Citations for
1ACAD9, ECSIT, NDUFAF1, TIMMDC1, TMEM126B, TMEM126BD
Mutations in Complex I Assembly Factor TMEM126B Result in Muscle Weakness and Isolated Complex I Deficiency.
Sánchez-Caballero L, Ruzzenente B, Bianchi L, Assouline Z, Barcia G, Metodiev MD, Rio M, Funalot B, van den Brand MA, Guerrero-Castillo S, Molenaar JP, Koolen D, Brandt U, Rodenburg RJ, Nijtmans LG, Rötig A.
Am J Hum Genet 99(1):208-16. doi: 10.1016/j.ajhg.2016.05.022. Epub 2016 Jun 30. 2016
2ECSIT, NFKB1, RELA
Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling.
Mi Wi S, Park J, Shim JH, Chun E, Lee KY.
Mol Biol Cell 26(1):151-60. doi: 10.1091/mbc.E14-08-1277. Epub 2014 Oct 29. 2015
3ECSIT, MAP3K7
TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB.
Wi SM, Moon G, Kim J, Kim ST, Shim JH, Chun E, Lee KY.
J Biol Chem 289(51):35205-14. doi: 10.1074/jbc.M114.597187. Epub 2014 Nov 4. 2014
4ACAD9, ECSIT, NDUFAF1, TIMMDC1, TMEM126B
TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.
Guarani V, Paulo J, Zhai B, Huttlin EL, Gygi SP, Harper JW.
Mol Cell Biol 34(5):847-61. doi: 10.1128/MCB.01551-13. Epub 2013 Dec 16. 2014
5ECSIT, TRIM59
TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.
Kondo T, Watanabe M, Hatakeyama S.
Biochem Biophys Res Commun 422(3):501-7. doi: 10.1016/j.bbrc.2012.05.028. Epub 2012 May 12. 2012
6ECSIT, NDUFAF1
Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.
Vogel RO, Janssen RJ, van den Brand MA, Dieteren CE, Verkaart S, Koopman WJ, Willems PH, Pluk W, van den Heuvel LP, Smeitink JA, Nijtmans LG.
Genes Dev 21(5):615-24. 2007
7ECSIT
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
Xiao C, Shim JH, Kluppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S.
Genes Dev 17(23):2933-49. Epub 2003 Nov 21. 2003
8ECSIT
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.
Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S.
Genes Dev 13(16):2059-71. 1999