zhu S, Li J, Yao K.
|
| Invest Ophthalmol Vis Sci. Nov 1;60(14):4717-4726. doi: 10.1167/iovs.19-27370 2019
|
| 4 | EPHA2
|
| EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma.
|
| Garcia-Monclús S, López-Alemany R, Almacellas-Rabaiget O, Herrero-Martín D, Huertas-Martinez J, Lagares-Tena L, Alba-Pavón P, Hontecillas-Prieto L, Mora J, de Álava E, Rello-Varona S, Giangrande PH, Tirado OM.
|
| Int J Cancer. Sep 1;143(5):1188-1201. doi: 10.1002/ijc.31405. Epub 2018 Apr 16 2018
|
| 5 | EFNA5, EPHA2
|
| Epha2 and Efna5 participate in lens cell pattern-formation.
|
| Zhou Y, Shiels A.
|
| Differentiation Jul-Aug;102:1-9. doi: 10.1016/j.diff.2018.05.002. Epub 2018 May 17 2018
|
| 6 | EPHA2
|
| The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures.
|
| Singh DR, Kanvinde P, King C, Pasquale EB, Hristova K.
|
| Commun Biol. Feb 22;1:15. doi: 10.1038/s42003-018-0017-7. eCollection 2018 2018
|
| 7 | EPHA2
|
| Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry.
|
| Zhang H, Li Y, Wang HB, Zhang A, Chen ML, Fang ZX, Dong XD, Li SB, Du Y, Xiong D, He JY, Li MZ, Liu YM, Zhou AJ, Zhong Q, Zeng YX, Kieff E, Zhang Z, Gewurz BE, Zhao B, Zeng MS.
|
| Nat Microbiol. Feb;3(2):1-8. doi: 10.1038/s41564-017-0080-8. Epub 2018 Jan 1 2018
|
| 8 | EPHA2
|
| Emerging and Diverse Functions of the EphA2 Noncanonical Pathway in Cancer Progression.
|
| Zhou Y, Sakurai H.
|
| Biol Pharm Bull. 40(10):1616-1624. doi: 10.1248/bpb.b17-00446 2017
|
| 9 | EPHA2
|
| The SAM domain inhibits EphA2 interactions in the plasma membrane.
|
| Singh DR, Ahmed F, Paul MD, Gedam M, Pasquale EB, Hristova K.
|
| Biochim Biophys Acta Mol Cell Res Jan;1864(1):31-38. doi: 10.1016/j.bbamcr.2016.10.011. Epub 2016 Oct 21 2017
|
| 10 | EFNA1, EPHA2, SOCS2
|
| SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.
|
| Pilling C, Cooper JA.
|
| Sci Rep. Sep 7;7(1):10838. doi: 10.1038/s41598-017-11040-3 2017
|
| 11 | EPHA2
|
| EphA2 is a key effector of the MEK/ERK/RSK pathway regulating glioblastoma cell proliferation.
|
| Hamaoka Y, Negishi M, Katoh H.
|
| Cell Signal. Aug;28(8):937-45. doi: 10.1016/j.cellsig.2016.04.009. Epub 2016 Apr 28 2016
|
| 12 | EPHA2
|
| EphA2 is a functional receptor for the growth factor progranulin.
|
| Neill T, Buraschi S, Goyal A, Sharpe C, Natkanski E, Schaefer L, Morrione A, Iozzo RV.
|
| J Cell Biol. Dec 5;215(5):687-703. doi: 10.1083/jcb.201603079. Epub 2016 Nov 30 2016
|
| 13 | EPHA2
|
| EphA2 Receptor Unliganded Dimers Suppress EphA2 Pro-tumorigenic Signaling.
|
| Singh DR, Ahmed F, King C, Gupta N, Salotto M, Pasquale EB, Hristova K.
|
| J Biol Chem. Nov 6;290(45):27271-9. doi: 10.1074/jbc.M115.676866. Epub 2015 Sep 11 2015
|
| 14 | CLDN4, EPHA2
|
| Claudin-4 controls the receptor tyrosine kinase EphA2 pro-oncogenic switch through ß-catenin.
