Citations for
1EIF4A1, EIF4B, EIF4E, EIF4G1
mRNA Recruiting eIF4 Factors Involved in Protein Synthesis and Its Regulation.
Mishra RK, Datey A, Hussain T.
Biochemistry 59(1):34-46. doi: 10.1021/acs.biochem.9b00788. Epub 2019 Dec 4. 2020
2EIF4A1, EIF4E, PHGDH
Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.
Ma X, Li B, Liu J, Fu Y, Luo Y.
J Exp Clin Cancer Res. Feb 11;38(1):66. doi: 10.1186/s13046-019-1053-y. 2019
3EIF1, EIF4E, EIF4G1
Dynamic interactions of eIF4G1 with eIF4E and eIF1 underlie scanning dependent and independent translation.
Haimov O, Sehrawat U, Tamarkin-Ben Harush A, Bahat A, Uzonyi A, Will A, Hiraishi H, Asano K, Dikstein R.
Mol Cell Biol ol Cell Biol. 2018 Jul 9. pii: MCB.00139-18. doi: 10.1128/MCB.00139-18. [Epub ahead of print] 2018
4EIF4E
A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.
Volpon L, Culjkovic-Kraljacic B, Sohn HS, Blanchet-Cohen A, Osborne MJ, Borden KLB.
RNA 23(6):927-937. doi: 10.1261/rna.060137.116. Epub 2017 Mar 21. 2017
5EIF4E, EIF4E2, EIF4E3
Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules.
Frydryskova K, Masek T, Borcin K, Mrvova S, Venturi V, Pospisek M.
BMC Mol Biol 17(1):21. doi: 10.1186/s12867-016-0072-x. 2016
6EIF4E, EIF4G1
The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
Grüner S, Peter D, Weber R, Wohlbold L, Chung MY, Weichenrieder O, Valkov E, Igreja C, Izaurralde E.
Mol Cell 64(3):467-479. doi: 10.1016/j.molcel.2016.09.020. Epub 2016 Oct 20. 2016
7EIF4E, EIF4EBP1
Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis.
Musa J, Orth MF, Dallmayer M, Baldauf M, Pardo C, Rotblat B, Kirchner T, Leprivier G, Grünewald TG.
Oncogene 35(36):4675-88. doi: 10.1038/onc.2015.515. Epub 2016 Feb 1. Review. 2016
8EIF4E, EIF4EBP1
Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP.
Ruoff R, Katsara O, Kolupaeva V.
Proc Natl Acad Sci U S A 113(27):7545-50. doi: 10.1073/pnas.1605451113. Epub 2016 Jun 16. 2016
9EIF4E, EIF4EBP1
4E-BP1, a multifactor regulated multifunctional protein.
Qin X, Jiang B, Zhang Y.
Cell Cycle 15(6):781-6. doi: 10.1080/15384101.2016.1151581. Review. 2016
10BDNF, CYFIP1, EIF4E, MKNK1
BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1.
Genheden M, Kenney JW, Johnston HE, Manousopoulou A, Garbis SD, Proud CG.
J Neurosci 35(3):972-84. doi: 10.1523/JNEUROSCI.2641-14.2015. 2015
11CYFIP1, EIF4E, FMR1, MKNK1, MKNK2
The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.
Beggs JE, Tian S, Jones GG, Xie J, Iadevaia V, Jenei V, Thomas G, Proud CG.
Biochem J 467(1):63-76. doi: 10.1042/BJ20141066. 2015
12EIF4E, HSPB1
Unphosphorylated HSP27 (HSPB1) regulates the translation initiation process via a direct association with eIF4E in osteoblasts.
Kuroyanagi G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
Int J Mol Med 36(3):881-9. doi: 10.3892/ijmm.2015.2274. Epub 2015 Jul 7. 2015
13EIF4E, EIF4ENIF1
The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5' and 3' Termini of Target mRNAs.
Nishimura T, Padamsi Z, Fakim H, Milette S, Dunham WH, Gingras AC, Fabian MR.
