| 1 | CIC, DYRK1A
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| Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua.
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| Yang L, Paul S, Trieu KG, Dent LG, Froldi F, Forés M, Webster K, Siegfried KR, Kondo S, Harvey K, Cheng L, Jiménez G, Shvartsman SY, Veraksa A.
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| Proc Natl Acad Sci U S A 113(38):10583-8. doi: 10.1073/pnas.1609417113. Epub 2016 Sep 6.
2016
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| 2 | CCND3, DYRK1A
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| DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3.
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| Thompson BJ, Bhansali R, Diebold L, Cook DE, Stolzenburg L, Casagrande AS, Besson T, Leblond B, Désiré L, Malinge S, Crispino JD.
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| J Exp Med 212(6):953-70. doi: 10.1084/jem.20150002. Epub 2015 May 25.
2015
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| 3 | DYRK1A, MAPT, SRSF6
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| Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.
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| Yin X, Jin N, Gu J, Shi J, Zhou J, Gong CX, Iqbal K, Grundke-Iqbal I, Liu F.
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| J Biol Chem 287(36):30497-506. doi: 10.1074/jbc.M112.355412. Epub 2012 Jul 5.
2012
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| 4 | DCX, DYRK1A, DYRK3, DYRK4
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| Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology.
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| Slepak TI, Salay LD, Lemmon VP, Bixby JL.
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| Cytoskeleton (Hoboken) 69(7):514-27. doi: 10.1002/cm.21021. Epub 2012 Mar 7.
2012
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| 5 | APBA1, DYRK1A, STX1A, STXBP1
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| Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.
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| Park JH, Jung MS, Kim YS, Song WJ, Chung SH.
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| J Neurochem 122(5):1081-91. doi: 10.1111/j.1471-4159.2012.07861.x.
2012
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| 6 | DYRK1A, MRD7
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| The DYRK1A gene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy.
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| Courcet JB, Faivre L, Malzac P, Masurel-Paulet A, Lopez E, Callier P, Lambert L, Lemesle M, Thevenon J, Gigot N, Duplomb L, Ragon C, Marle N, Mosca-Boidron AL, Huet F, Philippe C, Moncla A, Thauvin-Robinet C.
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| J Med Genet 49(12):731-6. doi: 10.1136/jmedgenet-2012-101251. Epub 2012 Oct 25.
2012
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| 7 | DYRK1A, REST
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| REST regulates DYRK1A transcription in a negative feedback loop.
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| Lu M, Zheng L, Han B, Wang L, Wang P, Liu H, Sun X.
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| J Biol Chem 286(12):10755-63. Epub 2011 Jan 20.
2011
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| 8 | DYRK1A, DYRK2, DYRK3, DYRK4
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| Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.
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| Papadopoulos C, Arato K, Lilienthal E, Zerweck J, Schutkowski M, Chatain N, Müller-Newen G, Becker W, de la Luna S.
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| J Biol Chem 286(7):5494-505. Epub 2010 Dec 2. 2011
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| 9 | DYRK1A, RCAN1
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| Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation.
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| Jung MS, Park JH, Ryu YS, Choi SH, Yoon SH, Kwen MY, Oh JY, Song WJ, Chung SH.
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| J Biol Chem. 286(46):40401-12. 2011
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| 10 | DYRK1A
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| DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.
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| Miyata Y, Nishida E.
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| Biochim Biophys Acta. 1813(10):1728-39. 2011
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| 11 | DCAF7, DYRK1A
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| DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.
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| Miyata Y, Nishida E.
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| Biochim Biophys Acta 1813(10):1728-39. doi: 10.1016/j.bbamcr.2011.06.023. Epub 2011 Jul 13.
2011
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| 12 | DYRK1A, MRD7
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| Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly.
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| van Bon BW, Hoischen A, Hehir-Kwa J, de Brouwer AP, Ruivenkamp C, Gijsbers AC, Marcelis CL, de Leeuw N, Veltman JA, Brunner HG, de Vries BB.
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| Clin Genet 79(3):296-9. doi: 10.1111/j.1399-0004.2010.01544.x. No abstract available.
2011
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| 13 | DYRK1A, DYRK3, SIRT1
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| DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
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| Guo X, Williams JG, Schug TT, Li X.
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| J Biol Chem 285(17):13223-32. Epub 2010 Feb 18.
2010
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| 14 | DEL21QD, DYRK1A, KCNJ6
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| Clinical manifestations of the deletion of Down syndrome critical region including DYRK1A and KCNJ6.
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| Yamamoto T, Shimojima K, Nishizawa T, Matsuo M, Ito M, Imai K.
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| Am J Med Genet A m J Med Genet A. 2010 Dec 10. [Epub ahead of print]PMID: 21154855 2010
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| 15 | DYRK1A, SPRED1, SPRED2
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| Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions.