|
| Shang X, Lin X, Howell SB.
|
| Cell Commun Signal 12(1):59. [Epub ahead of print]
2014
|
| 15 | EPHA2, MAGEA6
|
| Circulating Type-1 Anti-Tumor CD4(+) T Cells are Preferentially Pro-Apoptotic in Cancer Patients.
|
| Wesa AK, Mandic M, Taylor JL, Moschos S, Kirkwood JM, Kwok WW, Finke JH, Storkus WJ.
|
| Front Oncol. Sep 29;4:266. doi: 10.3389/fonc.2014.00266. eCollection 2014 2014
|
| 16 | EPHA2
|
| EphA2 promotes epithelial-mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells.
|
| Huang J, Xiao D, Li G, Ma J, Chen P, Yuan W, Hou F, Ge J, Zhong M, Tang Y, Xia X, Chen Z.
|
| Oncogene May 22;33(21):2737-47. doi: 10.1038/onc.2013.238. Epub 2013 Jun 10 2014
|
| 17 | EPHA2, MMP14
|
| EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.
|
| Sugiyama N, Gucciardo E, Tatti O, Varjosalo M, Hyytiäinen M, Gstaiger M, Lehti K.
|
| J Cell Biol 201(3):467-84. doi: 10.1083/jcb.201205176.
2013
|
| 18 | EPHA2
|
| EphA2 and Src regulate equatorial cell morphogenesis during lens development.
|
| Cheng C, Ansari MM, Cooper JA, Gong X.
|
| Development 140(20):4237-45. doi: 10.1242/dev.100727. Epub 2013 Sep 11.
2013
|
| 19 | EPHA2, HIC1
|
| The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1).
|
| Foveau B, Boulay G, Pinte S, Van Rechem C, Rood BR, Leprince D.
|
| J Biol Chem 287(8):5366-78. doi: 10.1074/jbc.M111.329466. Epub 2011 Dec 19.
2012
|
| 20 | EPHA2
|
| Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells.
|
| Yang NY, Fernandez C, Richter M, Xiao Z, Valencia F, Tice DA, Pasquale EB.
|
| Cell Signal 23(1):201-12. Epub 2010 Sep 15.PMID: 20837138 2011
|
| 21 | EFNA1, EPHA2
|
| The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction.
|
| Goichberg P, Bai Y, D'Amario D, Ferreira-Martins J, Fiorini C, Zheng H, Signore S, del Monte F, Ottolenghi S, D'Alessandro DA, Michler RE, Hosoda T, Anversa P, Kajstura J, Rota M, Leri A.
|
| Circ Res 108(9):1071-83. Epub 2011 Mar 17. 2011
|
| 22 | ARHGEF16, EPHA2, RHOG
|
| Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase.
|
| Harada K, Hiramoto-Yamaki N, Negishi M, Katoh H.
|
| Exp Cell Res 317(12):1701-13. Epub 2011 May 20.
2011
|
| 23 | EPHA2
|
| Structure-activity relationship analysis of peptides targeting the EphA2 receptor.
|
| Mitra S, Duggineni S, Koolpe M, Zhu X, Huang Z, Pasquale EB.
|
| Biochemistry 49(31):6687-95.PMID: 20677833 2010
|
| 24 | EPHA2
|
| Clinical and biological impact of EphA2 overexpression and angiogenesis in endometrial cancer.
|
| Merritt WM, Kamat AA, Hwang JY, Bottsford-Miller J, Lu C, Lin YG, Coffey D, Spannuth W, Nugent E, Han LY, Landen CN, Nick AM, Stone RL, Coffman KT, Bruckheimer E, Broaddus R, Gershenson DM, Coleman RL, Sood AK.
|
| Cancer Biol Ther 10(12). [Epub ahead of print]PMID: 20948320 2010
|
| 25 | EPHA2
|
| Ligand Targeting of EphA2 Enhances Keratinocyte Adhesion and Differentiation via Desmoglein 1.
