| 1 | CACNA1E, EDN1
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| Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells.
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| Bkaily G, Avedanian L, Al-Khoury J, Chamoun M, Semaan R, Jubinville-Leblanc C, D'Orléans-Juste P, Jacques D.
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| Can J Physiol Pharmacol 93(4):291-7. doi: 10.1139/cjpp-2014-0519. Epub 2015 Jan 21.
2015
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| 2 | ARF6, EDN1, EDNRA
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| ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes.
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| Davies JC, Bain SC, Kanamarlapudi V.
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| Biochem Pharmacol 90(4):406-13. doi: 10.1016/j.bcp.2014.06.012. Epub 2014 Jun 20.
2014
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| 3 | EDN1, NR4A1
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| Orphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cells.
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| Qin Q, Chen M, Yi B, You X, Yang P, Sun J.
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| J Mol Cell Cardiol 77:20-8. doi: 10.1016/j.yjmcc.2014.09.027. Epub 2014 Oct 2.
2014
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| 4 | EDN1, RETN
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| Endothelin-1 stimulates resistin gene expression.
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| Tang YC, Liu CW, Chang HH, Juan CC, Kuo YC, Kao CC, Huang YM, Kao YH.
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| Endocrinology 155(3):854-64. doi: 10.1210/en.2013-1847. Epub 2014 Jan 1.
2014
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| 5 | DLX5, DLX6, EDN1
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| Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms.
|
| Kim KS, Arima Y, Kitazawa T, Nishiyama K, Asai R, Uchijima Y, Sato T, Levi G, Kitanaka S, Igarashi T, Kurihara Y, Kurihara H.
|
| Mech Dev ech Dev. 2013 Aug 8. doi:pii: S0925-4773(13)00060-9. 10.1016/j.mod.2013.07.005. [Epub ahead of print]
2013
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| 6 | ACDS3, EDN1
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| Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark ears.
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| Gordon CT, Petit F, Kroisel PM, Jakobsen L, Zechi-Ceide RM, Oufadem M, Bole-Feysot C, Pruvost S, Masson C, Tores F, Hieu T, Nitschké P, Lindholm P, Pellerin P, Guion-Almeida ML, Kokitsu-Nakata NM, Vendramini-Pittoli S, Munnich A, Lyonnet S, Holder-Espinasse M, Amiel J.
|
| Am J Hum Genet 93(6):1118-25. doi: 10.1016/j.ajhg.2013.10.023. Epub 2013 Nov 21.
2013
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| 7 | ARRB1, CTNNB1, EDN1
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| β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.
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| Rosanò L, Cianfrocca R, Tocci P, Spinella F, Di Castro V, Spadaro F, Salvati E, Biroccio AM, Natali PG, Bagnato A.
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| Oncogene 32(42):5066-77. doi: 10.1038/onc.2012.527. Epub 2012 Dec 3.
2013
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| 8 | EDN1, FIGF, VEGFA, VEGFC
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| Endothelin-1 cooperates with hypoxia to induce vascular-like structures through vascular endothelial growth factor-C, -D and -A in lymphatic endothelial cells.
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| Garrafa E, Caprara V, Di Castro V, Rosanò L, Bagnato A, Spinella F.
|
| Life Sci 91(13-14):638-43. doi: 10.1016/j.lfs.2012.03.033. Epub 2012 Apr 13.
2012
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| 9 | EDN1
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| Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch.
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| Tavares AL, Garcia EL, Kuhn K, Woods CM, Williams T, Clouthier DE.
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| Dev Biol 371(1):47-56. doi: 10.1016/j.ydbio.2012.08.003. Epub 2012 Aug 11.
2012
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| 10 | ECE2, EDN1
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| Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-β.
|
| Palmer JC, Barker R, Kehoe PG, Love S.
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| J Alzheimers Dis 29(4):853-61. doi: 10.3233/JAD-2012-111760.
2012
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| 11 | EDN1, GPER1
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| GPER regulates endothelin-dependent vascular tone and intracellular calcium.
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| Meyer MR, Field AS, Kanagy NL, Barton M, Prossnitz ER.
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| Life Sci 91(13-14):623-7. doi: 10.1016/j.lfs.2012.01.007. Epub 2012 Feb 2. 2012
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| 12 | EDN1
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| Endothelin-1, the unfolded protein response, and persistent inflammation: role of pulmonary artery smooth muscle cells.
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| Yeager ME, Belchenko DD, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR.
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| Am J Respir Cell Mol Biol 46(1):14-22. doi: 10.1165/rcmb.2010-0506OC.
2012
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| 13 | ECE2, EDN1, EDNRB
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| Brain endothelial barrier passage by monocytes is controlled by the endothelin system.
