1 | E2F1, E2F2, E2F3, E2F5, E2F6
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| Roles of E2F family members in the diagnosis and prognosis of head and neck squamous cell carcinoma
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| Li Y, Huang Y, Li B, Yang K.
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| BMC Med Genomics. Feb 28;16(1):38. doi: 10.1186/s12920-023-01470-6 2023
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2 | E2F1, E2F7, SAPCD2
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| SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7
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| Zhang ZM, Cao HB, Li ZH, Zhuo R, Tao YF, Li XL, Li G, Liao XM, Fang F, Xie Y, Wu D, Wang HR, Wang JW, Chen YL, Yu JJ, Jia SQ, Yang RD, Guo XY, Yang Y, Feng CX, Xu YY, Qian GH, Pan J.
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| Cell Death Dis. Feb 23;13(2):174. doi: 10.1038/s41419-022-04624-z. 2022
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3 | E2F1, NOVA2, PPARG
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| Gene Expression Profiles Controlled by the Alternative Splicing Factor Nova2 in Endothelial Cells.
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| Belloni E, Di Matteo A, Pradella D, Vacca M, Wyatt CDR, Alfieri R, Maffia A, Sabbioneda S, Ghigna C.
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| Cell Nov 23;8(12):1498. doi: 10.3390/cells8121498 2019
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4 | E2F1
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| E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes.
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| Giralt A, Denechaud PD, Lopez-Mejia IC, Delacuisine B, Blanchet E, Bonner C, Pattou F, Annicotte JS, Fajas L.
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| Mol Metab. May;11:104-112. doi: 10.1016/j.molmet.2018.02.011. Epub 2018 Feb 26 2018
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5 | E2F1, RRM2B
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| E2F1 regulates p53R2 gene expression in p53-deficient cells.
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| Qi JJ, Liu L, Cao JX, An GS, Li SY, Li G, Jia HT, Ni JH.
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| Mol Cell Biochem 399(1-2):179-88. doi: 10.1007/s11010-014-2244-7. Epub 2014 Oct 14.
2015
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6 | E2F1, RRM2
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| E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide reductase small subunit M2.
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| Fang Z, Gong C, Liu H, Zhang X, Mei L, Song M, Qiu L, Luo S, Zhu Z, Zhang R, Gu H, Chen X.
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| Biochem Biophys Res Commun 464(2):407-15. doi: 10.1016/j.bbrc.2015.06.103. Epub 2015 Jun 18.
2015
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7 | E2F1, PSMD14
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| POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation.
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| Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y.
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| Nat Commun 6:8704. doi: 10.1038/ncomms9704.
2015
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8 | E2F1, UCHL5
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| Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37.
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| Mahanic CS, Budhavarapu V, Graves JD, Li G, Lin WC.
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| J Biol Chem 290(44):26508-22. doi: 10.1074/jbc.M115.659425. Epub 2015 Sep 22.
2015
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9 | E2F1, ELL
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| ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of histone deacetylase 1.
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| Zhang W, Ji W, Liu X, Ouyang G, Xiao W.
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| Mol Cell Biol 34(4):765-75. doi: 10.1128/MCB.00878-13. Epub 2013 Dec 16.
2014
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10 | E2F1, E2F3, E2F4
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| Regulation of ischemic neuronal death by E2F4-p130 protein complexes.
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| Iyirhiaro GO, Zhang Y, Estey C, O'Hare MJ, Safarpour F, Parsanejad M, Wang S, Abdel-Messih E, Callaghan SM, During MJ, Slack RS, Park DS.
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| J Biol Chem 289(26):18202-13. doi: 10.1074/jbc.M114.574145. Epub 2014 May 14.
2014
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11 | E2F1, VHL
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| pVHL acts as a downstream target of E2F1 to suppress E2F1 activity.
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| Ji W, Wang J, Zhang W, Liu X, Ouyang G, Xiao W.
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| Biochem J 457(1):185-95. doi: 10.1042/BJ20130793.
2014
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12 | E2F1, KDM2A
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| Mammalian lysine histone demethylase KDM2A regulates E2F1-mediated gene transcription in breast cancer cells.
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| Rizwani W, Schaal C, Kunigal S, Coppola D, Chellappan S.
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| PLoS One 9(7):e100888. doi: 10.1371/journal.pone.0100888. eCollection 2014.
