| 1 | EHMT2, TBC1D3
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| TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a.
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| Hou QQ, Xiao Q, Sun XY, Ju XC, Luo ZG.
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| Sci Adv. Jan 15;7(3):eaba8053. doi: 10.1126/sciadv.aba8053. 2021
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| 2 | EHMT1, EHMT2, MDC1
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| MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites.
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| Watanabe S, Iimori M, Chan DV, Hara E, Kitao H, Maehara Y
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| Sci Rep. Jul 18;8(1):10888. doi: 10.1038/s41598-018-29239-3. 2018
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| 3 | EHMT1, EHMT2
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| Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage.
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| Ginjala V, Rodriguez-Colon L, Ganguly B, Gangidi P, Gallina P, Al-Hraishawi H, Kulkarni A, Tang J, Gheeya J, Simhadri S, Yao M, Xia B, Ganesan S.
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| Sci Rep. Nov 30;7(1):16613. doi: 10.1038/s41598-017-16480-5. 2017
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| 4 | EHMT1, EHMT2
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| Differential patterns of histone methylase EHMT2 and its catalyzed histone modifications H3K9me1 and H3K9me2 during maturation of central auditory system.
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| Ebbers L, Runge K, Nothwang HG.
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| Cell Tissue Res 365(2):247-64. doi: 10.1007/s00441-016-2401-2. 2016
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| 5 | EHMT1, EHMT2
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| Regulation of cell differentiation and function by the euchromatin histone methyltranserfases G9a and GLP.
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| Kramer JM.
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| Biochem Cell Biol 94(1):26-32. doi: 10.1139/bcb-2015-0017. Review.
2016
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| 6 | EHMT1, EHMT2
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| EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.
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| Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL.
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| Blood 126(16):1930-9. doi: 10.1182/blood-2015-06-649087.
2015
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| 7 | EHMT1, EHMT2, WIZ, ZNF644
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| The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression.
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| Bian C, Chen Q, Yu X.
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| Elife 4. doi: 10.7554/eLife.05606. Erratum in: Elife. 2015;4. doi: 10.7554/eLife.08168.
2015
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| 8 | EHMT2, WIZ
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| A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin.
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| Simon JM, Parker JS, Liu F, Rothbart SB, Ait-Si-Ali S, Strahl BD, Jin J, Davis IJ, Mosley AL, Pattenden SG.
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| J Biol Chem 290(43):26088-102. doi: 10.1074/jbc.M115.654459.
2015
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| 9 | EHMT2, KDM7A, PHF19
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| G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation.
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| Pan MR, Hsu MC, Chen LT, Hung WC.
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| Sci Rep 5:18709. doi: 10.1038/srep18709.
2015
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| 10 | EHMT2, VEGFA
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| Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing.
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| Salton M, Voss TC, Misteli T.
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| Nucleic Acids Res 42(22):13662-73. doi: 10.1093/nar/gku1226.
2014
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| 11 | EHMT1, EHMT2
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| Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects.
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| Balan S, Iwayama Y, Maekawa M, Toyota T, Ohnishi T, Toyoshima M, Shimamoto C, Esaki K, Yamada K, Iwata Y, Suzuki K, Ide M, Ota M, Fukuchi S, Tsujii M, Mori N, Shinkai Y, Yoshikawa T.
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| Mol Autism 5(1):49. doi: 10.1186/2040-2392-5-49.
2014
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| 12 | EHMT2, HDAC5, HDAC7, PARP2
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| PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation.
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| Liang YC, Hsu CY, Yao YL, Yang WM.
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| Biochem Biophys Res Commun 431(1):58-64. doi: 10.1016/j.bbrc.2012.12.092. Epub 2013 Jan 3.
2013
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| 13 | EHMT2, FGF21, NFIL3
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| Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein.
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| Tong X, Zhang D, Buelow K, Guha A, Arthurs B, Brady HJ, Yin L.
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| J Biol Chem 288(8):5417-25. doi: 10.1074/jbc.M112.433482. Epub 2013 Jan 2.
2013
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| 14 | EHMT1, EHMT2
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| Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.
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| Inagawa M, Nakajima K, Makino T, Ogawa S, Kojima M, Ito S, Ikenishi A, Hayashi T, Schwartz RJ, Nakamura K, Obayashi T, Tachibana M, Shinkai Y, Maeda K, Miyagawa-Tomita S, Takeuchi T.
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| Mech Dev 130(11-12):519-31. doi: 10.1016/j.mod.2013.07.002.
2013
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| 15 | EHMT2, RUNX2
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| Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription.
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| Purcell DJ, Khalid O, Ou CY, Little GH, Frenkel B, Baniwal SK, Stallcup MR.
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| J Cell Biochem 113(7):2406-14. doi: 10.1002/jcb.24114.
2012
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| 16 | EHMT2, MYOD1
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| Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation.
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| Ling BM, Bharathy N, Chung TK, Kok WK, Li S, Tan YH, Rao VK, Gopinadhan S, Sartorelli V, Walsh MJ, Taneja R.
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| Proc Natl Acad Sci U S A 109(3):841-6. doi: 10.1073/pnas.1111628109. Epub 2012 Jan 3.
2012
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| 17 | EHMT2
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| Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1.
