Citations for
1EIF2AK3, WRS
Novel splice site mutation in EIF2AK3 gene causes Wolcott-Rallison syndrome in a consanguineous family from Saudi Arabia.
Al-Aama JY, Al-Zahrani HS, Jelani M, Sabir HS, Al-Saeedi SA, Ahmed S.
Congenit Anom (Kyoto) ongenit Anom (Kyoto). 2017 Feb 21. doi: 10.1111/cga.12217. [Epub ahead of print] No abstract available. 2017
2DDIT3, EIF2AK3, ELANE
Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response.
Grechowa I, Horke S, Wallrath A, Vahl CF, Dorweiler B.
FASEB J 31(9):3868-3881. doi: 10.1096/fj.201700012R. Epub 2017 May 15. 2017
3EIF2AK3
PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons.
Zhu S, McGrath BC, Bai Y, Tang X, Cavener DR.
Mol Brain 9(1):87. 2016
4CREB1, EIF2AK3, ERN1
CREB is activated by ER stress and modulates the unfolded protein response by regulating the expression of IRE1α and PERK.
Kikuchi D, Tanimoto K, Nakayama K.
Biochem Biophys Res Commun 469(2):243-50. doi: 10.1016/j.bbrc.2015.11.113. Epub 2015 Nov 28. 2016
5ATF4, EIF2AK3, TBL2
The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.
Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.
Biochem Biophys Res Commun 462(4):383-8. doi: 10.1016/j.bbrc.2015.04.144. Epub 2015 May 12. 2015
6EIF2AK3, IFNAR1
Type I interferons mediate pancreatic toxicities of PERK inhibition.
Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, Gao Y, Li C, Kushner JA, Koumenis C, Diehl JA, Fuchs SY.
Proc Natl Acad Sci U S A 112(50):15420-5. doi: 10.1073/pnas.1516362112. Epub 2015 Dec 1. 2015
7EIF2AK3, NCK1
Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.
Yamani L, Li B, Larose L.
Cell Signal 27(12):2555-67. doi: 10.1016/j.cellsig.2015.09.016. Epub 2015 Oct 3. 2015
8EIF2AK3
Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate.
Liu Z, Lv Y, Zhao N, Guan G, Wang J.
Cell Death Dis 6:e1822. doi: 10.1038/cddis.2015.183. Review. 2015
9ATF6, EIF2AK3, ERN1
The effects of IRE1, ATF6, and PERK signaling on adRP-linked rhodopsins.
Jerry Chiang WC, Lin JH.
Adv Exp Med Biol 801:661-7. doi: 10.1007/978-1-4614-3209-8_83. 2014
10EIF2AK3, TBL2
TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.
Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.
PLoS One 9(11):e112761. doi: 10.1371/journal.pone.0112761. eCollection 2014. 2014
11EIF2AK3, EIF2S1
Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.
Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q, Gupta PB.
Cancer Discov 4(6):702-15. doi: 10.1158/2159-8290.CD-13-0945. Epub 2014 Apr 4. 2014
12EIF2AK3, EIF2S1
Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.
Guan BJ, Krokowski D, Majumder M, Schmotzer CL, Kimball SR, Merrick WC, Koromilas AE, Hatzoglou M.
J Biol Chem 289(18):12593-611. doi: 10.1074/jbc.M113.543215. Epub 2014 Mar 19. 2014
13EIF2AK3
Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.
Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA.
Oncogene 32(41):4932-40. doi: 10.1038/onc.2012.512. Epub 2012 Nov 19. 2013
14EIF2AK3, EIF2AK4, EIF2S1
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E.
Nat Neurosci 16(9):1299-305. doi: 10.1038/nn.3486. Epub 2013 Aug 11. 2013
15EIF2AK3, ERN1, HSPA5
Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP.
Sou SN, Ilieva KM, Polizzi KM.
Biochem Biophys Res Commun 420(2):473-8. Epub 2012 Mar 13. 2012
16EIF2AK3, WRS
A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density.
Liu J, Hoppman N, O'Connell JR, Wang H, Streeten EA, McLenithan JC, Mitchell BD, Shuldiner AR.
J Bone Miner Res 27(2):331-41. 2012
17EIF2AK3, EIF2S1, PTPN1
Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.
Bettaieb A, Matsuo K, Matsuo I, Wang S, Melhem R, Koromilas AE, Haj FG.
PLoS One 7(4):e34412. Epub 2012 Apr 3. 2012
18ATF6, EIF2AK3
Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation.