2014
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13 | E2F1, RORA
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| RORα binds to E2F1 to inhibit cell proliferation and regulate mammary gland branching morphogenesis.
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| Xiong G, Xu R.
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| Mol Cell Biol 34(16):3066-75. doi: 10.1128/MCB.00279-14. Epub 2014 Jun 2.
2014
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14 | E2F1, TFDP3
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| TFDP3 was expressed in coordination with E2F1 to inhibit E2F1-mediated apoptosis in prostate cancer.
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| Ma Y, Xin Y, Li R, Wang Z, Yue Q, Xiao F, Hao X.
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| Gene 537(2):253-9. doi: 10.1016/j.gene.2013.12.051. Epub 2014 Jan 7.
2014
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15 | E2F1, NELL2
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| The E2F1 oncogene transcriptionally regulates NELL2 in cancer cells.
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| Kim DH, Roh YG, Lee HH, Lee SY, Kim SI, Lee BJ, Leem SH.
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| DNA Cell Biol 32(9):517-23. doi: 10.1089/dna.2013.1974. Epub 2013 Jul 5.
2013
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16 | E2F1, EI24
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| Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation.
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| Sung YH, Jin Y, Kang Y, Devkota S, Lee J, Roh JI, Lee HW.
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| J Biol Chem 288(43):31261-7. doi: 10.1074/jbc.M113.477570. Epub 2013 Sep 6.
2013
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17 | BCL2L11, E2F1
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| Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.
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| Gogada R, Yadav N, Liu J, Tang S, Zhang D, Schneider A, Seshadri A, Sun L, Aldaz CM, Tang DG, Chandra D.
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| J Biol Chem 288(1):368-81. doi: 10.1074/jbc.M112.386102. Epub 2012 Nov 14.
2013
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18 | E2F1, UHRF2
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| The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis.
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| Lu H, Hallstrom TC.
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| J Biol Chem 288(33):23833-43. doi: 10.1074/jbc.M112.447276. Epub 2013 Jul 5.
2013
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19 | E2F1, FOXO1, FOXO3
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| FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function.
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| Shats I, Gatza ML, Liu B, Angus SP, You L, Nevins JR.
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| Cancer Res 73(19):6056-67. doi: 10.1158/0008-5472.CAN-13-0453. Epub 2013 Aug 21.
2013
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20 | E2F1, MCPH1, SENP8
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| NEDDylation controls the target specificity of E2F1 and apoptosis induction.
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| Aoki I, Higuchi M, Gotoh Y.
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| Oncogene 32(34):3954-64. doi: 10.1038/onc.2012.428. Epub 2012 Sep 24.
2013
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21 | E2F1, MYC, PBK
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| c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas.
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| Hu F, Gartenhaus RB, Zhao XF, Fang HB, Minkove S, Poss DE, Rapoport AP.
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| Leuk Res 37(4):447-54. doi: 10.1016/j.leukres.2012.11.010. Epub 2012 Dec 10.
2013
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22 | E2F1, SRSF2
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| A new function of the splicing factor SRSF2 in the control of E2F1-mediated cell cycle progression in neuroendocrine lung tumors.
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| Edmond V, Merdzhanova G, Gout S, Brambilla E, Gazzeri S, Eymin B.
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| Cell Cycle Apr 15;12(8):1267-78. doi: 10.4161/cc.24363. Epub 2013 Mar 21 2013
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23 | ATM, BRCA1, E2F1, RBBP8
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| Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription.
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| Moiola C, De Luca P, Cotignola J, Gardner K, Vazquez E, De Siervi A.
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| Cell Physiol Biochem 30(3):596-608. doi: 10.1159/000341441. Epub 2012 Jul 27.
2012
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24 | E2F1, TFB1M
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| Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.
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| Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS.
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| Cell 148(4):716-26. doi: 10.1016/j.cell.2011.12.027.
2012
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25 | E2F1, NEDD8
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| NEDDylation regulates E2F-1-dependent transcription.
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| Loftus SJ, Liu G, Carr SM, Munro S, La Thangue NB.
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| EMBO Rep 13(9):811-8. doi: 10.1038/embor.2012.113. Epub 2012 Jul 27.
2012
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26 | CD2AP, E2F1
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| Transcriptional activation of the human CD2AP promoter by E2F1.
