Citations for
1E2F1, E2F2, E2F3, E2F5, E2F6
Roles of E2F family members in the diagnosis and prognosis of head and neck squamous cell carcinoma
Li Y, Huang Y, Li B, Yang K.
BMC Med Genomics. Feb 28;16(1):38. doi: 10.1186/s12920-023-01470-6 2023
2E2F1, E2F7, SAPCD2
SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7
Zhang ZM, Cao HB, Li ZH, Zhuo R, Tao YF, Li XL, Li G, Liao XM, Fang F, Xie Y, Wu D, Wang HR, Wang JW, Chen YL, Yu JJ, Jia SQ, Yang RD, Guo XY, Yang Y, Feng CX, Xu YY, Qian GH, Pan J.
Cell Death Dis. Feb 23;13(2):174. doi: 10.1038/s41419-022-04624-z. 2022
3E2F1, NOVA2, PPARG
Gene Expression Profiles Controlled by the Alternative Splicing Factor Nova2 in Endothelial Cells.
Belloni E, Di Matteo A, Pradella D, Vacca M, Wyatt CDR, Alfieri R, Maffia A, Sabbioneda S, Ghigna C.
Cell Nov 23;8(12):1498. doi: 10.3390/cells8121498 2019
4E2F1
E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes.
Giralt A, Denechaud PD, Lopez-Mejia IC, Delacuisine B, Blanchet E, Bonner C, Pattou F, Annicotte JS, Fajas L.
Mol Metab. May;11:104-112. doi: 10.1016/j.molmet.2018.02.011. Epub 2018 Feb 26 2018
5E2F1, RRM2B
E2F1 regulates p53R2 gene expression in p53-deficient cells.
Qi JJ, Liu L, Cao JX, An GS, Li SY, Li G, Jia HT, Ni JH.
Mol Cell Biochem 399(1-2):179-88. doi: 10.1007/s11010-014-2244-7. Epub 2014 Oct 14. 2015
6E2F1, RRM2
E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide reductase small subunit M2.
Fang Z, Gong C, Liu H, Zhang X, Mei L, Song M, Qiu L, Luo S, Zhu Z, Zhang R, Gu H, Chen X.
Biochem Biophys Res Commun 464(2):407-15. doi: 10.1016/j.bbrc.2015.06.103. Epub 2015 Jun 18. 2015
7E2F1, PSMD14
POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation.
Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y.
Nat Commun 6:8704. doi: 10.1038/ncomms9704. 2015
8E2F1, UCHL5
Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37.
Mahanic CS, Budhavarapu V, Graves JD, Li G, Lin WC.
J Biol Chem 290(44):26508-22. doi: 10.1074/jbc.M115.659425. Epub 2015 Sep 22. 2015
9E2F1, ELL
ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of histone deacetylase 1.
Zhang W, Ji W, Liu X, Ouyang G, Xiao W.
Mol Cell Biol 34(4):765-75. doi: 10.1128/MCB.00878-13. Epub 2013 Dec 16. 2014
10E2F1, E2F3, E2F4
Regulation of ischemic neuronal death by E2F4-p130 protein complexes.
Iyirhiaro GO, Zhang Y, Estey C, O'Hare MJ, Safarpour F, Parsanejad M, Wang S, Abdel-Messih E, Callaghan SM, During MJ, Slack RS, Park DS.
J Biol Chem 289(26):18202-13. doi: 10.1074/jbc.M114.574145. Epub 2014 May 14. 2014
11E2F1, VHL
pVHL acts as a downstream target of E2F1 to suppress E2F1 activity.
Ji W, Wang J, Zhang W, Liu X, Ouyang G, Xiao W.
Biochem J 457(1):185-95. doi: 10.1042/BJ20130793. 2014
12E2F1, KDM2A
Mammalian lysine histone demethylase KDM2A regulates E2F1-mediated gene transcription in breast cancer cells.