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| Li D, Jackson RA, Yusoff P, Guy GR.
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| J Biol Chem 285(46):35374-85. Epub 2010 Aug 24. 2010
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| 16 | DCAF7, DYRK1A, DYRK1B, HIPK2, MAP3K1
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| The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.
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| Ritterhoff S, Farah CM, Grabitzki J, Lochnit G, Skurat AV, Schmitz ML.
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| EMBO J 29(22):3750-61. Epub 2010 Oct 12. 2010
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| 17 | DYRK1A, REST, TRI21
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| DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome.
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| Lepagnol-Bestel AM, Zvara A, Maussion G, Quignon F, Ngimbous B, Ramoz N, Imbeaud S, Loe-Mie Y, Benihoud K, Agier N, Salin PA, Cardona A, Khung-Savatovsky S, Kallunki P, Delabar JM, Puskas LG, Delacroix H, Aggerbeck L, Delezoide AL, Delattre O, Gorwood P, Moalic JM, Simonneau M.
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| Hum Mol Genet 18(8):1405-1414. 2009
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| 18 | DYRK1A
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| Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A.
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| Fernandez-Martinez J, Vela EM, Tora-Ponsioen M, Ocańa OH, Nieto MA, Galceran J.
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| J Cell Sci 122(Pt 10):1574-83. Epub 2009 Apr 21.
2009
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| 19 | DYRK1A
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| DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy.
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| Kuhn C, Frank D, Will R, Jaschinski C, Frauen R, Katus HA, Frey N.
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| J Biol Chem 284(25):17320-7. Epub 2009 Apr 16.
2009
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| 20 | DYRK1A
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| Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation.
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| Göckler N, Jofre G, Papadopoulos C, Soppa U, Tejedor FJ, Becker W.
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| FEBS J 276(21):6324-37. Epub 2009 Oct 1.PMID: 19796173 2009
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| 21 | DYRK1A
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| Dyrk1A binds to multiple endocytic proteins required for formation of clathrin-coated vesicles.
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| Murakami N, Bolton D, Hwang YW.
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| Biochemistry. 48(39):9297-305 2009
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| 22 | DYRK1A, RCAN1, TRI21
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| Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.
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| Rachidi M, Lopes C.
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| Eur J Paediatr Neurol 12(3):168-82. Epub 2007 Oct 22. Review. 2008
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| 23 | DYRK1A, REST, TRI21
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| DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome.
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| Canzonetta C, Mulligan C, Deutsch S, Ruf S, O'Doherty A, Lyle R, Borel C, Lin-Marq N, Delom F, Groet J, Schnappauf F, De Vita S, Averill S, Priestley JV, Martin JE, Shipley J, Denyer G, Epstein CJ, Fillat C, Estivill X, Tybulewicz VL, Fisher EM, Antonarakis SE, Nizetic D.
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| Am J Hum Genet 83(3):388-400. Epub 2008 Sep 4. 2008
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| 24 | DYRK1A
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| Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly.
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| Moller RS, Kubart S, Hoeltzenbein M, Heye B, Vogel I, Hansen CP, Menzel C, Ullmann R, Tommerup N, Ropers HH, Tmer Z, Kalscheuer VM.
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| Am J Hum Genet 82(5):1165-70. Epub 2008 Apr 10. 2008
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| 25 | DYRK1A, TRI21
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| Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.
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| Ortiz-Abalia J, Sahún I, Altafaj X, Andreu N, Estivill X, Dierssen M, Fillat C.
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| Am J Hum Genet 83(4):479-88. 2008
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| 26 | CASP9, DYRK1A
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| The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.
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| Laguna A, Aranda S, Barallobre MJ, Barhoum R, Fernández E, Fotaki V, Delabar JM, de la Luna S, de la Villa P, Arbonés ML.
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| Dev Cell 15(6):841-53. 2008
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| 27 | DYRK1A
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| The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome.
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| Wegiel J, Dowjat K, Kaczmarski W, Kuchna I, Nowicki K, Frackowiak J, Mazur Kolecka B, Wegiel J, Silverman WP, Reisberg B, Deleon M, Wisniewski T, Gong CX, Liu F, Adayev T, Chen-Hwang MC, Hwang YW.
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| Acta Neuropathol 116(4):391-407. Epub 2008 Aug 12.
2008
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| 28 | DYRK1A, SPRY2
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| Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A.
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| Aranda S, Alvarez M, Turró S, Laguna A, de la Luna S.
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| Mol Cell Biol 28(19):5899-911. Epub 2008 Aug 4.
2008
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| 29 | DYRK1A, MRD7
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| Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly.
