| 1 | EIF2AK4, EIF2S1 |
| Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma. | |
| Wengrod J, Wang D, Weiss S, Zhong H, Osman I, Gardner LB. | |
| Sci Signal 8(367):ra27. doi: 10.1126/scisignal.aaa0899. 2015 | |
| 2 | EIF2AK3, EIF2AK4, EIF2S1 |
| Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. | |
| Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E. | |
| Nat Neurosci 16(9):1299-305. doi: 10.1038/nn.3486. Epub 2013 Aug 11. 2013 | |
| 3 | ATF4, EIF2AK4, NUPR1 |
| Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway. | |
| Averous J, Lambert-Langlais S, Cherasse Y, Carraro V, Parry L, B'chir W, Jousse C, Maurin AC, Bruhat A, Fafournoux P. | |
| Biochem Biophys Res Commun 413(1):24-9. Epub 2011 Aug 16. 2011 | |
| 4 | EIF2AK4 |
| Identification of GCN2 as new redox regulator for oxidative stress prevention in vivo. | |
| Chaveroux C, Lambert-Langlais S, Parry L, Carraro V, Jousse C, Maurin AC, Bruhat A, Marceau G, Sapin V, Averous J, Fafournoux P. | |
| Biochem Biophys Res Commun 415(1):120-4. Epub 2011 Oct 12. 2011 | |
| 5 | EIF2AK3, EIF2AK4 |
| The role of PERK and GCN2 in basal and hydrogen peroxide-regulated translation from the hepatitis C virus internal ribosome entry site. | |
| Jack SC, Chan SW. | |
| Virus Genes 43(2):208-14. Epub 2011 Jun 3. 2011 | |
| 6 | EIF2AK4, EIF2S1, PPP1R15B |
| Phosphorylation of eIF2α via the general control kinase, GCN2, modulates the ability of renal medullary cells to survive high urea stress. | |
| Cai Q, Brooks HL. | |
| Am J Physiol Renal Physiol 301(6):F1202-7. doi: 10.1152/ajprenal.00272.2011. Epub 2011 Aug 31. 2011 | |
| 7 | EIF2AK4 |
| The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. | |
| Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG. | |
| J Nutr 140(11):2020-7. Epub 2010 Sep 22. 2010 | |
| 8 | EIF2AK3, EIF2AK4 |
| Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation. | |
| Liu Y, László C, Liu Y, Liu W, Chen X, Evans SC, Wu S. | |
| Neoplasia 12(1):61-8. 2010 | |
| 9 | EIF2AK4 |
| Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways. | |
| Deval C, Chaveroux C, Maurin AC, Cherasse Y, Parry L, Carraro V, Milenkovic D, Ferrara M, Bruhat A, Jousse C, Fafournoux P. | |
| FEBS J 276(3):707-18. Epub 2008 Dec 19. 2009 | |
| 10 | EIF2AK4 |
| Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes. | |
| Deval C, Talvas J, Chaveroux C, Maurin AC, Mordier S, Cherasse Y, Parry L, Carraro V, Jousse C, Bruhat A, Fafournoux P. | |
| Biochimie 90(11-12):1716-21. Epub 2008 Jul 25. 2008 | |
| 11 | EIF2AK4 |
| The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. | |
| Guo F, Cavener DR. | |
| Cell Metab 5(2):103-14. 2007 | |
| 12 | EIF2AK3, EIF2AK4 |
| PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. | |
| Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA. | |
| Mol Biol Cell 16(12):5493-501. Epub 2005 Sep 21. 2005 | |
| 13 | EIF2AK4 |
| Activation of GCN2 in UV-irradiated cells inhibits translation. | |
| Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N. | |
| Curr Biol 12(15):1279-86. 2002 | |
| 14 | ALPK3, ARHGAP21, ARHGAP28, ASH1L, BOD1L, CASKIN1, CDH6, CGN, CHD7, COG1, CPSF2, CRAMP1L, DNAH1, EBF4, EIF2AK1, EIF2AK4, FAM135A, FAM63A, FBXO41, FBXO42, FGD6, FRMD4A, G2E3, HACE1, HEATR5B, HOMEZ, IBTK, IFT80, IGSF9, JMJD1C, KCNT1, KIAA1109, KIAA1328, KIAA1377, KIAA1383, KIAA1407, KIAA1430, KIF17, KLF17, KLHDC5, KLHL11, KLHL12, KLHL13, KLHL14, KLHL15, KLHL8, KLHL9, LRP2BP, LRRC7, MARCH4, MIB1, MRTFA, N4BP2, NFIA, NUFIP2, PCDH10, PDCD6IP, PDP2, PTCHD2, RBM27, RCOR3, RGAG1, RIC1, ROBO2, RPAP1, SEMA6A, SH3PXD2B, SIPA1L2, STAMBPL1, STARD9, TSR1, TULP4, TXNDC16, UPF2, WDFY1, WDR11, WDR35, ZMYM6, ZNF391, ZNF395, ZNF398, ZNF471, ZNF687, ZNFX1 |
| Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. | |
| Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O. | |
| DNA Res 7(1):65-73. 2000 | |
| 15 | EIF2AK4 |
| Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase. | |
| Berlanga JJ, Santoyo J, De Haro C. | |
| Eur J Biochem 265(2):754-62. 1999 | |