| 1 | EIF2S1, PPP1R15A, PPP1R15B
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| Complementary roles of GADD34- and CReP-containing eIF2α Phosphatases during the Unfolded Protein Response.
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| Reid DW, Tay AS, Sundaram JR, Lee IC, Chen Q, George SE, Nicchitta CV, Shenolikar S.
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| Mol Cell Biol ol Cell Biol. 2016 May 9. pii: MCB.00190-16. [Epub ahead of print]
2016
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| 2 | EIF2S1, NOX4, PPP1R15A
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| Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling.
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| Santos CX, Hafstad AD, Beretta M, Zhang M, Molenaar C, Kopec J, Fotinou D, Murray TV, Cobb AM, Martin D, Zeh Silva M, Anilkumar N, Schröder K, Shanahan CM, Brewer AC, Brandes RP, Blanc E, Parsons M, Belousov V, Cammack R, Hider RC, Steiner RA, Shah AM.
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| EMBO J 35(3):319-34. doi: 10.15252/embj.201592394. Epub 2016 Jan 7.
2016
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| 3 | EIF2S1, PPP1R15A
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| An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α.
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| Rojas M, Vasconcelos G, Dever TE.
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| Proc Natl Acad Sci U S A 112(27):E3466-75. doi: 10.1073/pnas.1501557112. Epub 2015 Jun 22.
2015
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| 4 | EIF2AK4, EIF2S1
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| Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
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| Wengrod J, Wang D, Weiss S, Zhong H, Osman I, Gardner LB.
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| Sci Signal 8(367):ra27. doi: 10.1126/scisignal.aaa0899.
2015
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| 5 | EIF2S1, PPP1R15A, PPP1R15B
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| Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.
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| Young SK, Willy JA, Wu C, Sachs MS, Wek RC.
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| J Biol Chem 290(47):28257-71. doi: 10.1074/jbc.M115.693184. Epub 2015 Oct 7.
2015
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| 6 | EIF2S1, PPP1CA, PPP1R15B
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| Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability.
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| Kernohan KD, Tétreault M, Liwak-Muir U, Geraghty MT, Qin W, Venkateswaran S, Davila J; Care4Rare Canada Consortium, Holcik M, Majewski J, Richer J, Boycott KM.
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| Hum Mol Genet 24(22):6293-300. doi: 10.1093/hmg/ddv337. Epub 2015 Aug 24.
2015
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| 7 | EIF2S1, ERN1, PPP1R15B
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| IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis.
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| So JS, Cho S, Min SH, Kimball SR, Lee AH.
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| Mol Cell Biol 35(16):2761-70. doi: 10.1128/MCB.00215-15. Epub 2015 Jun 1.
2015
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| 8 | BTRC, EIF2S1, PPP1R15B
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| DNA Damage Regulates Translation through β-TRCP Targeting of CReP.
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| Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski DP.
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| PLoS Genet 11(6):e1005292. doi: 10.1371/journal.pgen.1005292. eCollection 2015 Jun.
2015
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| 9 | EIF2AK3, EIF2S1
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| Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.
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| Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q, Gupta PB.
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| Cancer Discov 4(6):702-15. doi: 10.1158/2159-8290.CD-13-0945. Epub 2014 Apr 4.
2014
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| 10 | EIF2AK3, EIF2S1
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| Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.
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| Guan BJ, Krokowski D, Majumder M, Schmotzer CL, Kimball SR, Merrick WC, Koromilas AE, Hatzoglou M.
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| J Biol Chem 289(18):12593-611. doi: 10.1074/jbc.M113.543215. Epub 2014 Mar 19.
2014
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| 11 | EIF2S1
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| ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin.
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| Leitman J, Barak B, Benyair R, Shenkman M, Ashery U, Hartl FU, Lederkremer GZ.
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| PLoS One 9(3):e90803. doi: 10.1371/journal.pone.0090803. eCollection 2014.
2014
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| 12 | EIF2AK2, EIF2S1, STAT3
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| Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy.
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| Niso-Santano M, Shen S, Adjemian S, Malik SA, Mariño G, Lachkar S, Senovilla L, Kepp O, Galluzzi L, Maiuri MC, Kroemer G.
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| Autophagy 9(3):415-7. doi: 10.4161/auto.22910. Epub 2012 Dec 7.
2013
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| 13 | EIF2AK3, EIF2AK4, EIF2S1
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| Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
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| Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E.
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| Nat Neurosci 16(9):1299-305. doi: 10.1038/nn.3486. Epub 2013 Aug 11.
2013
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| 14 | CDC123, EIF2S1, EIF2S2, EIF2S3
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| Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2)
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| Perzlmaier AF, Richter F, Seufert W.