|
| Lin S, Gordon K, Kaplan N, Getsios S.
|
| Mol Biol Cell 21(22):3902-14. Epub 2010 Sep 22.PMID: 20861311 2010
|
| 26 | ARHGEF16, EPHA2, RHOG
|
| Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.
|
| Hiramoto-Yamaki N, Takeuchi S, Ueda S, Harada K, Fujimoto S, Negishi M, Katoh H.
|
| J Cell Biol 190(3):461-77. Epub 2010 Aug 2.PMID: 20679435 2010
|
| 27 | EPHA2
|
| Clinical significance of EphA2 expression in squamous-cell carcinoma of the head and neck.
|
| Liu Y, Zhang X, Qiu Y, Huang D, Zhang S, Xie L, Qi L, Yu C, Zhou X, Hu G, Tian Y.
|
| J Cancer Res Clin Oncol Cancer Res Clin Oncol. 2010 Jul 8. [Epub ahead of print]PMID: 20614133 2010
|
| 28 | CPP1, EPHA2
|
| Autosomal recessive congenital cataract linked to EPHA2 in a consanguineous Pakistani family.
|
| Kaul H, Riazuddin SA, Shahid M, Kousar S, Butt NH, Zafar AU, Khan SN, Husnain T, Akram J, Hejtmancik JF, Riazuddin S.
|
| Mol Vis 16:511-7.PMID: 20361013 2010
|
| 29 | EPHA2
|
| Restriction of receptor movement alters cellular response: physical force sensing by EphA2.
|
| Salaita K, Nair PM, Petit RS, Neve RM, Das D, Gray JW, Groves JT.
|
| Science 327(5971):1380-5.PMID: 20223987 2010
|
| 30 | EFNA1, EPHA2
|
| EFNA1 ligand and its receptor EphA2: potential biomarkers for hepatocellular carcinoma.
|
| Cui XD, Lee MJ, Yu GR, Kim IH, Yu HC, Song EY, Kim DG.
|
| Int J Cancer 126(4):940-9.
2010
|
| 31 | EFNA1, EPHA2
|
| De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway.
|
| Fritsche-Guenther R, Noske A, Ungethüm U, Kuban RJ, Schlag PM, Tunn PU, Karle J, Krenn V, Dietel M, Sers C.
|
| Histopathology 57(6):836-50. doi: 10.1111/j.1365-2559.2010.03713.x.
2010
|
| 32 | CPP1, EPHA2
|
| EPHA2 is associated with age-related cortical cataract in mice and humans.
|
| Jun G, Guo H, Klein BE, Klein R, Wang JJ, Mitchell P, Miao H, Lee KE, Joshi T, Buck M, Chugha P, Bardenstein D, Klein AP, Bailey-Wilson JE, Gong X, Spector TD, Andrew T, Hammond CJ, Elston RC, Iyengar SK, Wang B.
|
| PLoS Genet 5(7):e1000584. Epub 2009 Jul 31. 2009
|
| 33 | CPP1, EPHA2
|
| Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract.
|
| Zhang T, Hua R, Xiao W, Burdon KP, Bhattacharya SS, Craig JE, Shang D, Zhao X, Mackey DA, Moore AT, Luo Y, Zhang J, Zhang X.
|
| Hum Mutat 30(5):E603-11.PMID: 19306328 2009
|
| 34 | EPHA2
|
| EphA2 receptor mediates increased vascular permeability in lung injury due to viral infection and hypoxia.
|
| Cercone MA, Schroeder W, Schomberg S, Carpenter TC.
|
| Am J Physiol Lung Cell Mol Physiol 297(5):L856-63. Epub 2009 Aug 14.PMID: 19684201 2009
|
| 35 | EPHA2
|
| Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase.
|
| Vaught D, Chen J, Brantley-Sieders DM.
|
| Mol Biol Cell 20(10):2572-81. Epub 2009 Mar 25.PMID: 19321667 2009
|
| 36 | EFNA1, EPHA2
|
| Over-expression of EphA2 and EphrinA-1 in human gastric adenocarcinoma and its prognostic value for postoperative patients.
|
| Yuan WJ, Ge J, Chen ZK, Wu SB, Shen H, Yang P, Hu B, Zhang GW, Chen ZH.
|
| Dig Dis Sci 54(11):2410-7. Epub 2008 Dec 20.