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| Reijerkerk A, Lakeman KA, Drexhage JA, van Het Hof B, van Wijck Y, van der Pol SM, Kooij G, Geerts D, de Vries HE.
|
| J Neurochem 121(5):730-7. doi: 10.1111/j.1471-4159.2011.07393.x. Epub 2011 Aug 12.
2012
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| 14 | CDC42, EDN1
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| Endothelin-1 stimulates human trophoblast cell migration through Cdc42 activation.
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| Liu S, Li Q, Na Q, Liu C.
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| Placenta 33(9):712-6. doi: 10.1016/j.placenta.2012.06.010. Epub 2012 Jul 6.
2012
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| 15 | EDN1, GDF2
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| BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production.
|
| Park JE, Shao D, Upton PD, Desouza P, Adcock IM, Davies RJ, Morrell NW, Griffiths MJ, Wort SJ.
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| PLoS One 7(1):e30075. doi: 10.1371/journal.pone.0030075. Epub 2012 Jan 27.
2012
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| 16 | EDN1, FOXO1
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| FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival.
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| Cifarelli V, Lee S, Kim DH, Zhang T, Kamagate A, Slusher S, Bertera S, Luppi P, Trucco M, Dong HH.
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| Mol Endocrinol 26(7):1213-24. doi: 10.1210/me.2011-1276. Epub 2012 May 8.
2012
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| 17 | EDN1, EDN2
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| Endothelin system in intestinal villi: A possible role of endothelin-2/vasoactive intestinal contractor in the maintenance of intestinal architecture.
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| Bianchi M, Adur J, Takizawa S, Saida K, Casco VH.
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| Biochem Biophys Res Commun 417(4):1113-8. doi: 10.1016/j.bbrc.2011.12.053. Epub 2011 Dec 24.
2012
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| 18 | EDN1, PRKCE
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| PKC-ε mediates multiple endothelin-1 actions on systolic Ca2+ and contractility in ventricular myocytes.
|
| Kang M, Chung KY.
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| Biochem Biophys Res Commun 423(3):600-5. doi: 10.1016/j.bbrc.2012.06.024. Epub 2012 Jun 12.
2012
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| 19 | EDN1, GATA4, ZNF260
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| ZFP260 is an inducer of cardiac hypertrophy and a nuclear mediator of endothelin-1 signaling.
|
| Komati H, Maharsy W, Beauregard J, Hayek S, Nemer M.
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| J Biol Chem 286(2):1508-16. Epub 2010 Nov 4.
2011
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| 20 | CCL2, EDN1, IL6
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| Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop.
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| Simonson MS, Ismail-Beigi F.
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| J Biol Chem 286(13):11003-8. Epub 2010 Dec 17.
2011
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| 21 | EDN1, TLR7
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| A novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block.
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| Alvarez D, Briassouli P, Clancy RM, Zavadil J, Reed JH, Abellar RG, Halushka M, Fox-Talbot K, Barrat FJ, Buyon JP.
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| J Biol Chem 286(35):30444-54. Epub 2011 Jul 5.
2011
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| 22 | EDN1, EDNRA
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| The role of endothelin receptor A during myelination of developing oligodendrocytes.
|
| Jung KJ, Kim DW, Lee HN, Lee YS, Lee SJ, Che JH, Lee YH, Kang BC.
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| J Korean Med Sci 26(1):92-9. doi: 10.3346/jkms.2011.26.1.92. Epub 2010 Dec 22.
2011
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| 23 | EDN1
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| Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton.
|
| Alexander C, Zuniga E, Blitz IL, Wada N, Le Pabic P, Javidan Y, Zhang T, Cho KW, Crump JG, Schilling TF.
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| Development 138(23):5135-46. doi: 10.1242/dev.067801. Epub 2011 Oct 26.
2011
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| 24 | EDN1, PRKCA, PRKCB
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| Novel regulation of endothelin-1 promoter activity by protein kinase C.
|
| Stricklett PK, Strait KA, Kohan DE.
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| Cell Biochem Biophys 61(3):643-50. doi: 10.1007/s12013-011-9250-0.
2011
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| 25 | ABCG1, EDN1
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| Endothelin-1 exacerbates lipid accumulation by increasing the protein degradation of the ATP-binding cassette transporter G1 in macrophages.
|
| Lin CY, Lee TS, Chen CC, Chang CA, Lin YJ, Hsu YP, Ho LT.
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| J Cell Physiol 226(8):2198-205. doi: 10.1002/jcp.22556.
2011
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| 26 | EDN1, EDNRB
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| Endothelin axis induces metalloproteinase activation and invasiveness in human lymphatic endothelial cells.
|
| Spinella F, Caprara V, Garrafa E, Di Castro V, Rosanò L, Natali PG, Bagnato A.
|
| Can J Physiol Pharmacol 88(8):782-7. doi: 10.1139/Y10-050.