Rizwani W, Schaal C, Kunigal S, Coppola D, Chellappan S.
PLoS One 9(7):e100888. doi: 10.1371/journal.pone.0100888. eCollection 2014. 2014
13E2F1, RORA
RORα binds to E2F1 to inhibit cell proliferation and regulate mammary gland branching morphogenesis.
Xiong G, Xu R.
Mol Cell Biol 34(16):3066-75. doi: 10.1128/MCB.00279-14. Epub 2014 Jun 2. 2014
14E2F1, TFDP3
TFDP3 was expressed in coordination with E2F1 to inhibit E2F1-mediated apoptosis in prostate cancer.
Ma Y, Xin Y, Li R, Wang Z, Yue Q, Xiao F, Hao X.
Gene 537(2):253-9. doi: 10.1016/j.gene.2013.12.051. Epub 2014 Jan 7. 2014
15E2F1, NELL2
The E2F1 oncogene transcriptionally regulates NELL2 in cancer cells.
Kim DH, Roh YG, Lee HH, Lee SY, Kim SI, Lee BJ, Leem SH.
DNA Cell Biol 32(9):517-23. doi: 10.1089/dna.2013.1974. Epub 2013 Jul 5. 2013
16E2F1, EI24
Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation.
Sung YH, Jin Y, Kang Y, Devkota S, Lee J, Roh JI, Lee HW.
J Biol Chem 288(43):31261-7. doi: 10.1074/jbc.M113.477570. Epub 2013 Sep 6. 2013
17BCL2L11, E2F1
Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.
Gogada R, Yadav N, Liu J, Tang S, Zhang D, Schneider A, Seshadri A, Sun L, Aldaz CM, Tang DG, Chandra D.
J Biol Chem 288(1):368-81. doi: 10.1074/jbc.M112.386102. Epub 2012 Nov 14. 2013
18E2F1, UHRF2
The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis.
Lu H, Hallstrom TC.
J Biol Chem 288(33):23833-43. doi: 10.1074/jbc.M112.447276. Epub 2013 Jul 5. 2013
19E2F1, FOXO1, FOXO3
FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function.
Shats I, Gatza ML, Liu B, Angus SP, You L, Nevins JR.
Cancer Res 73(19):6056-67. doi: 10.1158/0008-5472.CAN-13-0453. Epub 2013 Aug 21. 2013
20E2F1, MCPH1, SENP8
NEDDylation controls the target specificity of E2F1 and apoptosis induction.
Aoki I, Higuchi M, Gotoh Y.
Oncogene 32(34):3954-64. doi: 10.1038/onc.2012.428. Epub 2012 Sep 24. 2013
21E2F1, MYC, PBK
c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas.
Hu F, Gartenhaus RB, Zhao XF, Fang HB, Minkove S, Poss DE, Rapoport AP.
Leuk Res 37(4):447-54. doi: 10.1016/j.leukres.2012.11.010. Epub 2012 Dec 10. 2013
22E2F1, SRSF2
A new function of the splicing factor SRSF2 in the control of E2F1-mediated cell cycle progression in neuroendocrine lung tumors.
Edmond V, Merdzhanova G, Gout S, Brambilla E, Gazzeri S, Eymin B.
Cell Cycle Apr 15;12(8):1267-78. doi: 10.4161/cc.24363. Epub 2013 Mar 21 2013
23ATM, BRCA1, E2F1, RBBP8
Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription.
Moiola C, De Luca P, Cotignola J, Gardner K, Vazquez E, De Siervi A.
Cell Physiol Biochem 30(3):596-608. doi: 10.1159/000341441. Epub 2012 Jul 27. 2012
24E2F1, TFB1M
Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.
Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS.
Cell 148(4):716-26. doi: 10.1016/j.cell.2011.12.027. 2012
25E2F1, NEDD8
NEDDylation regulates E2F-1-dependent transcription.