Chiang WC, Hiramatsu N, Messah C, Kroeger H, Lin JH.
Invest Ophthalmol Vis Sci 53(11):7159-66. doi: 10.1167/iovs.12-10222. 2012
19EIF2AK3, ERN1, PARP16
PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response.
Jwa M, Chang P.
Nat Cell Biol 14(11):1223-30. doi: 10.1038/ncb2593. Epub 2012 Oct 28. Erratum in: Nat Cell Biol. 2013 Jan;15(1):123. 2012
20DDIT4, EIF2AK3, EIF2S1
Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2α phosphorylation, ATF4-dependent cascade.
Kimball SR, Jefferson LS.
Biochem Biophys Res Commun 427(3):485-9. doi: 10.1016/j.bbrc.2012.09.074. Epub 2012 Sep 20. 2012
21EIF2AK3, IER3IP1, MEDS, WRS
A homozygous IER3IP1 mutation causes microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome (MEDS).
Abdel-Salam GM, Schaffer AE, Zaki MS, Dixon-Salazar T, Mostafa IS, Afifi HH, Gleeson JG.
Am J Med Genet A 158A(11):2788-96. doi: 10.1002/ajmg.a.35583. Epub 2012 Sep 18. 2012
22EIF2AK3
PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.
Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA.
Mol Cell Biol 32(12):2268-78. doi: 10.1128/MCB.00063-12. Epub 2012 Apr 9. 2012
23BMP2, DDIT3, EIF2AK3, PARM1
PARM-1 promotes cardiomyogenic differentiation through regulating the BMP/Smad signaling pathway.
Nakanishi N, Takahashi T, Ogata T, Adachi A, Imoto-Tsubakimoto H, Ueyama T, Matsubara H.
Biochem Biophys Res Commun 428(4):500-5. doi: 10.1016/j.bbrc.2012.10.078. Epub 2012 Nov 1. 2012
24EIF2AK3
PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.
Gao Y, Sartori DJ, Li C, Yu QC, Kushner JA, Simon MC, Diehl JA.
Mol Cell Biol 32(24):5129-39. doi: 10.1128/MCB.01009-12. Epub 2012 Oct 15. 2012
25EIF2AK3, ERP29
ERp29 regulates response to doxorubicin by a PERK-mediated mechanism.
Farmaki E, Mkrtchian S, Papazian I, Papavassiliou AG, Kiaris H.
Biochim Biophys Acta 1813(6):1165-71. Epub 2011 Mar 22. 2011
26EIF2AK3
PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment.
Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J, Aguirre-Ghiso JA.
Mol Cell Biol 31(17):3616-29. Epub 2011 Jun 27. 2011
27ATF6, EIF2AK3
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.
Teske BF, Wek SA, Bunpo P, Cundiff JK, McClintick JN, Anthony TG, Wek RC.
Mol Biol Cell 22(22):4390-405. Epub 2011 Sep 14. 2011
28EIF2AK3, WRS
A novel EIF2AK3 mutation leading to Wolcott-Rallison syndrome in a Chinese child.
Sang Y, Liu M, Yang W, Yan J, Chengzhu, Ni G.
J Pediatr Endocrinol Metab 24(3-4):181-4. 2011
29EIF2AK3
The structure of the PERK kinase domain suggests the mechanism for its activation.
Cui W, Li J, Ron D, Sha B.
Acta Crystallogr D Biol Crystallogr 67(Pt 5):423-8. Epub 2011 Apr 13. 2011
30EIF2AK3
PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cells.
Moore CE, Omikorede O, Gomez E, Willars GB, Herbert TP.
Mol Endocrinol 25(2):315-26. Epub 2010 Dec 30. 2011
31EIF2AK3, EIF2AK4
The role of PERK and GCN2 in basal and hydrogen peroxide-regulated translation from the hepatitis C virus internal ribosome entry site.
Jack SC, Chan SW.
Virus Genes 43(2):208-14. Epub 2011 Jun 3. 2011
32EIF2AK3, PPP3CA, PPP3CB
Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.
Bollo M, Paredes RM, Holstein D, Zheleznova N, Camacho P, Lechleiter JD.
PLoS One 5(8):e11925. 2010
33EIF2AK3
PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.
Gupta S, McGrath B, Cavener DR.
Diabetes 59(8):1937-47. Epub 2010 Jun 8. 2010
34EIF2AK3
Activation of PERK signaling attenuates Abeta-mediated ER stress.