2010
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| 27 | EDN1
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| Endothelin-1 is elevated in Alzheimer's disease brain microvessels and is neuroprotective.
|
| Luo J, Grammas P.
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| J Alzheimers Dis 21(3):887-96. doi: 10.3233/JAD-2010-091486.
2010
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| 28 | ARRB1, EDN1, ILK
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| Beta-arrestin-1 mediates the endothelin-1-induced activation of Akt and integrin-linked kinase.
|
| Cianfrocca R, Rosanò L, Spinella F, Di Castro V, Natali PG, Bagnato A.
|
| Can J Physiol Pharmacol 88(8):796-801. doi: 10.1139/Y10-052. 2010
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| 29 | EDN1, EDN2, EDN3
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| Endothelin promotes neurite elongation by a mechanism dependent on c-Jun N-terminal kinase.
|
| Uesugi N, Muramatsu R, Yamashita T.
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| Biochem Biophys Res Commun 383(4):509-12. Epub 2009 Apr 23.
2009
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| 30 | EDN1, KCNK3
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| Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells.
|
| Tang B, Li Y, Nagaraj C, Morty RE, Gabor S, Stacher E, Voswinckel R, Weissmann N, Leithner K, Olschewski H, Olschewski A.
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| Am J Respir Cell Mol Biol 41(4):476-83. Epub 2009 Feb 2.PMID: 1918866 2009
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| 31 | EDN1
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| Genetic Analysis of 103 Candidate Genes for Coronary Artery Disease and Associated Phenotypes in a Founder Population Reveals a New Association between Endothelin-1 and High-Density Lipoprotein Cholesterol.
|
| Pare G, Serre D, Brisson D, Anand SS, Montpetit A, Tremblay G, Engert JC, Hudson TJ, Gaudet D.
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| Am J Hum Genet 80(4):673-82. Epub 2007 Feb 21. 2007
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| 32 | CHGA, EDN1
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| Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function.
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| Lillie EO, Mahata M, Khandrika S, Rao F, Bundey RA, Wen G, Chen Y, Taupenot L, Smith DW, Mahata SK, Ziegler MG, Cockburn M, Schork NJ, O'Connor DT.
|
| Circulation 115(17):2282-91. Epub 2007 Apr 16.
2007
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| 33 | EDN1
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| Screening of the endothelin1 gene (EDN1) in a cohort of patients with essential left ventricular hypertrophy.
|
| Castro MG, Rodríguez-Pascual F, Magán-Marchal N, Reguero JR, Alonso-Montes C, Morís C, Alvarez V, Lamas S, Coto E.
|
| Ann Hum Genet 71(Pt 5):601-10. Epub 2007 Mar 2.
2007
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| 34 | EDN1
|
| Altered endothelin-1 vasoreactivity in patients with untreated normal-pressure glaucoma.
|
| Henry E, Newby DE, Webb DJ, Hadoke PW, O'Brien CJ.
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| Invest Ophthalmol Vis Sci 47(6):2528-32. 2006
|
| 35 | EDN1
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| Localized methylation in the key regulator gene endothelin-1 is associated with cell type-specific transcriptional silencing.
|
| Vallender TW, Lahn BT.
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| FEBS Lett 580(18):4560-6. Epub 2006 Jul 14. 2006
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| 36 | EDN1, RLN1
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| Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB.
|
| Dschietzig T, Bartsch C, Richter C, Laule M, Baumann G, Stangl K.
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| Circ Res 92(1):32-40. 2003
|
| 37 | EDNRA, EDNRB, EDN1
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| Localization of endothelin-1 mRNA expression and immunoreactivity in the anterior segment of human eye: expression of ETA and ETB receptors.
|
| Fernandez-Durango R, Rollin R, Mediero A, Roldan-Pallares M, Garcia Feijo J, Garcia Sanchez J, Fernandez-Cruz A, Ripodas A.
|
| Mol Vis 9:103-9. 2003
|
| 38 | EDN1
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| Effects of endothelin-1 on epithelial ion transport in human airways.
|
| Blouquit S, Sari A, Lombet A, D'herbomez M, Naline E, Matran R, Chinet T.
|
| Am J Respir Cell Mol Biol 29(2):245-51. Epub 2003 Mar 6. 2003
|
| 39 | EDN1
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| Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP.
|
| Yamashita K, Discher DJ, Hu J, Bishopric NH, Webster KA.
|
| J Biol Chem 276(16):12645-53. 2001
|
| 40 | EDN1, EDN2
|
| The prepro vasoactive intestinal contractor (VIC)/Endothelin-2 gene (EDN2): structure, evolution, production, and embryonic expression.
