| 1 | EDN2, EDNRB
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| Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination.
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| Yuen TJ, Johnson KR, Miron VE, Zhao C, Quandt J, Harrisingh MC, Swire M, Williams A, McFarland HF, Franklin RJ, Ffrench-Constant C.
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| Brain 136(Pt 4):1035-47. doi: 10.1093/brain/awt024. Epub 2013 Mar 21.
2013
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| 2 | ECE2, EDN1, EDNRB
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| Brain endothelial barrier passage by monocytes is controlled by the endothelin system.
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| Reijerkerk A, Lakeman KA, Drexhage JA, van Het Hof B, van Wijck Y, van der Pol SM, Kooij G, Geerts D, de Vries HE.
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| J Neurochem 121(5):730-7. doi: 10.1111/j.1471-4159.2011.07393.x. Epub 2011 Aug 12.
2012
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| 3 | COPS5, EDNRA, EDNRB
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| Jab1 regulates levels of endothelin type A and B receptors by promoting ubiquitination and degradation.
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| Nishimoto A, Lu L, Hayashi M, Nishiya T, Horinouchi T, Miwa S.
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| Biochem Biophys Res Commun 391(4):1616-22. Epub 2009 Dec 23.PMID: 20034471 2010
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| 4 | EDNRA, EDNRB
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| Endothelins as pronociceptive mediators of the rat trigeminal system: role of ETA and ETB receptors.
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| Chichorro JG, Fiuza CR, Bressan E, Claudino RF, Leite DF, Rae GA.
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| Brain Res 1345:73-83. doi: 10.1016/j.brainres.2010.04.075. Epub 2010 May 5.
2010
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| 5 | EDN1, EDNRB
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| Endothelin axis induces metalloproteinase activation and invasiveness in human lymphatic endothelial cells.
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| Spinella F, Caprara V, Garrafa E, Di Castro V, Rosanò L, Natali PG, Bagnato A.
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| Can J Physiol Pharmacol 88(8):782-7. doi: 10.1139/Y10-050.
2010
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| 6 | EDN3, EDNRB
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| New roles of EDNRB and EDN3 in the pathogenesis of Hirschsprung disease.
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| Sánchez-Mejías A, Fernández RM, López-Alonso M, Antiñolo G, Borrego S.
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| Genet Med 12(1):39-43. doi: 10.1097/GIM.0b013e3181c371b0.
2010
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| 7 | DEL13QV, EDNRB
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| Clinical variability of Waardenburg-Shah syndrome in patients with proximal 13q deletion syndrome including the endothelin-B receptor locus.
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| Tüysüz B, Collin A, Arapoðlu M, Suyugül N.
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| Am J Med Genet A 149A(10):2290-5.
2009
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| 8 | ECE1, EDNRA, EDNRB
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| Functional and molecular characterization of the endothelin system in retinal arterioles.
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| Hein TW, Ren Y, Yuan Z, Xu W, Somvanshi S, Nagaoka T, Yoshida A, Kuo L.
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| Invest Ophthalmol Vis Sci. 50(7):3329-36. 2009
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| 9 | AGTR1, EDNRB
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| Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease.
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| Dimitrijevic I, Edvinsson ML, Chen Q, Malmsjö M, Kimblad PO, Edvinsson L.
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| BMC Cardiovasc Disord 9:40.PMID: 19706169 2009
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| 10 | EDNRB
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| Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: a tissue microarray analysis.
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| Herrmann E, Eltze E, Bierer S, Bogemann M, Brinkmann OA, Balnowair H, Hertle L, Wulfing C.
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| Oncol Rep 17(2):275-80. 2007
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| 11 | EDNRB
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| Endothelin B receptor blockade accelerates disease progression in a murine model of autosomal dominant polycystic kidney disease.
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| Chang MY, Parker E, El Nahas M, Haylor JL, Ong AC.
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| J Am Soc Nephrol 18(2):560-9. Epub 2007 Jan 3. 2007
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| 12 | EDNRB
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| New variations of the EDNRB gene and its association with sporadic Hirschsprung's disease in Korea.