Cell Rep 11(9):1425-36. doi: 10.1016/j.celrep.2015.04.065. Epub 2015 May 28. 2015
14EIF4E, EIF4ENIF1
Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.
Martínez A, Sesé M, Losa JH, Robichaud N, Sonenberg N, Aasen T, Ramón Y Cajal S.
PLoS One 10(4):e0123352. doi: 10.1371/journal.pone.0123352. eCollection 2015. 2015
15EIF4E, EIF4E3, MKNK1, MKNK2
MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden KL, Gartenhaus RB.
Nat Commun 5:5413. doi: 10.1038/ncomms6413. 2014
16DDX6, EIF4E, EIF4ENIF1, LSM1
An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.
Yang G, Smibert CA, Kaplan DR, Miller FD.
Neuron 84(4):723-39. doi: 10.1016/j.neuron.2014.10.022. Epub 2014 Nov 6. 2014
17EIF4E, EIF4ENIF1
Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing.
Kamenska A, Lu WT, Kubacka D, Broomhead H, Minshall N, Bushell M, Standart N.
Nucleic Acids Res 42(5):3298-313. doi: 10.1093/nar/gkt1265. Epub 2013 Dec 13. 2014
18ANGEL1, EIF4E
An eIF4E-interacting peptide induces cell death in cancer cell lines.
Masse M, Glippa V, Saad H, Le Bloas R, Gauffeny I, Berthou C, Czjzek M, Cormier P, Cosson B.
Cell Death Dis 5:e1500. doi: 10.1038/cddis.2014.457. 2014
19EIF4E, EIF4G1
Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G.
Proc Natl Acad Sci U S A 111(31):E3187-95. doi: 10.1073/pnas.1410250111. Epub 2014 Jul 21. 2014
20EIF4E, EIF4EBP2
Autism-related deficits via dysregulated eIF4E-dependent translational control.
Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N.
Nature 493(7432):371-7. doi: 10.1038/nature11628. Epub 2012 Nov 21. 2013
21EIF4E, EIF4E3
eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition.
Osborne MJ, Volpon L, Kornblatt JA, Culjkovic-Kraljacic B, Baguet A, Borden KL.
Proc Natl Acad Sci U S A 110(10):3877-82. doi: 10.1073/pnas.1216862110. Epub 2013 Feb 19. 2013
22EIF4E, EIF4E2, EIF4E3
Hypoxia-inducible factor-1α (HIF-1α) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions.
Yi T, Papadopoulos E, Hagner PR, Wagner G.
J Biol Chem 288(26):18732-42. doi: 10.1074/jbc.M113.471466. Epub 2013 May 10. 2013
23BANK1, EIF4E, MKNK1, MKNK2
BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway.
Wu YY, Kumar R, Haque MS, Castillejo-López C, Alarcón-Riquelme ME.
J Immunol 191(12):6110-6. doi: 10.4049/jimmunol.1301203. Epub 2013 Nov 13. 2013
24EIF4E, EIF4E2, EIF4ENIF1
Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells.
Kubacka D, Kamenska A, Broomhead H, Minshall N, Darzynkiewicz E, Standart N.
PLoS One 8(8):e72761. doi: 10.1371/journal.pone.0072761. eCollection 2013. 2013
25ANGEL1, EIF4E
Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E.
Gosselin P, Martineau Y, Morales J, Czjzek M, Glippa V, Gauffeny I, Morin E, Le Corguillé G, Pyronnet S, Cormier P, Cosson B.
Nucleic Acids Res 41(16):7783-92. doi: 10.1093/nar/gkt569. Epub 2013 Jun 27. 2013
26EIF4E, NOS2, XPO1
Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.
Bollmann F, Fechir K, Nowag S, Koch K, Art J, Kleinert H, Pautz A.
Nitric Oxide 30:49-59. doi: 10.1016/j.niox.2013.02.083. Epub 2013 Mar 5. 2013
27EIF4E, EIF4G1
Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity.
Feoktistova K, Tuvshintogs E, Do A, Fraser CS.