|
| Saida K, Hashimoto M, Mitsui Y, Ishida N, Uchide T.
|
| Genomics 64(1):51-61. 2000
|
| 41 | EDN1, OFC1
|
| Linkage analysis of candidate endothelin pathway genes in nonsyndromic familial orofacial cleft.
|
| Pezzetti F, Scapoli L, Martinelli M, Carinci F, Brunelli G, Carls FP, Palomba F, Gombos F, Carinci P, Tognon M.
|
| Ann Hum Genet 64 : 341-347. 2000
|
| 42 | ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
|
| Sequence diversity in 36 candidate genes for cardiovascular disorders.
|
| Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
|
| Am J Hum Genet 65(1):183-91. 1999
|
| 43 | EDN1
|
| Endothelin-1 induces expression of fetal genes through the interleukin-6 family of cytokines in cardiac myocytes.
|
| Saito S, Aikawa R, Shiojima I, Nagai R, Yazaki Y, Komuro I.
|
| FEBS Lett 456(1):103-7 1999
|
| 44 | CAPZB, CD83, EDN1, GCNT2, HIVEP1, TFAP2A
|
| Fine mapping of 39 ESTs on human chromosome 6p23-p25.
|
| Olavesen MG, Bentley E, Mason RV, Stephens RJ, Ragoussis J.
|
| Genomics 46(2):303-6. 1997
|
| 45 | EDN1, EDN2, EDN3, EDNRA, EDNRB
|
| Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.
|
| Bourgeois C, Robert B, Rebourcet R, Mondon F, Mignot TM, Duc-Goiran P, Ferre F.
|
| J Clin Endocrinol Metab 82(9):3116-23. 1997
|
| 46 | EDN1, GMPR, SCA1, DEK
|
| An integrated map of human chromosome 6p23.
|
| Olavesen MG, et al.
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| Genome Res 5 : 342-358. 1995
|
| 47 | ATXN1, EDN1
|
| Endothelin 1 is not a candidate gene for spinal cerebellar ataxia 1.
|
| Cancel G, et al.
|
| Hum Mol Genet 2 : 1477-1479. 1993
|
| 48 | EDN1
|
| A short tandem repeat polymorphism at the endothelin 1 (EDN1) locus.
|
| Pages JC, et al.
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| Hum Mol Genet 2 : 90. 1993
|
| 49 | EDN1
|
| The human endothelin-1 gene (EDN1) encoding a peptide with potent vasoactive properties maps distal to HLA on chromosome arm 6p in close linkage to D6S89.
|
| Hoehe MR, et al.
|
| Cytogenet Cell Genet 62 : 131-135. 1993
|
| 50 | EDN1
|
| Human endometrial adenocarcinoma cells express endothelin-1.
|
| Pekonen F, et al.
|
| Mol Cell Endocrinol 84 : 203-207. 1992
|
| 51 | EDN1
|
| Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes.
|
| Imokawa G, et al.
|
| J Biol Chem 267 : 24675-24680. 1992
|
| 52 | EDN1, EDN2, EDN3
|
| Chromosomal assignments of the human endothelin family genes : the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13.2-q13.3.
|
| Arinami T, Ishikawa M, Inoue A, Yanagisawa M, Masaki T, Yoshida MC, Hamaguchi H.
|
| Am J Hum Genet 48 : 990-996. 1991
|
| 53 | EDN1
|
| TaqI identifies a four allele DNA polymorphism of the human endothelin-1 gene (EDN1).
|
| Hoehe MR, et al.
|
| Nucleic Acids Res 19 : 3161. 1991
|
| 54 | EDN1
|
| TaqI polymorphism at the human preproendothelin-1 gene (EDN1).
|
| Watanabe M, et al.
|
| Nucleic Acids Res 19 : 5099. 1991
|
| 55 | EDN1
|
| A Taq1 RFLP at the EDN1 gene locus.
|
| Berge KE, et al.
|
| Nucleic Acids Res 18 : 6176. 1990
|
| 56 | EDN1
|
| Structural organization and chromosomal assignment of the gene encoding endothelin.
|
| Bloch KD, Friedrich SP, Lee ME, Eddy RL, Shows TB, Quertermous T.
|
| J Biol Chem 264 : 10851-10857. 1989
|
| 57 | EDN1
|
| The human endothelin family : three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
|
| Inoue A, et al.
|
| Proc Natl Acad Sci U S A 86 : 2863-2867. 1989
|
| 58 | EDN1
|
| Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells.
|
| Resink TJ, et al.
|
| Biochem Biophys Res Commun 157 : 1360-1368. 1988
|