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| Zou L, Xu HG, Ren W, Jin R, Wang Y, Zhou GP.
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| PLoS One 7(8):e42774. doi: 10.1371/journal.pone.0042774. Epub 2012 Aug 3.
2012
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27 | E2F1, TP53
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| Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response.
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| Yoshihara Y, Wu D, Kubo N, Sang M, Nakagawara A, Ozaki T.
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| Biochem Biophys Res Commun 421(1):57-63. doi: 10.1016/j.bbrc.2012.03.108. Epub 2012 Mar 29.
2012
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28 | DOK1, E2F1
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| Transcriptional regulation of the human tumor suppressor DOK1 by E2F1.
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| Siouda M, Yue J, Shukla R, Guillermier S, Herceg Z, Creveaux M, Accardi R, Tommasino M, Sylla BS.
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| Mol Cell Biol 32(23):4877-90. doi: 10.1128/MCB.01050-12. Epub 2012 Oct 1.
2012
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29 | E2F1, KLF15
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| Kruppel-like factor-15 inhibits the proliferation of mesangial cells.
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| Hong Q, Li C, Xie Y, Lv Y, Liu X, Shi S, Ding R, Zhang X, Zhang L, Liu S, Chen X.
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| Cell Physiol Biochem 29(5-6):893-904. doi: 10.1159/000178518. Epub 2012 May 11.
2012
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30 | CCNA2, E2F1, PCNA, RSL1D1
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| The retinoblastoma protein selectively represses E2F1 targets via a TAAC DNA element during cellular senescence.
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| Chen T, Xue L, Niu J, Ma L, Li N, Cao X, Li Q, Wang M, Zhao W, Li G, Wang J, Tong T.
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| J Biol Chem 287(44):37540-51. doi: 10.1074/jbc.M111.260679. Epub 2012 Sep 6.
2012
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31 | E2F1
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| E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.
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| Ingram L, Munro S, Coutts AS, La Thangue NB.
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| Cell Death Differ. 18(1):122-32. 2011
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32 | E2F1, IRF3
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| Direct repression of the human IRF-3 promoter by E2F1.
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| Xu HG, Ren W, Zou L, Wang Y, Jin R, Zhou GP.
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| Immunogenetics 63(4):189-96. Epub 2011 Jan 12.
2011
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33 | E2F1, HELLS
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| Transcriptional activation of the senescence regulator Lsh by E2F1.
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| Niu J, Chen T, Han L, Wang P, Li N, Tong T.
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| Mech Ageing Dev 132(4):180-6. Epub 2011 Mar 29.
2011
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34 | BIRC2, E2F1
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| Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.
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| Cartier J, Berthelet J, Marivin A, Gemble S, Edmond V, Plenchette S, Lagrange B, Hammann A, Dupoux A, Delva L, Eymin B, Solary E, Dubrez L.
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| J Biol Chem 286(30):26406-17. Epub 2011 Jun 8.
2011
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35 | CDKN2A, E2F1, HNRNPD
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| p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.
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| Al-Khalaf HH, Colak D, Al-Saif M, Al-Bakheet A, Hendrayani SF, Al-Yousef N, Kaya N, Khabar KS, Aboussekhra A.
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| PLoS One 6(7):e21111. Epub 2011 Jul 20.
2011
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36 | E2F1, ZNF346
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| JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1.
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| Yang M, Wu S, Jia J, May WS.
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| Cell Cycle 10(14):2390-9. Epub 2011 Jul 15.
2011
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37 | CTNNBIP1, E2F1
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| E2F1 suppresses Wnt/β-catenin activity through transactivation of β-catenin interacting protein ICAT.
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| Wu Z, Zheng S, Li Z, Tan J, Yu Q.
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| Oncogene 30(37):3979-84. doi: 10.1038/onc.2011.129. Epub 2011 May 2.
2011
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38 | E2F1, QKI
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| E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulation.
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| Yang G, Lu X, Wang L, Bian Y, Fu H, Wei M, Pu J, Jin L, Yao L, Lu Z.
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| Cell Cycle 10(16):2703-13. Epub 2011 Aug 15.
2011
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39 | E2F1, TFDP1, TFDP3
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| E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.
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| Ingram L, Munro S, Coutts AS, La Thangue NB.
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| Cell Death Differ 18(1):122-32. doi: 10.1038/cdd.2010.70. Epub 2010 Jun 18.