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| Cho HS, Kelly JD, Hayami S, Toyokawa G, Takawa M, Yoshimatsu M, Tsunoda T, Field HI, Neal DE, Ponder BA, Nakamura Y, Hamamoto R.
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| Neoplasia 13(8):676-84.
2011
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| 18 | EHMT2
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| Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing.
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| Leung DC, Dong KB, Maksakova IA, Goyal P, Appanah R, Lee S, Tachibana M, Shinkai Y, Lehnertz B, Mager DL, Rossi F, Lorincz MC.
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| Proc Natl Acad Sci U S A 108(14):5718-23. Epub 2011 Mar 22.
2011
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| 19 | EHMT2, HELLS
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| LSH and G9a/GLP complex are required for developmentally programmed DNA methylation.
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| Myant K, Termanis A, Sundaram AY, Boe T, Li C, Merusi C, Burrage J, de Las Heras JI, Stancheva I.
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| Genome Res 21(1):83-94. Epub 2010 Dec 13. 2011
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| 20 | EHMT2, RUVBL2
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| Negative regulation of hypoxic responses via induced Reptin methylation.
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| Lee JS, Kim Y, Kim IS, Kim B, Choi HJ, Lee JM, Shin HJ, Kim JH, Kim JY, Seo SB, Lee H, Binda O, Gozani O, Semenza GL, Kim M, Kim KI, Hwang D, Baek SH.
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| Mol Cell 39(1):71-85.
2010
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| 21 | EHMT2
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| Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.
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| Lehnertz B, Northrop JP, Antignano F, Burrows K, Hadidi S, Mullaly SC, Rossi FM, Zaph C.
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| J Exp Med 207(5):915-22. Epub 2010 Apr 26.
2010
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| 22 | EHMT2
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| H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.
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| Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, Lai TC, Chang JS, Jan YH, Chien MH, Yang CJ, Huang MS, Hsiao M, Kuo ML.
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| Cancer Res 70(20):7830-40. Epub 2010 Oct 12.
2010
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| 23 | EHMT2
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| G9a selectively represses a class of late-replicating genes at the nuclear periphery.
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| Yokochi T, Poduch K, Ryba T, Lu J, Hiratani I, Tachibana M, Shinkai Y, Gilbert DM.
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| Proc Natl Acad Sci U S A 106(46):19363-8. Epub 2009 Nov 4.
2009
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| 24 | EHMT2
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| Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells.
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| Chaturvedi CP, Hosey AM, Palii C, Perez-Iratxeta C, Nakatani Y, Ranish JA, Dilworth FJ, Brand M.
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| Proc Natl Acad Sci U S A 106(43):18303-8. Epub 2009 Oct 12.
2009
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| 25 | EHMT2, UHRF1
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| UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells.
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| Kim JK, Estève PO, Jacobsen SE, Pradhan S.
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| Nucleic Acids Res 37(2):493-505. Epub 2008 Dec 4.
2009
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| 26 | ESCO2, EHMT2, SETDB1, SUV39H1
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| Esco2 is a novel corepressor that associates with various chromatin modifying enzymes.
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| Kim BJ, Kang KM, Jung SY, Choi HK, Seo JH, Chae JH, Cho EJ, Youn HD, Qin J, Kim ST.
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| Biochem Biophys Res Commun 372(2):298-304. Epub 2008 May 21. 2008
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| 27 | CEBPB, EHMT2
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| G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.
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| Pless O, Kowenz-Leutz E, Knoblich M, Lausen J, Beyermann M, Walsh MJ, Leutz A.
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| J Biol Chem 283(39):26357-63. Epub 2008 Jul 21.
2008
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| 28 | EHMT2, ZNF200
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| Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a.
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| Nishida M, Kato M, Kato Y, Sasai N, Ueda J, Tachibana M, Shinkai Y, Yamaguchi M.
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| Genes Cells 12(7):877-88. 2007
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| 29 | EHMT1, EHMT2, WIZ
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| Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.
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| Ueda J, Tachibana M, Ikura T, Shinkai Y.
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| J Biol Chem 281(29):20120-8.
2006
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| 30 | EHMT2, GFI1
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| Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.
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| Duan Z, Zarebski A, Montoya-Durango D, Grimes HL, Horwitz M.
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| Mol Cell Biol 25(23):10338-51. 2005
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| 31 | EHMT2
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| Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes.
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| Roopra A, Qazi R, Schoenike B, Daley TJ, Morrison JF.
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| Mol Cell 14(6):727-38. 2004
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| 32 | EHMT2
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| CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription.
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| Nishio H, Walsh MJ.
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| Proc Natl Acad Sci U S A 101(31):11257-62. Epub 2004 Jul 21. 2004
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| 33 | EHMT2
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| Novel NG36/G9a gene products encoded within the human and mouse MHC class III regions.
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| Brown SE, Campbell RD, Sanderson CM.
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| Mamm Genome 12(12):916-24. 2001
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| 34 | BAT@, HTFAG@, EHMT2
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| The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats.
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| Milner CM, Campbell RD.
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| Biochem J 290 ( Pt 3):811-8. 1993
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| 35 | ABHD16A, BAG6, BAT2, BAT4, BAT@, DDX39B, EHMT2, ZBTB12
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| Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B.
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| Spies T, Bresnahan M, Strominger JL.
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| Proc Natl Acad Sci U S A 86(22):8955-8. 1989
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