1 | EGLN2, SPOP
|
| Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.
|
| Zhang L, Peng S, Dai X, Gan W, Nie X, Wei W, Hu G, Guo J.
|
| Cancer Lett 390:11-20. doi: 10.1016/j.canlet.2017.01.003. Epub 2017 Jan 13.
2017
|
2 | EGLN2, FOXO3
|
| Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
|
| Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q.
|
| Genes Dev enes Dev. 2014 2014
|
3 | CEP192, EGLN2
|
| PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192.
|
| Moser SC, Bensaddek D, Ortmann B, Maure JF, Mudie S, Blow JJ, Lamond AI, Swedlow JR, Rocha S.
|
| Dev Cell 26(4):381-92. doi: 10.1016/j.devcel.2013.06.014. Epub 2013 Aug 8.
2013
|
4 | EGLN2, EGLN3
|
| EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase γ ubiquitination.
|
| Fu J, Taubman MB.
|
| Mol Cell Biol 33(15):3050-61. doi: 10.1128/MCB.00273-13. Epub 2013 Jun 3.
2013
|
5 | EGLN1, EGLN2, EGLN3
|
| The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3.
|
| Jaakkola PM, Rantanen K.
|
| Biol Chem 394(4):449-57. doi: 10.1515/hsz-2012-0330. Review.
2013
|
6 | EGLN1, EGLN2, EGLN3
|
| Molecular cloning of phd1 and comparative analysis of phd1, 2, and 3 expression in Xenopus laevis.
|
| Han D, Wen L, Chen Y.
|
| ScientificWorldJournal 2012:689287. doi: 10.1100/2012/689287. Epub 2012 May 3.
2012
|
7 | ATF4, EGLN1, EGLN2, EGLN3
|
| PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation.
|
| Hiwatashi Y, Kanno K, Takasaki C, Goryo K, Sato T, Torii S, Sogawa K, Yasumoto K.
|
| Exp Cell Res 317(20):2789-99. doi: 10.1016/j.yexcr.2011.09.005. Epub 2011 Sep 17.
2011
|
8 | EGLN2
|
| Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.
|
| Tambuwala MM, Cummins EP, Lenihan CR, Kiss J, Stauch M, Scholz CC, Fraisl P, Lasitschka F, Mollenhauer M, Saunders SP, Maxwell PH, Carmeliet P, Fallon PG, Schneider M, Taylor CT.
|
| Gastroenterology 139(6):2093-101. doi: 10.1053/j.gastro.2010.06.068. Epub 2010 Jun 30.
2010
|
9 | EGLN1, EGLN2, EGLN3
|
| Role of the intracellular localization of HIF-prolyl hydroxylases.
|
| Yasumoto K, Kowata Y, Yoshida A, Torii S, Sogawa K.
|
| Biochim Biophys Acta 1793(5):792-7. Epub 2009 Feb 5.
2009
|
10 | EGLN2
|
| Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.
|
| Aragonˇs J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P.
|
| Nat Genet 40(2):170-80. Epub 2008 Jan 6. 2008
|
11 | EGLN2
|
| Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro.
|
| Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC.
|
| Mol Cell Biol 27(3):912-25. Epub 2006 Nov 13. 2007
|
12 | EGLN2
|
| Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
|
| Tian YM, Mole DR, Ratcliffe PJ, Gleadle JM.
|
| Biochem J 397(1):179-86. 2006
|
13 | SIAH2, EGLN2, EGLN3
|
| Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.
|
| Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell PB, Bowtell DD, Ronai Z.
|
| Cell 117(7):941-52. 2004
|
14 | EGLN1, EGLN2, EGLN3
|
| Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
|
| Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM.
|
| J Biol Chem 279(37):38458-65. Epub 2004 Jul 7. 2004
|
15 | EGLN1, EGLN2, EGLN3
|
| Mammalian EGLN genes have distinct patterns of mRNA expression and regulation.
|
| Lieb ME, Menzies K, Moschella MC, Ni R, Taubman MB.
|
| Biochem Cell Biol 80(4):421-6. 2002
|
16 | EGLN2
|
| Falkor, a novel cell growth regulator isolated by a functional genetic screen.
|
| Erez N, Milyavsky M, Goldfinger N, Peles E, Gudkov AV, Rotter V.
|
| Oncogene 21(44):6713-21. 2002
|
17 | EGLN2
|
| A conserved family of prolyl-4-hydroxylases that modify HIF.
|
| Bruick RK, McKnight SL.
|
| Science 294(5545):1337-40. 2001
|
18 | EGLN1, EGLN2
|
| C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
|
| Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ.
|
| Cell 107(1):43-54. 2001
|
19 | EGLN1, EGLN2, EGLN3, SCAND2
|
| Characterization and comparative analysis of the EGLN gene family.
|
| Taylor MS.
|
| Gene 275(1):125-32. 2001
|