2011
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40 | E2F1, RRP1B
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| Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.
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| Paik JC, Wang B, Liu K, Lue JK, Lin WC.
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| J Biol Chem 285(9):6348-63. Epub 2009 Dec 29.PMID: 20040599 2010
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41 | CDKN1B, CDKN1C, E2F1
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| CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner.
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| Ma Y, Chen L, Wright GM, Pillai SR, Chellappan SP, Cress WD.
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| J Biol Chem 285(13):9813-22. Epub 2010 Jan 27.PMID: 20106982 2010
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42 | E2F1, LRRK2, PARK8
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| Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.
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| Gehrke S, Imai Y, Sokol N, Lu B.
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| Nature 466(7306):637-41. 2010
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43 | E2F1, TAPBP
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| Identification of E2F1 as an important transcription factor for the regulation of tapasin expression.
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| Bukur J, Herrmann F, Handke D, Recktenwald C, Seliger B.
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| J Biol Chem 285(40):30419-26. Epub 2010 Jul 27.
2010
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44 | CTBP1, E2F1, RB1, RBBP8, TRIM28, ZNF350
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| RBˇE2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1.
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| Liao CC, Tsai CY, Chang WC, Lee WH, Wang JM.
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| J Biol Chem 285(43):33134-43. Epub 2010 Aug 16.
2010
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45 | E2F1, PCYT1A
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| Specific interaction between E2F1 and Sp1 regulates the expression of murine CTP:phosphocholine cytidylyltransferase alpha during the S phase.
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| Elena C, Banchio C.
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| Biochim Biophys Acta 1801(4):537-46. doi: 10.1016/j.bbalip.2010.01.005. Epub 2010 Jan 21.
2010
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46 | E2F1, FGFR1
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| Transcriptional regulation of human fibroblast growth factor receptor 1 by E2F-1.
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| Kanai M, Tashiro E, Maruki H, Minato Y, Imoto M.
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| Gene 438(1-2):49-56. Epub 2009 Mar 19.
2009
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47 | ARID1A, E2F1, HIC1, SMARCA4
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| HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A.
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| Van Rechem C, Boulay G, Leprince D.
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| Biochem Biophys Res Commun 385(4):586-90. Epub 2009 May 30. 2009
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48 | E2F1, HIC1
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| Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control.
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| Zhang B, Chambers KJ, Leprince D, Faller DV, Wang S.
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| Oncogene 28(5):651-61. Epub 2008 Nov 17.
2009
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49 | CUX1, E2F1
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| CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.
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| Seguin L, Liot C, Mzali R, Harada R, Siret A, Nepveu A, Bertoglio J.
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| Mol Cell Biol 29(2):570-81. Epub 2008 Nov 17.
2009
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50 | E2F1, HCFC1
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| E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases.
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| Tyagi S, Herr W.
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| EMBO J 28(20):3185-95. Epub 2009 Sep 17.PMID: 19763085 2009
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51 | CCNE1, CCNE2, E2F1
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| Role of E2F1-cyclin E1-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs.
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| Dapas B, Farra R, Grassi M, Giansante C, Fiotti N, Uxa L, Rainaldi G, Mercatanti A, Colombatti A, Spessotto P, Lacovich V, Guarnieri G, Grassi G.
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| Mol Med 15(9-10):297-306. doi: 10.2119/molmed.2009.00030. Epub 2009 Jun 25.
2009
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52 | CUX1, E2F1, ECT2, KIF23
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| CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.
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| Seguin L, Liot C, Mzali R, Harada R, Siret A, Nepveu A, Bertoglio J.
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| Mol Cell Biol 29(2):570-81. doi: 10.1128/MCB.01275-08.
2009
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53 | RHOBTB2, E2F1
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| RhoBTB2 (DBC2) Is a Mitotic E2F1 Target Gene with a Novel Role in Apoptosis.
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| Freeman SN, Ma Y, Cress WD.
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| J Biol Chem 283(4):2353-62. Epub 2007 Nov 26. 2008
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54 | E2F1, CTNND1
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| Identification of E2F1 as a positive transcriptional regulator for delta-catenin.
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| Kim K, Oh M, Ki H, Wang T, Bareiss S, Fini ME, Li D, Lu Q.