Loftus SJ, Liu G, Carr SM, Munro S, La Thangue NB.
EMBO Rep 13(9):811-8. doi: 10.1038/embor.2012.113. Epub 2012 Jul 27. 2012
26CD2AP, E2F1
Transcriptional activation of the human CD2AP promoter by E2F1.
Zou L, Xu HG, Ren W, Jin R, Wang Y, Zhou GP.
PLoS One 7(8):e42774. doi: 10.1371/journal.pone.0042774. Epub 2012 Aug 3. 2012
27E2F1, TP53
Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response.
Yoshihara Y, Wu D, Kubo N, Sang M, Nakagawara A, Ozaki T.
Biochem Biophys Res Commun 421(1):57-63. doi: 10.1016/j.bbrc.2012.03.108. Epub 2012 Mar 29. 2012
28DOK1, E2F1
Transcriptional regulation of the human tumor suppressor DOK1 by E2F1.
Siouda M, Yue J, Shukla R, Guillermier S, Herceg Z, Creveaux M, Accardi R, Tommasino M, Sylla BS.
Mol Cell Biol 32(23):4877-90. doi: 10.1128/MCB.01050-12. Epub 2012 Oct 1. 2012
29E2F1, KLF15
Kruppel-like factor-15 inhibits the proliferation of mesangial cells.
Hong Q, Li C, Xie Y, Lv Y, Liu X, Shi S, Ding R, Zhang X, Zhang L, Liu S, Chen X.
Cell Physiol Biochem 29(5-6):893-904. doi: 10.1159/000178518. Epub 2012 May 11. 2012
30CCNA2, E2F1, PCNA, RSL1D1
The retinoblastoma protein selectively represses E2F1 targets via a TAAC DNA element during cellular senescence.
Chen T, Xue L, Niu J, Ma L, Li N, Cao X, Li Q, Wang M, Zhao W, Li G, Wang J, Tong T.
J Biol Chem 287(44):37540-51. doi: 10.1074/jbc.M111.260679. Epub 2012 Sep 6. 2012
31E2F1
E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.
Ingram L, Munro S, Coutts AS, La Thangue NB.
Cell Death Differ. 18(1):122-32. 2011
32E2F1, IRF3
Direct repression of the human IRF-3 promoter by E2F1.
Xu HG, Ren W, Zou L, Wang Y, Jin R, Zhou GP.
Immunogenetics 63(4):189-96. Epub 2011 Jan 12. 2011
33E2F1, HELLS
Transcriptional activation of the senescence regulator Lsh by E2F1.
Niu J, Chen T, Han L, Wang P, Li N, Tong T.
Mech Ageing Dev 132(4):180-6. Epub 2011 Mar 29. 2011
34BIRC2, E2F1
Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.
Cartier J, Berthelet J, Marivin A, Gemble S, Edmond V, Plenchette S, Lagrange B, Hammann A, Dupoux A, Delva L, Eymin B, Solary E, Dubrez L.
J Biol Chem 286(30):26406-17. Epub 2011 Jun 8. 2011
35CDKN2A, E2F1, HNRNPD
p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.
Al-Khalaf HH, Colak D, Al-Saif M, Al-Bakheet A, Hendrayani SF, Al-Yousef N, Kaya N, Khabar KS, Aboussekhra A.
PLoS One 6(7):e21111. Epub 2011 Jul 20. 2011
36E2F1, ZNF346
JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1.
Yang M, Wu S, Jia J, May WS.
Cell Cycle 10(14):2390-9. Epub 2011 Jul 15. 2011
37CTNNBIP1, E2F1
E2F1 suppresses Wnt/β-catenin activity through transactivation of β-catenin interacting protein ICAT.
Wu Z, Zheng S, Li Z, Tan J, Yu Q.
Oncogene 30(37):3979-84. doi: 10.1038/onc.2011.129. Epub 2011 May 2. 2011
38E2F1, QKI
E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulation.
