| 1 | DYRK1B, SMO
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| DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.
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| Gruber W, Hutzinger M, Elmer DP, Parigger T, Sternberg C, Cegielkowski L, Zaja M, Leban J, Michel S, Hamm S, Vitt D, Aberger F.
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| Oncotarget 7(6):7134-48. doi: 10.18632/oncotarget.6910.
2016
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| 2 | DYRK1B, NKX3-1
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| The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase.
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| Song LN, Silva J, Koller A, Rosenthal A, Chen EI, Gelmann EP.
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| Mol Cancer Res 13(5):913-22. doi: 10.1158/1541-7786.MCR-14-0680. Epub 2015 Mar 16.
2015
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| 3 | AOMS3, DYRK1B
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| The metabolic syndrome and DYRK1B.
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| He JL, Qiao GF, Li BY.
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| N Engl J Med 371(8):785. doi: 10.1056/NEJMc1408235#SA2. No abstract available.
2014
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| 4 | AOMS3, DYRK1B
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| A form of the metabolic syndrome associated with mutations in DYRK1B.
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| Keramati AR, Fathzadeh M, Go GW, Singh R, Choi M, Faramarzi S, Mane S, Kasaei M, Sarajzadeh-Fard K, Hwa J, Kidd KK, Babaee Bigi MA, Malekzadeh R, Hosseinian A, Babaei M, Lifton RP, Mani A.
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| N Engl J Med 370(20):1909-19. doi: 10.1056/NEJMoa1301824.
2014
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| 5 | DYRK1B
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| Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells.
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| Gao J, Zhao Y, Lv Y, Chen Y, Wei B, Tian J, Yang Z, Kong F, Pang J, Liu J, Shi H.
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| Cancer Cell Int 13(1):2. doi: 10.1186/1475-2867-13-2.
2013
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| 6 | CCND1, CIRBP, DYRK1B, RBM3
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| Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice.
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| Masuda T, Itoh K, Higashitsuji H, Higashitsuji H, Nakazawa N, Sakurai T, Liu Y, Tokuchi H, Fujita T, Zhao Y, Nishiyama H, Tanaka T, Fukumoto M, Ikawa M, Okabe M, Fujita J.
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| Proc Natl Acad Sci U S A 109(27):10885-90. doi: 10.1073/pnas.1121524109. Epub 2012 Jun 18.
2012
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| 7 | DYRK1B, HRAS
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| DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.
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| Lauth M, Bergström A, Shimokawa T, Tostar U, Jin Q, Fendrich V, Guerra C, Barbacid M, Toftgård R.
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| Nat Struct Mol Biol 17(6):718-25. Epub 2010 May 30. 2010
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| 8 | DYRK1B
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| The kinase Mirk is a potential therapeutic target in osteosarcoma.
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| Yang C, Ji D, Weinstein EJ, Choy E, Hornicek FJ, Wood KB, Liu X, Mankin H, Duan Z.
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| Carcinogenesis 31(4):552-8. Epub 2009 Dec 30.PMID: 20042639 2010
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| 9 | DYRK1B
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| The zebrafish dyrk1b gene is important for endoderm formation.
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| Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A, Nissen RM.
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| Genesis 48(1):20-30.PMID: 20014342 2010
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| 10 | DCAF7, DYRK1A, DYRK1B, HIPK2, MAP3K1
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| The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.
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| Ritterhoff S, Farah CM, Grabitzki J, Lochnit G, Skurat AV, Schmitz ML.
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| EMBO J 29(22):3750-61. Epub 2010 Oct 12. 2010
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| 11 | DYRK1B
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| Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species.
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| Deng X, Ewton DZ, Friedman E.
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| Cancer Res 69(8):3317-24. Epub 2009 Apr 7.PMID: 19351855 2009
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| 12 | DYRK1B
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| The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.
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| Jin K, Park S, Ewton DZ, Friedman E.
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| Cancer Res 67(15):7247-55.PMID: 17671193 2007
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| 13 | DYRK1B
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| Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival.
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| Mercer SE, Friedman E.
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| Cell Biochem Biophys 45(3):303-15. Review.PMID: 16845176 2006
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| 14 | DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4
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| DYRK gene structure and erythroid-restricted features of DYRK3 gene expression.
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| Zhang D, Li K, Erickson-Miller CL, Weiss M, Wojchowski DM.
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| Genomics 85(1):117-30. 2005
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| 15 | DYRK1B, MAP2K3, PCBD2
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| Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.
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| Lim S, Jin K, Friedman E.
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| J Biol Chem 277(28):25040-6. Epub 2002 Apr 29. Erratum in: J Biol Chem. 2004 Feb 6;279(6):5047. 2002
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| 16 | DYRK1B
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| Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases.
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| Leder S, et al.
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| Biochem Biophys Res Commun 254(2):474-9. 1999
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