Citations for
1APOB, ELAVL1, NDUFB6, UQCRB
. Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Zhang Z, Zong C, Jiang M, Hu H, Cheng X, Ni J, Yi X, Jiang B, Tian F, Chang MW, Su W, Zhu L, Li J, Xiang X, Miao C, Gorospe M, de Cabo R, Dou Y, Ju Z, Yang J, Jiang C, Yang Z, Wang W
Nat Commun. Jun 16;11(1):3067. doi: 10.1038/s41467-020-16918-x. 2020
2ATP6V0D2, ELAVL1, TLR3
Innate immune responses through Toll-like receptor 3 require human-antigen-R-mediated Atp6v0d2 mRNA stabilization
Zainol MIB, Kawasaki T, Monwan W, Murase M, Sueyoshi T, Kawai T.
Sci Rep. Dec 31;9(1):20406. doi: 10.1038/s41598-019-56914-w. 2019
3ADARB1, ELAVL1, PARN
ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins.
Anantharaman A, Tripathi V, Khan A, Yoon JH, Singh DK, Gholamalamdari O, Guang S, Ohlson J, Wahlstedt H, Öhman M, Jantsch MF, Conrad NK, Ma J, Gorospe M, Prasanth SG, Prasanth KV.
Nucleic Acids Res 45(7):4189-4201. doi: 10.1093/nar/gkw1304. 2017
4CTNNB1, ELAVL1, HSF1
HSF1 regulation of β-catenin in mammary cancer cells through control of HuR/elavL1 expression.
Chou SD, Murshid A, Eguchi T, Gong J, Calderwood SK.
Oncogene ncogene. 2014 Jun 23. doi: 10.1038/onc.2014.177. [Epub ahead of print] 2014
5ELAVL1
Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs.
Yoon JH, Abdelmohsen K, Srikantan S, Guo R, Yang X, Martindale JL, Gorospe M.
Nucleic Acids Res 42(2):1196-208. doi: 10.1093/nar/gkt903. Epub 2013 Oct 7. 2014
6ABCA1, ELAVL1
RNA binding protein HuR regulates the expression of ABCA1.
Ramírez CM, Lin CS, Abdelmohsen K, Goedeke L, Yoon JH, Madrigal-Matute J, Martin-Ventura JL, Vo DT, Uren PJ, Penalva LO, Gorospe M, Fernández-Hernando C.
J Lipid Res 55(6):1066-76. doi: 10.1194/jlr.M044925. Epub 2014 Apr 11. 2014
7ELAVL1, SQSTM1
Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells.
Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K.
PLoS One 8(7):e69563. doi: 10.1371/journal.pone.0069563. Print 2013. 2013
8EIF4A3, ELAVL1, FMR1, HNRNPC, PABPC1, RALY
Proteome-wide characterization of the RNA-binding protein RALY-interactome using the in vivo-biotinylation-pulldown-quant (iBioPQ) approach.
Tenzer S, Moro A, Kuharev J, Francis AC, Vidalino L, Provenzani A, Macchi P.
J Proteome Res 12(6):2869-84. doi: 10.1021/pr400193j. Epub 2013 May 6. 2013
9CARM1, CCNA1, CCNB1, ELAVL1, FOS, SIRT1
Loss of CARM1 is linked to reduced HuR function in replicative senescence.
Pang L, Tian H, Chang N, Yi J, Xue L, Jiang B, Gorospe M, Zhang X, Wang W.
BMC Mol Biol 14:15. doi: 10.1186/1471-2199-14-15. 2013
10CELF1, ELAVL1, OCLN
Competitive binding of CUGBP1 and HuR to occludin mRNA controls its translation and modulates epithelial barrier function.
Yu TX, Rao JN, Zou T, Liu L, Xiao L, Ouyang M, Cao S, Gorospe M, Wang JY.
Mol Biol Cell 24(2):85-99. doi: 10.1091/mbc.E12-07-0531. Epub 2012 Nov 14. 2013
11ELAVL1, HNRNPD, VEGFA
Association of the von Hippel-Lindau protein with AUF1 and posttranscriptional regulation of VEGFA mRNA.
Xin H, Brown JA, Gong C, Fan H, Brewer G, Gnarra JR.