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| Kim JH, Yoon KO, Kim H, Kim JK, Kim JW, Lee SK, Seo JM.
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| J Pediatr Surg 41(10):1708-12. 2006
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| 13 | EDN3, EDNRB, SOX10
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| Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development.
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| Stanchina L, Baral V, Robert F, Pingault V, Lemort N, Pachnis V, Goossens M, Bondurand N.
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| Dev Biol 295(1):232-49. Epub 2006 Apr 3.
2006
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| 14 | EDNRB
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| Endothelin B receptor in human glaucoma and experimentally induced optic nerve damage.
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| Wang, L.; Fortune, B.; Cull, G.; Dong, J.; Cioffi, G. A.
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| Arch. Ophthal. 124: 717-724 2006
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| 15 | SOX10, EDNRB
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| Spatiotemporal regulation of endothelin receptor-B by SOX10 in neural crest-derived enteric neuron precursors.
|
| Zhu L, Lee HO, Jordan CS, Cantrell VA, Southard-Smith EM, Shin MK.
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| Nat Genet 36(7):732-7. Epub 2004 May 30. 2004
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| 16 | EDNRB
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| Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease.
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| Cantrell VA, Owens SE, Chandler RL, Airey DC, Bradley KM, Smith JR, Southard-Smith EM.
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| Hum. Molec. Genet. 13(24):3241. 2004
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| 17 | EDNRB, GDNF, GFRA1, RET, SOX10
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| Hirschsprung disease is linked to defects in neural crest stem cell function.
|
| Iwashita T, Kruger GM, Pardal R, Kiel MJ, Morrison SJ.
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| Science 301(5635):972-6. 2003
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| 18 | EDNRA, EDNRB, EDN1
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| Localization of endothelin-1 mRNA expression and immunoreactivity in the anterior segment of human eye: expression of ETA and ETB receptors.
|
| Fernandez-Durango R, Rollin R, Mediero A, Roldan-Pallares M, Garcia Feijo J, Garcia Sanchez J, Fernandez-Cruz A, Ripodas A.
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| Mol Vis 9:103-9. 2003
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| 19 | EDN3, EDNRB
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| Clinical relationship between EDN-3 gene, EDNRB gene and Hirschsprung's disease.
|
| Duan XL, Zhang XS, Li GW.
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| World J Gastroenterol 9(12):2839-42. 2003
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| 20 | EDNRB
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| Regulated interaction of endothelin B receptor with caveolin-1.
|
| Yamaguchi T, Murata Y, Fujiyoshi Y, Doi T.
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| Eur J Biochem. 270(8):1816-27. 2003
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| 21 | EDNRB
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| Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury.
|
| Khodorova, A.; Navarro, B.; Jouaville, L. S.; Murphy, J.-E.; Rice, F. I.; Mazurkiewicz, J. E.; Long-Woodward, D.; Stoffel, M.; Strichartz, G. R.; Yukhananov, R.; Davar, G.
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| Nature Med. 9: 1055-1061 2003
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| 22 | EDNRB
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| Endothelin B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression.
|
| Carpenter, T.; Schomberg, S.; Steudel, W.; Ozimek, J.; Colvin, K.; Stenmark, K.; Ivy, D. D.
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| Circ. Res. 93: 456-463 2003
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| 23 | ABCD, EDNRB, WS4A
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| ABCD syndrome is caused by a homozygous mutation in the EDNRB gene.
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| Verheij JB, Kunze J, Osinga J, van Essen AJ, Hofstra RM.
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| Am J Med Genet 108(3):223-5. 2002
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| 24 | EDNRB
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| Promoter hypermethylation of the EDNRB gene in nasopharyngeal carcinoma.
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| Lo KW, Tsang YS, Kwong J, To KF, Teo PM, Huang DP.
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| Int J Cancer 98(5):651-5. 2002
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| 25 | EDN3, EDNRB, WS4B
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| A mouse model of Waardenburg syndrome type 4 with a new spontaneous mutation of the endothelin-B receptor gene.
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| Matsushima Y, Shinkai Y, Kobayashi Y, Sakamoto M, Kunieda T, Tachibana M.