2009
|
| 37 | EFNA2, EPHA2
|
| Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.
|
| Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, Iwakura Y, Suda T, Matsuo K.
|
| J Biol Chem 284(21):14637-44. Epub 2009 Mar 19.
2009
|
| 38 | ACP1, EPHA2, SRC
|
| Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism.
|
| Fang WB, Ireton RC, Zhuang G, Takahashi T, Reynolds A, Chen J.
|
| J Cell Sci 121(Pt 3):358-68. Epub 2008 Jan 15. 2008
|
| 39 | EPHA2, EPHA3
|
| Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system.
|
| Jiao JW, Feldheim DA, Chen DF.
|
| Proc Natl Acad Sci U S A 105(25):8778-83. Epub 2008 Jun 18. 2008
|
| 40 | EFNA5, EPHA2
|
| Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract.
|
| Cooper MA, Son AI, Komlos D, Sun Y, Kleiman NJ, Zhou R.
|
| Proc Natl Acad Sci U S A 105(43):16620-5. Epub 2008 Oct 23.
2008
|
| 41 | CPP1, EPHA2
|
| The EPHA2 gene is associated with cataracts linked to chromosome 1p.
|
| Shiels A, Bennett TM, Knopf HL, Maraini G, Li A, Jiao X, Hejtmancik JF.
|
| Mol Vis 14:2042-55. Epub 2008 Nov 12.PMID: 19005574 2008
|
| 42 | EPHA2
|
| The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting.
|
| Wykosky J, Debinski W.
|
| Mol Cancer Res 6(12):1795-806. Review.PMID: 19074825 2008
|
| 43 | EPHA2
|
| EphA2 overexpression is associated with angiogenesis in ovarian cancer.
|
| Lin YG, Han LY, Kamat AA, Merritt WM, Landen CN, Deavers MT, Fletcher MS, Urbauer DL, Kinch MS, Sood AK.
|
| Cancer 109(2):332-40. 2007
|
| 44 | EGFR, EPHA2
|
| Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motility.
|
| Larsen AB, Pedersen MW, Stockhausen MT, Grandal MV, van Deurs B, Poulsen HS.
|
| Mol Cancer Res 5(3):283-93.
2007
|
| 45 | EPHA2, CLDN4
|
| EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability.
|
| Tanaka M, Kamata R, Sakai R.
|
| J Biol Chem 280(51):42375-82. Epub 2005 Oct 18. 2005
|
| 46 | EFNA1, EPHA2
|
| EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase.
|
| Parri M, Buricchi F, Taddei ML, Giannoni E, Raugei G, Ramponi G, Chiarugi P.
|
| J Biol Chem 280(40):34008-18. Epub 2005 Jul 28.
2005
|
| 47 | EFNA1, EPHA2
|
| EPHA2/EFNA1 expression in human gastric cancer.
|
| Nakamura R, Kataoka H, Sato N, Kanamori M, Ihara M, Igarashi H, Ravshanov S, Wang YJ, Li ZY, Shimamura T, Kobayashi T, Konno H, Shinmura K, Tanaka M, Sugimura H.
|
| Cancer Sci 96(1):42-7.
2005
|
| 48 | EPHA2, EPHB1, TIAM1
|
| Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.
|
| Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, Sugimura H.
|
| EMBO J 23(5):1075-88. Epub 2004 Feb 26.
2004
|
| 49 | EPHA2, EPHB3
|
| ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers.
|
| Sulman EP, et al.
|
| Genomics 40 : 371-374. 1997
|