| 1 | EN1, EN2
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| Clinical Phenotypes Associated to Engrailed 2 Gene Alterations in a Series of Neuropediatric Patients.
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| Carratala-Marco F, Andreo-Lillo P, Martinez-Morga M, Escamez-Martínez T, Botella-López A, Bueno C, Martinez S.
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| Front Neuroanat 12:61. doi: 10.3389/fnana.2018.00061. eCollection 2018.
2018
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| 2 | EN1
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| Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells.
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| Miura K, Akashi T, Ando N, Ayabe S, Kayamori K, Namiki T, Eishi Y.
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| Histopathology 72(7):1199-1208. doi: 10.1111/his.13486. Epub 2018 Mar 25.
2018
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| 3 | EN1, PITX3
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| Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.
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| Kouwenhoven WM, von Oerthel L, Smidt MP.
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| PLoS One 12(8):e0182421. doi: 10.1371/journal.pone.0182421. eCollection 2017.
2017
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| 4 | EN1
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| En1 is necessary for survival of neurons in the ventral nuclei of the lateral lemniscus.
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| Altieri SC, Zhao T, Jalabi W, Romito-DiGiacomo RR, Maricich SM.
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| Dev Neurobiol 76(11):1266-1274. doi: 10.1002/dneu.22388. Epub 2016 Apr 5.
2016
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| 5 | EN1
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| En1 is necessary for survival of neurons in the ventral nuclei of the lateral lemniscus.
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| Altieri SC, Zhao T, Jalabi W, Romito-DiGiacomo RR, Maricich SM.
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| Dev Neurobiol 76(11):1266-1274. doi: 10.1002/dneu.22388. Epub 2016 Apr 5.
2016
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| 6 | EN1, EN2
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| Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms.
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| Huettl RE, Luxenhofer G, Bianchi E, Haupt C, Joshi R, Prochiantz A, Huber AB.
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| PLoS One 10(2):e0118505. doi: 10.1371/journal.pone.0118505. eCollection 2015.
2015
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| 7 | EN1
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| Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function.
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| Beltran AS, Graves LM, Blancafort P.
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| Oncogene 33(39):4767-77. doi: 10.1038/onc.2013.422. Epub 2013 Oct 21.
2014
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| 8 | EN1, PITX3
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| Specification of dopaminergic subsets involves interplay of En1 and Pitx3.
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| Veenvliet JV, Dos Santos MT, Kouwenhoven WM, von Oerthel L, Lim JL, van der Linden AJ, Koerkamp MJ, Holstege FC, Smidt MP.
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| Development 140(16):3373-84. doi: 10.1242/dev.094565. Epub 2013 Jul 17. Erratum in: Development. 2013 Oct;140(19):4116.
2013
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| 9 | EN1, EN2
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| The engrailed homeobox genes are required in multiple cell lineages to coordinate sequential formation of fissures and growth of the cerebellum.
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| Orvis GD, Hartzell AL, Smith JB, Barraza LH, Wilson SL, Szulc KU, Turnbull DH, Joyner AL.
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| Dev Biol 367(1):25-39. doi: 10.1016/j.ydbio.2012.04.018. Epub 2012 Apr 28.
2012
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| 10 | EN1
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| Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1.
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| Deckelbaum RA, Holmes G, Zhao Z, Tong C, Basilico C, Loomis CA.
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| Development 139(7):1346-58. doi: 10.1242/dev.076729.
2012
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| 11 | EN1, EN2
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| Spatially restricted and developmentally dynamic expression of engrailed genes in multiple cerebellar cell types.
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| Wilson SL, Kalinovsky A, Orvis GD, Joyner AL.
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| Cerebellum 10(3):356-72. doi: 10.1007/s12311-011-0254-5.
2011
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| 12 | EN1, EN2
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| The Engrailed homeobox genes determine the different foliation patterns in the vermis and hemispheres of the mammalian cerebellum.
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| Cheng Y, Sudarov A, Szulc KU, Sgaier SK, Stephen D, Turnbull DH, Joyner AL.
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| Development 137(3):519-29. doi: 10.1242/dev.027045.
2010
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| 13 | INHBB, SCTR, EN1
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| Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.
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| Frigola J, Song J, Stirzaker C, Hinshelwood RA, Peinado MA, Clark SJ.
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| Nat Genet 38(5):540-549. Epub 2006 Apr 23. 2006
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| 14 | DEL2Q14, EN1
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| Deletions of 2q14 that include the homeobox engrailed 1 (EN1) transcription factor are compatible with a normal phenotype.
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| Barber JC, Maloney VK, Bewes B, Wakeling E.
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| Eur J Hum Genet 14(6):739-43. 2006
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| 15 | EN1,EN2
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| Engrailed: complexity and economy of a multi-functional transcription factor.
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| Morgan R.
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| FEBS Lett 580(11):2531-3. Epub 2006 Apr 27. 2006
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| 16 | EN1,GSK3B
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| Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway.
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| Bachar-Dahan L, Goltzmann J, Yaniv A, Gazit A.
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| Mol Biol Cell 17(6):2572-80. Epub 2006 Mar 29. 2006
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| 17 | SMARCA1, SMARCA5, BPTF, RBBP4, RBBP7, EN1, EN2
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| Isolation of human NURF: a regulator of Engrailed gene expression.
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| Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R.
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| EMBO J 22(22):6089-100. 2003
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| 18 | BARHL1, EN1, EN2, FGF8, JBTS1, WNT1
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| Search for genes involved in Joubert syndrome: evidence that one or more major loci are yet to be identified and exclusion of candidate genes EN1, EN2, FGF8, and BARHL1.
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| Blair IP, Gibson RR, Bennett CL, Chance PF.
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| Am J Med Genet 107(3):190-6. 2002
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| 19 | EN1
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| The role of Engrailed in establishing the dorsoventral axis of the chick limb.
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| Logan C, et al.
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| Development 124(12):2317-24. 1997
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| 20 | EN1
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| The mouse Engrailed-1 gene and ventral limb patterning.
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| Loomis CA, et al.
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| Nature 382(6589):360-3. 1996
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| 21 | EN1, EN2, GBX1, GBX2
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| The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosome 2 and 7 in humans.
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| Matsui T, et al.
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| FEBS Lett 336 : 107-110. 1993
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| 22 | EN1
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| Regional assignment of the human homeobox-containing gene EN1 to chromosome 2q13-q21.
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| Kšhler A, et al.
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| Genomics 15 : 233-235. 1993
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| 23 | EN1, EN2
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| Chromosomal localization of the human homeo-box containing genes, EN1 and EN2.
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| Logan C, Willard HF, Rommens JM, Joyner AL.
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| Genomics 4 : 206-209. 1989
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| 24 | EN1
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| An HaeIII RFLP for the human homeo box-containing gene EN1.
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| Logan C, et al.
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| Nucleic Acids Res 17 : 2877. 1989
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