Citations for
1EIF2AK1
The host-encoded Heme Regulated Inhibitor (HRI) facilitates virulence-associated activities of bacterial pathogens.
Shrestha N, Boucher J, Bahnan W, Clark ES, Rosqvist R, Fields KA, Khan WN, Schesser K.
PLoS One 8(7):e68754. doi: 10.1371/journal.pone.0068754. Print 2013. 2013
2EIF2AK1
Vimentin is a component of a complex that binds to the 5'-UTR of human heme-regulated eIF2α kinase mRNA and regulates its translation.
Chatterjee S, Panda AC, Berwal SK, Sreejith RK, Ritvika C, Seshadri V, Pal JK.
FEBS Lett 587(5):474-80. doi: 10.1016/j.febslet.2013.01.013. Epub 2013 Jan 26. 2013
3EIF2AK1
Autophosphorylation of heme-regulated eukaryotic initiation factor 2α kinase and the role of the modification in catalysis.
Igarashi J, Sasaki T, Kobayashi N, Yoshioka S, Matsushita M, Shimizu T.
FEBS J 278(6):918-28. doi: 10.1111/j.1742-4658.2011.08007.x. Epub 2011 Feb 3. 2011
4EIF2AK1
Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.
Acharya P, Chen JJ, Correia MA.
Mol Pharmacol 77(4):575-92. Epub 2010 Jan 13. 2010
5EIF2AK1, EIF2S1, OGFOD1
OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress.
Wehner KA, Schütz S, Sarnow P.
Mol Cell Biol 30(8):2006-16. doi: 10.1128/MCB.01350-09. Epub 2010 Feb 12. 2010
6EIF2AK1
Stress-induced overexpression of the heme-regulated eIF-2alpha kinase is regulated by Elk-1 activated through ERK pathway.
Singh VB, Pavithra L, Chattopadhyay S, Pal JK.
Biochem Biophys Res Commun 379(3):710-5. Epub 2009 Jan 6. 2009
7EIF2AK1
Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.
Liu S, Suragani RN, Han A, Zhao W, Andrews NC, Chen JJ.
Haematologica 93(5):753-6. Epub 2008 Mar 26. 2008
8EIF2AK1
The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation.
Liu S, Suragani RN, Wang F, Han A, Zhao W, Andrews NC, Chen JJ.
J Clin Invest 117(11):3296-305. 2007
9ABL2, AKAP8, ANKRD13D, AP3D1, ARFGAP3, ARMCX6, ASUN, BAT2L, BCl2L13, BNIP3L, BPTF, BRD7, BZW1, BZW2, C12orf43, C19orf21, C19orf26, C1orf105, C2orf49, C6orf81, CA10, CAD, CARHSP1, CBX4, CCDC55, CCDC61, CCNK, CDC42BPB, CDC42EP3, CDC42EP4, CDS2, CENPN, CLK1, COPA, CSDA, CTPS2, DBN1, DCP1A, DECR2, DPF2, DPM1, EIF2AK1, EPB41L4A, EPN1, FAM91A1, FOSL2, FOXK1, GDF5OS, GFOD2, GIGYF2, GPATCH8, GTPBP1, HES7, HNRNPUL1, KIF1C, LPIN2, LRCH4, MAN2C1, MAST1, MED13, MED24, MED26, MINK1, MYO10, NKTR, OSBP, PAM, PCDH7, PEX14, PHF16, PHRF1, PLCB4, PLXNC1, POM121, POM121L2, PPHLN1, PRICKLE3, PRX, PUM2, RABGGTB, RBEL1, RIMS1, RIMS2, RPL14, RRP1B, RRP8, SAFB, SCAMP3, SCMH1, SCYL1, SENP6, SERBP1, SFRS13A, SFRS17A, SIPA1L1, SLC26A6, SLIRP, SLMAP, SNTA1, SORBS3, SPICE1, SSFA2, STAM, SUB1, TFIP11, TLN2, TMC6, TMEM104, TMEM106B, TMEM22, TOM1, UHRF1, UTP14A, WDR43, ZNF324, ZNF648
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M.
Cell. 127(3):635-48. 2006
10EIF2AK1
Characterization of heme-regulated eIF2alpha kinase: roles of the N-terminal domain in the oligomeric state, heme binding, catalysis, and inhibition.
Miksanova M, Igarashi J, Minami M, Sagami I, Yamauchi S, Kurokawa H, Shimizu T.
Biochemistry 45(32):9894-905. 2006
11EIF2AK1
Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI.
Rafie-Kolpin M, Han AP, Chen JJ.
Biochemistry 42(21):6536-44. 2003
12EIF2AK1, HSP90AA1
Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase.
Shao J, Grammatikakis N, Scroggins BT, Uma S, Huang W, Chen JJ, Hartson SD, Matts RL.
J Biol Chem 276(1):206-14. 2001
13ALPK3, ARHGAP21, ARHGAP28, ASH1L, BOD1L, CASKIN1, CDH6, CGN, CHD7, COG1, CPSF2, CRAMP1L, DNAH1, EBF4, EIF2AK1, EIF2AK4, FAM135A, FAM63A, FBXO41, FBXO42, FGD6, FRMD4A, G2E3, HACE1, HEATR5B, HOMEZ, IBTK, IFT80, IGSF9, JMJD1C, KCNT1, KIAA1109, KIAA1328, KIAA1377, KIAA1383, KIAA1407, KIAA1430, KIAA1432, KIF17, KLF17, KLHDC5, KLHL11, KLHL12, KLHL13, KLHL14, KLHL15, KLHL8, KLHL9, LRP2BP, LRRC7, MARCH4, MIB1, MRTFA, N4BP2, NFIA, NUFIP2, PCDH10, PDCD6IP, PDP2, PTCHD2, RBM27, RCOR3, RGAG1, ROBO2, RPAP1, SEMA6A, SH3PXD2B, SIPA1L2, STAMBPL1, STARD9, TSR1, TULP4, TXNDC16, UPF2, WDFY1, WDR11, WDR35, ZMYM6, ZNF391, ZNF395, ZNF398, ZNF471, ZNF687, ZNFX1
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O.
DNA Res 7(1):65-73. 2000
14EIF2AK1
Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase.
Chen JJ, London IM.
Trends Biochem Sci 20(3):105-8. Review. 1995