Citations for
1EIF2AK4, EIF2S1
Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
Wengrod J, Wang D, Weiss S, Zhong H, Osman I, Gardner LB.
Sci Signal 8(367):ra27. doi: 10.1126/scisignal.aaa0899. 2015
2EIF2AK3, EIF2AK4, EIF2S1
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E.
Nat Neurosci 16(9):1299-305. doi: 10.1038/nn.3486. Epub 2013 Aug 11. 2013
3ATF4, EIF2AK4, NUPR1
Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway.
Averous J, Lambert-Langlais S, Cherasse Y, Carraro V, Parry L, B'chir W, Jousse C, Maurin AC, Bruhat A, Fafournoux P.
Biochem Biophys Res Commun 413(1):24-9. Epub 2011 Aug 16. 2011
4EIF2AK4
Identification of GCN2 as new redox regulator for oxidative stress prevention in vivo.
Chaveroux C, Lambert-Langlais S, Parry L, Carraro V, Jousse C, Maurin AC, Bruhat A, Marceau G, Sapin V, Averous J, Fafournoux P.
Biochem Biophys Res Commun 415(1):120-4. Epub 2011 Oct 12. 2011
5EIF2AK3, EIF2AK4
The role of PERK and GCN2 in basal and hydrogen peroxide-regulated translation from the hepatitis C virus internal ribosome entry site.
Jack SC, Chan SW.
Virus Genes 43(2):208-14. Epub 2011 Jun 3. 2011
6EIF2AK4, EIF2S1, PPP1R15B
Phosphorylation of eIF2α via the general control kinase, GCN2, modulates the ability of renal medullary cells to survive high urea stress.
Cai Q, Brooks HL.
Am J Physiol Renal Physiol 301(6):F1202-7. doi: 10.1152/ajprenal.00272.2011. Epub 2011 Aug 31. 2011
7EIF2AK4
The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase.
Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG.
J Nutr 140(11):2020-7. Epub 2010 Sep 22. 2010
8EIF2AK3, EIF2AK4
Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.
Liu Y, László C, Liu Y, Liu W, Chen X, Evans SC, Wu S.
Neoplasia 12(1):61-8. 2010
9EIF2AK4
Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways.
Deval C, Chaveroux C, Maurin AC, Cherasse Y, Parry L, Carraro V, Milenkovic D, Ferrara M, Bruhat A, Jousse C, Fafournoux P.
FEBS J 276(3):707-18. Epub 2008 Dec 19. 2009
10EIF2AK4
Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes.
Deval C, Talvas J, Chaveroux C, Maurin AC, Mordier S, Cherasse Y, Parry L, Carraro V, Jousse C, Bruhat A, Fafournoux P.
Biochimie 90(11-12):1716-21. Epub 2008 Jul 25. 2008
11EIF2AK4
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.
Guo F, Cavener DR.
Cell Metab 5(2):103-14. 2007
12EIF2AK3, EIF2AK4
PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway.
Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA.
Mol Biol Cell 16(12):5493-501. Epub 2005 Sep 21. 2005
13EIF2AK4
Activation of GCN2 in UV-irradiated cells inhibits translation.
Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N.
Curr Biol 12(15):1279-86. 2002
14ALPK3, ARHGAP21, ARHGAP28, ASH1L, BOD1L, CASKIN1, CDH6, CGN, CHD7, COG1, CPSF2, CRAMP1L, DNAH1, EBF4, EIF2AK1, EIF2AK4, FAM135A, FAM63A, FBXO41, FBXO42, FGD6, FRMD4A, G2E3, HACE1, HEATR5B, HOMEZ, IBTK, IFT80, IGSF9, JMJD1C, KCNT1, KIAA1109, KIAA1328, KIAA1377, KIAA1383, KIAA1407, KIAA1430, KIAA1432, KIF17, KLF17, KLHDC5, KLHL11, KLHL12, KLHL13, KLHL14, KLHL15, KLHL8, KLHL9, LRP2BP, LRRC7, MARCH4, MIB1, MRTFA, N4BP2, NFIA, NUFIP2, PCDH10, PDCD6IP, PDP2, PTCHD2, RBM27, RCOR3, RGAG1, ROBO2, RPAP1, SEMA6A, SH3PXD2B, SIPA1L2, STAMBPL1, STARD9, TSR1, TULP4, TXNDC16, UPF2, WDFY1, WDR11, WDR35, ZMYM6, ZNF391, ZNF395, ZNF398, ZNF471, ZNF687, ZNFX1
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O.
DNA Res 7(1):65-73. 2000
15EIF2AK4
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.
Berlanga JJ, Santoyo J, De Haro C.
Eur J Biochem 265(2):754-62. 1999