Yang G, Lu X, Wang L, Bian Y, Fu H, Wei M, Pu J, Jin L, Yao L, Lu Z.
Cell Cycle 10(16):2703-13. Epub 2011 Aug 15. 2011
39E2F1, TFDP1, TFDP3
E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.
Ingram L, Munro S, Coutts AS, La Thangue NB.
Cell Death Differ 18(1):122-32. doi: 10.1038/cdd.2010.70. Epub 2010 Jun 18. 2011
40E2F1, RRP1B
Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.
Paik JC, Wang B, Liu K, Lue JK, Lin WC.
J Biol Chem 285(9):6348-63. Epub 2009 Dec 29.PMID: 20040599 2010
41CDKN1B, CDKN1C, E2F1
CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner.
Ma Y, Chen L, Wright GM, Pillai SR, Chellappan SP, Cress WD.
J Biol Chem 285(13):9813-22. Epub 2010 Jan 27.PMID: 20106982 2010
42E2F1, LRRK2, PARK8
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.
Gehrke S, Imai Y, Sokol N, Lu B.
Nature 466(7306):637-41. 2010
43E2F1, TAPBP
Identification of E2F1 as an important transcription factor for the regulation of tapasin expression.
Bukur J, Herrmann F, Handke D, Recktenwald C, Seliger B.
J Biol Chem 285(40):30419-26. Epub 2010 Jul 27. 2010
44CTBP1, E2F1, RB1, RBBP8, TRIM28, ZNF350
RBˇE2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1.
Liao CC, Tsai CY, Chang WC, Lee WH, Wang JM.
J Biol Chem 285(43):33134-43. Epub 2010 Aug 16. 2010
45E2F1, PCYT1A
Specific interaction between E2F1 and Sp1 regulates the expression of murine CTP:phosphocholine cytidylyltransferase alpha during the S phase.
Elena C, Banchio C.
Biochim Biophys Acta 1801(4):537-46. doi: 10.1016/j.bbalip.2010.01.005. Epub 2010 Jan 21. 2010
46E2F1, FGFR1
Transcriptional regulation of human fibroblast growth factor receptor 1 by E2F-1.
Kanai M, Tashiro E, Maruki H, Minato Y, Imoto M.
Gene 438(1-2):49-56. Epub 2009 Mar 19. 2009
47ARID1A, E2F1, HIC1, SMARCA4
HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A.
Van Rechem C, Boulay G, Leprince D.
Biochem Biophys Res Commun 385(4):586-90. Epub 2009 May 30. 2009
48E2F1, HIC1
Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control.
Zhang B, Chambers KJ, Leprince D, Faller DV, Wang S.
Oncogene 28(5):651-61. Epub 2008 Nov 17. 2009
49CUX1, E2F1
CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.
Seguin L, Liot C, Mzali R, Harada R, Siret A, Nepveu A, Bertoglio J.
Mol Cell Biol 29(2):570-81. Epub 2008 Nov 17. 2009
50E2F1, HCFC1
E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases.
Tyagi S, Herr W.
EMBO J 28(20):3185-95. Epub 2009 Sep 17.PMID: 19763085 2009
51CCNE1, CCNE2, E2F1
Role of E2F1-cyclin E1-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs.
Dapas B, Farra R, Grassi M, Giansante C, Fiotti N, Uxa L, Rainaldi G, Mercatanti A, Colombatti A, Spessotto P, Lacovich V, Guarnieri G, Grassi G.
Mol Med 15(9-10):297-306. doi: 10.2119/molmed.2009.00030. Epub 2009 Jun 25. 2009
52CUX1, E2F1, ECT2, KIF23
CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.
Seguin L, Liot C, Mzali R, Harada R, Siret A, Nepveu A, Bertoglio J.
