1 | E2F1, E2F2, E2F3, E2F5, E2F6
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| Roles of E2F family members in the diagnosis and prognosis of head and neck squamous cell carcinoma
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| Li Y, Huang Y, Li B, Yang K.
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| BMC Med Genomics. Feb 28;16(1):38. doi: 10.1186/s12920-023-01470-6 2023
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2 | E2F6
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| E2F6 initiates stable epigenetic silencing of germline genes during embryonic development. 2021 PMID:
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| Dahlet T, Truss M, Frede U, Al Adhami H, Bardet AF, Dumas M, Vallet J, Chicher J, Hammann P, Kottnik S, Hansen P, Luz U, Alvarez G, Auclair G, Hecht J, Robinson PN, Hagemeier C, Weber M.
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| Nat Commun. Jun 11;12(1):3582. doi: 10.1038/s41467-021-23596-w. 2021
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3 | DUSP1, E2F6, USP22
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| Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma
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| Jing T, Wang B, Yang Z, Liu Y, Xu G, Xu X, Jiao K, Chen Z, Xiang L, Zhang L, Liu Y.
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| Cancer Lett. Oct 10;518:266-277. doi: 10.1016/j.canlet.2021.07.044. Epub 2021 Jul 30. 2021
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4 | E2F6
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| E2F-dependent transcription determines replication capacity and S phase length.
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| Pennycook BR, Vesela E, Peripolli S, Singh T, Barr AR, Bertoli C, de Bruin RAM.
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| Nat Commun. Jul 14;11(1):3503. doi: 10.1038/s41467-020-17146-z 2020
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5 | E2F6, NR2E1
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| Nuclear receptor TLX regulates islet beta cell proliferation via E2F6.
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| Shi X, Ma D, Li M, Zeng L, Chen J, Yang Y.
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| Biochem Biophys Res Commun. Jun 4;513(3):560-566. doi: 10.1016/j.bbrc.2019.04.033. Epub 2019 Apr 10. 2019
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6 | E2F6
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| E2F6 functions as a competing endogenous RNA, and transcriptional repressor, to promote ovarian cancer stemness.
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| Cheng FHC, Lin HY, Hwang TW, Chen YC, Huang RL, Chang CB, Yang W, Lin RI, Lin CW, Chen GCW, Mai SY, Lin JMJ, Chuang YM, Chou JL, Kuo LW, Li C, Cheng ASL, Lai HC, Wu SF, Tsai JC, Chan MWY.
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| Cancer Sci. Mar;110(3):1085-1095. doi: 10.1111/cas.13920. Epub 2019 Jan 25. 2019
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7 | E2F6
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| E2F6 protein levels modulate drug induced apoptosis in cardiomyocytes.
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| Major JL, Salih M, Tuana BS.
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| Cell Signal. Dec;40:230-238. doi: 10.1016/j.cellsig.2017.09.022. Epub 2017 Sep 28. 2017
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8 | CHEK1, E2F6
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| Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription
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| Bertoli C, Klier S, McGowan C, Wittenberg C, de Bruin RA.
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| Curr Biol. Sep 9;23(17):1629-37. doi: 10.1016/j.cub.2013.06.063. Epub 2013 Aug 15. 2013
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9 | E2F6, SMARCA4
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| E2F6 associates with BRG1 in transcriptional regulation
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| Leung JY, Nevins JR.
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| PLoS One. 7(10):e47967. doi: 10.1371/journal.pone.0047967. Epub 2012 Oct 17 2012
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10 | E2F6
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| The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy
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| Westendorp B, Major JL, Nader M, Salih M, Leenen FH, Tuana BS.
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| FASEB J. Jun;26(6):2569-79. doi: 10.1096/fj.11-203174. Epub 2012 Mar 7. 2012
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11 | E2F1, E2F6
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| E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1.
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| Yang WW, Shu B, Zhu Y, Yang HT.
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| Mol Biol Cell 19(9):3691-700. Epub 2008 Jun 18.PMID: 18562691 2008
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12 | E2F1, E2F2, E2F3, E2F4, E2F5, E2F6
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| Comparative analysis of E2F family member oncogenic activity.
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| Chen C, Wells AD.
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| PLoS ONE 2(9):e912.
2007
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13 | E2F1, E2F2, E2F4, E2F6
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| E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1.
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| Kikuchi J, Shimizu R, Wada T, Ando H, Nakamura M, Ozawa K, Furukawa Y.
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| Stem Cells 25(10):2439-47. Epub 2007 Jun 28.PMID: 17600109 2007
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14 | E2F6
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| A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.
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| Attwooll C, Oddi S, Cartwright P, Prosperini E, Agger K, Steensgaard P, Wagener C, Sardet C, Moroni MC, Helin K.
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| J Biol Chem 280(2):1199-208. Epub 2004 Nov 8. 2005
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15 | E2F6, EPC1, EZH2
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| A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.
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| Attwooll C, Oddi S, Cartwright P, Prosperini E, Agger K, Steensgaard P, Wagener C, Sardet C, Moroni MC, Helin K.
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| J Biol Chem 280(2):1199-208. Epub 2004 Nov 8.PMID: 15536069 2005
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16 | E2F6, E2F6P
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| Human E2F6 is alternatively spliced to generate multiple protein isoforms.
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| Kherrouche Z, De Launoit Y, Monte D.
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| Biochem Biophys Res Commun 317(3):749-60. 2004
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17 | E2F6
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| E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription.
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| Cartwright P, Muller H, Wagener C, Holm K, Helin K.
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| Oncogene 17(5):611-23. 1998
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18 | E2F6
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| Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6.
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| Gaubatz S, Wood JG, Livingston DM.
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| Proc Natl Acad Sci U S A 95(16):9190-5. 1998
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19 | E2F6
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| E2F-6, a member of the E2F family that can behave as a transcriptional repressor.
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| Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA.
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| Proc Natl Acad Sci U S A 95(6):2850-5. 1998
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