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| Biochem Biophys Res Commun 369(2):414-20. Epub 2008 Feb 25. 2008
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55 | E2F1, KIR3DL1
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| E2F1 contributes to the transcriptional activation of the KIR3DL1 gene.
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| Gao XN, Yu L.
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| Biochem Biophys Res Commun 370(3):399-403. Epub 2008 Mar 20. 2008
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56 | E2F1, TNFSF11
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| Transcriptional regulation of human RANK ligand gene expression by E2F1.
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| Hu Y, Sun M, Nadiminty N, Lou W, Pinder E, Gao AC.
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| Biochem Biophys Res Commun 370(3):440-4. Epub 2008 Mar 31. 2008
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57 | CHEK1, E2F1, MCPH1
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| MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.
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| Yang SZ, Lin FT, Lin WC.
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| EMBO Rep 9(9):907-15. Epub 2008 Jul 25.
2008
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58 | CDK8, E2F1
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| E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.
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| Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, Kwon EJ, Haigis KM, Näär AM, Dyson NJ.
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| Nature 455(7212):552-6. Epub 2008 Sep 14.
2008
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59 | E2F1, HSPA5
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| Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1.
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| Racek T, Buhlmann S, Rüst F, Knoll S, Alla V, Pützer BM.
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| J Biol Chem 283(49):34305-14. Epub 2008 Oct 7.
2008
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60 | E2F1, SRSF2
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| E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35.
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| Merdzhanova G, Edmond V, De Seranno S, Van den Broeck A, Corcos L, Brambilla C, Brambilla E, Gazzeri S, Eymin B.
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| Cell Death Differ 15(12):1815-23. Epub 2008 Sep 19. 2008
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61 | E2F1, MDM2
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| ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.
|
| Stevens C, Pettersson S, Wawrzynow B, Wallace M, Ball K, Zylicz A, Hupp TR.
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| FEBS J 275(19):4875-86. Epub 2008 Aug 27.
2008
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62 | E2F1, E2F3
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| E2F1 and E2F3 activate ATM through distinct mechanisms to promote E1A-induced apoptosis.
|
| Hong S, Paulson QX, Johnson DG.
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| Cell Cycle 7(3):391-400. Epub 2007 Nov 6.
2008
|
63 | E2F1, ETV4
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| Identification of E1AF as a target gene of E2F1-induced apoptosis in response to DNA damage.
|
| Wei Y, Liu D, Ge Y, Zhou F, Xu J, Chen H, Gu J, Jiang J.
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| J Biochem 144(4):539-46. Epub 2008 Aug 7.
2008
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64 | CUX1, E2F1
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| p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes.
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| Truscott M, Harada R, Vadnais C, Robert F, Nepveu A.
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| Mol Cell Biol 28(10):3127-38. Epub 2008 Mar 17.
2008
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65 | E2F1, GSK3B
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| The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation.
|
| Zhou F, Zhang L, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong Y.
|
| J Biol Chem. 283(21):14506-15. 2008
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66 | AHR, E2F1
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| The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis.
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| Marlowe JL, Fan Y, Chang X, Peng L, Knudsen ES, Xia Y, Puga A.
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| Mol Biol Cell 19(8):3263-71. Epub 2008 Jun 4.PMID: 18524851 2008
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67 | E2F1, E2F6
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| E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1.
|
| Yang WW, Shu B, Zhu Y, Yang HT.
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| Mol Biol Cell 19(9):3691-700. Epub 2008 Jun 18.PMID: 18562691 2008
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68 | BNIP3, E2F1
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| The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes.
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| Yurkova N, Shaw J, Blackie K, Weidman D, Jayas R, Flynn B, Kirshenbaum LA.
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| Circ Res 102(4):472-9. Epub 2007 Dec 20.PMID: 18096822 2008
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69 | DAPK2, E2F1, KLF6
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| DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function.
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| Britschgi A, Trinh E, Rizzi M, Jenal M, Ress A, Tobler A, Fey MF, Helin K, Tschan MP.
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| Oncogene 27(43):5706-16. Epub 2008 Jun 2.
2008
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70 | E2F1
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| MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.
|
| Yang SZ, Lin FT, Lin WC.
|
| EMBO Rep. 9(9):907-15. 2008
|
71 | E2F1
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| LEF-1 activates the transcription of E2F1.
