1 | ACAD9, ECSIT, NDUFAF1, TIMMDC1, TMEM126B, TMEM126BD
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| Mutations in Complex I Assembly Factor TMEM126B Result in Muscle Weakness and Isolated Complex I Deficiency.
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| Sánchez-Caballero L, Ruzzenente B, Bianchi L, Assouline Z, Barcia G, Metodiev MD, Rio M, Funalot B, van den Brand MA, Guerrero-Castillo S, Molenaar JP, Koolen D, Brandt U, Rodenburg RJ, Nijtmans LG, Rötig A.
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| Am J Hum Genet 99(1):208-16. doi: 10.1016/j.ajhg.2016.05.022. Epub 2016 Jun 30. 2016
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2 | ECSIT, NFKB1, RELA
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| Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling.
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| Mi Wi S, Park J, Shim JH, Chun E, Lee KY.
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| Mol Biol Cell 26(1):151-60. doi: 10.1091/mbc.E14-08-1277. Epub 2014 Oct 29.
2015
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3 | ECSIT, MAP3K7
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| TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB.
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| Wi SM, Moon G, Kim J, Kim ST, Shim JH, Chun E, Lee KY.
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| J Biol Chem 289(51):35205-14. doi: 10.1074/jbc.M114.597187. Epub 2014 Nov 4.
2014
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4 | ACAD9, ECSIT, NDUFAF1, TIMMDC1, TMEM126B
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| TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.
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| Guarani V, Paulo J, Zhai B, Huttlin EL, Gygi SP, Harper JW.
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| Mol Cell Biol 34(5):847-61. doi: 10.1128/MCB.01551-13. Epub 2013 Dec 16.
2014
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5 | ECSIT, TRIM59
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| TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.
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| Kondo T, Watanabe M, Hatakeyama S.
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| Biochem Biophys Res Commun 422(3):501-7. doi: 10.1016/j.bbrc.2012.05.028. Epub 2012 May 12.
2012
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6 | ECSIT, NDUFAF1
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| Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.
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| Vogel RO, Janssen RJ, van den Brand MA, Dieteren CE, Verkaart S, Koopman WJ, Willems PH, Pluk W, van den Heuvel LP, Smeitink JA, Nijtmans LG.
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| Genes Dev 21(5):615-24. 2007
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7 | ECSIT
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| Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
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| Xiao C, Shim JH, Kluppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S.
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| Genes Dev 17(23):2933-49. Epub 2003 Nov 21. 2003
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8 | ECSIT
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| ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.
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| Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S.
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| Genes Dev 13(16):2059-71. 1999
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