| 1 | EIF4E, EIF4EBP1
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| Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis.
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| Musa J, Orth MF, Dallmayer M, Baldauf M, Pardo C, Rotblat B, Kirchner T, Leprivier G, Grünewald TG.
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| Oncogene 35(36):4675-88. doi: 10.1038/onc.2015.515. Epub 2016 Feb 1. Review.
2016
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| 2 | EIF4E, EIF4EBP1
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| Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP.
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| Ruoff R, Katsara O, Kolupaeva V.
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| Proc Natl Acad Sci U S A 113(27):7545-50. doi: 10.1073/pnas.1605451113. Epub 2016 Jun 16.
2016
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| 3 | EIF4EBP1
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| The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction.
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| Miller WP, Mihailescu ML, Yang C, Barber AJ, Kimball SR, Jefferson LS, Dennis MD.
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| Invest Ophthalmol Vis Sci 57(3):1327-37. doi: 10.1167/iovs.15-18719.
2016
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| 4 | EIF4E, EIF4EBP1
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| 4E-BP1, a multifactor regulated multifunctional protein.
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| Qin X, Jiang B, Zhang Y.
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| Cell Cycle 15(6):781-6. doi: 10.1080/15384101.2016.1151581. Review.
2016
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| 5 | EIF4EBP1
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| Translational control of nociception via 4E-binding protein 1.
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| Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, Sonenberg N.
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| Elife 4. pii: e12002. doi: 10.7554/eLife.12002.
2015
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| 6 | EIF4EBP1, MTOR
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| Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity.
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| Tsai S, Sitzmann JM, Dastidar SG, Rodriguez AA, Vu SL, McDonald CE, Academia EC, O'Leary MN, Ashe TD, La Spada AR, Kennedy BK.
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| J Clin Invest 125(8):2952-64. doi: 10.1172/JCI77361. Epub 2015 Jun 29.
2015
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| 7 | EIF4EBP1
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| A pre-structured helix in the intrinsically disordered 4EBP1.
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| Kim DH, Lee C, Cho YJ, Lee SH, Cha EJ, Lim JE, Sabo TM, Griesinger C, Lee D, Han KH.
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| Mol Biosyst 11(2):366-9. doi: 10.1039/c4mb00532e. Epub 2014 Nov 28.
2015
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| 8 | EIF4EBP1, GSPT2
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| eRF3b, a biomarker for hepatocellular carcinoma, influences cell cycle and phosphoralation status of 4E-BP1.
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| Li M, Wang J, Yang L, Gao P, Tian QB, Liu DW.
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| PLoS One 9(1):e86371. doi: 10.1371/journal.pone.0086371. eCollection 2014.
2014
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| 9 | EIF4EBP1, MTOR, RPS6KB1
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| The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.
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| Yang L, Miao L, Liang F, Huang H, Teng X, Li S, Nuriddinov J, Selzer ME, Hu Y.
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| Nat Commun 5:5416. doi: 10.1038/ncomms6416.
2014
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| 10 | EIF4EBP1, MTOR, RPTOR
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| Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.
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| Coffman K, Yang B, Lu J, Tetlow AL, Pelliccio E, Lu S, Guo DC, Tang C, Dong MQ, Tamanoi F.
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| J Biol Chem 289(8):4723-34. doi: 10.1074/jbc.M113.482067. Epub 2014 Jan 8.
2014
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| 11 | EIF4EBP1, PPM1G
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| Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1).
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| Liu J, Stevens PD, Eshleman NE, Gao T.
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| J Biol Chem 288(32):23225-33. doi: 10.1074/jbc.M113.492371. Epub 2013 Jun 28.
2013
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| 12 | EIF4EBP1, EIF4EBP2, MTOR
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| mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.
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| Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N.
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| Cell Metab 18(5):698-711. doi: 10.1016/j.cmet.2013.10.001. 2013
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| 13 | EIF4EBP1, EIF4EBP2
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| Requirement for the eIF4E binding proteins for the synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibition.
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| Clemens MJ, Elia A, Morley SJ.
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| PLoS One 8(8):e71138. doi: 10.1371/journal.pone.0071138. Print 2013.
2013
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| 14 | EIF4EBP1, EIF4EBP2
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| Anti-oncogenic potential of the eIF4E-binding proteins.
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| Martineau Y, Azar R, Bousquet C, Pyronnet S.
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| Oncogene 32(6):671-7. doi: 10.1038/onc.2012.116. Epub 2012 Apr 16. Review.
2013
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| 15 | EIF4E, EIF4EBP1, KLHL25
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| Translational homeostasis via the mRNA cap-binding protein, eIF4E.
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| Yanagiya A, Suyama E, Adachi H, Svitkin YV, Aza-Blanc P, Imataka H, Mikami S, Martineau Y, Ronai ZA, Sonenberg N.
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| Mol Cell 46(6):847-58. doi: 10.1016/j.molcel.2012.04.004. Epub 2012 May 10. 2012
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| 16 | EIF4EBP1, LRRK2
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| Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
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| Trancikova A, Mamais A, Webber PJ, Stafa K, Tsika E, Glauser L, West AB, Bandopadhyay R, Moore DJ.
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| PLoS One 7(10):e47784. doi: 10.1371/journal.pone.0047784. Epub 2012 Oct 17.
2012
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| 17 | EIF4EBP1, PLK1
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| 4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1.
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| Shang ZF, Yu L, Li B, Tu WZ, Wang Y, Liu XD, Guan H, Huang B, Rang WQ, Zhou PK.
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| Cell Cycle 11(18):3463-71. doi: 10.4161/cc.21770. Epub 2012 Aug 23.
2012
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| 18 | EIF4E, EIF4EBP1
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| A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E.