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| Zhou F, Zhang L, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X, Gong Y.
|
| Biochem Biophys Res Commun. 365(1):149-53. 2008
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72 | YY1, PHB, E2F1, TP53, CASP7
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| Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites.
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| Joshi B, Rastogi S, Morris M, Carastro LM, DeCook C, Seto E, Chellappan SP.
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| Biochem J 401(1):155-66. 2007
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73 | BTG3, E2F1
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| The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1.
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| Ou YH, Chung PH, Hsu FF, Sun TP, Chang WY, Shieh SY.
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| EMBO J 26(17):3968-80. Epub 2007 Aug 9. 2007
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74 | E2F1, PDGFRA
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| Transcriptional regulation of a new variant of human platelet-derived growth factor receptor alpha transcript by E2F-1.
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| Minato Y, Tashiro E, Kanai M, Nihei Y, Kodama Y, Imoto M.
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| Gene 403(1-2):89-97. Epub 2007 Aug 25. 2007
|
75 | E2F1, E2F2, E2F3, E2F4, E2F5, E2F6
|
| Comparative analysis of E2F family member oncogenic activity.
|
| Chen C, Wells AD.
|
| PLoS ONE 2(9):e912.
2007
|
76 | E2F1, NRP1
|
| Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo.
|
| Jiang SX, Sheldrick M, Desbois A, Slinn J, Hou ST.
|
| Mol Cell Biol 27(5):1696-705. Epub 2006 Dec 18. 2007
|
77 | COPS2, E2F1
|
| Alien inhibits E2F1 gene expression and cell proliferation.
|
| Tenbaum SP, Papaioannou M, Reeb CA, Goeman F, Escher N, Kob R, von Eggeling F, Melle C, Baniahmad A.
|
| Biochim Biophys Acta 1773(9):1447-54. Epub 2007 May 10.
2007
|
78 | E2F1, E2F2, E2F4, E2F6
|
| E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1.
|
| Kikuchi J, Shimizu R, Wada T, Ando H, Nakamura M, Ozawa K, Furukawa Y.
|
| Stem Cells 25(10):2439-47. Epub 2007 Jun 28.PMID: 17600109 2007
|
79 | DUSP2, E2F1
|
| PAC1 is a direct transcription target of E2F-1 in apoptotic signaling.
|
| Wu J, Jin YJ, Calaf GM, Huang WL, Yin Y.
|
| Oncogene 26(45):6526-35. Epub 2007 Apr 30.PMID: 17471234 2007
|
80 | E2F1
|
| E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.
|
| Tyagi S, Chabes AL, Wysocka J, Herr W.
|
| Mol Cell 27(1):107-19. 2007
|
81 | E2F1, TFDP3
|
| TFDP3 inhibits E2F1-induced, p53-mediated apoptosis.
|
| Tian C, Lv D, Qiao H, Zhang J, Yin YH, Qian XP, Wang YP, Zhang Y, Chen WF.
|
| Biochem Biophys Res Commun 361(1):20-5. Epub 2007 Jul 5.
2007
|
82 | E2F1, DIABLO
|
| Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.
|
| Xie W, Jiang P, Miao L, Zhao Y, Zhimin Z, Qing L, Zhu WG, Wu M.
|
| Nucleic Acids Res 34(7):2046-55. Print 2006. 2006
|
83 | E2F1, MAP3K5
|
| ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene.
|
| Kherrouche Z, Blais A, Ferreira E, De Launoit Y, Monte D.
|
| Biochem J 396(3):547-56. 2006
|
84 | SKP2, E2F1
|
| F-box protein Skp2: a novel transcriptional target of E2F.
|
| Zhang L, Wang C.
|
| Oncogene 25(18):2615-27. 2006
|
85 | E2F1
|
| p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation.
|
| Devgan V, Mammucari C, Millar SE, Brisken C, Dotto GP.
|
| Genes Dev. 19(12):1485-95. 2005
|
86 | E2F1, EAPP
|
| EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.
|
| Novy M, Pohn R, Andorfer P, Novy-Weiland T, Galos B, Schwarzmayr L, Rotheneder H.
|
| Mol Biol Cell 16(5):2181-90. Epub 2005 Feb 16. 2005
|
87 | E2F1, PPP1R13B, TP53BP2
|
| ASPP1 and ASPP2 are new transcriptional targets of E2F.