Lee do Y, Lee KS, Lee HJ, Kim do H, Noh YH, Yu K, Jung HY, Lee SH, Lee JY, Youn YC, Jeong Y, Kim DK, Lee WB, Kim SS.
PLoS One 5(5):e10489. 2010
35EIF2AK3
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage.
Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zhang F, Ye J, Koumenis C, Cavener D, Diehl JA.
Oncogene 29(27):3881-95. Epub 2010 May 10. 2010
36EIF2AK3, EIF2AK4
Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.
Liu Y, László C, Liu Y, Liu W, Chen X, Evans SC, Wu S.
Neoplasia 12(1):61-8. 2010
37EIF2AK3
PERK-dependent regulation of IAP translation during ER stress.
Hamanaka RB, Bobrovnikova-Marjon E, Ji X, Liebhaber SA, Diehl JA.
Oncogene 28(6):910-20. Epub 2008 Nov 24. 2009
38EIF2AK3
Novel function of PERK as a mediator of force-induced apoptosis.
Mak BC, Wang Q, Laschinger C, Lee W, Ron D, Harding HP, Kaufman RJ, Scheuner D, Austin RC, McCulloch CA.
J Biol Chem 283(34):23462-72. Epub 2008 Jun 11. 2008
39EIF2AK3
Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK.
Yamaguchi Y, Larkin D, Lara-Lemus R, Ramos-Castańeda J, Liu M, Arvan P.
J Biol Chem 283(25):17020-9. Epub 2008 Apr 21. 2008
40EIF2AK3, PKD2
Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha.
Liang G, Yang J, Wang Z, Li Q, Tang Y, Chen XZ.
Hum Mol Genet 17(20):3254-62. Epub 2008 Jul 29. 2008
41ATF4, EIF2AK3, TRAF3
The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis.
Lee DY, Sugden B.
Blood 111(4):2280-9. Epub 2007 Nov 27. 2008
42EIF2AK3
A novel mutation in the EIF2AK3 gene with variable expressivity in two patients with Wolcott-Rallison syndrome.
Durocher F, Faure R, Labrie Y, Pelletier L, Bouchard I, Laframboise R.
Clin Genet 70(1):34-8. 2006
43WRS, EIF2AK3, SLC19A2, TRMA, FRDA, FXN, ABCC8
Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure.
Porter JR, Barrett TG.
J Med Genet 42(12):893-902. Epub 2005 Mar 16. 2005
44EIF2AK3, EIF2AK4
PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway.
Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA.
Mol Biol Cell 16(12):5493-501. Epub 2005 Sep 21. 2005
45WRS, EIF2AK3
Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity.
Senee V, Vattem KM, Delepine M, Rainbow LA, Haton C, Lecoq A, Shaw NJ, Robert JJ, Rooman R, Diatloff-Zito C, Michaud JL, Bin-Abbas B, Taha D, Zabel B, Franceschini P, Topaloglu AK, Lathrop GM, Barrett TG, Nicolino M, Wek RC, Julier C.
Diabetes 53(7):1876-83. 2004
46WRS, EIF2AK3
Wolcott-Rallison syndrome: a clinical and genetic study of three children, novel mutation in EIF2AK3 and a review of the literature.
Iyer S, Korada M, Rainbow L, Kirk J, Brown RM, Shaw N, Barrett TG.
Acta Paediatr 93(9):1195-201. Review. 2004
47EIF2AK3, WRS
Wolcott-Rallison syndrome: pathogenic insights into neonatal diabetes from new mutation and expression studies of EIF2AK3.
Brickwood S, Bonthron DT, Al-Gazali LI, Piper K, Hearn T, Wilson DI, Hanley NA.
J Med Genet 40(9):685-9. Review. No abstract available. 2003
48EIF2AK3, WRS
Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene.
Biason-Lauber A, Lang-Muritano M, Vaccaro T, Schoenle EJ.
Diabetes 51(7):2301-5. 2002
49EIF2AK3, WRS
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome.
Delepine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM, Julier C.
Nat Genet 25(4):406-9. 2000
50EIF2AK3
Assignment(1) of pancreatic eIF-2alpha kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization.
Hayes SE, et al.
Cytogenet Cell Genet 86(3-4):327-328. No abstract available 1999
51EIF2AK3
Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.
Shi Y, et al.
J Biol Chem 274(9):5723-30 1999