Citations for
1EGLN2, SPOP
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.
Zhang L, Peng S, Dai X, Gan W, Nie X, Wei W, Hu G, Guo J.
Cancer Lett 390:11-20. doi: 10.1016/j.canlet.2017.01.003. Epub 2017 Jan 13. 2017
2EGLN2, FOXO3
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q.
Genes Dev enes Dev. 2014 2014
3CEP192, EGLN2
PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192.
Moser SC, Bensaddek D, Ortmann B, Maure JF, Mudie S, Blow JJ, Lamond AI, Swedlow JR, Rocha S.
Dev Cell 26(4):381-92. doi: 10.1016/j.devcel.2013.06.014. Epub 2013 Aug 8. 2013
4EGLN2, EGLN3
EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase γ ubiquitination.
Fu J, Taubman MB.
Mol Cell Biol 33(15):3050-61. doi: 10.1128/MCB.00273-13. Epub 2013 Jun 3. 2013
5EGLN1, EGLN2, EGLN3
The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3.
Jaakkola PM, Rantanen K.
Biol Chem 394(4):449-57. doi: 10.1515/hsz-2012-0330. Review. 2013
6EGLN1, EGLN2, EGLN3
Molecular cloning of phd1 and comparative analysis of phd1, 2, and 3 expression in Xenopus laevis.
Han D, Wen L, Chen Y.
ScientificWorldJournal 2012:689287. doi: 10.1100/2012/689287. Epub 2012 May 3. 2012
7ATF4, EGLN1, EGLN2, EGLN3
PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation.
Hiwatashi Y, Kanno K, Takasaki C, Goryo K, Sato T, Torii S, Sogawa K, Yasumoto K.
Exp Cell Res 317(20):2789-99. doi: 10.1016/j.yexcr.2011.09.005. Epub 2011 Sep 17. 2011
8EGLN2
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.
Tambuwala MM, Cummins EP, Lenihan CR, Kiss J, Stauch M, Scholz CC, Fraisl P, Lasitschka F, Mollenhauer M, Saunders SP, Maxwell PH, Carmeliet P, Fallon PG, Schneider M, Taylor CT.
Gastroenterology 139(6):2093-101. doi: 10.1053/j.gastro.2010.06.068. Epub 2010 Jun 30. 2010
9EGLN1, EGLN2, EGLN3
Role of the intracellular localization of HIF-prolyl hydroxylases.
Yasumoto K, Kowata Y, Yoshida A, Torii S, Sogawa K.
Biochim Biophys Acta 1793(5):792-7. Epub 2009 Feb 5. 2009
10EGLN2
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.
Aragonˇs J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P.
Nat Genet 40(2):170-80. Epub 2008 Jan 6. 2008
11EGLN2
Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro.
Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC.
Mol Cell Biol 27(3):912-25. Epub 2006 Nov 13. 2007
12EGLN2
Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
Tian YM, Mole DR, Ratcliffe PJ, Gleadle JM.
Biochem J 397(1):179-86. 2006
13SIAH2, EGLN2, EGLN3
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.
Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell PB, Bowtell DD, Ronai Z.
Cell 117(7):941-52. 2004
14EGLN1, EGLN2, EGLN3
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM.
J Biol Chem 279(37):38458-65. Epub 2004 Jul 7. 2004
15EGLN1, EGLN2, EGLN3
Mammalian EGLN genes have distinct patterns of mRNA expression and regulation.
Lieb ME, Menzies K, Moschella MC, Ni R, Taubman MB.
Biochem Cell Biol 80(4):421-6. 2002
16EGLN2
Falkor, a novel cell growth regulator isolated by a functional genetic screen.
Erez N, Milyavsky M, Goldfinger N, Peles E, Gudkov AV, Rotter V.
Oncogene 21(44):6713-21. 2002
17EGLN2
A conserved family of prolyl-4-hydroxylases that modify HIF.
Bruick RK, McKnight SL.
Science 294(5545):1337-40. 2001
18EGLN1, EGLN2
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ.
Cell 107(1):43-54. 2001
19EGLN1, EGLN2, EGLN3, SCAND2
Characterization and comparative analysis of the EGLN gene family.
Taylor MS.
Gene 275(1):125-32. 2001