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| Mřller RS, Kübart S, Hoeltzenbein M, Heye B, Vogel I, Hansen CP, Menzel C, Ullmann R, Tommerup N, Ropers HH, Tümer Z, Kalscheuer VM.
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| Am J Hum Genet 82(5):1165-70. doi: 10.1016/j.ajhg.2008.03.001. Epub 2008 Apr 10.
2008
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| 30 | DYRK1A, TRI21
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| Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome.
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| Dowjat WK, Adayev T, Kuchna I, Nowicki K, Palminiello S, Hwang YW, Wegiel J.
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| Neurosci Lett 413(1):77-81. Epub 2006 Dec 4.
2007
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| 31 | DYRK1A
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| The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
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| Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H, Tabara Y, Miki T, Akatsu H, Kosaka K, Funakoshi E, Nishitomi K, Sakaguchi G, Kato A, Hattori H, Uema T, Takeda M.
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| Hum Mol Genet 16(1):15-23. Epub 2006 Nov 29. 2007
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| 32 | DYRK1A, TRI21
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| Familial 4.3 Mb duplication of 21q22 sheds new light on the Down syndrome critical region.
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| Ronan A, Fagan K, Christie L, Conroy J, Nowak NJ, Turner G.
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| J Med Genet 44(7):448-51. Epub 2007 Jan 19. 2007
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| 33 | DYRK1A, TRI21
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| DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.
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| Ryoo SR, Jeong HK, Radnaabazar C, Yoo JJ, Cho HJ, Lee HW, Kim IS, Cheon YH, Ahn YS, Chung SH, Song WJ.
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| J Biol Chem 282(48):34850-7. Epub 2007 Sep 28. 2007
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| 34 | RCAN1, DYRK1A, NFATC1, NFATC2, NFATC3, NFATC4, TRI21
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| NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.
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| Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR.
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| Nature 441(7093):595-600. Epub 2006 Mar 22. 2006
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| 35 | DYRK1A, GMNN, TFAP4, STMN2, REST
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| A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells.
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| Kim MY, Jeong BC, Lee JH, Kee HJ, Kook H, Kim NS, Kim YH, Kim JK, Ahn KY, Kim KK.
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| Proc Natl Acad Sci U S A 103(35):13074-9. Epub 2006 Aug 21. 2006
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| 36 | DYRK1A,NFATC1,NFATC2,NFATC3,NFATC4
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| A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT.
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| Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A.
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| Nature 441(7093):646-50. Epub 2006 Mar 1. 2006
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| 37 | RCAN1, DYRK1A, NFAT, TRI21
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| Down's syndrome: critical genes in a critical region.
|
| Epstein CJ.
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| Nature 441(7093):582-3. No abstract available. 2006
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| 38 | DYRK1A, SYNJ1
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| MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins.
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| Adayev T, Chen-Hwang MC, Murakami N, Wang R, Hwang YW.
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| Biochem Biophys Res Commun 351(4):1060-5. Epub 2006 Nov 7.
2006
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| 39 | DYRK1A, SF3B1
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| The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site.
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| de Graaf K, Czajkowska H, Rottmann S, Packman LC, Lilischkis R, Lüscher B, Becker W.
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| BMC Biochem 7:7.
2006
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| 40 | DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4
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| DYRK gene structure and erythroid-restricted features of DYRK3 gene expression.
|
| Zhang D, Li K, Erickson-Miller CL, Weiss M, Wojchowski DM.
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| Genomics 85(1):117-30. 2005
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| 41 | DYRK1A
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| Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein.
|
| Bescond M, Rahmani Z.
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| Int J Biochem Cell Biol. 37(4):775-83. 2005
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| 42 | DYRK1A
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| Raf-1 is a binding partner of DSCR1.
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| Cho YJ, Abe M, Kim SY, Sato Y.
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| Arch Biochem Biophys. 439(1):121-8. 2005
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| 43 | DYRK1A
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| Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction.
|
| Martinez de Lagran M, Altafaj X, Gallego X, Marti E, Estivill X, Sahun I, Fillat C, Dierssen M.
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| Neurobiol Dis 15(1):132-42. 2004
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| 44 | DYRK1A
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| Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.
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| de Graaf K, Hekerman P, Spelten O, Herrmann A, Packman LC, Büssow K, Müller-Newen G, Becker W.
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| J Biol Chem. 279(6):4612-24. 2004
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| 45 | DYRK1A
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| Regulation of Dyrk1A kinase activity by 14-3-3.
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| Kim D, Won J, Shin DW, Kang J, Kim YJ, Choi SY, Hwang MK, Jeong BW, Kim GS, Joe CO, Chung SH, Song WJ.