Mol Cancer Res 10(1):108-20. Epub 2011 Nov 15. 2012
12ELAVL1, MYC, RBM38
The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation.
Cho SJ, Jung YS, Zhang J, Chen X.
J Biol Chem 287(18):14535-44. doi: 10.1074/jbc.M111.326827. Epub 2012 Feb 27. 2012
13ELAVL1, TNPO2
Transportin 2 regulates apoptosis through the RNA-binding protein HuR.
von Roretz C, Macri AM, Gallouzi IE.
J Biol Chem 286(29):25983-91. Epub 2011 Jun 6. 2011
14ELAVL1
Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites.
Uren PJ, Burns SC, Ruan J, Singh KK, Smith AD, Penalva LO.
J Biol Chem 286(43):37063-6. doi: 10.1074/jbc.C111.266882. Epub 2011 Sep 2. 2011
15ELAVL1, HSPA2
The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages.
Chi MN, Auriol J, Jégou B, Kontoyiannis DL, Turner JM, de Rooij DG, Morello D.
Mol Biol Cell 22(16):2875-85. doi: 10.1091/mbc.E11-03-0212. Epub 2011 Jul 7. 2011
16ELAVL1, FGF10, TBX4
HuR controls lung branching morphogenesis and mesenchymal FGF networks.
Sgantzis N, Yiakouvaki A, Remboutsika E, Kontoyiannis DL.
Dev Biol 354(2):267-79. doi: 10.1016/j.ydbio.2011.04.003. Epub 2011 Apr 16. 2011
17ELAVL1, ZNF385A
Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation.
Nakamura H, Kawagishi H, Watanabe A, Sugimoto K, Maruyama M, Sugimoto M.
Mol Cell Biol 31(10):1997-2009. doi: 10.1128/MCB.01424-10. Epub 2011 Mar 14. 2011
18CDKN1A, ELAVL1, RBM38
RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability.
Cho SJ, Zhang J, Chen X.
Nucleic Acids Res 38(7):2256-67. Epub 2010 Jan 11.PMID: 20064878 2010
19ELAVL1, PRKCB
The PKCbeta/HuR/VEGF pathway in diabetic retinopathy.
Amadio M, Bucolo C, Leggio GM, Drago F, Govoni S, Pascale A.
Biochem Pharmacol 80(8):1230-7. Epub 2010 Jul 1. 2010
20ELAVL1, HNRNPD, JUND
Polyamines regulate the stability of JunD mRNA by modulating the competitive binding of its 3' untranslated region to HuR and AUF1.
Zou T, Rao JN, Liu L, Xiao L, Yu TX, Jiang P, Gorospe M, Wang JY.
Mol Cell Biol 30(21):5021-32. doi: 10.1128/MCB.00807-10. Epub 2010 Aug 30. 2010
21ELAVL1
The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites.
Rivas-Aravena A, Ramdohr P, Vallejos M, Valiente-Echeverría F, Dormoy-Raclet V, Rodríguez F, Pino K, Holzmann C, Huidobro-Toro JP, Gallouzi IE, López-Lastra M.
Virology 392(2):178-85. Epub 2009 Aug 3.PMID: 19647848 2009
22BCL2, ELAVL1
Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells.
Ishimaru D, Ramalingam S, Sengupta TK, Bandyopadhyay S, Dellis S, Tholanikunnel BG, Fernandes DJ, Spicer EK.
Mol Cancer Res 7(8):1354-66. Epub 2009 Aug 11.PMID: 19671677 2009
23ELAVL1
Ubiquitin-mediated proteolysis of HuR by heat shock.
Abdelmohsen K, Srikantan S, Yang X, Lal A, Kim HH, Kuwano Y, Galban S, Becker KG, Kamara D, de Cabo R, Gorospe M.
EMBO J 28(9):1271-82. Epub 2009 Mar 26.PMID: 19322201 2009
24ELAVL1
Cloning, expression, purification and preliminary crystallographic studies of the adenylate/uridylate-rich element-binding protein HuR complexed with its target RNA.
Iyaguchi D, Yao M, Tanaka I, Toyota E.