Proc Natl Acad Sci U S A 110(33):13339-44. doi: 10.1073/pnas.1303781110. Epub 2013 Jul 30. 2013
28DDX3X, EIF4E, PABPC1
Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response.
Shih JW, Wang WT, Tsai TY, Kuo CY, Li HK, Wu Lee YH.
Biochem J 441(1):119-29. 2012
29EIF4E, EIF4EBP1, KLHL25
Translational homeostasis via the mRNA cap-binding protein, eIF4E.
Yanagiya A, Suyama E, Adachi H, Svitkin YV, Aza-Blanc P, Imataka H, Mikami S, Martineau Y, Ronai ZA, Sonenberg N.
Mol Cell 46(6):847-58. doi: 10.1016/j.molcel.2012.04.004. Epub 2012 May 10. 2012
30EIF4E, EIF4EBP1
A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E.
Paku KS, Umenaga Y, Usui T, Fukuyo A, Mizuno A, In Y, Ishida T, Tomoo K.
Biochem J 441(1):237-45. doi: 10.1042/BJ20101481. 2012
31EIF4E, PRKN
Diminution of eIF4E activity suppresses parkin mutant phenotypes.
Ottone C, Galasso A, Gemei M, Pisa V, Gigliotti S, Piccioni F, Graziani F, Verrotti di Pianella A.
Gene 470(1-2):12-9. Epub 2010 Sep 29. 2011
32EIF4E, EIF4G1
Identification and function of the second eIF4E-binding region in N-terminal domain of eIF4G: comparison with eIF4E-binding protein.
Umenaga Y, Paku KS, In Y, Ishida T, Tomoo K.
Biochem Biophys Res Commun 414(3):462-7. Epub 2011 Sep 21. 2011
33EIF4E, MKNK1, MKNK2
Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis.
Joshi S, Sharma B, Kaur S, Majchrzak B, Ueda T, Fukunaga R, Verma AK, Fish EN, Platanias LC.
J Biol Chem 286(8):6017-26. doi: 10.1074/jbc.M110.197921. Epub 2010 Dec 13. 2011
34EIF4E, EIF4E2
Diminution of eIF4E activity suppresses parkin mutant phenotypes.
Ottone C, Galasso A, Gemei M, Pisa V, Gigliotti S, Piccioni F, Graziani F, Verrotti di Pianella A.
Gene 470(1-2):12-9. doi: 10.1016/j.gene.2010.09.003. Epub 2010 Sep 29. 2011
35EIF4E, EIF4EBP1
Eukaryotic translation initiation factor 4E binding protein 1 (4EBP-1) function is suppressed by Src and protein phosphatase 2A (PP2A) on extracellular matrix.
Nho RS, Peterson M.
J Biol Chem 286(37):31953-65. doi: 10.1074/jbc.M111.222299. Epub 2011 Jul 22. 2011
36EIF4E
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.
Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg N.
Proc Natl Acad Sci U S A 107(32):14134-9. Epub 2010 Aug 2.PMID: 20679199 2010
37EIF4E, HDAC2, SUMO1, SUMO2, SUMO3, SUMO4
HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically.
Xu X, Vatsyayan J, Gao C, Bakkenist CJ, Hu J.
J Biol Chem 285(24):18139-43. Epub 2010 Apr 26.PMID: 20421305 2010
38EIF4E, EIF4G1, MKNK1, MKNK2
Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
Shveygert M, Kaiser C, Bradrick SS, Gromeier M.
Mol Cell Biol 30(21):5160-7. doi: 10.1128/MCB.00448-10. Epub 2010 Sep 7. 2010
39EIF4E, LRPPRC
Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP.
Topisirovic I, Siddiqui N, Lapointe VL, Trost M, Thibault P, Bangeranye C, Pińol-Roma S, Borden KL.
EMBO J 28(8):1087-98. Epub 2009 Mar 5. 2009
40EIF4E, PRMT5, TP53
PRMT5 is required for cell-cycle progression and p53 tumor suppressor function.
Scoumanne A, Zhang J, Chen X.