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| Biochem Biophys Res Commun. 323(2):499-504. 2004
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| 46 | DYRK1A
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| Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation.
|
| Hammerle B, Carnicero A, Elizalde C, Ceron J, Martinez S, Tejedor FJ.
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| Eur J Neurosci 17(11):2277-86. 2003
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| 47 | DYRK1A
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| Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.
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| Vega RB, Rothermel BA, Weinheimer CJ, Kovacs A, Naseem RH, Bassel-Duby R, Williams RS, Olson EN.
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| Proc Natl Acad Sci U S A. 100(2):669-74. 2003
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| 48 | DYRK1A
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| Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice.
|
| Fotaki V, Dierssen M, Alcántara S, Martínez S, Martí E, Casas C, Visa J, Soriano E, Estivill X, Arbonés ML.
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| Mol Cell Biol. 22(18):6636-47. 2002
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| 49 | DYRK1A
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| The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.
|
| Woods YL, Cohen P, Becker W, Jakes R, Goedert M, Wang X, Proud CG.
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| Biochem J 355(Pt 3):609-15. 2001
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| 50 | DYRK1A
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| The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
|
| Woods YL, Rena G, Morrice N, Barthel A, Becker W, Guo S, Unterman TG, Cohen P.
|
| Biochem J 355(Pt 3):597-607. 2001
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| 51 | DYRK1A
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| Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.
|
| Altafaj X, Dierssen M, Baamonde C, Martí E, Visa J, Guimerŕ J, Oset M, González JR, Flórez J, Fillat C, Estivill X.
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| Hum Mol Genet. 10(18):1915-23. 2001
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| 52 | DYRK1A, TRI21
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| Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in down syndrome.
|
| Guimera J, et al.
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| Genomics 57(3):407-18. 1999
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| 53 | DYRK1A
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| High level expression of the MNB/DYRK gene in brain and heart during rat early development
|
| Ito F, Okui M, Funakoshi E, Morita K, Ogita K, Yoneda T, Ide T, Kudoh J, Shimizu N.
|
| Cytogenet Cell Genet 86:17 1999
|
| 54 | DYRK1A, EHD1, EMX1, EYA3, JAG2, UBE3A, USP9Y
|
| The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres) : a comparative and topographic approach to predict gene function.
|
| Bulfone A, et al.
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| Hum Mol Genet 7 : 1997-2006. 1998
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| 55 | DYRK1A, DYRK2, DYRK3, DYRK4
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| Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.
|
| Becker W, et al.
|
| J Biol Chem 273 : 25893-25902. 1998
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| 56 | DYRK1A
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| Identification of two novel 5' noncoding exons in human MNB/DYRK gene and alternatively spliced transcripts.
|
| Wang J, et al.
|
| Biochem Biophys Res Commun 250 : 704-710. 1998
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| 57 | DYRK1A
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| Localisation of a human homologue of the Drosophila mnb and rat Dyrk genes to chromosome 21q22.2.
|
| Chen H, et al.
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| Hum Genet 99 : 262-265. 1997
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| 58 | DYRK1A, HLCS, KCNJ6, TTC1
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| Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.
|
| Ohira M, et al.
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| Genome Res 7 : 47-58. 1997
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| 59 | DYRK1A, TRI21
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| Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome.
|
| Smith DJ, et al.
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| Nat Genet 16 : 28-36. 1997
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| 60 | DYRK1A
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| Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2.
|
| Guimera J, Pritchard M, Nadal M, Estivill X.
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| Cytogenet Cell Genet 77(3-4):182-4. 1997
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| 61 | DYRK1A, RCAN1
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| Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene.
|
| Fuentes JJ, Pritchard MA, Estivill X.
|
| Genomics 44(3):358-61. 1997
|
| 62 | TTC3, RCAN1, DYRK1A, KCNJ6
|
| Cosmid contig and transcriptional map of three regions of human chromosome 21q22: identification of 37 novel transcripts by direct selection.
|
| Guimera J, Pucharcos C, Domenech A, Casas C, Solans A, Gallardo T, Ashley J, Lovett M, Estivill X, Pritchard M.
|
| Genomics 45(1):59-67. 1997
|
| 63 | DYRK1A, TRI21
|
| A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region.
|
| Guimera J, et al.
|
| Hum Mol Genet 5 : 1305-1310. 1996
|
| 64 | DYRK1A
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| Isolation of human and murine homologues of the Drosophila minibrain gene : human homologue maps to 21q22.2 in the Down syndrome critical region.
|
| Song WJ, et al.
|
| Genomics 38 : 331-339. 1996
|
| 65 | DYRK1A
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| Cloning of a human homolog of the Drosophila minibrain/rat dyrk gene from the Down syndrome critical region of chromosome 21.
|
| Shindoh N, et al.
|
| Biochem Biophys Res Commun 225 : 92-99. 1996
|