Mol Cell Biol 29(2):570-81. doi: 10.1128/MCB.01275-08. 2009
53RHOBTB2, E2F1
RhoBTB2 (DBC2) Is a Mitotic E2F1 Target Gene with a Novel Role in Apoptosis.
Freeman SN, Ma Y, Cress WD.
J Biol Chem 283(4):2353-62. Epub 2007 Nov 26. 2008
54E2F1, CTNND1
Identification of E2F1 as a positive transcriptional regulator for delta-catenin.
Kim K, Oh M, Ki H, Wang T, Bareiss S, Fini ME, Li D, Lu Q.
Biochem Biophys Res Commun 369(2):414-20. Epub 2008 Feb 25. 2008
55E2F1, KIR3DL1
E2F1 contributes to the transcriptional activation of the KIR3DL1 gene.
Gao XN, Yu L.
Biochem Biophys Res Commun 370(3):399-403. Epub 2008 Mar 20. 2008
56E2F1, TNFSF11
Transcriptional regulation of human RANK ligand gene expression by E2F1.
Hu Y, Sun M, Nadiminty N, Lou W, Pinder E, Gao AC.
Biochem Biophys Res Commun 370(3):440-4. Epub 2008 Mar 31. 2008
57CHEK1, E2F1, MCPH1
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.
Yang SZ, Lin FT, Lin WC.
EMBO Rep 9(9):907-15. Epub 2008 Jul 25. 2008
58CDK8, E2F1
E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.
Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, Kwon EJ, Haigis KM, Näär AM, Dyson NJ.
Nature 455(7212):552-6. Epub 2008 Sep 14. 2008
59E2F1, HSPA5
Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1.
Racek T, Buhlmann S, Rüst F, Knoll S, Alla V, Pützer BM.
J Biol Chem 283(49):34305-14. Epub 2008 Oct 7. 2008
60E2F1, SRSF2
E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35.
Merdzhanova G, Edmond V, De Seranno S, Van den Broeck A, Corcos L, Brambilla C, Brambilla E, Gazzeri S, Eymin B.
Cell Death Differ 15(12):1815-23. Epub 2008 Sep 19. 2008
61E2F1, MDM2
ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.
Stevens C, Pettersson S, Wawrzynow B, Wallace M, Ball K, Zylicz A, Hupp TR.
FEBS J 275(19):4875-86. Epub 2008 Aug 27. 2008
62E2F1, E2F3
E2F1 and E2F3 activate ATM through distinct mechanisms to promote E1A-induced apoptosis.
Hong S, Paulson QX, Johnson DG.
Cell Cycle 7(3):391-400. Epub 2007 Nov 6. 2008
63E2F1, ETV4
Identification of E1AF as a target gene of E2F1-induced apoptosis in response to DNA damage.
Wei Y, Liu D, Ge Y, Zhou F, Xu J, Chen H, Gu J, Jiang J.
J Biochem 144(4):539-46. Epub 2008 Aug 7. 2008
64CUX1, E2F1
p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes.
Truscott M, Harada R, Vadnais C, Robert F, Nepveu A.
Mol Cell Biol 28(10):3127-38. Epub 2008 Mar 17. 2008
65E2F1, GSK3B
The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation.
Zhou F, Zhang L, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong Y.
J Biol Chem. 283(21):14506-15. 2008
66AHR, E2F1
The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis.
Marlowe JL, Fan Y, Chang X, Peng L, Knudsen ES, Xia Y, Puga A.
Mol Biol Cell 19(8):3263-71. Epub 2008 Jun 4.PMID: 18524851 2008
67E2F1, E2F6
E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1.
Yang WW, Shu B, Zhu Y, Yang HT.
Mol Biol Cell 19(9):3691-700. Epub 2008 Jun 18.PMID: 18562691 2008
68BNIP3, E2F1
The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes.
Yurkova N, Shaw J, Blackie K, Weidman D, Jayas R, Flynn B, Kirshenbaum LA.