|
| Fogal V, Kartasheva NN, Trigiante G, Llanos S, Yap D, Vousden KH, Lu X.
|
| Cell Death Differ 12(4):369-76. 2005
|
88 | E2F1, GRAMD4
|
| A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
|
| Stanelle J, Tu-Rapp H, Ptzer BM.
|
| Cell Death Differ 12(4):347-57. 2005
|
89 | E2F1
|
| Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway.
|
| Zhang Z, Wang H, Li M, Rayburn ER, Agrawal S, Zhang R.
|
| Oncogene. 24(48):7238-47. 2005
|
90 | E2F1, PURA
|
| Interaction between the pura and E2F-1 transcription factors.
|
| Darbinian N, White MK, Gallia GL, Amini S, Rappaport J, Khalili K.
|
| Anticancer Res 24(5A):2585-94.
2004
|
91 | E2F1, NGFR, NSMCE3
|
| Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor.
|
| Kuwako K, Taniura H, Yoshikawa K.
|
| J Biol Chem. 279(3):1703-12. 2004
|
92 | E2F1
|
| E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1.
|
| Taubert S, Gorrini C, Frank SR, Parisi T, Fuchs M, Chan HM, Livingston DM, Amati B.
|
| Mol Cell Biol. 24(10):4546-56. 2004
|
93 | E2F1, TOPBP1
|
| Regulation of E2F1 by BRCT domain-containing protein TopBP1.
|
| Liu K, Lin FT, Ruppert JM, Lin WC.
|
| Mol Cell Biol 23(9):3287-304. 2003
|
94 | E2F1, PHB
|
| A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis.
|
| Joshi B, Ko D, Ordonez-Ercan D, Chellappan SP.
|
| Biochem Biophys Res Commun 312(2):459-66. 2003
|
95 | E2F1
|
| Chk2 activates E2F-1 in response to DNA damage.
|
| Stevens C, Smith L, La Thangue NB.
|
| Nat Cell Biol. 5(5):401-9. 2003
|
96 | E2F1
|
| Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation.
|
| Kong HJ, Yu HJ, Hong S, Park MJ, Choi YH, An WG, Lee JW, Cheong J.
|
| Mol Cancer Res. 1(13):948-58. 2003
|
97 | E2F1
|
| PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.
|
| Simbulan-Rosenthal CM, Rosenthal DS, Luo R, Samara R, Espinoza LA, Hassa PO, Hottiger MO, Smulson ME.
|
| Oncogene. 22(52):8460-71. 2003
|
98 | E2F1, GRAMD4
|
| Gene expression changes in response to E2F1 activation.
|
| Stanelle J, Stiewe T, Theseling CC, Peter M, Ptzer BM.
|
| Nucleic Acids Res 30(8):1859-67. 2002
|
99 | E2F1
|
| Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.
|
| Hsieh JK, Yap D, O'Connor DJ, Fogal V, Fallis L, Chan F, Zhong S, Lu X.
|
| Mol Cell Biol. 22(1):78-93. 2002
|
100 | E2F1
|
| p14(ARF) regulates E2F activity.
|
| Mason SL, Loughran O, La Thangue NB.
|
| Oncogene. 21(27):4220-30. 2002
|
101 | E2F1
|
| E2F-1 represses transcription of the human telomerase reverse transcriptase gene.
|
| Crowe DL, Nguyen DC, Tsang KJ, Kyo S.
|
| Nucleic Acids Res 29(13):2789-94. 2001
|
102 | E2F1,RB,RB1
|
| The Rb/E2F pathway and cancer.
|
| Nevins JR.
|
| Hum Mol Genet 10(7):699-703. Review. 2001
|
103 | E2F1
|
| Human ARF binds E2F1 and inhibits its transcriptional activity.
|
| Eymin B, Karayan L, Séité P, Brambilla C, Brambilla E, Larsen CJ, Gazzéri S.
|
| Oncogene. 20(9):1033-41. 2001
|
104 | E2F1
|
| The paradox of E2F1: oncogene and tumor suppressor gene.
|
| Johnson DG.
|
| Mol Carcinog 27(3):151-7. 2000
|
105 | DNMT1, E2F1
|
| DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.
|
| Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP.
|
| Nat Genet 25(3):338-42. 2000
|
106 | E2F1, TP73
|
| Role for the p53 homologue p73 in E2F-1-induced apoptosis.