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| Mamm Genome 13(1):30-5. 2002
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| 26 | EDNRB
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| Galpha13 induces preproET-1 gene expression via JNK.
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| Yamakaw K, Kitamura K, Nonoguchi H, Takasu N, Miller RT, Tomita K.
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| Hypertens Res. 25(3):427-32. 2002
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| 27 | EDNRB
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| The endothelin receptor B (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cells.
|
| Pao MM, Tsutsumi M, Liang G, Uzvolgyi E, Gonzales FA, Jones PA.
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| Hum Mol Genet 10(9):903-10. 2001
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| 28 | EDNRB, HSCR2, WS4A
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| Functional analysis of five endothelin-B receptor mutations found in human Hirschsprung disease patients.
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| Abe Y, Sakurai T, Yamada T, Nakamura T, Yanagisawa M, Goto K.
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| Biochem Biophys Res Commun 275(2):524-31. 2000
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| 29 | ECE1, EDNRA, EDNRB
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| Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons.
|
| Maggi, M.; Barni, T.; Fantoni, G.; Mancina, R.; Pupilli, C.; Luconi, M.; Crescioli, C.; Serio, M.; Vannelli, G. B.
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| J. Clin. Endocr. Metab. 85: 1658-1665 2000
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| 30 | EDNRB
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| Salt-sensitive hypertension in endothelin-B receptor-deficient rats.
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| Gariepy, C. E.; Ohuchi, T.; Williams, S. C.; Richardson, J. A.; Yanagisawa, M.
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| J. Clin. Invest. 105: 925-933 2000
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| 31 | ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
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| Sequence diversity in 36 candidate genes for cardiovascular disorders.
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| Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
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| Am J Hum Genet 65(1):183-91. 1999
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| 32 | EDNRB, HSCR2
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| Novel nonsense mutation of the endothelin-B receptor gene in a family with Waardenburg-Hirschsprung disease.
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| Syrris P, Carter ND, Patton MA.
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| Am J Med Genet 87(1):69-71 1999
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| 33 | EDNRB
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| Novel endothelin B receptor transcripts with the potential of generating a new receptor.
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| Tsutsumi M, Liang G, Jones PA.
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| Gene 228(1-2):43-9. 1999
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| 34 | EDNRB
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| Endothelial nitric oxide synthase interactions with G-protein-coupled receptors.
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| Marrero MB, Venema VJ, Ju H, He H, Liang H, Caldwell RB, Venema RC.
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| Biochem J. 343 Pt 2:335-40. 1999
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| 35 | EDNRB
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| The temporal requirement for endothelin receptor-B signalling during neural crest development.
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| Shin, M. K.; Levorse, J. M.; Ingram, R. S.; Tilghman, S. M.
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| Nature 402: 496-501 1999
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| 36 | EDNRB
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| Allele frequency distributions in pooled DNA samples : applications to mapping complex disease genes.
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| Shaw SH, Carrasquillo MM, Kashuk C, Puffenberger EG, Chakravarti A.
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| Genome Res 8(2):111-23. 1998
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| 37 | EDNRB, HSCR2
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| Novel mutations of the endothelin B receptor gene in patients with Hirschsprung's disease and their characterization.
|
| Tanaka H, et al.
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| J Biol Chem 273 : 11378-11383. 1998
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| 38 | EDNRB, HSCR1, HSCR2, RET
|
| Phenotypic variation in a family with mutations in two Hirschsprung-related genes (RET and endothelin receptor B).
|
| Svensson PJ, et al.
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| Hum Genet 103 : 145-148. 1998
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| 39 | EDN3, EDNRB
|
| Endothelin 3 selectively promotes survival and proliferation of neural crest-derived glial and melanocytic precursors in vitro.
|
| Lahav R, Dupin E, Lecoin L, Glavieux C, Champeval D, Ziller C, Le Douarin NM.
|
| Proc Natl Acad Sci U S A 95 : 14214-14219. 1998
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| 40 | EDNRB
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| A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung disease (HSCR).
|
| Yang, G. C.; Croaker, D.; Zhang, A. L.; Manglick, P.; Cartmill, T.; Cass, D.