Circ Res 102(4):472-9. Epub 2007 Dec 20.PMID: 18096822 2008
69DAPK2, E2F1, KLF6
DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function.
Britschgi A, Trinh E, Rizzi M, Jenal M, Ress A, Tobler A, Fey MF, Helin K, Tschan MP.
Oncogene 27(43):5706-16. Epub 2008 Jun 2. 2008
70E2F1
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.
Yang SZ, Lin FT, Lin WC.
EMBO Rep. 9(9):907-15. 2008
71E2F1
LEF-1 activates the transcription of E2F1.
Zhou F, Zhang L, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X, Gong Y.
Biochem Biophys Res Commun. 365(1):149-53. 2008
72YY1, PHB, E2F1, TP53, CASP7
Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites.
Joshi B, Rastogi S, Morris M, Carastro LM, DeCook C, Seto E, Chellappan SP.
Biochem J 401(1):155-66. 2007
73BTG3, E2F1
The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1.
Ou YH, Chung PH, Hsu FF, Sun TP, Chang WY, Shieh SY.
EMBO J 26(17):3968-80. Epub 2007 Aug 9. 2007
74E2F1, PDGFRA
Transcriptional regulation of a new variant of human platelet-derived growth factor receptor alpha transcript by E2F-1.
Minato Y, Tashiro E, Kanai M, Nihei Y, Kodama Y, Imoto M.
Gene 403(1-2):89-97. Epub 2007 Aug 25. 2007
75E2F1, E2F2, E2F3, E2F4, E2F5, E2F6
Comparative analysis of E2F family member oncogenic activity.
Chen C, Wells AD.
PLoS ONE 2(9):e912. 2007
76E2F1, NRP1
Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo.
Jiang SX, Sheldrick M, Desbois A, Slinn J, Hou ST.
Mol Cell Biol 27(5):1696-705. Epub 2006 Dec 18. 2007
77COPS2, E2F1
Alien inhibits E2F1 gene expression and cell proliferation.
Tenbaum SP, Papaioannou M, Reeb CA, Goeman F, Escher N, Kob R, von Eggeling F, Melle C, Baniahmad A.
Biochim Biophys Acta 1773(9):1447-54. Epub 2007 May 10. 2007
78E2F1, E2F2, E2F4, E2F6
E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1.
Kikuchi J, Shimizu R, Wada T, Ando H, Nakamura M, Ozawa K, Furukawa Y.
Stem Cells 25(10):2439-47. Epub 2007 Jun 28.PMID: 17600109 2007
79DUSP2, E2F1
PAC1 is a direct transcription target of E2F-1 in apoptotic signaling.
Wu J, Jin YJ, Calaf GM, Huang WL, Yin Y.
Oncogene 26(45):6526-35. Epub 2007 Apr 30.PMID: 17471234 2007
80E2F1
E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.
Tyagi S, Chabes AL, Wysocka J, Herr W.
Mol Cell 27(1):107-19. 2007
81E2F1, TFDP3
TFDP3 inhibits E2F1-induced, p53-mediated apoptosis.
Tian C, Lv D, Qiao H, Zhang J, Yin YH, Qian XP, Wang YP, Zhang Y, Chen WF.
Biochem Biophys Res Commun 361(1):20-5. Epub 2007 Jul 5. 2007
82E2F1, DIABLO
Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.
Xie W, Jiang P, Miao L, Zhao Y, Zhimin Z, Qing L, Zhu WG, Wu M.
Nucleic Acids Res 34(7):2046-55. Print 2006. 2006
83E2F1, MAP3K5
ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene.
Kherrouche Z, Blais A, Ferreira E, De Launoit Y, Monte D.
Biochem J 396(3):547-56. 2006
84SKP2, E2F1
F-box protein Skp2: a novel transcriptional target of E2F.
Zhang L, Wang C.
Oncogene 25(18):2615-27. 2006
85E2F1
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation.
