| 1 | DUSP1, DUSP10, DUSP16, DUSP2, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9
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| Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability.
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| Chen HF, Chuang HC, Tan TH.
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| Int J Mol Sci. May 30;20(11):2668. doi: 10.3390/ijms20112668. 2019
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| 2 | CMD1A, DUSP4, LMNA
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| Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival.
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| Choi JC, Wu W, Phillips E, Plevin R, Sera F, Homma S, Worman HJ.
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| Hum Mol Genet 27(13):2290-2305. doi: 10.1093/hmg/ddy134.
2018
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| 3 | DUSP4
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| Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas.
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| Ichimanda M, Hijiya N, Tsukamoto Y, Uchida T, Nakada C, Akagi T, Etoh T, Iha H, Inomata M, Takekawa M, Moriyama M.
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| Cancer Sci 109(1):250-258. doi: 10.1111/cas.13444. Epub 2017 Dec 8.
2018
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| 4 | DUSP4
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| Impaired Dual-Specificity Protein Phosphatase DUSP4 Reduces Corticosteroid Sensitivity.
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| Kobayashi Y, Ito K, Kanda A, Tomoda K, Mercado N, Barnes PJ.
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| Mol Pharmacol 91(5):475-481. doi: 10.1124/mol.116.107656. Epub 2017 Mar 10.
2017
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| 5 | DUSP4
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| Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
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| Mazumdar A, Poage GM, Shepherd J, Tsimelzon A, Hartman ZC, Den Hollander P, Hill J, Zhang Y, Chang J, Hilsenbeck SG, Fuqua S, Kent Osborne C, Mills GB, Brown PH.
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| Breast Cancer Res Treat 158(3):441-54. doi: 10.1007/s10549-016-3892-y. Epub 2016 Jul 8.
2016
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| 6 | DUSP4, STAT5B
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| Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization.
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| Hsiao WY, Lin YC, Liao FH, Chan YC, Huang CY.
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| PLoS One 10(12):e0145880. doi: 10.1371/journal.pone.0145880. eCollection 2015.
2015
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| 7 | DUSP4
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| DUSP4 regulates neuronal differentiation and calcium homeostasis by modulating ERK1/2 phosphorylation.
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| Kim SY, Han YM, Oh M, Kim WK, Oh KJ, Lee SC, Bae KH, Han BS.
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| Stem Cells Dev 24(6):686-700. doi: 10.1089/scd.2014.0434. Epub 2014 Dec 23.
2015
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| 8 | DUSP4
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| Dual specificity phosphatase 4 gene expression in association with triple-negative breast cancer outcome.
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| Baglia ML, Cai Q, Zheng Y, Wu J, Su Y, Ye F, Bao PP, Cai H, Zhao Z, Balko J, Zheng W, Lu W, Shu XO.
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| Breast Cancer Res Treat 148(1):211-20. doi: 10.1007/s10549-014-3127-z. Epub 2014 Oct 4.
2014
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| 9 | DUSP4, TNF
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| Tumor necrosis factor-α-mediated suppression of dual-specificity phosphatase 4: crosstalk between NFκB and MAPK regulates endothelial cell survival.
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| Kao DD, Oldebeken SR, Rai A, Lubos E, Leopold JA, Loscalzo J, Handy DE.
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| Mol Cell Biochem 382(1-2):153-62. doi: 10.1007/s11010-013-1730-7. Epub 2013 Jun 28.
2013
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| 10 | DUSP4, LMNA
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| Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation.
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| Choi JC, Wu W, Muchir A, Iwata S, Homma S, Worman HJ.
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| J Biol Chem 287(48):40513-24. doi: 10.1074/jbc.M112.404541. Epub 2012 Oct 9.
2012
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| 11 | DUSP4, IL2, STAT5B
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| DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development.
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| Huang CY, Lin YC, Hsiao WY, Liao FH, Huang PY, Tan TH.
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| Eur J Immunol 42(2):476-88. doi: 10.1002/eji.201041295. Epub 2011 Dec 27.
2012
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| 12 | DUSP1, DUSP4
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| Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival.
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| Lawan A, Al-Harthi S, Cadalbert L, McCluskey AG, Shweash M, Grassia G, Grant A, Boyd M, Currie S, Plevin R.
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| J Biol Chem 286(15):12933-43. Epub 2011 Feb 11.
2011
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| 13 | DUSP4
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| Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2.
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| Cadalbert LC, Sloss CM, Cunningham MR, Al-Mutairi M, McIntire A, Shipley J, Plevin R.
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| Cell Signal 22(3):357-65. Epub .PMID: 19843478 2010
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| 14 | DUSP4, KRAS, SMYD3
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| Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.
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| Gaedcke J, Grade M, Jung K, Camps J, Jo P, Emons G, Gehoff A, Sax U, Schirmer M, Becker H, Beissbarth T, Ried T, Ghadimi BM.
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| Genes Chromosomes Cancer 49(11):1024-34.
2010
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| 15 | DUSP13, DUSP4
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| Dual-specificity phosphatases: critical regulators with diverse cellular targets.
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| Patterson KI, Brummer T, O'Brien PM, Daly RJ.
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| Biochem J 418(3):475-89. Review. 2009
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| 16 | DUSP4
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| An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.
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| Chitale D, Gong Y, Taylor BS, Broderick S, Brennan C, Somwar R, Golas B, Wang L, Motoi N, Szoke J, Reinersman JM, Major J, Sander C, Seshan VE, Zakowski MF, Rusch V, Pao W, Gerald W, Ladanyi M.
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| Oncogene 28(31):2773-83. Epub 2009 Jun 15.
2009
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| 17 | DUSP4
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| Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly.
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| Jeong DG, Jung SK, Yoon TS, Woo EJ, Kim JH, Park BC, Ryu SE, Kim SJ.
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| Proteins 76(3):763-7. No abstract available. PMID: 19415758 2009
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| 18 | DUSP1, DUSP2, DUSP4, MAPK1
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| Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases.
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| Caunt CJ, Rivers CA, Conway-Campbell BL, Norman MR, McArdle CA.
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| J Biol Chem 283(10):6241-52. Epub 2008 Jan 3.PMID: 18178562 2008
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| 19 | DUSP4, DUSP6, DUSP7
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| Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7).
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| Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A.
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| Genomics 42(3):524-7. 1997
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| 20 | DUSP4, MAPK1, MAPK3
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| Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase.
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| Guan KL, et al.
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| J Biol Chem 270 : 7197-7203. 1995
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