|
| Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG Jr.
|
| Nature 407(6804):645-8. 2000
|
107 | E2F1, TP73
|
| A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.
|
| Lissy NA, Davis PK, Irwin M, Kaelin WG, Dowdy SF.
|
| Nature 407(6804):642-5. 2000
|
108 | E2F1
|
| NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity.
|
| Sansal I, Dupont E, Toru D, Evrard C, Rouget P.
|
| Oncogene. 19(43):5000-9. 2000
|
109 | E2F1
|
| Increased levels of E2F-1-dependent DNA binding activity after UV- or gamma-irradiation.
|
| Hofferer M, et al.
|
| Nucleic Acids Res 27(2):491-5. 1999
|
110 | E2F1, PHB, RB1
|
| Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function.
|
| Wang S, Nath N, Adlam M, Chellappan S.
|
| Oncogene 18(23):3501-10. 1999
|
111 | E2F1
|
| Regulation and deregulation of E2F1 in postmitotic neurons differentiated from embryonal carcinoma P19 cells.
|
| Azuma-Hara M, Taniura H, Uetsuki T, Niinobe M, Yoshikawa K.
|
| Exp Cell Res 251(2):442-51 1999
|
112 | E2F1, NDN, TP53
|
| Physical and functional interactions of neuronal growth suppressor necdin with p53.
|
| Taniura H, Matsumoto K, Yoshikawa K.
|
| J Biol Chem 274(23):16242-8 1999
|
113 | E2F1
|
| Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation.
|
| Marti A, Wirbelauer C, Scheffner M, Krek W.
|
| Nat Cell Biol. 1(1):14-9. 1999
|
114 | E2F1
|
| Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.
|
| Rotheneder H, Geymayer S, Haidweger E.
|
| J Mol Biol. 293(5):1005-15. 1999
|
115 | E2F1, NDN
|
| Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1.
|
| Taniura H, Taniguchi N, Hara M, Yoshikawa K.
|
| J Biol Chem 273(2):720-8 1998
|
116 | E2F1, TRRAP
|
| The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.
|
| McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD.
|
| Cell. 94(3):363-74. 1998
|
117 | E2F1
|
| A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer.
|
| Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K.
|
| Oncogene. 17(7):853-65. 1998
|
118 | E2F1
|
| DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1.
|
| Hayes S, Shiyanov P, Chen X, Raychaudhuri P.
|
| Mol Cell Biol. 18(1):240-9. 1998
|
119 | BRCA1, CDK5, E2F1
|
| BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.
|
| Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN.
|
| Oncogene. 15(2):143-57. 1997
|
120 | E2F1
|
| Interaction between cell cycle regulator, E2F-1, and NF-kappaB mediates repression of HIV-1 gene transcription.
|
| Kundu M, Guermah M, Roeder RG, Amini S, Khalili K.
|
| J Biol Chem. 272(47):29468-74. 1997
|
121 | E2F1
|
| Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.
|
| Vidal M, Braun P, Chen E, Boeke JD, Harlow E.
|
| Proc Natl Acad Sci U S A. 93(19):10321-6 1996
|
122 | E2F1
|
| The CBP co-activator stimulates E2F1/DP1 activity.
|
| Trouche D, Cook A, Kouzarides T.
|
| Nucleic Acids Res. 24(21):4139-45. 1996
|
123 | E2F1
|
| Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line.
|
| Saito M, et al.
|
| Genomics 25 : 130-138. 1995
|
124 | CDK2, E2F1
|
| Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.
|
| Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H.
|
| Mol Cell Biol. 14(12):8420-31. 1994
|
125 | E2F1
|
| Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein.
|
| Fagan R, Flint KJ, Jones N.
|
| Cell. 78(5):799-811. 1994
|
126 | ARID4A, E2F1, KDM5A
|
| Characterization of the retinoblastoma binding proteins RBP1 and RBP2.
|
| Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, HanobikMG, Haskell KM, Oliff A, Defeo-Jones D, et al.
|
| Oncogene 8(11):3149-56. 1993
|
127 | E2F1
|
| A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.
|
| Helin K, et al.
|
| Cell 70 : 337-350. 1992
|
128 | E2F1
|
| Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties.
|
| Kaelin WG, et al.
|
| Cell 70 : 351-364. 1992
|