Devgan V, Mammucari C, Millar SE, Brisken C, Dotto GP.
Genes Dev. 19(12):1485-95. 2005
86E2F1, EAPP
EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.
Novy M, Pohn R, Andorfer P, Novy-Weiland T, Galos B, Schwarzmayr L, Rotheneder H.
Mol Biol Cell 16(5):2181-90. Epub 2005 Feb 16. 2005
87E2F1, PPP1R13B, TP53BP2
ASPP1 and ASPP2 are new transcriptional targets of E2F.
Fogal V, Kartasheva NN, Trigiante G, Llanos S, Yap D, Vousden KH, Lu X.
Cell Death Differ 12(4):369-76. 2005
88E2F1, GRAMD4
A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
Stanelle J, Tu-Rapp H, PŸtzer BM.
Cell Death Differ 12(4):347-57. 2005
89E2F1
Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway.
Zhang Z, Wang H, Li M, Rayburn ER, Agrawal S, Zhang R.
Oncogene. 24(48):7238-47. 2005
90E2F1, PURA
Interaction between the pura and E2F-1 transcription factors.
Darbinian N, White MK, Gallia GL, Amini S, Rappaport J, Khalili K.
Anticancer Res 24(5A):2585-94. 2004
91E2F1, NGFR, NSMCE3
Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor.
Kuwako K, Taniura H, Yoshikawa K.
J Biol Chem. 279(3):1703-12. 2004
92E2F1
E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1.
Taubert S, Gorrini C, Frank SR, Parisi T, Fuchs M, Chan HM, Livingston DM, Amati B.
Mol Cell Biol. 24(10):4546-56. 2004
93E2F1, TOPBP1
Regulation of E2F1 by BRCT domain-containing protein TopBP1.
Liu K, Lin FT, Ruppert JM, Lin WC.
Mol Cell Biol 23(9):3287-304. 2003
94E2F1, PHB
A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis.
Joshi B, Ko D, Ordonez-Ercan D, Chellappan SP.
Biochem Biophys Res Commun 312(2):459-66. 2003
95E2F1
Chk2 activates E2F-1 in response to DNA damage.
Stevens C, Smith L, La Thangue NB.
Nat Cell Biol. 5(5):401-9. 2003
96E2F1
Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation.
Kong HJ, Yu HJ, Hong S, Park MJ, Choi YH, An WG, Lee JW, Cheong J.
Mol Cancer Res. 1(13):948-58. 2003
97E2F1
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.
Simbulan-Rosenthal CM, Rosenthal DS, Luo R, Samara R, Espinoza LA, Hassa PO, Hottiger MO, Smulson ME.
Oncogene. 22(52):8460-71. 2003
98E2F1, GRAMD4
Gene expression changes in response to E2F1 activation.
Stanelle J, Stiewe T, Theseling CC, Peter M, PŸtzer BM.
Nucleic Acids Res 30(8):1859-67. 2002
99E2F1
Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.
Hsieh JK, Yap D, O'Connor DJ, Fogal V, Fallis L, Chan F, Zhong S, Lu X.
Mol Cell Biol. 22(1):78-93. 2002
100E2F1
p14(ARF) regulates E2F activity.
Mason SL, Loughran O, La Thangue NB.
Oncogene. 21(27):4220-30. 2002
101E2F1
E2F-1 represses transcription of the human telomerase reverse transcriptase gene.
Crowe DL, Nguyen DC, Tsang KJ, Kyo S.
Nucleic Acids Res 29(13):2789-94. 2001
102E2F1,RB,RB1
The Rb/E2F pathway and cancer.
Nevins JR.
Hum Mol Genet 10(7):699-703. Review. 2001
103E2F1
Human ARF binds E2F1 and inhibits its transcriptional activity.
Eymin B, Karayan L, Séité P, Brambilla C, Brambilla E, Larsen CJ, Gazzéri S.