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| Paku KS, Umenaga Y, Usui T, Fukuyo A, Mizuno A, In Y, Ishida T, Tomoo K.
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| Biochem J 441(1):237-45. doi: 10.1042/BJ20101481.
2012
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| 19 | EIF4E, EIF4EBP1
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| Eukaryotic translation initiation factor 4E binding protein 1 (4EBP-1) function is suppressed by Src and protein phosphatase 2A (PP2A) on extracellular matrix.
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| Nho RS, Peterson M.
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| J Biol Chem 286(37):31953-65. doi: 10.1074/jbc.M111.222299. Epub 2011 Jul 22.
2011
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| 20 | EIF4EBP1, EIF4EBP2
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| mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.
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| Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Thomas G, Sonenberg N.
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| Science 328(5982):1172-6. doi: 10.1126/science.1187532.
2010
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| 21 | EIF4E, EIF4EBP1, RND3
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| RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation.
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| Villalonga P, de Mattos SF, Ridley AJ.
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| J Biol Chem 284(51):35287-96. Epub .PMID: 19850923 2009
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| 22 | EIF4EBP1, SMAD4
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| 4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation.
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| Azar R, Alard A, Susini C, Bousquet C, Pyronnet S.
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| EMBO J 28(22):3514-22. Epub 2009 Oct 15.PMID: 19834456 2009
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| 23 | EIF4EBP1
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| Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis.
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| Castellvi J, Garcia A, Ruiz-Marcellan C, Hernández-Losa J, Peg V, Salcedo M, Gil-Moreno A, Ramon y Cajal S.
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| Hum Pathol 40(10):1418-26. Epub 2009 May 9.PMID: 19428047 2009
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| 24 | EIF4EBP1
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| Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma.
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| Jacobson BA, De A, Kratzke MG, Patel MR, Jay-Dixon J, Whitson BA, Sadiq AA, Bitterman PB, Polunovsky VA, Kratzke RA.
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| Br J Cancer 101(3):424-31. Epub 2009 Jul 14.PMID: 19603014 2009
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| 25 | EIF4EBP1
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| Expression of selected tumor suppressor and oncogenes in endometrium of women with endometriosis.
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| Laudanski P, Szamatowicz J, Kowalczuk O, Kuźmicki M, Grabowicz M, Chyczewski L.
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| Hum Reprod 24(8):1880-90. Epub 2009 May 8.PMID: 19429661 2009
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| 26 | EIF4EBP1
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| Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to rapamycin treatment in vitro.
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| Darb-Esfahani S, Faggad A, Noske A, Weichert W, Buckendahl AC, Müller B, Budczies J, Röske A, Dietel M, Denkert C.
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| J Cancer Res Clin Oncol 135(7):933-41. Epub 2008 Dec 24.PMID: 19107520 2009
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| 27 | EIF4EBP1
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| Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.
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| Coleman LJ, Peter MB, Teall TJ, Brannan RA, Hanby AM, Honarpisheh H, Shaaban AM, Smith L, Speirs V, Verghese ET, McElwaine JN, Hughes TA.
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| Br J Cancer 100(9):1393-9. Epub 2009 Apr 14.PMID: 19367274 2009
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| 28 | EIF4EBP1
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| The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.
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| Sukarieh R, Sonenberg N, Pelletier J.
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| Am J Physiol Cell Physiol 296(5):C1207-17. Epub 2009 Feb 25.PMID: 19244480 2009
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| 29 | EIF4EBP1
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| Phosphorylated 4E-BP1 is associated with poor survival in melanoma.
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| O'Reilly KE, Warycha M, Davies MA, Rodrik V, Zhou XK, Yee H, Polsky D, Pavlick AC, Rosen N, Bhardwaj N, Mills G, Osman I.
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| Clin Cancer Res 15(8):2872-8. Epub 2009 Mar 31.PMID: 19336517 2009
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| 30 | EIF4E, EIF4EBP1, EIF4EBP2
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| The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.
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| Sukarieh R, Sonenberg N, Pelletier J.
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| Am J Physiol Cell Physiol 296(5):C1207-17. doi: 10.1152/ajpcell.00511.2008. Epub 2009 Feb 25.
2009
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| 31 | EIF4EBP1, EIF4EBP2, EIF4EBP3
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| Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.
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| Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G.
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| Cell 128(2):257-67. 2007
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| 32 | EIF4EBP1, MAP4K3
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| A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling.
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| Findlay GM, Yan L, Procter J, Mieulet V, Lamb RF.
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| Biochem J 403(1):13-20.
2007
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| 33 | EIF4EBP1, EIF4EBP2, EIF4EBP3, CPEB1, CPEB2, CPEB3, CPEB4
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| Regulation of cap-dependent translation by eIF4E inhibitory proteins.
|
| Richter JD, Sonenberg N.
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| Nature 433(7025):477-80. Review. 2005
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| 34 | EIF4E, EIF4EBP1
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| The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.
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| Wang X, Li W, Parra JL, Beugnet A, Proud CG.
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| Mol Cell Biol 23(5):1546-57. 2003
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| 35 | EIF4EBP1
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| Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency.
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| Li S, Sonenberg N, Gingras AC, Peterson M, Avdulov S, Polunovsky VA, Bitterman PB.
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| Mol Cell Biol 22(8):2853-61. 2002
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| 36 | EIF4EBP1, EIF4EBP2
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| Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2.
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| Tsukiyama-Kohara K, et al.
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| Genomics 38 : 353-363. 1996
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| 37 | EIF4EBP1, EIF4EBP2
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| Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.
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| Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, Lawrence JC Jr, Sonenberg N.
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| Nature 371(6500):762-7. 1994
|