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| Hum. Molec. Genet. 7: 1047-1052 1998
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| 41 | EDN1, EDN2, EDN3, EDNRA, EDNRB
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| Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.
|
| Bourgeois C, Robert B, Rebourcet R, Mondon F, Mignot TM, Duc-Goiran P, Ferre F.
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| J Clin Endocrinol Metab 82(9):3116-23. 1997
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| 42 | EDNRB
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| Molecular characterization of four induced alleles at the Ednrb locus.
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| Shin, M. K.; Russell, L. B.; Tilghman, S. M.
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| Proc. Nat. Acad. Sci. 94: 13105-13110 1997
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| 43 | HSCR2, EDNRB
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| Endothelin receptor-mediated signaling in Hirschsprung disease.
|
| Chakravarti A.
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| Hum Mol Genet 5 : 303-307. 1996
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| 44 | HSCR2, EDNRB
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| Novel mutations of the endothelin-B receptor gene in isolated patients with Hirschsprung's disease.
|
| Kusafuka T, et al.
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| Hum Mol Genet 5 : 347-349. 1996
|
| 45 | EDNRB, HSCR2
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| Heterozygous endothelin receptor B (EDNRB) mutations in isolated Hirschsprung disease.
|
| Amiel J, et al.
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| Hum Mol Genet 5 : 355-357. 1996
|
| 46 | EDNRB, HSCR2
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| Endothelin-B receptor mutations in patients with isolated Hirschsprung disease from a non-inbred population.
|
| Auricchio A, et al.
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| Hum Mol Genet 5 : 351-354. 1996
|
| 47 | EDNRB, HSCR2
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| Null mutation of endothelin receptor type B gene in spotting lethal ratscauses aganglionic megacolon and white coat color.
|
| Gariepy CE, et al.
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| Proc Natl Acad Sci U S A 93 : 867-872. 1996
|
| 48 | EDNRB, HSCR2
|
| Mutation of the endothelin-receptor B gene in Waardenburg-Hirschsprung disease.
|
| AttiŽ T, et al.
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| Hum Mol Genet 4 : 2407-2409. 1995
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| 49 | ABCD, EDNRB
|
| Autosomal-recessive neural crest syndrome with albinism, black lock, cell migration disorder of the neurocytes of the gut, and deafness: ABCD syndrome.
|
| Gross A, Kunze J, Maier RF, Stoltenburg-Didinger G, Grimmer I, Obladen M.
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| Am J Med Genet 56(3):322-6. 1995
|
| 50 | EDNRB, HSCR2
|
| Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons.
|
| Greenstein Baynash A, et al.
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| Cell 79 : 1277-1285. 1994
|
| 51 | EDNRB, HSCR2
|
| Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice.
|
| Hosoda K, et al.
|
| Cell 79 : 1267-1276. 1994
|
| 52 | HSCR2, EDNRB
|
| A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease.
|
| Puffenberger EG, et al.
|
| Cell 79 : 1257-1266. 1994
|
| 53 | EDNRB
|
| The human endothelin-B receptor gene, structural organization and chromosomal assignment.
|
| Arai H, et al.
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| J Biol Chem 268 : 3463-3470. 1993
|
| 54 | EDNRB
|
| Molecular cloning of a non-isopeptide-selective human endothelin receptor.
|
| Ogawa Y, Nakao K, Arai H, Nakagawa O, Hosoda K, Suga S, Nakanishi S, Imura H.
|
| Biochem Biophys Res Commun 178(1):248-55. 1991
|
| 55 | EDNRB
|
| Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor.
|
| Nakamuta M, Takayanagi R, Sakai Y, Sakamoto S, Hagiwara H, Mizuno T, Saito Y, Hirose S, Yamamoto M, Nawata H.
|
| Biochem Biophys Res Commun 177(1):34-9. 1991
|
| 56 | EDNRB
|
| Cloning and functional expression of human cDNA for the ETB endothelin receptor.
|
| Sakamoto A, Yanagisawa M, Sakurai T, Takuwa Y, Yanagisawa H, Masaki T.
|
| Biochem Biophys Res Commun. 178(2):656-63. 1991
|