Acta Crystallogr Sect F Struct Biol Cryst Commun 65(Pt 3):285-7. Epub 2009 Feb 26.PMID: 19255485 2009
25ELAVL1, RNASEL
RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth.
Al-Ahmadi W, Al-Haj L, Al-Mohanna FA, Silverman RH, Khabar KS.
Oncogene 28(15):1782-91. Epub 2009 Mar 2.PMID: 19252527 2009
26ELAVL1, PTGS2
Expression of embryonic lethal abnormal vision (ELAV)-like protein HuR and cyclooxygenase-2 (COX-2) in Ewing sarcoma.
Do SI, Araujo ES, Kalil RK, Bacchini P, Bertoni F, Unni KK, Park YK.
Tumori 94(3):347-50.PMID: 18705402 2008
27CDK1, ELAVL1
Nuclear HuR accumulation through phosphorylation by Cdk1.
Kim HH, Abdelmohsen K, Lal A, Pullmann R Jr, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, Gorospe M.
Genes Dev 22(13):1804-15.PMID: 18593881 2008
28ATF2, ELAVL1
Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells.
Xiao L, Rao JN, Zou T, Liu L, Marasa BS, Chen J, Turner DJ, Zhou H, Gorospe M, Wang JY.
Mol Biol Cell 18(11):4579-90. Epub 2007 Sep 5.PMID: 17804813 2007
29ELAVL1, TNPO2
Involvement of transportin 2-mediated HuR import in muscle cell differentiation.
van der Giessen K, Gallouzi IE.
Mol Biol Cell 18(7):2619-29. Epub 2007 May 2.PMID: 17475777 2007
30ELAVL1, ELAVL2, ELAVL3, ELAVL4, MSI1
A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA.
Ratti A, Fallini C, Cova L, Fantozzi R, Calzarossa C, Zennaro E, Pascale A, Quattrone A, Silani V.
J Cell Sci 119(Pt 7):1442-52. 2006
31SLC11A1, ELAVL1
RNA-binding protein HuR is required for stabilization of SLC11A1 mRNA and SLC11A1 protein expression.
Xu YZ, Di Marco S, Gallouzi I, Rola-Pleszczynski M, Radzioch D.
Mol Cell Biol 25(18):8139-49. 2005
32NXF1, ELAVL1, ELAVL2, ELAVL3, ELAVL4
TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD.
Saito K, Fujiwara T, Katahira J, Inoue K, Sakamoto H.
Biochem Biophys Res Commun 321(2):291-7. 2004
33REN, ELAVL1, PCBP1, HADHB
HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression.
Adams DJ, Beveridge DJ, van der Weyden L, Mangs H, Leedman PJ, Morris BJ.
J Biol Chem 278(45):44894-903. Epub 2003 Aug 21. 2003
34ANP32B, ELAVL1
Protein ligands to HuR modulate its interaction with target mRNAs in vivo.
Brennan CM, Gallouzi IE, Steitz JA.
J Cell Biol 151(1):1-14. 2000
35ELAVL1, ELAVL2, ELAVL3, ELAVL4
Why is Hu where ? Shuttling of early-response-gene messenger RNA subsets.
Keene JD.
Proc Natl Acad Sci U S A 96 : 5-7. 1999
36ELAVL1
Localization of the human HuR gene to chromosome 19p13.2.
Ma WJ, et al.
Hum Genet 99 : 32-33. 1997
37ELAVL1, ELAVL2, ELAVL4
The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA.
Ma WJ, Chung S, Furneaux H.
Nucleic Acids Res 25(18):3564-9. 1997
38ELAVL1, ELAVL2, ELAVL3, ELAVL4
A hierarchy of Hu RNA binding proteins in developing and adult neurons.
Okano HJ, et al.
J Neurosci 17 : 3024-3037. 1997
39AMPH, CDR1, CDR2, GAD1, ELAVL1, ELAVL2, ELAVL3, ELAVL4, NOVA1
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.
Fletcher CF, et al.
Genomics 45 : 313-319. 1997
40ELAVL1
Cloning and characterization of HuR, a ubiquitously expressed elav-like protein.
Ma WJ, et al.
J Biol Chem 271 : 8144-8151. 1996