Oncogene. 20(9):1033-41. 2001
104E2F1
The paradox of E2F1: oncogene and tumor suppressor gene.
Johnson DG.
Mol Carcinog 27(3):151-7. 2000
105DNMT1, E2F1
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.
Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP.
Nat Genet 25(3):338-42. 2000
106E2F1, TP73
Role for the p53 homologue p73 in E2F-1-induced apoptosis.
Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG Jr.
Nature 407(6804):645-8. 2000
107E2F1, TP73
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.
Lissy NA, Davis PK, Irwin M, Kaelin WG, Dowdy SF.
Nature 407(6804):642-5. 2000
108E2F1
NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity.
Sansal I, Dupont E, Toru D, Evrard C, Rouget P.
Oncogene. 19(43):5000-9. 2000
109E2F1
Increased levels of E2F-1-dependent DNA binding activity after UV- or gamma-irradiation.
Hofferer M, et al.
Nucleic Acids Res 27(2):491-5. 1999
110E2F1, PHB, RB1
Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function.
Wang S, Nath N, Adlam M, Chellappan S.
Oncogene 18(23):3501-10. 1999
111E2F1
Regulation and deregulation of E2F1 in postmitotic neurons differentiated from embryonal carcinoma P19 cells.
Azuma-Hara M, Taniura H, Uetsuki T, Niinobe M, Yoshikawa K.
Exp Cell Res 251(2):442-51 1999
112E2F1, NDN, TP53
Physical and functional interactions of neuronal growth suppressor necdin with p53.
Taniura H, Matsumoto K, Yoshikawa K.
J Biol Chem 274(23):16242-8 1999
113E2F1
Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation.
Marti A, Wirbelauer C, Scheffner M, Krek W.
Nat Cell Biol. 1(1):14-9. 1999
114E2F1
Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.
Rotheneder H, Geymayer S, Haidweger E.
J Mol Biol. 293(5):1005-15. 1999
115E2F1, NDN
Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1.
Taniura H, Taniguchi N, Hara M, Yoshikawa K.
J Biol Chem 273(2):720-8 1998
116E2F1, TRRAP
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.
McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD.
Cell. 94(3):363-74. 1998
117E2F1
A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer.
Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K.
Oncogene. 17(7):853-65. 1998
118E2F1
DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1.
Hayes S, Shiyanov P, Chen X, Raychaudhuri P.
Mol Cell Biol. 18(1):240-9. 1998
119BRCA1, CDK5, E2F1
BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.
Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN.
Oncogene. 15(2):143-57. 1997
120E2F1
Interaction between cell cycle regulator, E2F-1, and NF-kappaB mediates repression of HIV-1 gene transcription.
Kundu M, Guermah M, Roeder RG, Amini S, Khalili K.
J Biol Chem. 272(47):29468-74. 1997
121E2F1
Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.
Vidal M, Braun P, Chen E, Boeke JD, Harlow E.
Proc Natl Acad Sci U S A. 93(19):10321-6 1996
122E2F1
The CBP co-activator stimulates E2F1/DP1 activity.
Trouche D, Cook A, Kouzarides T.
Nucleic Acids Res. 24(21):4139-45. 1996
123E2F1
Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line.
Saito M, et al.
Genomics 25 : 130-138. 1995
124CDK2, E2F1
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.
Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H.
Mol Cell Biol. 14(12):8420-31. 1994
125E2F1
Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein.
Fagan R, Flint KJ, Jones N.
Cell. 78(5):799-811. 1994
126ARID4A, E2F1, KDM5A
Characterization of the retinoblastoma binding proteins RBP1 and RBP2.
Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, HanobikMG, Haskell KM, Oliff A, Defeo-Jones D, et al.
Oncogene 8(11):3149-56. 1993
127E2F1
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.
Helin K, et al.
Cell 70 : 337-350. 1992
128E2F1
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties.
Kaelin WG, et al.
Cell 70 : 351-364. 1992