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| J Biol Chem. Jul 26;288(30):21537-46. doi: 10.1074/jbc.M113.472290. Epub 2013 Jun 17. 2013
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| 15 | EIF2AK3, EIF2S1, PTPN1
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| Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.
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| Bettaieb A, Matsuo K, Matsuo I, Wang S, Melhem R, Koromilas AE, Haj FG.
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| PLoS One 7(4):e34412. Epub 2012 Apr 3. 2012
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| 16 | EIF2S1, PPP1R15B
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| A subunit of eukaryotic translation initiation factor 2α-phosphatase (CreP/PPP1R15B) regulates membrane traffic.
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| Kloft N, Neukirch C, von Hoven G, Bobkiewicz W, Weis S, Boller K, Husmann M.
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| J Biol Chem 287(42):35299-317. doi: 10.1074/jbc.M112.379883. Epub 2012 Aug 22.
2012
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| 17 | DDIT4, EIF2AK3, EIF2S1
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| Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2α phosphorylation, ATF4-dependent cascade.
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| Kimball SR, Jefferson LS.
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| Biochem Biophys Res Commun 427(3):485-9. doi: 10.1016/j.bbrc.2012.09.074. Epub 2012 Sep 20.
2012
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| 18 | EIF2S1
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| Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
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| Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, Halliday M, Morgan J, Dinsdale D, Ortori CA, Barrett DA, Tsaytler P, Bertolotti A, Willis AE, Bushell M, Mallucci GR.
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| Nature 485(7399):507-11. doi: 10.1038/nature11058. Erratum in: Nature.2014 Jul 17;511(7509):370.
2012
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| 19 | EIF2S1, PPP1R15B, PTEN
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| Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes.
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| Zeng N, Li Y, He L, Xu X, Galicia V, Deng C, Stiles BL.
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| Mol Cancer Res 9(12):1708-17. doi: 10.1158/1541-7786.MCR-11-0299. Epub 2011 Oct 18.
2011
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| 20 | EIF2AK4, EIF2S1, PPP1R15B
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| Phosphorylation of eIF2α via the general control kinase, GCN2, modulates the ability of renal medullary cells to survive high urea stress.
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| Cai Q, Brooks HL.
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| Am J Physiol Renal Physiol 301(6):F1202-7. doi: 10.1152/ajprenal.00272.2011. Epub 2011 Aug 31.
2011
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| 21 | EIF2S1
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| Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51.
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| Dey M, Velyvis A, Li JJ, Chiu E, Chiovitti D, Kay LE, Sicheri F, Dever TE.
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| Proc Natl Acad Sci U S A 108(11):4316-21. doi: 10.1073/pnas.1014872108. Epub 2011 Feb 28.
2011
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| 22 | EIF2S1
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| Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.
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| Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, Scheuner D, Kaufman RJ, Hatzoglou M, Koromilas AE.
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| Mol Biol Cell 21(18):3220-31. doi: 10.1091/mbc.E10-01-0023. Epub 2010 Jul 21.
2010
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| 23 | EIF2AK1, EIF2S1, OGFOD1
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| OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress.
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| Wehner KA, Schütz S, Sarnow P.
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| Mol Cell Biol 30(8):2006-16. doi: 10.1128/MCB.01350-09. Epub 2010 Feb 12.
2010
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| 24 | EIF2S1
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| Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.
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| Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ.
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| Cell Metab 10(1):13-26. doi: 10.1016/j.cmet.2009.06.002.
2009
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| 25 | EIF2S1, EIF2S2
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| Intersubunit and interprotein interactions of alpha- and beta-subunits of human eIF2: Effect of phosphorylation.
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| Rajesh K, Iyer A, Suragani RN, Ramaiah KV.
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| Biochem Biophys Res Commun 374(2):336-40. doi: 10.1016/j.bbrc.2008.07.022. Epub 2008 Jul 17.
2008
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| 26 | EIF2S1
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| Identification of mRNAs that continue to associate with polysomes during hypoxia.
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| Thomas JD, Johannes GJ.
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| RNA 13(7):1116-31. Epub 2007 May 8. 2007
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| 27 | EIF1,EIF2S1,EIF3A,EIF5
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| The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G.
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| Yamamoto Y, Singh CR, Marintchev A, Hall NS, Hannig EM, Wagner G, Asano K.
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| Proc Natl Acad Sci U S A 102(45):16164-9. Epub 2005 Oct 27. 2005
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| 28 | EIF2S1, EIF2S2, EIF2S3
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| Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases.
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| Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV.
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| Biochem Biophys Res Commun 338(4):1766-72. Epub 2005 Nov 2. 2005
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| 29 | EIF2S1
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| Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha.
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| Nonato MC, Widom J, Clardy J.
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| J Biol Chem 277(19):17057-61. 2002
|