Nucleic Acids Res 37(15):4965-76. Epub 2009 Jun 15. 2009
41EIF4E
Deregulation of EIF4E: a novel mechanism for autism.
Neves-Pereira M, Müller B, Massie D, Williams JH, O'Brien PC, Hughes A, Shen SB, Clair DS, Miedzybrodzka Z.
J Med Genet 46(11):759-65. Epub 2009 Jun 25. 2009
42EIF4E, EIF4EBP1, RND3
RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation.
Villalonga P, de Mattos SF, Ridley AJ.
J Biol Chem 284(51):35287-96. Epub .PMID: 19850923 2009
43EIF4E, EIF4EBP1, EIF4EBP2
The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.
Sukarieh R, Sonenberg N, Pelletier J.
Am J Physiol Cell Physiol 296(5):C1207-17. doi: 10.1152/ajpcell.00511.2008. Epub 2009 Feb 25. 2009
44CYFIP1, EIF4E, FMR1
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.
Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, Di Marino D, Mohr E, Massimi M, Falconi M, Witke W, Costa-Mattioli M, Sonenberg N, Achsel T, Bagni C.
Cell 134(6):1042-54. 2008
45EIF4E
The eIF4E RNA regulon promotes the Akt signaling pathway.
Culjkovic B, Tan K, Orolicki S, Amri A, Meloche S, Borden KL.
J Cell Biol 181(1):51-63. 2008
46EIF4E, EIF4E3
Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila.
Hernández G, Altmann M, Sierra JM, Urlaub H, Diez del Corral R, Schwartz P, Rivera-Pomar R.
Mech Dev 122(4):529-43. Epub 2004 Dec 8. Erratum in: Mech Dev. 2006 Jan;123(1):97. 2005
47AKT1, EIF4E, MTOR
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.
Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW.
Nature 428(6980):332-7. 2004
48EIF4E, EIF4E2, EIF4E3, EIF4G1
Characterization of mammalian eIF4E-family members.
Joshi B, Cameron A, Jagus R.
Eur J Biochem 271(11):2189-203. 2004
49EIF4E, EIF4E2, EIF4E3
Characterization of mammalian eIF4E-family members.
Joshi B, Cameron A, Jagus R.
Eur J Biochem 271(11):2189-203. 2004
50EIF4E, EIF4EBP1
The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.
Wang X, Li W, Parra JL, Beugnet A, Proud CG.
Mol Cell Biol 23(5):1546-57. 2003
51EIF4E
Mutations in the S4-H2 loop of eIF4E which increase the affinity for m7GTP.
Spivak-Kroizman T, Friedland DE, De Staercke C, Gernert KM, Goss DJ, Hagedorn CH.
FEBS Lett 516(1-3):9-14. 2002
52EIF4E, EIF4EBP3
Localisation and regulation of the eIF4E-binding protein 4E-BP3.
Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG.
FEBS Lett 532(3):319-23. 2002
53EIF4E
Ectopic expression of eIF-4E in human colon cancer cells promotes the stimulation of adhesion molecules by transforming growth factorbeta.
Rajagopal S, Chakrabarty S.
Cell Adhes Commun 8(2):87-97. 2001
54EIF4E
Detection of the proto-oncogene eIF4E in larynx and hypopharynx cancers.
Franklin S, et al.
Arch Otolaryngol Head Neck Surg 125(2):177-82. 1999
55EIF4E, EIF4E4
Cloning and characterization of human eIF4E genes.
Gao M, et al.
J Biol Chem 273(8):4622-8. 1998
56EIF4E
Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4.
Jones RM, MacDonald ME, Branda J, Altherr MR, Louis DN, Schmidt EV.
Somat Cell Mol Genet 23(3):221-3. 1997
57EIF4E
A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.
Lejbkowicz F, Goyer C, Darveau A, Neron S, Lemieux R, Sonenberg N.
Proc Natl Acad Sci U S A 89(20):9612-6.PMID: 1384058 1992
58EIF4E, EIF4EP1
Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20.
Pelletier J, Brook JD, Housman DE.
Genomics 10(4):1079-82. 1991